"Pyruvic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Below are MeSH descriptors whose meaning is more general than "Pyruvic Acid".
Below are MeSH descriptors whose meaning is more specific than "Pyruvic Acid".
This graph shows the total number of publications written about "Pyruvic Acid" by people in Harvard Catalyst Profiles by year, and whether "Pyruvic Acid" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 2 | 1 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 4 | 4 |
| 2007 | 1 | 3 | 4 |
| 2008 | 0 | 5 | 5 |
| 2009 | 5 | 0 | 5 |
| 2010 | 7 | 2 | 9 |
| 2011 | 4 | 3 | 7 |
| 2012 | 8 | 2 | 10 |
| 2013 | 3 | 3 | 6 |
| 2014 | 1 | 7 | 8 |
| 2015 | 2 | 3 | 5 |
| 2016 | 2 | 3 | 5 |
| 2017 | 3 | 3 | 6 |
| 2018 | 3 | 4 | 7 |
| 2019 | 6 | 4 | 10 |
| 2020 | 1 | 3 | 4 |
| 2021 | 2 | 1 | 3 |
| 2022 | 1 | 6 | 7 |
| 2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Pyruvic Acid" by people in Profiles.
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Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with Hyperpolarized 13C Pyruvate MRI and Mass Spectrometry. Radiol Imaging Cancer. 2024 Mar; 6(2):e230056.
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A 13C/31P surface coil to visualize metabolism and energetics in the rodent brain at 3 Tesla. J Magn Reson. 2022 10; 343:107286.
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells. Cell Metab. 2022 08 02; 34(8):1137-1150.e6.
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Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. Elife. 2022 07 11; 11.
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Hyperpolarized [1-13C]Pyruvate Magnetic Resonance Spectroscopic Imaging for Evaluation of Early Response to Tyrosine Kinase Inhibition Therapy in Gastric Cancer. Mol Imaging Biol. 2022 10; 24(5):769-779.
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Glyoxylate protects against cyanide toxicity through metabolic modulation. Sci Rep. 2022 03 23; 12(1):4982.
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Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo. Hum Mol Genet. 2022 02 21; 31(4):587-603.
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Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 03; 380(3):210-219.
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Phosphorylation status of pyruvate dehydrogenase in the mousebird Colius striatus undergoing torpor. J Exp Zool A Ecol Integr Physiol. 2022 04; 337(4):337-345.
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Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. NMR Biomed. 2021 08; 34(8):e4560.