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Selwyn Samuel Jayakar, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. 2020 09; 133(3):583-594. PMID: 32541553.
    Citations:    
  2. Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB. Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors. J Biol Chem. 2020 Aug 14; 295(33):11495-11512. PMID: 32540960.
    Citations:    
  3. Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB. Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the a1ß3?2 GABAAR Transmembrane Domain. Mol Pharmacol. 2019 06; 95(6):615-628. PMID: 30952799.
    Citations:    
  4. Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Inhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors. Eur J Med Chem. 2019 Jan 15; 162:810-824. PMID: 30544077.
    Citations:    Fields:    
  5. McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE. Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. 2018 11; 129(5):959-969. PMID: 30052529.
    Citations:    Fields:    
  6. Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE. Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 11; 127(5):824-837. PMID: 28857763.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Jayakar SS, Ang G, Chiara DC, Hamouda AK. Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites. Methods Mol Biol. 2017; 1598:157-197. PMID: 28508361.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Mohamed TS, Jayakar SS, Hamouda AK. Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation. Front Mol Neurosci. 2015; 8:71. PMID: 26635524.
    Citations: 4     
  9. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an a1ß3?2 ?-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the ?+-ß- Interface. J Biol Chem. 2015 Sep 18; 290(38):23432-46. PMID: 26229099.
    Citations: 8     Fields:    Translation:HumansCells
  10. Jayakar SS, Pugh PC, Dale Z, Starr ER, Cole S, Margiotta JF. PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting. Mol Cell Neurosci. 2014 Nov; 63:1-12. PMID: 25168001.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a ?-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. J Biol Chem. 2014 Oct 03; 289(40):27456-68. PMID: 25086038.
    Citations: 33     Fields:    Translation:HumansCells
  12. Hamouda AK, Jayakar SS, Chiara DC, Cohen JB. Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites! J Mol Neurosci. 2014 Jul; 53(3):480-6. PMID: 24158732.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human a1ß3?2 ?-aminobutyric acid type A (GABAA) receptor. J Biol Chem. 2013 Jul 05; 288(27):19343-57. PMID: 23677991.
    Citations: 50     Fields:    Translation:HumansCells
  14. Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog. J Biol Chem. 2013 Mar 01; 288(9):6178-89. PMID: 23300078.
    Citations: 30     Fields:    Translation:AnimalsCells
  15. Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human a1ß3 ?-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 2012 Jan 31; 51(4):836-47. PMID: 22243422.
    Citations: 46     Fields:    Translation:HumansCells
  16. Jayakar SS, Margiotta JF. Abelson family tyrosine kinases regulate the function of nicotinic acetylcholine receptors and nicotinic synapses on autonomic neurons. Mol Pharmacol. 2011 Jul; 80(1):97-109. PMID: 21502378.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Pugh PC, Jayakar SS, Margiotta JF. PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses. Mol Cell Neurosci. 2010 Feb; 43(2):244-57. PMID: 19958833.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Pugh PC, Zhou X, Jayakar SS, Margiotta JF. Depolarization promotes survival of ciliary ganglion neurons by BDNF-dependent and -independent mechanisms. Dev Biol. 2006 Mar 01; 291(1):182-91. PMID: 16426601.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Yogeeswari P, Thirumurugan R, Kavya R, Samuel JS, Stables J, Sriram D. 3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity. Eur J Med Chem. 2004 Aug; 39(8):729-34. PMID: 15276306.
    Citations: 3     Fields:    Translation:Animals
  20. Jayakar SS, Dikshit M. AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs. Int J Neurosci. 2004 Jun; 114(6):695-734. PMID: 15204061.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.