"Photoaffinity Labels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.
Below are MeSH descriptors whose meaning is more general than "Photoaffinity Labels".
Below are MeSH descriptors whose meaning is more specific than "Photoaffinity Labels".
This graph shows the total number of publications written about "Photoaffinity Labels" by people in Harvard Catalyst Profiles by year, and whether "Photoaffinity Labels" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 3 | 3 |
| 1999 | 4 | 3 | 7 |
| 2000 | 2 | 1 | 3 |
| 2001 | 1 | 2 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 3 | 0 | 3 |
| 2005 | 3 | 1 | 4 |
| 2006 | 4 | 0 | 4 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 2 | 3 | 5 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 0 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Photoaffinity Labels" by people in Profiles.
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A Versatile Isocyanate-Mediated Strategy for Appending Chemical Tags onto Drug-Like Small Molecules. Bioconjug Chem. 2023 12 20; 34(12):2181-2186.
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Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents. ACS Chem Biol. 2021 08 20; 16(8):1493-1507.
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Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 05 05; 143(17):6691-6700.
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Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors. J Biol Chem. 2020 08 14; 295(33):11495-11512.
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Inhibitable photolabeling by neurosteroid diazirine analog in the ß3-Subunit of human hetereopentameric type A GABA receptors. Eur J Med Chem. 2019 Jan 15; 162:810-824.
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Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation. ACS Chem Biol. 2017 05 19; 12(5):1353-1362.
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Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites. Methods Mol Biol. 2017; 1598:157-197.
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Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling. Chembiochem. 2016 Apr 15; 17(8):689-92.
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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS. Mol Biosyst. 2015 Oct; 11(10):2709-12.
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Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor. Mol Pharmacol. 2015 Jul; 88(1):1-11.