Harvard Catalyst Profiles

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Christian A. Leguern, Ph.D.

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Research
research activities and funding
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  1. R01AI063408 (LEGUERN, CHRISTIAN) Jun 1, 2005 - Feb 28, 2011
    NIH
    MODULATION OF T LYMPHOCYTE REGULATION
    Role: Principal Investigator
  2. R01AI064344 (LEGUERN, CHRISTIAN) Mar 1, 2005 - Feb 28, 2011
    NIH
    MODULATION OF REGULATORY TOLERANCE TO TRANSPLANTS
    Role: Principal Investigator
  3. R01AI033053 (LEGUERN, CHRISTIAN A) Jul 1, 1992 - Apr 30, 2003
    NIH
    GENE TRANSFER FOR TRANSPLANT TOLERANCE
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee KM, Fu Q, Huai G, Deng K, Lei J, Kojima L, Agarwal D, van Galen P, Kimura S, Tanimine N, Washburn L, Yeh H, Naji A, Rickert CG, LeGuern C, Markmann JF. Suppression of allograft rejection by regulatory B cells induced via TLR signaling. JCI Insight. 2022 09 08; 7(17). PMID: 35943811; PMCID: PMC9536278.
    Citations:    Fields:    Translation:AnimalsCells
  2. Dwyer LJ, Stowe AM, Doyle K, Popovich P, Engler-Chiurazzi E, LeGuern C, Buckwalter MS, Poznansky MC, Sîrbulescu RF. The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022. FASEB J. 2022 08; 36(8):e22459. PMID: 35857314; PMCID: PMC9337863.
    Citations:    Fields:    Translation:Cells
  3. Matheson R, Deng K, Huai G, Lee KM, Feeney N, Coe TM, Cloonan D, Serifis N, Fu Q, Robson SC, Markmann JF, LeGuern C. Interleukin-27 in liver xenotransplantation: A rational target to mitigate ischemia reperfusion injury and increase xenograft survival. Transplant Rev (Orlando). 2022 01; 36(1):100674. PMID: 34861509.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Fu Q, Lee KM, Huai G, Deng K, Agarwal D, Rickert CG, Feeney N, Matheson R, Yang H, LeGuern C, Deng S, Markmann JF. Properties of regulatory B cells regulating B cell targets. Am J Transplant. 2021 12; 21(12):3847-3857. PMID: 34327838; PMCID: PMC8639638.
    Citations:    Fields:    Translation:AnimalsCells
  5. Tanimine N, Burrell BE, Deng K, Rickert C, Lee KM, Feeney N, Pardo J, LeGuern C, Markmann JF. Detection of alloreactive T cells from cryopreserved human peripheral blood mononuclear cells. J Immunol Methods. 2021 04; 491:112987. PMID: 33556344.
    Citations:    Fields:    Translation:HumansCells
  6. LeGuern C, Germana S. On the elusive TCR specificity of thymic regulatory T cells. Am J Transplant. 2019 01; 19(1):15-20. PMID: 30378738.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol. 2016 Jul 14; 1(1). PMID: 27942611.
    Citations: 89     Fields:    
  8. Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol. 2016 Jul 14; 1(1):aaf8759. PMID: 28783676.
    Citations: 11     Fields:    
  9. Scalea JR, Okumi M, Villani V, Shimizu A, Nishimura H, Gillon BC, Torabi R, Cormack T, Moran S, LeGuern C, Sachs DH, Yamada K. Abrogation of renal allograft tolerance in MGH miniature swine: the role of intra-graft and peripheral factors in long-term tolerance. Am J Transplant. 2014 Sep; 14(9):2001-10. PMID: 25100613; PMCID: PMC4194165.
    Citations: 10     Fields:    Translation:AnimalsCells
  10. Kant CD, Akiyama Y, Tanaka K, Shea S, Connolly SE, Germana S, Winn HJ, LeGuern C, Tocco G, Benichou G. Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis. J Immunol. 2013 Aug 15; 191(4):1948-56. PMID: 23833234; PMCID: PMC3735678.
    Citations: 10     Fields:    Translation:AnimalsCells
  11. Porcheray F, DeVito J, Helou Y, Dargon I, Fraser JW, Nobecourt P, Ferdman J, Germana S, Girouard TC, Kawai T, Saidman SL, Wong W, Colvin RB, Leguern C, Zorn E. Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection. Am J Transplant. 2012 Aug; 12(8):2088-97. PMID: 22510337; PMCID: PMC3402627.
    Citations: 22     Fields:    Translation:HumansCells
  12. Leguern C. Regulatory T cells for tolerance therapy: revisiting the concept. Crit Rev Immunol. 2011; 31(3):189-207. PMID: 21740350.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. LeGuern C, Akiyama Y, Germana S, Tanaka K, Fernandez L, Iwamoto Y, Houser S, Benichou G. Intracellular MHC class II controls regulatory tolerance to allogeneic transplants. J Immunol. 2010 Mar 01; 184(5):2394-400. PMID: 20100928; PMCID: PMC2881546.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. LeGuern C. Tolerogenic property of MHC class I and class II molecules: lessons from a gene therapy approach. Front Biosci. 2007 May 01; 12:3133-9. PMID: 17485288.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. LeGuern C. Switching on immune regulation to prevent graft rejection. Transplantation. 2005 May 27; 79(10):1308-9. PMID: 15912096.
    Citations:    Fields:    Translation:HumansAnimals
  16. LeGuern C. Potential role of major histocompatibility complex class II peptides in regulatory tolerance to vascularized grafts. Transplantation. 2004 Jan 15; 77(1 Suppl):S35-7. PMID: 14726769.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Matter-Reissmann UB, Sonntag KC, Gilli UO, Leguern C, Schneider MK, Seebach JD. Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity. Xenotransplantation. 2004 Jan; 11(1):43-52. PMID: 14962292.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Houser SL, McMorrow IM, LeGuern C, Schwarze ML, Fuchimoto Y, Sachs DH, Madsen JC. Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine. J Heart Lung Transplant. 2004 Jan; 23(1):50-60. PMID: 14734127.
    Citations: 2     Fields:    Translation:Animals
  19. LeGuern C. Regulation of T-cell functions by MHC class II self-presentation. Trends Immunol. 2003 Dec; 24(12):633-8. PMID: 14644136.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Lima B, Gleit ZL, Cameron AM, Germana S, Murphy MC, Consorti R, Chang Q, Down JD, LeGuern C, Sachs DH, Huang CA. Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine. Biol Blood Marrow Transplant. 2003 Sep; 9(9):571-82. PMID: 14506659.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Andersson G, Illigens BM, Johnson KW, Calderhead D, LeGuern C, Benichou G, White-Scharf ME, Down JD. Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice. Blood. 2003 Jun 01; 101(11):4305-12. PMID: 12576326.
    Citations: 25     Fields:    Translation:AnimalsCells
  22. Shimada H, Germana S, Hayashi H, Sachs DH, LeGuern C. Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes. Surg Today. 2003; 33(3):183-9. PMID: 12658383.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Haller GW, Lima B, Kunisaki SM, Germana S, Leguern C, Huang CA, Sachs DH. MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses. J Immunol. 2002 Oct 01; 169(7):3613-21. PMID: 12244152.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Gojo S, Yamamoto S, Patience C, LeGuern C, Cooper DK. Gene therapy--its potential in surgery. Ann R Coll Surg Engl. 2002 Sep; 84(5):297-301. PMID: 12398117.
    Citations: 4     Fields:    Translation:HumansCells
  25. McMorrow IM, Buhler L, Treter S, Neethling FA, Alwayn IP, Comrack CA, Kitamura H, Awwad M, DerSimonian H, Cooper DK, Sachs DH, LeGuern C. Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies. Xenotransplantation. 2002 Mar; 9(2):106-14. PMID: 11897003.
    Citations: 4     Fields:    Translation:HumansAnimals
  26. Denaro M, Kolber-Simonds D, Schad V, Muthukumar S, Germana S, White-Scharf ME, Banerjee PT, LeGuern C, Andersson G. Expression of xenogeneic MHC class II molecules in HLA-DR(+) and -DR(-) cells: influence of retrovirus vector design and cellular context. Xenotransplantation. 2002 Mar; 9(2):115-24. PMID: 11897004.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. McMorrow IM, Narayan K, Sachs DH, LeGuern C. New intra-renal graft genes associated with tolerance or rejection. Kidney Int. 2002 Jan; 61(1 Suppl):S85-93. PMID: 11841619.
    Citations:    Fields:    Translation:AnimalsCells
  28. Elliott T, Bonneville M, Kruisbeek A, Walker PR, Essayan D, Glaichenhaus N, Vyakarnam A, Casanova JL, Liu Y, AuchinclossJr H, Waneck G, LeGuern C, Akdis C. Paper alert. Immunology. Curr Opin Immunol. 2001 Dec; 13(6):625-34. PMID: 11677080.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Baron C, McMorrow I, Sachs DH, LeGuern C. Persistence of dominant T cell clones in accepted solid organ transplants. J Immunol. 2001 Oct 15; 167(8):4154-60. PMID: 11591735.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Baron C, Sachs DH, LeGuern C. A particular TCR beta variable region used by T cells infiltrating kidney transplants. J Immunol. 2001 Feb 15; 166(4):2589-96. PMID: 11160320.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Seebach JD, Schneider MK, Comrack CA, LeGuern A, Kolb SA, Knolle PA, Germana S, DerSimonian H, LeGuern C, Sachs DH. Immortalized bone-marrow derived pig endothelial cells. Xenotransplantation. 2001 Feb; 8(1):48-61. PMID: 11208191.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  32. Sonntag KC, Emery DW, Yasumoto A, Haller G, Germana S, Sablinski T, Shimizu A, Yamada K, Shimada H, Arn S, Sachs DH, LeGuern C. Tolerance to solid organ transplants through transfer of MHC class II genes. J Clin Invest. 2001 Jan; 107(1):65-71. PMID: 11134181; PMCID: PMC198548.
    Citations: 13     Fields:    Translation:AnimalsCells
  33. Sonntag KC, Nebhard N, Haller GW, Yasumoto A, Sachs DH, LeGuern C. Assessment of transduction rates of porcine bone marrow. J Hematother Stem Cell Res. 2000 Oct; 9(5):721-6. PMID: 11091496.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Sonntag KC, Haller GW, Giauffret D, Germana S, Reeves SA, Levy J, Sachs DH, LeGuern C. Regulated expression of an MHC class II gene from a promoter-inducible retrovirus. Hum Gene Ther. 2000 Sep 20; 11(14):1961-9. PMID: 11020796.
    Citations: 2     Fields:    Translation:AnimalsCells
  35. Salmon H, Johnson I, Germana S, Haller GW, Sachs DH, Leguern C. Dendritic cells enriched from swine thymus co-express CD1, CD2 and major histocompatibility complex class II and actively stimulate alloreactive T lymphocytes. Scand J Immunol. 2000 Aug; 52(2):164-72. PMID: 10931384.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Bühler L, Treter S, McMorrow I, Neethling FA, Alwayn I, Awwad M, Thall A, Cooper DK, LeGuern C, Sachs DH. Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon. Transplant Proc. 2000 Aug; 32(5):1102. PMID: 10936379.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Gojo S, Cooper DK, Iacomini J, LeGuern C. Gene therapy and transplantation. Transplantation. 2000 May 27; 69(10):1995-9. PMID: 10852583.
    Citations: 3     Fields:    Translation:HumansAnimals
  38. Gojo S, Shimizu A, Ierino FL, Banerjee PT, Cooper DK, LeGuern C, Sachs DH. Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons. Transplant Proc. 2000 Mar; 32(2):289-90. PMID: 10715420.
    Citations: 1     Fields:    Translation:AnimalsCells
  39. Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern C. MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome. Hum Gene Ther. 1999 Sep 20; 10(14):2397-405. PMID: 10515459.
    Citations: 1     Fields:    Translation:AnimalsCells
  40. Seebach JD, Pazmany L, Waneck GL, Minja F, Germana S, LeGuern C, Sachs DH. HLA-G expression on porcine endothelial cells protects partially against direct human NK cytotoxicity but not against ADCC. Transplant Proc. 1999 Jun; 31(4):1864-5. PMID: 10371975.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  41. Ierino FL, Gojo S, Banerjee PT, Giovino M, Xu Y, Gere J, Kaynor C, Awwad M, Monroy R, Rembert J, Hatch T, Foley A, Kozlowski T, Yamada K, Neethling FA, Fishman J, Bailin M, Spitzer TR, Cooper DK, Cosimi AB, LeGuern C, Sachs DH. Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers. Transplantation. 1999 Apr 27; 67(8):1119-28. PMID: 10232561.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Shimada H, Alexander RC, Germana S, Sachs DH, LeGuern C. Recombinant retrovirus vectors for the expression of MHC class II heterodimers. Surg Today. 1999; 29(6):533-41. PMID: 10385368.
    Citations:    Fields:    Translation:AnimalsCells
  43. Emery DW, Shimada H, Germana S, Sachs DH, LeGuern C. Transfer of porcine MHC DRalpha into IEalpha-deficient murine bone marrow results in reduced IE-restricted Vbeta usage. Transplantation. 1998 Oct 27; 66(8):1081-8. PMID: 9808495.
    Citations:    Fields:    Translation:AnimalsCells
  44. Emery DW, Sablinski T, Shimada H, Germana S, Gianello P, Foley A, Shulman S, Arn S, Fishman J, Lorf T, Nickeleit V, Colvin RB, Sachs DH, LeGuern C. Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity. Transplantation. 1997 Nov 27; 64(10):1414-23. PMID: 9392304.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Seebach JD, Comrack C, Germana S, LeGuern C, Sachs DH, DerSimonian H. HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells. J Immunol. 1997 Oct 01; 159(7):3655-61. PMID: 9317166.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  46. Mayfield RS, Hayashi H, Sawada T, Bergen K, LeGuern C, Sykes M, Sachs DH, Iacomini J. The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy. Eur J Immunol. 1997 May; 27(5):1177-81. PMID: 9174608.
    Citations:    Fields:    Translation:AnimalsCells
  47. Giangrande I, Yamada K, Arn S, Lorf T, Sachs DH, LeGuern C. Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection. Transplantation. 1997 Mar 15; 63(5):722-8. PMID: 9075845.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Hayashi H, Mayfield RS, Sawada T, Germana S, Sykes M, Iacomini J, Sachs DH, LeGuern C. Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene. Transplant Proc. 1997 Feb-Mar; 29(1-2):1133. PMID: 9123234.
    Citations:    Fields:    Translation:AnimalsCells
  49. Giangrande I, Yamada K, Germana S, Sachs D, LeGuern C. Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TCR gene expression. Transplant Proc. 1997 Feb-Mar; 29(1-2):1164. PMID: 9123254.
    Citations:    Fields:    Translation:AnimalsCells
  50. Yasumoto A, Yamada K, Sablinski T, LeGuern C, Sykes M, Sachs DH. Mechanism of tolerance following class II gene transduction of autologous swine bone marrow. Transplant Proc. 1997 Feb-Mar; 29(1-2):1132. PMID: 9123233.
    Citations:    Fields:    Translation:AnimalsCells
  51. Germana S, Shimada H, Sachs DH, LeGuern C. Retroviral vectors transfer functional MHC class II heterodimers into bone marrow: a genetic approach to tolerance induction. Transplant Proc. 1997 Feb-Mar; 29(1-2):1129. PMID: 9123230.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  52. Blancho G, Gianello PR, Lorf T, Germana S, Giangrande I, Mourad G, Colvin RB, Sachs DH, LeGuern C. Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine. Transplantation. 1997 Jan 15; 63(1):26-33. PMID: 9000656.
    Citations: 4     Fields:    Translation:AnimalsCells
  53. Hayashi H, LeGuern C, Sachs DH, Sykes M. Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells. Bone Marrow Transplant. 1996 Aug; 18(2):285-92. PMID: 8864436.
    Citations: 4     Fields:    Translation:AnimalsCells
  54. Emery DW, Sachs DH, LeGuern C. Culture and characterization of hematopoietic progenitor cells from miniature swine. Exp Hematol. 1996 Jul; 24(8):927-35. PMID: 8690052.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. Shimada H, Emery DW, Shafer G, Germana S, Sachs DH, LeGuern C. Miniature swine MHC class II heterodimers expressed through double-copy retroviral vectors. Transplant Proc. 1996 Jun; 28(3):1986-9. PMID: 8658969.
    Citations:    Fields:    Translation:AnimalsCells
  56. Paguio CG, Germana S, LeGuern C, Jubinsky P, Sachs DH, Emery DW. Derivation of immortalized swine stromal cell lines. Transplant Proc. 1996 Apr; 28(2):791. PMID: 8623401.
    Citations: 1     Fields:    Translation:AnimalsCells
  57. Banerjee PT, Ierino F, Kaynor GC, Giovino M, Sablinski T, Emery DW, Rosa MD, LeGuern C, Sachs DH, Monroy RL. Retrovirus-mediated transfer and expression of swine MHC class II genes in CD34+ monkey stem cells. Transplant Proc. 1996 Apr; 28(2):747-8. PMID: 8623378.
    Citations:    Fields:    Translation:HumansAnimalsCells
  58. Hayashi H, LeGuern C, Sachs DH, Sykes M. Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction. Transpl Immunol. 1996 Mar; 4(1):86-90. PMID: 8762020.
    Citations:    Fields:    Translation:AnimalsCells
  59. LeGuern C, Shimada H, Emery DW, Germana S, Shafer GE, Sachs DH. Retrovirus-mediated transfer of MHC class II cDNA into swine bone marrow cells. J Mol Med (Berl). 1995 Jun; 73(6):269-78. PMID: 7583449.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  60. Blancho G, Gianello P, Germana S, Baetscher M, Sachs DH, LeGuern C. Molecular identification of porcine interleukin 10: regulation of expression in a kidney allograft model. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2800-4. PMID: 7708727; PMCID: PMC42306.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  61. Fraser CC, Sykes M, Lee RS, Sachs DH, LeGuern C. Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway. J Immunol. 1995 Feb 15; 154(4):1587-95. PMID: 7836744.
    Citations: 3     Fields:    Translation:AnimalsCells
  62. Shimada H, Germana S, Banerjee P, Hayashi H, Sachs DH, LeGuern C. A single retroviral vector for transfer of multiple major histocompatibility complex genes: a genetic tool for transplantation tolerance. Transplant Proc. 1995 Feb; 27(1):180-1. PMID: 7878964.
    Citations:    Fields:    Translation:HumansCells
  63. Giangrande I, Gianello P, Lorf T, Vitiello D, LeGuern C, Sachs DH. Humoral response of miniature swine tolerant to class I mismatched renal allografts. Transplant Proc. 1995 Feb; 27(1):559-60. PMID: 7879098.
    Citations:    Fields:    Translation:Animals
  64. Hayashi H, Lee RS, Germana S, Fraser C, Sykes M, Sachs DH, LeGuern C. Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells. Transplant Proc. 1995 Feb; 27(1):178-9. PMID: 7878962.
    Citations:    Fields:    Translation:AnimalsCells
  65. Emery DW, Sykes M, Sachs DH, LeGuern C. Mixed swine/human long-term bone marrow cultures. Transplant Proc. 1994 Jun; 26(3):1313-4. PMID: 8029921.
    Citations:    Fields:    Translation:HumansAnimalsCells
  66. Emery DW, Sablinski T, Arn JS, LeGuern C, Sachs DH. Bone marrow culture and transduction of stem cells in a miniature swine model. Blood Cells. 1994; 20(2-3):498-502; discussion 502-3. PMID: 7749117.
    Citations: 1     Fields:    Translation:AnimalsCells
  67. Gustafsson K, Germana S, Sundt TM, Sachs DH, LeGuern C. Extensive allelic polymorphism in the CDR2-like region of the miniature swine CD4 molecule. J Immunol. 1993 Aug 01; 151(3):1365-70. PMID: 8335933.
    Citations: 6     Fields:    Translation:AnimalsCells
  68. Emery DW, Shafer GE, Karson EM, Sachs DH, LeGuern C. Retrovirus-mediated transfer and expression of an allogeneic major histocompatibility complex class II DRB cDNA in swine bone marrow cultures. Blood. 1993 May 01; 81(9):2460-5. PMID: 8386951.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  69. Sachs DH, Smith CV, Emery DW, LeGuern C, Bodine D, Nienhuis A, Sykes M. Induction of specific tolerance to MHC-disparate allografts through genetic engineering. Exp Nephrol. 1993 Mar-Apr; 1(2):128-33. PMID: 8081957.
    Citations: 1     Fields:    Translation:Animals
  70. Emery DW, Smith CV, Shafer GE, Karson EM, Sachs DH, LeGuern C. Expression of allogeneic class II cDNA in swine peripheral blood mononuclear cells following retroviral-mediated gene transfer into bone marrow. Transplant Proc. 1993 Feb; 25(1 Pt 1):140-1. PMID: 7679808.
    Citations:    Fields:    Translation:AnimalsCells
  71. Hirsch F, Germana S, Gustafsson K, Pratt K, Sachs DH, Leguern C. Structure and expression of class II alpha genes in miniature swine. J Immunol. 1992 Aug 01; 149(3):841-6. PMID: 1634772.
    Citations: 7     Fields:    Translation:AnimalsCells
  72. Sundt TM, LeGuern C, Germana S, Smith CV, Nakajima K, Lunney JK, Sachs DH. Characterization of a polymorphism of CD4 in miniature swine. J Immunol. 1992 May 15; 148(10):3195-201. PMID: 1578144.
    Citations: 8     Fields:    Translation:Animals
  73. Emery DW, Shafer GE, Karson EM, Sachs DH, LeGuern C. Expression of allogeneic class II cDNA in swine bone marrow cells transduced with a recombinant retrovirus. Transplant Proc. 1992 Apr; 24(2):468-9. PMID: 1566392.
    Citations:    Fields:    Translation:AnimalsCells
  74. Shafer GE, Emery DW, Gustafsson K, Germana S, Anderson WF, Sachs DH, LeGuern C. Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9760-4. PMID: 1946400; PMCID: PMC52800.
    Citations: 3     Fields:    Translation:AnimalsCells
  75. Marche PN, Laverrière A, LeGuern C, Kindt TJ. A gene remnant in the rabbit MHC related to HLA-DR alpha. Res Immunol. 1991 Sep; 142(7):525-32. PMID: 1812548.
    Citations:    Fields:    Translation:HumansAnimalsCells
  76. Sundt TM, LeGuern C, Smith CV, Sachs DH. Identification of a CD4 polymorphism in swine. Transplant Proc. 1991 Feb; 23(1 Pt 1):419-20. PMID: 1990575.
    Citations: 1     Fields:    Translation:Animals
  77. LeGuern C, Shafer GE, Alexander RC, Germana S, Gustafsson K, el-Gamil M, Sachs DH. Expression of swine class II genes using recombinant retroviral vectors. Transplant Proc. 1991 Feb; 23(1 Pt 1):427-8. PMID: 1846714.
    Citations: 1     Fields:    Translation:AnimalsCells
  78. Gustafsson K, Germana S, Hirsch F, Pratt K, LeGuern C, Sachs DH. Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9798-802. PMID: 2124703; PMCID: PMC55261.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  79. Gustafsson K, LeGuern C, Hirsch F, Germana S, Pratt K, Sachs DH. Class II genes of miniature swine. IV. Characterization and expression of two allelic class II DQB cDNA clones. J Immunol. 1990 Sep 15; 145(6):1946-51. PMID: 2391424.
    Citations: 10     Fields:    Translation:AnimalsCells
  80. Cam P, Jouvin-Marche E, LeGuern C, Marche PN. Structure of class II genes in wild mouse Mus saxicola: functional and evolutionary implications. Eur J Immunol. 1990 Jun; 20(6):1337-43. PMID: 2369919.
    Citations: 3     Fields:    Translation:AnimalsCells
  81. Hirsch F, Sachs DH, Gustafsson K, Pratt K, Germana S, LeGuern C. Class II genes of miniature swine. III. Characterization of an expressed pig class II gene homologous to HLA-DQA. Immunogenetics. 1990; 31(1):52-6. PMID: 2298465.
    Citations: 15     Fields:    Translation:AnimalsCells
  82. Pratt K, Sachs DH, Germana S, el-Gamil M, Hirsch F, Gustafsson K, LeGuern C. Class II genes of miniature swine. II. Molecular identification and characterization of B (beta) genes from the SLAc haplotype. Immunogenetics. 1990; 31(1):1-6. PMID: 2298461.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Jouvin-Marche E, Morgado MG, Leguern C, Voegtle D, Bonhomme F, Cazenave PA. The mouse Igh-1a and Igh-1b H chain constant regions are derived from two distinct isotypic genes. Immunogenetics. 1989; 29(2):92-7. PMID: 2563358.
    Citations: 41     Fields:    Translation:Animals
  84. Marche PN, Rebiere MC, Laverrière A, English DW, LeGuern C, Kindt TJ. Definition of rabbit class I and class II MHC gene haplotypes using molecular typing procedures. Immunogenetics. 1989; 29(4):273-6. PMID: 2564845.
    Citations: 2     Fields:    Translation:Animals
  85. Marche PN, Rebiere MC, Leguern C, Kindt TJ. Structure and expression of rabbit MHC genes. Ann Rech Vet. 1989; 20(3):361-5. PMID: 2683959.
    Citations:    Fields:    Translation:Animals
  86. Laverriere A, Kulaga H, Kindt TJ, LeGuern C, Marche PN. A rabbit class II MHC gene with strong similarities to HLA-DRA. Immunogenetics. 1989; 30(2):137-40. PMID: 2759665.
    Citations: 4     Fields:    Translation:AnimalsCells
  87. Kulaga H, Sogn JA, Weissman JD, Marche PN, LeGuern C, Long EO, Kindt TJ. Expression patterns of MHC class II genes in rabbit tissues indicate close homology to human counterparts. J Immunol. 1987 Jul 15; 139(2):587-92. PMID: 3474276.
    Citations: 7     Fields:    Translation:HumansAnimals
  88. LeGuern C, Weissman JD, Marche PN, Jouvin-Marche E, Laverrière A, Bagnato MR, Kindt TJ. Sequence determination of a transcribed rabbit class II gene with homology to HLA-DQ alpha. Immunogenetics. 1987; 25(2):104-9. PMID: 3493213.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  89. LeGuern C, Marche PN, Kindt TJ. Molecular evidence for five distinct MHC class II alpha genes in the rabbit. Immunogenetics. 1985; 22(2):141-8. PMID: 3861576.
    Citations: 10     Fields:    Translation:Animals
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