Harvard Catalyst Profiles

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Vijaya Ramesh, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA201130 (RAMESH, VIJAYA) Aug 10, 2016 - Jul 31, 2020
    NIH/NCI
    Phase II trial of mTORC1/mTORC2 inhibitor AZD2014 for sporadic meningioma
    Role: Co-Principal Investigator
  2. R21NS082482 (RAMESH, VIJAYA) Mar 1, 2013 - Feb 28, 2015
    NIH/NINDS
    Preclinical Treatment for NF2-Associated Tumors
    Role: Co-Principal Investigator
  3. R21MH079213 (RAMESH, VIJAYA) Aug 24, 2007 - Jul 31, 2009
    NIH/NIMH
    Genes that deregulate mTOR signaling as candidates for autism spectrum disorders
    Role: Principal Investigator
  4. R13NS056801 (RAMESH, VIJAYA) Jul 15, 2006 - Jun 30, 2007
    NIH/NINDS
    2006 NF Consortium for NF1, NF2 and Schwannomatosis
    Role: Principal Investigator
  5. P30NS045776 (BREAKEFIELD, XANDRA OWENS) May 1, 2003 - Nov 30, 2018
    NIH/NINDS
    Interdepartmental Neuroscience Center
    Role: Co-Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rauen KA, Alsaegh A, Ben-Shachar S, Berman Y, Blakeley J, Cordeiro I, Elgersma Y, Evans DG, Fisher MJ, Frayling IM, George J, Huson SM, Kerr B, Khire U, Korf B, Legius E, Messiaen L, van Minkelen R, Nampoothiri S, Ngeow J, Parada LF, Phadke S, Pillai A, Plotkin SR, Puri R, Raji A, Ramesh V, Ratner N, Shankar SP, Sharda S, Tambe A, Vikkula M, Widemann BC, Wolkenstein P, Upadhyaya M. First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics. Am J Med Genet A. 2019 Jun; 179(6):1091-1097. PMID: 30908877.
    Citations:    
  2. Angus SP, Oblinger JL, Stuhlmiller TJ, DeSouza PA, Beauchamp RL, Witt L, Chen X, Jordan JT, Gilbert TSK, Stemmer-Rachamimov A, Gusella JF, Plotkin SR, Haggarty SJ, Chang LS, Johnson GL, Ramesh V. EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma. Neuro Oncol. 2018 Aug 02; 20(9):1185-1196. PMID: 29982664.
    Citations:    Fields:    
  3. Allaway R, Angus SP, Beauchamp RL, Blakeley JO, Bott M, Burns SS, Carlstedt A, Chang LS, Chen X, Clapp DW, Desouza PA, Erdin S, Fernandez-Valle C, Guinney J, Gusella JF, Haggarty SJ, Johnson GL, La Rosa S, Morrison H, Petrilli AM, Plotkin SR, Pratap A, Ramesh V, Sciaky N, Stemmer-Rachamimov A, Stuhlmiller TJ, Talkowski ME, Welling DB, Yates CW, Zawistowski JS, Zhao WN. Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2. PLoS One. 2018; 13(6):e0197350. PMID: 29897904.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Jordan JT, Smith MJ, Walker JA, Erdin S, Talkowski ME, Merker VL, Ramesh V, Cai W, Harris GJ, Bredella MA, Seijo M, Suuberg A, Gusella JF, Plotkin SR. Pain correlates with germline mutation in schwannomatosis. Medicine (Baltimore). 2018 Feb; 97(5):e9717. PMID: 29384852.
    Citations:    Fields:    Translation:Humans
  5. Blakeley JO, Bakker A, Barker A, Clapp W, Ferner R, Fisher MJ, Giovannini M, Gutmann DH, Karajannis MA, Kissil JL, Legius E, Lloyd AC, Packer RJ, Ramesh V, Riccardi VM, Stevenson DA, Ullrich NJ, Upadhyaya M, Stemmer-Rachamimov A. The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis. Am J Med Genet A. 2017 Jun; 173(6):1714-1721. PMID: 28436162.
    Citations: 2     Fields:    Translation:Humans
  6. Nigim F, Esaki S, Hood M, Lelic N, James MF, Ramesh V, Stemmer-Rachamimov A, Cahill DP, Brastianos PK, Rabkin SD, Martuza RL, Wakimoto H. A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus. Neuro Oncol. 2016 09; 18(9):1278-87. PMID: 26951380.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Li L, Walsh RM, Wagh V, James MF, Beauchamp RL, Chang YS, Gusella JF, Hochedlinger K, Ramesh V. Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency. PLoS One. 2015; 10(10):e0140192. PMID: 26445504.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Beauchamp RL, James MF, DeSouza PA, Wagh V, Zhao WN, Jordan JT, Stemmer-Rachamimov A, Plotkin SR, Gusella JF, Haggarty SJ, Ramesh V. A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas. Oncotarget. 2015 Jul 10; 6(19):16981-97. PMID: 26219339.
    Citations: 10     Fields:    Translation:HumansCells
  9. Kim T, Ramesh V, Dworak M, Choi DS, McCarley RW, Kalinchuk AV, Basheer R. Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice. Neuroscience. 2015 Sep 10; 303:211-9. PMID: 26143012.
    Citations: 3     Fields:    Translation:Animals
  10. Prabhakar S, Zhang X, Goto J, Han S, Lai C, Bronson R, Sena-Esteves M, Ramesh V, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO. Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. Neurobiol Dis. 2015 Oct; 82:22-31. PMID: 26019056.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A. 2014 Mar; 164A(3):563-78. PMID: 24443315.
    Citations: 5     Fields:    Translation:Humans
  12. Bahl S, Chiang C, Beauchamp RL, Neale BM, Daly MJ, Gusella JF, Talkowski ME, Ramesh V. Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder. Mol Autism. 2013 Mar 20; 4(1):5. PMID: 23514105.
    Citations: 4     Fields:    
  13. Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V. The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. J Biol Chem. 2012 Aug 31; 287(36):30063-72. PMID: 22798074.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  14. James MF, Stivison E, Beauchamp R, Han S, Li H, Wallace MR, Gusella JF, Stemmer-Rachamimov AO, Ramesh V. Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types. Mol Cancer Res. 2012 May; 10(5):649-59. PMID: 22426462.
    Citations: 33     Fields:    Translation:HumansCells
  15. Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. Am J Med Genet A. 2010 Feb; 152A(2):269-83. PMID: 20082461.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Shen Y, Nunes F, Stemmer-Rachamimov A, James M, Mohapatra G, Plotkin S, Betensky RA, Engler DA, Roy J, Ramesh V, Gusella JF. Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas. BMC Med Genomics. 2009 Jul 09; 2:42. PMID: 19589153.
    Citations: 8     Fields:    
  17. James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V. NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. Mol Cell Biol. 2009 Aug; 29(15):4250-61. PMID: 19451225.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  18. Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V. Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clin Cancer Res. 2009 Mar 15; 15(6):1940-6. PMID: 19276265.
    Citations: 17     Fields:    Translation:HumansCells
  19. Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med. 2008 Aug; 14(8):843-8. PMID: 18568033.
    Citations: 302     Fields:    Translation:AnimalsCells
  20. Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell Signal. 2008 Jun; 20(6):1084-91. PMID: 18308511.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  21. Basheer R, Bauer A, Elmenhorst D, Ramesh V, McCarley RW. Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain. Neuroreport. 2007 Dec 03; 18(18):1895-9. PMID: 18007182.
    Citations: 27     Fields:    Translation:AnimalsCells
  22. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 01; 283(5):2986-96. PMID: 18055461.
    Citations: 22     Fields:    Translation:AnimalsCells
  23. Blalock TD, Spurr-Michaud SJ, Tisdale AS, Heimer SR, Gilmore MS, Ramesh V, Gipson IK. Functions of MUC16 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2007 Oct; 48(10):4509-18. PMID: 17898272.
    Citations: 71     Fields:    Translation:HumansCells
  24. James MF, Lelke JM, Maccollin M, Plotkin SR, Stemmer-Rachamimov AO, Ramesh V, Gusella JF. Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth. Neurobiol Dis. 2008 Feb; 29(2):278-92. PMID: 17962031.
    Citations: 15     Fields:    Translation:HumansCells
  25. Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V. Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. J Biol Chem. 2007 Nov 02; 282(44):32152-7. PMID: 17848560.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  26. Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris T, Zmuda JM, Ziv E. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007 Apr; 80(4):716-26. PMID: 17357077.
    Citations: 80     Fields:    Translation:HumansCells
  27. Ramesh V, Thatte HS, McCarley RW, Basheer R. Adenosine and sleep deprivation promote NF-kappaB nuclear translocation in cholinergic basal forebrain. J Neurochem. 2007 Mar; 100(5):1351-63. PMID: 17316404.
    Citations: 13     Fields:    Translation:AnimalsCells
  28. Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V. Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):826-31. PMID: 16899217.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Santos TM, Han S, Bowser M, Sazani K, Beauchamp RL, Murthy V, Bhide PG, Ramesh V. Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc. J Neurosci Res. 2006 Feb 01; 83(2):222-32. PMID: 16342205.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  30. Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. J Neurosci Res. 2005 Dec 01; 82(5):650-8. PMID: 16273548.
    Citations: 23     Fields:    Translation:AnimalsCells
  31. Nunes F, Shen Y, Niida Y, Beauchamp R, Stemmer-Rachamimov AO, Ramesh V, Gusella J, MacCollin M. Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma. Cancer Genet Cytogenet. 2005 Oct 15; 162(2):135-9. PMID: 16213361.
    Citations: 16     Fields:    Translation:HumansCells
  32. Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Exp Cell Res. 2005 Aug 01; 308(1):177-87. PMID: 15913605.
    Citations: 10     Fields:    Translation:AnimalsCells
  33. Manchanda N, Lyubimova A, Ho HY, James MF, Gusella JF, Ramesh N, Snapper SB, Ramesh V. The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function. J Biol Chem. 2005 Apr 01; 280(13):12517-22. PMID: 15699051.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  34. Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene. 2004 Nov 18; 23(54):8815-25. PMID: 15467741.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Lee-Jones L, Aligianis I, Davies PA, Puga A, Farndon PA, Stemmer-Rachamimov A, Ramesh V, Sampson JR. Sacrococcygeal chordomas in patients with tuberous sclerosis complex show somatic loss of TSC1 or TSC2. Genes Chromosomes Cancer. 2004 Sep; 41(1):80-5. PMID: 15236319.
    Citations: 20     Fields:    Translation:Humans
  36. Ramesh V, Thakkar MM, Strecker RE, Basheer R, McCarley RW. Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav Brain Res. 2004 Jul 09; 152(2):271-8. PMID: 15196795.
    Citations: 12     Fields:    Translation:Animals
  37. Hewett JW, Kamm C, Boston H, Beauchamp R, Naismith T, Ozelius L, Hanson PI, Breakefield XO, Ramesh V. TorsinB--perinuclear location and association with torsinA. J Neurochem. 2004 Jun; 89(5):1186-94. PMID: 15147511.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  38. Ramesh V. Merlin and the ERM proteins in Schwann cells, neurons and growth cones. Nat Rev Neurosci. 2004 Jun; 5(6):462-70. PMID: 15152196.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  39. James MF, Beauchamp RL, Manchanda N, Kazlauskas A, Ramesh V. A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. J Cell Sci. 2004 Jun 15; 117(Pt 14):2951-61. PMID: 15161943.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  40. Kamm C, Boston H, Hewett J, Wilbur J, Corey DP, Hanson PI, Ramesh V, Breakefield XO. The early onset dystonia protein torsinA interacts with kinesin light chain 1. J Biol Chem. 2004 May 07; 279(19):19882-92. PMID: 14970196.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  41. Han S, Santos TM, Puga A, Roy J, Thiele EA, McCollin M, Stemmer-Rachamimov A, Ramesh V. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions. Cancer Res. 2004 Feb 01; 64(3):812-6. PMID: 14871804.
    Citations: 21     Fields:    Translation:HumansCells
  42. Roberts PS, Ramesh V, Dabora S, Kwiatkowski DJ. A 34 bp deletion within TSC2 is a rare polymorphism, not a pathogenic mutation. Ann Hum Genet. 2003 Nov; 67(Pt 6):495-503. PMID: 14641237.
    Citations: 4     Fields:    Translation:HumansCells
  43. Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. J Biol Chem. 2004 Jan 09; 279(2):1351-8. PMID: 14559897.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  44. Augood SJ, Keller-McGandy CE, Siriani A, Hewett J, Ramesh V, Sapp E, DiFiglia M, Breakefield XO, Standaert DG. Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain. Brain Res. 2003 Oct 03; 986(1-2):12-21. PMID: 12965225.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  45. Ramesh V. Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem Soc Trans. 2003 Jun; 31(Pt 3):579-83. PMID: 12773159.
    Citations: 7     Fields:    Translation:HumansCells
  46. Hewett J, Ziefer P, Bergeron D, Naismith T, Boston H, Slater D, Wilbur J, Schuback D, Kamm C, Smith N, Camp S, Ozelius LJ, Ramesh V, Hanson PI, Breakefield XO. TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress. J Neurosci Res. 2003 Apr 15; 72(2):158-68. PMID: 12671990.
    Citations: 45     Fields:    Translation:AnimalsCells
  47. Rostasy K, Augood SJ, Hewett JW, Leung JC, Sasaki H, Ozelius LJ, Ramesh V, Standaert DG, Breakefield XO, Hedreen JC. TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion. Neurobiol Dis. 2003 Feb; 12(1):11-24. PMID: 12609485.
    Citations: 49     Fields:    Translation:HumansCells
  48. Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V. The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. J Biol Chem. 2002 Nov 15; 277(46):44180-6. PMID: 12226091.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  49. Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V, Hough LB, McCarley RW. Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study. Neuroscience. 2002; 113(3):663-70. PMID: 12150786.
    Citations: 19     Fields:    Translation:AnimalsCells
  50. Niida Y, Stemmer-Rachamimov AO, Logrip M, Tapon D, Perez R, Kwiatkowski DJ, Sims K, MacCollin M, Louis DN, Ramesh V. Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am J Hum Genet. 2001 Sep; 69(3):493-503. PMID: 11468687.
    Citations: 44     Fields:    Translation:HumansCells
  51. Sharma N, Hewett J, Ozelius LJ, Ramesh V, McLean PJ, Breakefield XO, Hyman BT. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001 Jul; 159(1):339-44. PMID: 11438481.
    Citations: 23     Fields:    Translation:HumansCells
  52. James MF, Manchanda N, Gonzalez-Agosti C, Hartwig JH, Ramesh V. The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J. 2001 Jun 01; 356(Pt 2):377-86. PMID: 11368764.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  53. Thakkar MM, Ramesh V, Strecker RE, McCarley RW. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats. Arch Ital Biol. 2001 Apr; 139(3):313-28. PMID: 11330208.
    Citations: 37     Fields:    Translation:AnimalsCells
  54. Murthy V, Stemmer-Rachamimov AO, Haddad LA, Roy JE, Cutone AN, Beauchamp RL, Smith N, Louis DN, Ramesh V. Developmental expression of the tuberous sclerosis proteins tuberin and hamartin. Acta Neuropathol. 2001 Mar; 101(3):202-10. PMID: 11307618.
    Citations: 10     Fields:    Translation:HumansAnimals
  55. Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan; 158(1):57-62. PMID: 11141479.
    Citations: 42     Fields:    Translation:HumansCells
  56. Basheer R, Rainnie DG, Porkka-Heiskanen T, Ramesh V, McCarley RW. Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat. Neuroscience. 2001; 104(3):731-9. PMID: 11440805.
    Citations: 19     Fields:    Translation:AnimalsCells
  57. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem. 2000 Dec 01; 275(48):37559-64. PMID: 10980202.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  58. Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D. The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem. 2000 Jun 16; 275(24):18219-24. PMID: 10748165.
    Citations: 36     Fields:    Translation:AnimalsCells
  59. Castells A, Gusella JF, Ramesh V, Rustgi AK. A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers. Cancer Res. 2000 Jun 01; 60(11):2836-9. PMID: 10850424.
    Citations: 25     Fields:    Translation:HumansCells
  60. Hewett J, Gonzalez-Agosti C, Slater D, Ziefer P, Li S, Bergeron D, Jacoby DJ, Ozelius LJ, Ramesh V, Breakefield XO. Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells. Hum Mol Genet. 2000 May 22; 9(9):1403-13. PMID: 10814722.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  61. Murthy V, Haddad LA, Smith N, Pinney D, Tyszkowski R, Brown D, Ramesh V. Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney. Am J Physiol Renal Physiol. 2000 May; 278(5):F737-46. PMID: 10807585.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  62. Gonzalez-Agosti C, Wiederhold T, Herndon ME, Gusella J, Ramesh V. Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF. J Biol Chem. 1999 Nov 26; 274(48):34438-42. PMID: 10567424.
    Citations: 17     Fields:    Translation:AnimalsCells
  63. Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK. Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. Gastroenterology. 1999 Oct; 117(4):831-7. PMID: 10500065.
    Citations: 16     Fields:    Translation:HumansCells
  64. Choy YS, Dabora SL, Hall F, Ramesh V, Niida Y, Franz D, Kasprzyk-Obara J, Reeve MP, Kwiatkowski DJ. Superiority of denaturing high performance liquid chromatography over single-stranded conformation and conformation-sensitive gel electrophoresis for mutation detection in TSC2. Ann Hum Genet. 1999 Sep; 63(Pt 5):383-91. PMID: 10735580.
    Citations: 15     Fields:    Translation:Humans
  65. Ikeda K, Saeki Y, Gonzalez-Agosti C, Ramesh V, Chiocca EA. Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. J Neurosurg. 1999 Jul; 91(1):85-92. PMID: 10389885.
    Citations: 14     Fields:    Translation:HumansCells
  66. Gusella JF, Ramesh V, MacCollin M, Jacoby LB. Merlin: the neurofibromatosis 2 tumor suppressor. Biochim Biophys Acta. 1999 Mar 25; 1423(2):M29-36. PMID: 10214350.
    Citations: 18     Fields:    Translation:Humans
  67. Niida Y, Lawrence-Smith N, Banwell A, Hammer E, Lewis J, Beauchamp RL, Sims K, Ramesh V, Ozelius L. Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis. Hum Mutat. 1999; 14(5):412-22. PMID: 10533067.
    Citations: 33     Fields:    Translation:HumansCells
  68. Thakkar MM, Ramesh V, Cape EG, Winston S, Strecker RE, McCarley RW. REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation. Sleep Res Online. 1999; 2(4):112-20. PMID: 11382892.
    Citations: 20     Fields:    Translation:Animals
  69. Stemmer-Rachamimov AO, Ino Y, Lim ZY, Jacoby LB, MacCollin M, Gusella JF, Ramesh V, Louis DN. Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2. J Neuropathol Exp Neurol. 1998 Dec; 57(12):1164-7. PMID: 9862639.
    Citations: 8     Fields:    Translation:Humans
  70. Stemmer-Rachamimov AO, Nielsen GP, Rosenberg AE, Louis DN, Jones D, Ramesh V, Gusella JF, Jacoby LB. The NF2 gene and merlin protein in human osteosarcomas. Neurogenetics. 1998 Dec; 2(1):73-4. PMID: 9933303.
    Citations: 7     Fields:    Translation:Humans
  71. Coughlin EM, Christensen E, Kunz PL, Krishnamoorthy KS, Walker V, Dennis NR, Chalmers RA, Elpeleg ON, Whelan D, Pollitt RJ, Ramesh V, Mandell R, Shih VE. Molecular analysis and prenatal diagnosis of human fumarase deficiency. Mol Genet Metab. 1998 Apr; 63(4):254-62. PMID: 9635293.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  72. Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem. 1998 Jan 16; 273(3):1273-6. PMID: 9430655.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  73. Xu L, Gonzalez-Agosti C, Beauchamp R, Pinney D, Sterner C, Ramesh V. Analysis of molecular domains of epitope-tagged merlin isoforms in Cos-7 cells and primary rat Schwann cells. Exp Cell Res. 1998 Jan 10; 238(1):231-40. PMID: 9457076.
    Citations: 9     Fields:    Translation:AnimalsCells
  74. Beauchamp RL, Banwell A, McNamara P, Jacobsen M, Higgins E, Northrup H, Short P, Sims K, Ozelius L, Ramesh V. Exon scanning of the entire TSC2 gene for germline mutations in 40 unrelated patients with tuberous sclerosis. Hum Mutat. 1998; 12(6):408-16. PMID: 9829910.
    Citations: 10     Fields:    Translation:HumansCells
  75. Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, Burwick JA, Pinney D, Beauchamp R, Jacoby LB, Gusella JF, Ramesh V, Louis DN. Universal absence of merlin, but not other ERM family members, in schwannomas. Am J Pathol. 1997 Dec; 151(6):1649-54. PMID: 9403715.
    Citations: 22     Fields:    Translation:Humans
  76. Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L, Burwick JA, Beauchamp R, Pinney D, Louis DN, Ramesh V. Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system. J Neuropathol Exp Neurol. 1997 Jun; 56(6):735-42. PMID: 9184664.
    Citations: 9     Fields:    Translation:HumansCells
  77. Gonzalez-Agosti C, Xu L, Pinney D, Beauchamp R, Hobbs W, Gusella J, Ramesh V. The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene. 1996 Sep 19; 13(6):1239-47. PMID: 8808698.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  78. Jacoby LB, MacCollin M, Barone R, Ramesh V, Gusella JF. Frequency and distribution of NF2 mutations in schwannomas. Genes Chromosomes Cancer. 1996 Sep; 17(1):45-55. PMID: 8889506.
    Citations: 30     Fields:    Translation:HumansCells
  79. Long KR, Trofatter JA, Ramesh V, McCormick MK, Buckler AJ. Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL). Genomics. 1996 Aug 01; 35(3):466-72. PMID: 8844170.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  80. Wilson PJ, Ramesh V, Kristiansen A, Bove C, Jozwiak S, Kwiatkowski DJ, Short MP, Haines JL. Novel mutations detected in the TSC2 gene from both sporadic and familial TSC patients. Hum Mol Genet. 1996 Feb; 5(2):249-56. PMID: 8824881.
    Citations: 16     Fields:    Translation:HumansCells
  81. Gusella JF, Ramesh V, MacCollin M, Jacoby LB. Neurofibromatosis 2: loss of merlin's protective spell. Curr Opin Genet Dev. 1996 Feb; 6(1):87-92. PMID: 8791482.
    Citations: 7     Fields:    Translation:HumansAnimals
  82. Rustgi AK, Xu L, Pinney D, Sterner C, Beauchamp R, Schmidt S, Gusella JF, Ramesh V. Neurofibromatosis 2 gene in human colorectal cancer. Cancer Genet Cytogenet. 1995 Oct 01; 84(1):24-6. PMID: 7497438.
    Citations: 12     Fields:    Translation:HumansCells
  83. Shih VE, Fringer JM, Mandell R, Kraus JP, Berry GT, Heidenreich RA, Korson MS, Levy HL, Ramesh V. A missense mutation (I278T) in the cystathionine beta-synthase gene prevalent in pyridoxine-responsive homocystinuria and associated with mild clinical phenotype. Am J Hum Genet. 1995 Jul; 57(1):34-9. PMID: 7611293.
    Citations: 11     Fields:    Translation:HumansCells
  84. Xu L, Sterner C, Maheshwar MM, Wilson PJ, Nellist M, Short PM, Haines JL, Sampson JR, Ramesh V. Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. Genomics. 1995 Jun 10; 27(3):475-80. PMID: 7558029.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  85. Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol. 1995 Apr; 5(2):163-72. PMID: 7670657.
    Citations: 9     Fields:    Translation:Humans
  86. Wellenreuther R, Kraus JA, Lenartz D, Menon AG, Schramm J, Louis DN, Ramesh V, Gusella JF, Wiestler OD, von Deimling A. Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. Am J Pathol. 1995 Apr; 146(4):827-32. PMID: 7717450.
    Citations: 43     Fields:    Translation:HumansCells
  87. von Deimling A, Kraus JA, Stangl AP, Wellenreuther R, Lenartz D, Schramm J, Louis DN, Ramesh V, Gusella JF, Wiestler OD. Evidence for subarachnoid spread in the development of multiple meningiomas. Brain Pathol. 1995 Jan; 5(1):11-4. PMID: 7767486.
    Citations: 2     Fields:    Translation:HumansCells
  88. Ueki K, Rubio MP, Ramesh V, Correa KM, Rutter JL, von Deimling A, Buckler AJ, Gusella JF, Louis DN. MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p. Hum Mol Genet. 1994 Oct; 3(10):1841-5. PMID: 7849711.
    Citations: 16     Fields:    Translation:HumansCells
  89. MacCollin M, Ramesh V, Jacoby LB, Louis DN, Rubio MP, Pulaski K, Trofatter JA, Short MP, Bove C, Eldridge R, et al. Mutational analysis of patients with neurofibromatosis 2. Am J Hum Genet. 1994 Aug; 55(2):314-20. PMID: 7913580.
    Citations: 19     Fields:    Translation:HumansCells
  90. Jacoby LB, MacCollin M, Louis DN, Mohney T, Rubio MP, Pulaski K, Trofatter JA, Kley N, Seizinger B, Ramesh V, et al. Exon scanning for mutation of the NF2 gene in schwannomas. Hum Mol Genet. 1994 Mar; 3(3):413-9. PMID: 8012353.
    Citations: 37     Fields:    Translation:HumansCells
  91. Haase VH, Trofatter JA, MacCollin M, Tarttelin E, Gusella JF, Ramesh V. The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms. Hum Mol Genet. 1994 Mar; 3(3):407-11. PMID: 8012352.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  92. Beena KR, Zaheer SA, Guleria I, Mukherjee R, Talwar GP, Mukherjee A, Ramesh V, Misra RS. Localized lepromatous leprosy and its response to chemo-immunotherapy. Int J Dermatol. 1994 Jan; 33(1):64-7. PMID: 8112948.
    Citations:    Fields:    Translation:Humans
  93. Rubio MP, Correa KM, Ramesh V, MacCollin MM, Jacoby LB, von Deimling A, Gusella JF, Louis DN. Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas. Cancer Res. 1994 Jan 01; 54(1):45-7. PMID: 8261460.
    Citations: 30     Fields:    Translation:HumansCells
  94. MacCollin M, Mohney T, Trofatter J, Wertelecki W, Ramesh V, Gusella J. DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree. JAMA. 1993 Nov 17; 270(19):2316-20. PMID: 8230593.
    Citations: 13     Fields:    Translation:HumansCells
  95. Hu FL, Gu Z, Kozich V, Kraus JP, Ramesh V, Shih VE. Molecular basis of cystathionine beta-synthase deficiency in pyridoxine responsive and nonresponsive homocystinuria. Hum Mol Genet. 1993 Nov; 2(11):1857-60. PMID: 7506602.
    Citations: 17     Fields:    Translation:HumansCells
  96. Ramesh N, Fuleihan R, Ramesh V, Lederman S, Yellin MJ, Sharma S, Chess L, Rosen FS, Geha RS. Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Int Immunol. 1993 Jul; 5(7):769-73. PMID: 8103673.
    Citations: 21     Fields:    Translation:HumansCells
  97. Ramesh N, Ramesh V, Gusella JF, Geha R. Chromosomal localization of the gene for human B-cell antigen CD40. Somat Cell Mol Genet. 1993 May; 19(3):295-8. PMID: 7687385.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  98. Park JK, Herron BJ, O'Donnell JJ, Shih VE, Ramesh V. Three novel mutations of the ornithine aminotransferase (OAT) gene in gyrate atrophy. Genomics. 1992 Oct; 14(2):553-4. PMID: 1427882.
    Citations: 2     Fields:    Translation:HumansCells
  99. Park JK, O'Donnell JJ, Shih VE, Gusella JF, Ramesh V. A 15-bp deletion in exon 5 of the ornithine aminotransferase (OAT) locus associated with gyrate atrophy. Hum Mutat. 1992; 1(4):293-7. PMID: 1301936.
    Citations: 1     Fields:    Translation:HumansCells
  100. Ramesh V, Cheng SV, Kozak CA, Herron BJ, Shih VE, Taylor BA, Gusella JF. Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3. Mamm Genome. 1992; 3(1):17-22. PMID: 1349842.
    Citations: 4     Fields:    Translation:AnimalsCells
  101. Ramesh V, Gusella JF, Shih VE. Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency. Mol Biol Med. 1991 Feb; 8(1):81-93. PMID: 1682785.
    Citations: 4     Fields:    Translation:HumansCells
  102. McClatchey AI, Kaufman DL, Berson EL, Tobin AJ, Shih VE, Gusella JF, Ramesh V. Splicing defect at the ornithine aminotransferase (OAT) locus in gyrate atrophy. Am J Hum Genet. 1990 Nov; 47(5):790-4. PMID: 2220818.
    Citations: 6     Fields:    Translation:HumansCells
  103. Ramesh V, McClatchey AI, Ramesh N, Benoit LA, Berson EL, Shih VE, Gusella JF. Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3777-80. PMID: 3375240.
    Citations: 10     Fields:    Translation:Humans
  104. Ramesh V, Benoit LA, Crawford P, Harvey PT, Shows TB, Shih VE, Gusella JF. The ornithine aminotransferase (OAT) locus: analysis of RFLPs in gyrate atrophy. Am J Hum Genet. 1988 Feb; 42(2):365-72. PMID: 2893548.
    Citations: 11     Fields:    Translation:HumansCells
  105. Ramesh V, Eddy R, Bruns GA, Shih VE, Shows TB, Gusella JF. Localization of the ornithine aminotransferase gene and related sequences on two human chromosomes. Hum Genet. 1987 Jun; 76(2):121-6. PMID: 2886418.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  106. Ramesh V, Shaffer MM, Allaire JM, Shih VE, Gusella JF. Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase. DNA. 1986 Dec; 5(6):493-501. PMID: 3816496.
    Citations: 19     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.