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Sellers, William
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William Raj Sellers, M.D.
Title
Professor of Medicine
Institution
Dana-Farber Cancer Institute
Department
Medicine
Address
Dana-Farber Cancer Institute
Division of Molec/Cellular Oncology DA-1628
450 Brookline Ave
Boston MA 02215
Phone
617/632-5261
Fax
617/582-7790
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
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to make corrections and additions.
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R01CA233626
(SELLERS, WILLIAM R)
Jul 1, 2019 - Jun 30, 2024
NIH
The function of the PRMT5 methylosome in MTAP deleted cancers
Role: Principal Investigator
R01CA085912
(GARRAWAY, LEVI ALEXANDER)
Jun 1, 2000 - May 31, 2010
NIH
Functional Analysis of the PTEN Tumor Suppressor Protein
Role: Co-Principal Investigator
K11CA065594
(SELLERS, WILLIAM R)
Apr 1, 1995 - Mar 31, 2000
NIH
FUNCTIONAL ANALYSIS OF RBAP2
Role: Principal Investigator
F32CA059312
(SELLERS, WILLIAM R)
Jul 1, 1994
NIH
CLONING &CHARACTERIZATION OF P54, AN RB BINDING PROTEIN
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
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Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Chang L, Ruiz P,
Ito T
,
Sellers WR
. Targeting pan-essential genes in cancer: challenges and opportunities. Cancer Cell. 2021 Jan 14.
PMID:
33450197
.
Citations:
Fields:
Neo
Neoplasms
LaMarche MJ, Acker M, Argintaru A, Bauer D, Boisclair J, Chan H, Chen CH, Chen YN, Chen Z, Deng Z, Dore M, Dunstan D, Fan J, Fekkes P, Firestone B, Fodor M, Garcia-Fortanet J, Fortin PD, Fridrich C, Giraldes J, Glick M, Grunenfelder D, Hao HX, Hentemann M, Ho S, Jouk A, Kang ZB, Karki R, Kato M, Keen N, Koenig R, LaBonte LR, Larrow J, Liu G, Liu S, Majumdar D, Mathieu S, Meyer MJ,
Mohseni M
, Ntaganda R, Palermo M, Perez L, Pu M, Ramsey T, Reilly J, Sarver P,
Sellers WR
, Sendzik M, Shultz MD, Slisz J, Slocum K, Smith T, Spence S, Stams T, Straub C, Tamez V, Toure BB, Towler C, Wang P, Wang H, Williams SL, Yang F, Yu B, Zhang JH, Zhu S. Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J Med Chem. 2020 11 25; 63(22):13578-13594.
PMID:
32910655
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Humans
Animals
Cells
Atack TC, Raymond DD, Blomquist CA, Pasaje CF, McCarren PR, Moroco J, Befekadu HB, Robinson FP,
Pal D
, Esherick LY, Ianari A, Niles JC,
Sellers WR
. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Med Chem Lett. 2020 Nov 12; 11(11):2131-2138.
PMID:
33209191
.
Citations:
Palmer AC,
Plana D
, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Muszynski J, Bullock C, Rivera S, Rakiec DP, Elliott G, Fordjour P, Meyer R, Loo A, Kurth E, Engelman JA, Bitter H,
Sellers WR
, Williams JA,
Sorger PK
. A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts. Cancer Res. 2020 10 01; 80(19):4278-4287.
PMID:
32747364
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Kim S, Tiedt R, Loo A, Horn T, Delach S, Kovats S, Haas K, Engstler BS, Cao A, Pinzon-Ortiz M, Mulford I, Acker MG, Chopra R, Brain C, Tomaso ED,
Sellers WR
, Caponigro G. Correction: The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models. Oncotarget. 2020 Apr 07; 11(14):1289.
PMID:
32292577
.
Citations:
Fields:
Neo
Neoplasms
Nusinow DP, Szpyt J, Ghandi M, Rose CM, McDonald ER,
Kalocsay M
, Jané-Valbuena J, Gelfand E, Schweppe DK,
Jedrychowski M
, Golji J, Porter DA, Rejtar T, Wang YK, Kryukov GV, Stegmeier F,
Erickson BK
, Garraway LA,
Sellers WR
,
Gygi SP
. Quantitative Proteomics of the Cancer Cell Line Encyclopedia. Cell. 2020 01 23; 180(2):387-402.e16.
PMID:
31978347
.
Citations:
37
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Li H, Bullock K, Gurjao C,
Braun D
, Shukla SA, Bossé D, Lalani AA, Gopal S, Jin C, Horak C, Wind-Rotolo M,
Signoretti S
,
McDermott DF
,
Freeman GJ
,
Van Allen EM
, Schreiber SL, Stephen Hodi F,
Sellers WR
, Garraway LA, Clish CB,
Choueiri TK
,
Giannakis M
. Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Nat Commun. 2019 09 25; 10(1):4346.
PMID:
31554815
.
Citations:
31
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Weiss A, Adler F, Buhles A, Stamm C, Fairhurst RA, Kiffe M, Sterker D, Centeleghe M, Wartmann M, Kinyamu-Akunda J, Schadt HS, Couttet P, Wolf A, Wang Y, Barzaghi-Rinaudo P, Murakami M, Kauffmann A, Knoepfel T, Buschmann N, Leblanc C, Mah R, Furet P, Blank J, Hofmann F,
Sellers WR
, Graus Porta D. FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer. . 2019 12; 18(12):2194-2206.
PMID:
31409633
.
Citations:
7
Translation:
Humans
Animals
Cells
Zamanighomi M, Jain SS,
Ito T
,
Pal D
, Daley TP,
Sellers WR
. GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens. Genome Biol. 2019 07 12; 20(1):137.
PMID:
31300006
.
Citations:
5
Fields:
Gen
Genetics
Translation:
Cells
Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M,
Sellers WR
, Lees E, Shao W, Dillon MP, Stuart DD. Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J Med Chem. 2020 03 12; 63(5):2013-2027.
PMID:
31059256
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Humans
Animals
Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE,
Hahn WC
, Tsherniak A,
Giannakis M
, Schreiber SL, Clish CB, Garraway LA,
Sellers WR
. The landscape of cancer cell line metabolism. Nat Med. 2019 05; 25(5):850-860.
PMID:
31068703
.
Citations:
62
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Aguet F, Weir BA, Rothberg MV, Paolella BR,
Lawrence MS
, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE,
Cherniack AD
, Tsherniak A, Vazquez F, Jaffe JD,
Lane AA
,
Weinstock DM
, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R,
Hahn WC
,
Getz G
, Mills GB, Boehm JS,
Golub TR
, Garraway LA,
Sellers WR
. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 05; 569(7757):503-508.
PMID:
31068700
.
Citations:
248
Fields:
Sci
Science
Translation:
Humans
Cells
Baltschukat S, Engstler BS, Huang A, Hao HX, Tam A, Wang HQ, Liang J, DiMare MT, Bhang HC, Wang Y, Furet P,
Sellers WR
, Hofmann F, Schoepfer J, Tiedt R. Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation. Clin Cancer Res. 2019 05 15; 25(10):3164-3175.
PMID:
30674502
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T,
MacConaill L
, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB,
Getz G
, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL,
Meyerson M
,
Golub TR
, Morrissey MP,
Sellers WR
, Schlegel R, Garraway LA. Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2019 01; 565(7738):E5-E6.
PMID:
30559381
.
Citations:
14
Fields:
Sci
Science
Witwicki RM, Ekram MB,
Qiu X
, Janiszewska M, Shu S,
Kwon M
,
Trinh A
, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S,
Sellers WR
, Jagani Z, Hogarty MD, Roberts C, Brown M,
Stegmaier K
,
Long H
,
Shivdasani RA
,
Pellman D
,
Polyak K
. TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 10 30; 25(5):1255-1267.e5.
PMID:
30380416
.
Citations:
8
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Kim S, Tiedt R, Loo A, Horn T, Delach S, Kovats S, Haas K, Engstler BS, Cao A, Pinzon-Ortiz M, Mulford I, Acker MG, Chopra R, Brain C, di Tomaso E,
Sellers WR
, Caponigro G. The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models. Oncotarget. 2018 Oct 16; 9(81):35226-35240.
PMID:
30443290
.
Citations:
10
Fields:
Neo
Neoplasms
Jeay S, Ferretti S, Holzer P, Fuchs J, Chapeau EA, Wartmann M, Sterker D, Romanet V, Murakami M, Kerr G, Durand EY, Gaulis S, Cortes-Cros M, Ruetz S, Stachyra TM, Kallen J, Furet P, Würthner J, Guerreiro N, Halilovic E, Jullion A, Kauffmann A, Kuriakose E, Wiesmann M, Jensen MR, Hofmann F,
Sellers WR
. Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201. Cancer Res. 2018 11 01; 78(21):6257-6267.
PMID:
30135191
.
Citations:
6
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
CT
Clinical Trials
Abrams T, Connor A, Fanton C, Cohen SB, Huber T, Miller K, Hong EE, Niu X, Kline J, Ison-Dugenny M, Harris S, Walker D, Krauser K, Galimi F, Wang Z, Ghoddusi M, Mansfield K, Lee-Hoeflich ST, Holash J, Pryer N, Kluwe W, Ettenberg SA,
Sellers WR
, Lees E, Kwon P, Abraham JA, Schleyer SC. Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid Tumors. Clin Cancer Res. 2018 09 01; 24(17):4297-4308.
PMID:
29764854
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Jiang P,
Sellers WR
, Liu XS. Big Data Approaches for Modeling Response and Resistance to Cancer Drugs. Annu Rev Biomed Data Sci. 2018 Jul; 1:1-27.
PMID:
31342013
.
Citations:
3
Shao W, Mishina YM, Feng Y, Caponigro G, Cooke VG, Rivera S, Wang Y, Shen F, Korn JM, Mathews Griner LA, Nishiguchi G, Rico A, Tellew J, Haling JR, Aversa R, Polyakov V, Zang R, Hekmat-Nejad M, Amiri P, Singh M, Keen N, Dillon MP, Lees E, Ramurthy S,
Sellers WR
, Stuart DD. Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF. Cancer Res. 2018 03 15; 78(6):1537-1548.
PMID:
29343524
.
Citations:
3
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Tripathy D,
Bardia A
,
Sellers WR
. Mechanism of Action and Clinical Impact of Ribociclib-Response. Clin Cancer Res. 2017 09 15; 23(18):5658.
PMID:
28916619
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
McDonald ER, de Weck A, Schlabach MR, Billy E, Mavrakis KJ, Hoffman GR, Belur D, Castelletti D, Frias E, Gampa K, Golji J, Kao I, Li L, Megel P, Perkins TA, Ramadan N, Ruddy DA, Silver SJ, Sovath S, Stump M, Weber O, Widmer R, Yu J, Yu K, Yue Y, Abramowski D, Ackley E, Barrett R, Berger J, Bernard JL, Billig R, Brachmann SM, Buxton F, Caothien R, Caushi JX, Chung FS, Cortés-Cros M, deBeaumont RS, Delaunay C, Desplat A, Duong W, Dwoske DA, Eldridge RS, Farsidjani A, Feng F, Feng J, Flemming D, Forrester W, Galli GG, Gao Z, Gauter F, Gibaja V, Haas K, Hattenberger M, Hood T, Hurov KE, Jagani Z, Jenal M, Johnson JA, Jones MD, Kapoor A, Korn J, Liu J, Liu Q, Liu S, Liu Y, Loo AT, Macchi KJ, Martin T, McAllister G, Meyer A, Mollé S, Pagliarini RA, Phadke T, Repko B, Schouwey T, Shanahan F, Shen Q, Stamm C, Stephan C, Stucke VM, Tiedt R, Varadarajan M, Venkatesan K, Vitari AC, Wallroth M, Weiler J, Zhang J, Mickanin C, Myer VE, Porter JA, Lai A, Bitter H, Lees E, Keen N, Kauffmann A, Stegmeier F, Hofmann F, Schmelzle T,
Sellers WR
. Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening. Cell. 2017 Jul 27; 170(3):577-592.e10.
PMID:
28753431
.
Citations:
143
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Bialucha CU, Collins SD, Li X, Saxena P, Zhang X, Dürr C, Lafont B, Prieur P, Shim Y, Mosher R, Lee D, Ostrom L, Hu T, Bilic S, Rajlic IL, Capka V, Jiang W, Wagner JP, Elliott G, Veloso A, Piel JC, Flaherty MM, Mansfield KG, Meseck EK, Rubic-Schneider T, London AS, Tschantz WR, Kurz M, Nguyen D, Bourret A, Meyer MJ, Faris JE, Janatpour MJ, Chan VW, Yoder NC, Catcott KC, McShea MA, Sun X, Gao H, Williams J, Hofmann F, Engelman JA, Ettenberg SA,
Sellers WR
, Lees E. Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov. 2017 09; 7(9):1030-1045.
PMID:
28526733
.
Citations:
7
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Wang HQ, Halilovic E, Li X, Liang J, Cao Y, Rakiec DP, Ruddy DA, Jeay S, Wuerthner JU, Timple N, Kasibhatla S, Li N, Williams JA,
Sellers WR
, Huang A, Li F. Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models. Elife. 2017 04 20; 6.
PMID:
28425916
.
Citations:
12
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Tripathy D,
Bardia A
,
Sellers WR
. Ribociclib (LEE011): Mechanism of Action and Clinical Impact of This Selective Cyclin-Dependent Kinase 4/6 Inhibitor in Various Solid Tumors. Clin Cancer Res. 2017 07 01; 23(13):3251-3262.
PMID:
28351928
.
Citations:
30
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ,
Sellers WR
. The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature. 2017 03 30; 543(7647):733-737.
PMID:
28329763
.
Citations:
80
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Chapeau EA, Gembarska A, Durand EY, Mandon E, Estadieu C, Romanet V, Wiesmann M, Tiedt R, Lehar J, de Weck A, Rad R, Barys L, Jeay S, Ferretti S, Kauffmann A, Sutter E, Grevot A, Moulin P, Murakami M,
Sellers WR
, Hofmann F, Jensen MR. Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3151-3156.
PMID:
28265066
.
Citations:
13
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Jeay S, Gaulis S, Ferretti S, Bitter H, Ito M, Valat T, Murakami M, Ruetz S, Guthy DA, Rynn C, Jensen MR, Wiesmann M, Kallen J, Furet P, Gessier F, Holzer P, Masuya K, Würthner J, Halilovic E, Hofmann F,
Sellers WR
, Graus Porta D. Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097. Elife. 2016 11 17; 5.
PMID:
27852439
.
Citations:
2
Fields:
Bio
Biology
Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, Farsidjani A, Zubrowski M,
Sellers WR
, Schlegel R, Porter D, Morris E, Wuerthner J, Jeay S, Greshock J, Halilovic E, Garraway LA, Caponigro G, Lehár J. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016 12 01; 76(23):6950-6963.
PMID:
27659046
.
Citations:
13
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Garcia Fortanet J, Chen CH, Chen YN, Chen Z, Deng Z, Firestone B, Fekkes P, Fodor M, Fortin PD, Fridrich C, Grunenfelder D, Ho S, Kang ZB, Karki R, Kato M, Keen N, LaBonte LR, Larrow J, Lenoir F, Liu G, Liu S, Lombardo F, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Ramsey T,
Sellers WR
, Shultz MD, Stams T, Towler C, Wang P, Williams SL, Zhang JH, LaMarche MJ. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 09 08; 59(17):7773-82.
PMID:
27347692
.
Citations:
43
Fields:
Che
Chemistry
Translation:
Humans
Animals
Cells
Mirzaa GM, Campbell CD, Solovieff N, Goold C, Jansen LA, Menon S, Timms AE, Conti V, Biag JD, Adams C, Boyle EA, Collins S, Ishak G, Poliachik S, Girisha KM, Yeung KS, Chung BHY, Rahikkala E, Gunter SA, McDaniel SS, Macmurdo CF, Bernstein JA, Martin B, Leary R, Mahan S, Liu S, Weaver M, Doerschner M, Jhangiani S, Muzny DM, Boerwinkle E, Gibbs RA, Lupski JR, Shendure J, Saneto RP, Novotny EJ, Wilson CJ,
Sellers WR
, Morrissey M, Hevner RF, Ojemann JG, Guerrini R, Murphy LO, Winckler W, Dobyns WB. Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism. JAMA Neurol. 2016 07 01; 73(7):836-845.
PMID:
27159400
.
Citations:
54
Fields:
Neu
Neurology
Translation:
Humans
Animals
Cells
Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ,
Sellers WR
, Stams T, Fortin PD. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 07 07; 535(7610):148-52.
PMID:
27362227
.
Citations:
153
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Munoz DM, Cassiani PJ, Li L, Billy E, Korn JM, Jones MD, Golji J, Ruddy DA, Yu K, McAllister G, DeWeck A, Abramowski D, Wan J, Shirley MD, Neshat SY, Rakiec D, de Beaumont R, Weber O, Kauffmann A, McDonald ER, Keen N, Hofmann F,
Sellers WR
, Schmelzle T, Stegmeier F, Schlabach MR. CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions. Cancer Discov. 2016 08; 6(8):900-13.
PMID:
27260157
.
Citations:
106
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N,
Sellers WR
, Brown M, Pagliarini RA. ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor. Elife. 2016 05 16; 5.
PMID:
27183006
.
Citations:
18
Fields:
Bio
Biology
Translation:
Humans
Cells
Siu LL, Lawler M, Haussler D, Knoppers BM, Lewin J, Vis DJ, Liao RG, Andre F, Banks I, Barrett JC, Caldas C, Camargo AA, Fitzgerald RC, Mao M, Mattison JE, Pao W,
Sellers WR
, Sullivan P, Teh BT, Ward RL, ZenKlusen JC, Sawyers CL, Voest EE. Facilitating a culture of responsible and effective sharing of cancer genome data. Nat Med. 2016 05 05; 22(5):464-71.
PMID:
27149219
.
Citations:
29
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Mavrakis KJ, McDonald ER, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F,
Sellers WR
. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science. 2016 Mar 11; 351(6278):1208-13.
PMID:
26912361
.
Citations:
99
Fields:
Sci
Science
Translation:
Humans
Cells
Reddy A, Growney JD, Wilson NS, Emery CM, Johnson JA, Ward R, Monaco KA, Korn J, Monahan JE, Stump MD, Mapa FA, Wilson CJ, Steiger J, Ledell J, Rickles RJ, Myer VE, Ettenberg SA, Schlegel R,
Sellers WR
, Huet HA, Lehár J. Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages. PLoS One. 2016; 11(1):e0146635.
PMID:
26731447
.
Citations:
Fields:
Med
Medicine (General)
Sci
Science
Huang FW, Bielski CM,
Rinne ML
,
Hahn WC
,
Sellers WR
, Stegmeier F, Garraway LA, Kryukov GV. TERT promoter mutations and monoallelic activation of TERT in cancer. Oncogenesis. 2015 Dec 14; 4:e176.
PMID:
26657580
.
Citations:
27
Herkert B, Kauffmann A, Mollé S, Schnell C, Ferrat T, Voshol H, Juengert J, Erasimus H, Marszalek G, Kazic-Legueux M, Billy E, Ruddy D, Stump M, Guthy D, Ristov M, Calkins K, Maira SM,
Sellers WR
, Hofmann F, Hall MN, Brachmann SM. Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition. Cancer Res. 2016 Jan 15; 76(2):390-402.
PMID:
26577700
.
Citations:
10
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA,
Sellers WR
. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nat Med. 2015 Nov; 21(11):1318-25.
PMID:
26479923
.
Citations:
314
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Reddy A, Growney JD, Wilson NS, Emery CM, Johnson JA, Ward R, Monaco KA, Korn J, Monahan JE, Stump MD, Mapa FA, Wilson CJ, Steiger J, Ledell J, Rickles RJ, Myer VE, Ettenberg SA, Schlegel R,
Sellers WR
, Huet HA, Lehár J. Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages. PLoS One. 2015; 10(9):e0138486.
PMID:
26378449
.
Citations:
3
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O'Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R,
Sellers WR
, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL. CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell. 2015 Jul 13; 28(1):15-28.
PMID:
26175413
.
Citations:
45
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Jeay S, Gaulis S, Ferretti S, Bitter H, Ito M, Valat T, Murakami M, Ruetz S, Guthy DA, Rynn C, Jensen MR, Wiesmann M, Kallen J, Furet P, Gessier F, Holzer P, Masuya K, Würthner J, Halilovic E, Hofmann F,
Sellers WR
, Graus Porta D. A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097. Elife. 2015 May 12; 4.
PMID:
25965177
.
Citations:
30
Fields:
Bio
Biology
Translation:
Humans
Cells
Bhang HE, Ruddy DA, Krishnamurthy Radhakrishna V, Caushi JX, Zhao R, Hims MM, Singh AP, Kao I, Rakiec D, Shaw P, Balak M, Raza A, Ackley E, Keen N, Schlabach MR, Palmer M, Leary RJ, Chiang DY,
Sellers WR
,
Michor F
, Cooke VG, Korn JM, Stegmeier F. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nat Med. 2015 May; 21(5):440-8.
PMID:
25849130
.
Citations:
132
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Pagliarini R, Shao W,
Sellers WR
. Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. . 2015 Mar; 16(3):280-96.
PMID:
25680965
.
Citations:
67
Translation:
Humans
Schoumacher M, Hurov KE, Lehár J, Yan-Neale Y, Mishina Y, Sonkin D, Korn JM, Flemming D, Jones MD, Antonakos B, Cooke VG, Steiger J, Ledell J, Stump MD,
Sellers WR
,
Danial NN
, Shao W. Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling. Cancer Res. 2014 Jun 15; 74(12):3294-305.
PMID:
24747911
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Fritsch C, Huang A, Chatenay-Rivauday C, Schnell C, Reddy A, Liu M, Kauffmann A, Guthy D, Erdmann D, De Pover A, Furet P, Gao H, Ferretti S, Wang Y, Trappe J, Brachmann SM, Maira SM, Wilson C, Boehm M, Garcia-Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hofmann F,
Sellers WR
. Characterization of the novel and specific PI3Ka inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. . 2014 May; 13(5):1117-29.
PMID:
24608574
.
Citations:
124
Translation:
Humans
Animals
Cells
Huet HA, Growney JD, Johnson JA, Li J, Bilic S, Ostrom L, Zafari M, Kowal C, Yang G, Royo A, Jensen M, Dombrecht B, Meerschaert KR, Kolkman JA, Cromie KD, Mosher R, Gao H, Schuller A, Isaacs R,
Sellers WR
, Ettenberg SA. Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction. MAbs. 2014; 6(6):1560-70.
PMID:
25484045
.
Citations:
21
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C,
Sellers WR
, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F. Pharmacological and genomic profiling identifies NF-?B-targeted treatment strategies for mantle cell lymphoma. Nat Med. 2014 Jan; 20(1):87-92.
PMID:
24362935
.
Citations:
110
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P,
Sellers WR
, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20224-9.
PMID:
24277854
.
Citations:
278
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Wöhrle S, Weiss A, Ito M, Kauffmann A, Murakami M, Jagani Z, Thuery A, Bauer-Probst B, Reimann F, Stamm C, Pornon A, Romanet V, Guagnano V, Brümmendorf T,
Sellers WR
, Hofmann F, Roberts CW, Graus Porta D. Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. PLoS One. 2013; 8(10):e77652.
PMID:
24204904
.
Citations:
19
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV, Bhang HE, Taylor JE, Hu M, Englund NP, Yan F, Wang Z, Robert McDonald E, Wei L, Ma J, Easton J, Yu Z, deBeaumount R, Gibaja V, Venkatesan K, Schlegel R,
Sellers WR
, Keen N, Liu J, Caponigro G, Barretina J, Cooke VG, Mullighan C, Carr SA, Downing JR, Garraway LA, Stegmeier F. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet. 2013 Nov; 45(11):1386-91.
PMID:
24076604
.
Citations:
103
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Garner AP, Bialucha CU, Sprague ER, Garrett JT, Sheng Q, Li S, Sineshchekova O, Saxena P, Sutton CR, Chen D, Chen Y, Wang H, Liang J, Das R, Mosher R, Gu J, Huang A, Haubst N, Zehetmeier C, Haberl M, Elis W, Kunz C, Heidt AB, Herlihy K, Murtie J, Schuller A, Arteaga CL,
Sellers WR
, Ettenberg SA. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 01; 73(19):6024-35.
PMID:
23928993
.
Citations:
48
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F,
Roberts TM
,
Sellers WR
, Zhou W, Zhu P. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov. 2013 Sep; 3(9):1030-43.
PMID:
23842682
.
Citations:
186
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Stuart DD,
Sellers WR
. Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer. Nat Med. 2013 May; 19(5):538-40.
PMID:
23652103
.
Citations:
12
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Michaloglou C, Lehmann W, Martin T, Delaunay C, Hueber A, Barys L, Niu H, Billy E, Wartmann M, Ito M, Wilson CJ, Digan ME, Bauer A, Voshol H, Christofori G,
Sellers WR
, Hofmann F, Schmelzle T. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One. 2013; 8(4):e61916.
PMID:
23613971
.
Citations:
35
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Wöhrle S, Henninger C, Bonny O, Thuery A, Beluch N, Hynes NE, Guagnano V,
Sellers WR
, Hofmann F, Kneissel M, Graus Porta D. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res. 2013 Apr; 28(4):899-911.
PMID:
23129509
.
Citations:
49
Fields:
Met
Metabolism
Ort
Orthopedics
Translation:
Animals
Cells
Das Thakur M, Salangsang F, Landman AS,
Sellers WR
, Pryer NK, Levesque MP, Dummer R, McMahon M, Stuart DD. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature. 2013 Feb 14; 494(7436):251-5.
PMID:
23302800
.
Citations:
287
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Cortés-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P,
Sellers WR
, Hofmann F. M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):489-94.
PMID:
23267074
.
Citations:
65
Fields:
Sci
Science
Translation:
Humans
Cells
Guagnano V, Kauffmann A, Wöhrle S, Stamm C, Ito M, Barys L, Pornon A, Yao Y, Li F, Zhang Y, Chen Z, Wilson CJ, Bordas V, Le Douget M, Gaither LA, Borawski J, Monahan JE, Venkatesan K, Brümmendorf T, Thomas DM, Garcia-Echeverria C, Hofmann F,
Sellers WR
, Graus-Porta D. FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2012 Dec; 2(12):1118-33.
PMID:
23002168
.
Citations:
112
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M,
Roberts TM
,
Sellers WR
, Hofmann F, Maira SM. K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One. 2012; 7(8):e44146.
PMID:
22952903
.
Citations:
38
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Harbinski F, Craig VJ, Sanghavi S, Jeffery D, Liu L, Sheppard KA, Wagner S, Stamm C, Buness A, Chatenay-Rivauday C, Yao Y, He F, Lu CX, Guagnano V, Metz T, Finan PM, Hofmann F,
Sellers WR
, Porter JA, Myer VE, Graus-Porta D, Wilson CJ, Buckler A, Tiedt R. Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discov. 2012 Oct; 2(10):948-59.
PMID:
22874768
.
Citations:
52
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Brachmann SM, Kleylein-Sohn J, Gaulis S, Kauffmann A, Blommers MJ, Kazic-Legueux M, Laborde L, Hattenberger M, Stauffer F, Vaxelaire J, Romanet V, Henry C, Murakami M, Guthy DA, Sterker D, Bergling S, Wilson C, Brümmendorf T, Fritsch C, Garcia-Echeverria C,
Sellers WR
, Hofmann F, Maira SM. Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations. . 2012 Aug; 11(8):1747-57.
PMID:
22653967
.
Citations:
60
Translation:
Humans
Animals
Cells
Andraos R, Qian Z, Bonenfant D, Rubert J, Vangrevelinghe E, Scheufler C, Marque F, Régnier CH, De Pover A, Ryckelynck H, Bhagwat N, Koppikar P, Goel A, Wyder L, Tavares G, Baffert F, Pissot-Soldermann C, Manley PW, Gaul C, Voshol H, Levine RL,
Sellers WR
, Hofmann F, Radimerski T. Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent. Cancer Discov. 2012 Jun; 2(6):512-523.
PMID:
22684457
.
Citations:
49
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T,
MacConaill L
, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB,
Getz G
, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL,
Meyerson M
,
Golub TR
, Morrissey MP,
Sellers WR
, Schlegel R, Garraway LA. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28; 483(7391):603-7.
PMID:
22460905
.
Citations:
2530
Fields:
Sci
Science
Translation:
Humans
Cells
Menezes DL, Taverna P, Jensen MR, Abrams T, Stuart D, Yu GK, Duhl D, Machajewski T,
Sellers WR
, Pryer NK, Gao Z. The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. . 2012 Mar; 11(3):730-9.
PMID:
22246440
.
Citations:
21
Translation:
Humans
Animals
Cells
Maira SM, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, Schnell C, Guthy D, Nagel T, Wiesmann M, Brachmann S, Fritsch C, Dorsch M, Chène P, Shoemaker K, De Pover A, Menezes D, Martiny-Baron G, Fabbro D, Wilson CJ, Schlegel R, Hofmann F, García-Echeverría C,
Sellers WR
, Voliva CF. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. . 2012 Feb; 11(2):317-28.
PMID:
22188813
.
Citations:
203
Translation:
Humans
Animals
Cells
Wöhrle S, Bonny O, Beluch N, Gaulis S, Stamm C, Scheibler M, Müller M, Kinzel B, Thuery A, Brueggen J, Hynes NE,
Sellers WR
, Hofmann F, Graus-Porta D. FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone. J Bone Miner Res. 2011 Oct; 26(10):2486-97.
PMID:
21812026
.
Citations:
45
Fields:
Met
Metabolism
Ort
Orthopedics
Translation:
Animals
Cells
Sellers WR
. A blueprint for advancing genetics-based cancer therapy. Cell. 2011 Sep 30; 147(1):26-31.
PMID:
21962504
.
Citations:
31
Fields:
Cel
Cell Biology
Translation:
Humans
Scholer-Dahirel A, Schlabach MR, Loo A, Bagdasarian L, Meyer R, Guo R, Woolfenden S, Yu KK, Markovits J, Killary K, Sonkin D, Yao YM, Warmuth M,
Sellers WR
, Schlegel R, Stegmeier F, Mosher RE, McLaughlin ME. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17135-40.
PMID:
21949247
.
Citations:
45
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Tiedt R, Degenkolbe E, Furet P, Appleton BA, Wagner S, Schoepfer J, Buck E, Ruddy DA, Monahan JE, Jones MD, Blank J, Haasen D, Drueckes P, Wartmann M, McCarthy C,
Sellers WR
, Hofmann F. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res. 2011 Aug 01; 71(15):5255-64.
PMID:
21697284
.
Citations:
31
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Caponigro G,
Sellers WR
. Advances in the preclinical testing of cancer therapeutic hypotheses. Nat Rev Drug Discov. 2011 03; 10(3):179-87.
PMID:
21358737
.
Citations:
29
Fields:
Dru
Drug Therapy
Pha
Pharmacology
Translation:
Humans
Animals
Cells
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K,
Hill DE
,
Vidal M
,
Zhao JJ
, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE,
Roberts TM
,
Golub T
,
Flaherty KT
, Dummer R, Weber BL,
Sellers WR
, Schlegel R, Wargo JA,
Hahn WC
, Garraway LA. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 Dec 16; 468(7326):968-72.
PMID:
21107320
.
Citations:
615
Fields:
Sci
Science
Translation:
Humans
Cells
Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M,
Park PJ
, Cho YJ, Hsiao K, Buonamici S,
Pomeroy SL
, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M,
Sellers WR
, Roberts CW, Dorsch M. Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat Med. 2010 Dec; 16(12):1429-33.
PMID:
21076395
.
Citations:
100
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira SM, García-Echeverría C, Briggs KJ, Watkins DN, Yao YM, Lengauer C, Warmuth M,
Sellers WR
, Dorsch M. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med. 2010 Sep 29; 2(51):51ra70.
PMID:
20881279
.
Citations:
181
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA,
Sellers WR
, Klagge IM, Cong F. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15473-8.
PMID:
20713706
.
Citations:
64
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Halilovic E, She QB, Ye Q, Pagliarini R,
Sellers WR
, Solit DB, Rosen N. PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Res. 2010 Sep 01; 70(17):6804-14.
PMID:
20699365
.
Citations:
67
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH,
Getz G
, Antipin Y,
Beroukhim R
, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A,
Greulich H
, Root DE,
Sellers WR
, Schwartz GK, Antonescu CR,
Lander ES
, Varmus HE, Ladanyi M,
Sander C
,
Sander C
,
Meyerson M
, Singer S. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010 Aug; 42(8):715-21.
PMID:
20601955
.
Citations:
287
Fields:
Gen
Genetics
Translation:
Humans
Jagani Z, Wiederschain D, Loo A, He D, Mosher R, Fordjour P, Monahan J, Morrissey M, Yao YM, Lengauer C, Warmuth M,
Sellers WR
, Dorsch M. The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells. Cancer Res. 2010 Jul 01; 70(13):5528-38.
PMID:
20530672
.
Citations:
35
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Beroukhim R
, Mermel CH, Porter D, Wei G,
Raychaudhuri S
, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM,
Ligon AH
, Cho YJ, Haery L,
Greulich H
,
Reich M
, Winckler W,
Lawrence MS
, Weir BA, Tanaka KE, Chiang DY,
Bass AJ
, Loo A, Hoffman C,
Prensner J
, Liefeld T, Gao Q, Yecies D,
Signoretti S
, Maher E, Kaye FJ, Sasaki H, Tepper JE,
Fletcher JA
, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA,
Janne PA
,
Daly MJ
,
Nucera C
, Levine RL,
Ebert BL
, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M,
Letai A
, Garraway LA,
Loda M
, Beer DG, True LD, Okamoto A,
Pomeroy SL
, Singer S,
Golub TR
,
Lander ES
,
Getz G
,
Sellers WR
,
Meyerson M
. The landscape of somatic copy-number alteration across human cancers. Nature. 2010 Feb 18; 463(7283):899-905.
PMID:
20164920
.
Citations:
1474
Fields:
Sci
Science
Translation:
Humans
Cells
Jané-Valbuena J,
Widlund HR
, Perner S, Johnson LA, Dibner AC,
Lin WM
, Baker AC,
Nazarian RM
, Vijayendran KG,
Sellers WR
,
Hahn WC
,
Duncan LM
, Rubin MA,
Fisher DE
, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Res. 2010 Mar 01; 70(5):2075-84.
PMID:
20160028
.
Citations:
56
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB,
MacConaill LE
, Zhang J,
Gray NS
,
Sellers WR
, Dummer R, Garraway LA. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20411-6.
PMID:
19915144
.
Citations:
247
Fields:
Sci
Science
Translation:
Humans
Cells
Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T,
Beroukhim R
, Kashkar H, Shokat KM,
Sellers WR
, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18351-6.
PMID:
19805051
.
Citations:
112
Fields:
Sci
Science
Translation:
Humans
Cells
Rabinovsky R, Pochanard P, McNear C, Brachmann SM,
Duke-Cohan JS
, Garraway LA,
Sellers WR
. p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol. 2009 Oct; 29(19):5377-88.
PMID:
19635806
.
Citations:
47
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Vasudevan KM,
Barbie DA
, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE,
Lander ES
, Mills GB,
Hahn WC
,
Sellers WR
, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 2009 Jul 07; 16(1):21-32.
PMID:
19573809
.
Citations:
233
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Beroukhim R
, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA,
Sellers WR
,
Meyerson M
, Linehan WM,
Kaelin WG
,
Signoretti S
. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res. 2009 Jun 01; 69(11):4674-81.
PMID:
19470766
.
Citations:
182
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM,
Sellers WR
, Lengauer C, Stegmeier F. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 2009 May 15; 69(10):4286-93.
PMID:
19401449
.
Citations:
162
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Stuart D,
Sellers WR
. Linking somatic genetic alterations in cancer to therapeutics. Curr Opin Cell Biol. 2009 Apr; 21(2):304-10.
PMID:
19328671
.
Citations:
32
Fields:
Cel
Cell Biology
Translation:
Humans
Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A, Chen Y, Caponigro G, Yao YM, Lengauer C,
Sellers WR
, Benson JD. Single-vector inducible lentiviral RNAi system for oncology target validation. . 2009 Feb 01; 8(3):498-504.
PMID:
19177017
.
Citations:
184
Translation:
Humans
Animals
Cells
Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, LeBlanc AC, Donovan DJ, Thung SN, Solé M, Tovar V, Alsinet C, Ramos AH, Barretina J, Roayaie S, Schwartz M, Waxman S, Bruix J, Mazzaferro V,
Ligon AH
, Najfeld V, Friedman SL,
Sellers WR
,
Meyerson M
, Llovet JM. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 2008 Aug 15; 68(16):6779-88.
PMID:
18701503
.
Citations:
209
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, Sawyers CL,
Signoretti S
,
Hahn WC
,
Loda M
,
Sellers WR
. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 2008 Aug 12; 14(2):146-55.
PMID:
18691549
.
Citations:
84
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Dutt A, Salvesen HB, Chen TH, Ramos AH, Onofrio RC, Hatton C, Nicoletti R, Winckler W, Grewal R, Hanna M, Wyhs N, Ziaugra L, Richter DJ, Trovik J, Engelsen IB, Stefansson IM, Fennell T, Cibulskis K, Zody MC, Akslen LA, Gabriel S, Wong KK,
Sellers WR
,
Meyerson M
,
Greulich H
. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8713-7.
PMID:
18552176
.
Citations:
144
Fields:
Sci
Science
Translation:
Animals
Cells
Li C,
Beroukhim R
, Weir BA, Winckler W, Garraway LA,
Sellers WR
,
Meyerson M
. Major copy proportion analysis of tumor samples using SNP arrays. BMC Bioinformatics. 2008 Apr 21; 9:204.
PMID:
18426588
.
Citations:
25
Fields:
Com
Computational Biology
Translation:
Humans
Cells
Chang CJ, Mulholland DJ, Valamehr B, Mosessian S,
Sellers WR
, Wu H. PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol. 2008 May; 28(10):3281-9.
PMID:
18332125
.
Citations:
65
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Demichelis F,
Greulich H
, Macoska JA,
Beroukhim R
,
Sellers WR
, Garraway L, Rubin MA. SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines. Nucleic Acids Res. 2008 Apr; 36(7):2446-56.
PMID:
18304946
.
Citations:
32
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Engelsen IB, Stefansson IM,
Beroukhim R
,
Sellers WR
,
Meyerson M
, Akslen LA, Salvesen HB. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. Int J Oncol. 2008 Feb; 32(2):307-16.
PMID:
18202752
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Humans
Lin WM
, Baker AC,
Beroukhim R
, Winckler W, Feng W, Marmion JM, Laine E,
Greulich H
, Tseng H, Gates C,
Hodi FS
, Dranoff G,
Sellers WR
, Thomas RK,
Meyerson M
,
Golub TR
, Dummer R, Herlyn M,
Getz G
, Garraway LA. Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res. 2008 Feb 01; 68(3):664-73.
PMID:
18245465
.
Citations:
135
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Gaither A, Porter D, Yao Y, Borawski J, Yang G, Donovan J, Sage D, Slisz J, Tran M, Straub C, Ramsey T, Iourgenko V, Huang A, Chen Y, Schlegel R, Labow M, Fawell S,
Sellers WR
, Zawel L. A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res. 2007 Dec 15; 67(24):11493-8.
PMID:
18089776
.
Citations:
101
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Beroukhim R
,
Getz G
, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S,
Prensner J
, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mischel PS, Cloughesy TF,
Meyerson M
,
Golub TA
,
Lander ES
, Mellinghoff IK,
Sellers WR
. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):20007-12.
PMID:
18077431
.
Citations:
510
Fields:
Sci
Science
Translation:
Humans
Cells
Xu Q, Majumder PK,
Ross K
, Shim Y,
Golub TR
,
Loda M
,
Sellers WR
. Identification of prostate cancer modifier pathways using parental strain expression mapping. Proc Natl Acad Sci U S A. 2007 Nov 06; 104(45):17771-6.
PMID:
17978178
.
Citations:
9
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Hill AD,
Chang BS
, Hill RS, Garraway LA, Bodell A,
Sellers WR
,
Walsh CA
. A 2-Mb critical region implicated in the microcephaly associated with terminal 1q deletion syndrome. . 2007 Aug 01; 143A(15):1692-8.
PMID:
17603806
.
Citations:
22
Translation:
Humans
Cells
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T,
Lin WM
, Wang M, Feng W, Zander T,
MacConaill L
, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S,
Beroukhim R
, Peyton M, Barretina J, Dutt A, Emery C,
Greulich H
, Shah K, Sasaki H, Gazdar A, Minna J,
Armstrong SA
, Mellinghoff IK,
Hodi FS
, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H,
Loda M
, Catalona W,
Fletcher J
,
Signoretti S
, Kaye F,
Anderson KC
,
Demetri GD
, Dummer R, Wagner S, Herlyn M,
Sellers WR
,
Meyerson M
, Garraway LA. High-throughput oncogene mutation profiling in human cancer. Nat Genet. 2007 Mar; 39(3):347-51.
PMID:
17293865
.
Citations:
449
Fields:
Gen
Genetics
Translation:
Humans
Lee JC, Vivanco I,
Beroukhim R
, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q,
Greulich H
, Thomas RK, Paez JG, Peck TC, Linhart DJ, Glatt KA,
Getz G
, Onofrio R, Ziaugra L, Levine RL, Gabriel S, Kawaguchi T, O'Neill K, Khan H, Liau LM, Nelson SF, Rao PN, Mischel P, Pieper RO, Cloughesy T, Leahy DJ,
Sellers WR
, Sawyers CL,
Meyerson M
, Mellinghoff IK. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med. 2006 Dec; 3(12):e485.
PMID:
17177598
.
Citations:
129
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Perner S, Demichelis F,
Beroukhim R
, Schmidt FH, Mosquera JM, Setlur S, Tchinda J, Tomlins SA, Hofer MD, Pienta KG, Kuefer R, Vessella R, Sun XW,
Meyerson M
, Lee C,
Sellers WR
, Chinnaiyan AM, Rubin MA. TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res. 2006 Sep 01; 66(17):8337-41.
PMID:
16951139
.
Citations:
214
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Li AG
, Piluso LG, Cai X, Wei G,
Sellers WR
, Liu X. Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell. 2006 Aug; 23(4):575-87.
PMID:
16916644
.
Citations:
75
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Garraway LA,
Sellers WR
. Lineage dependency and lineage-survival oncogenes in human cancer. Nat Rev Cancer. 2006 Aug; 6(8):593-602.
PMID:
16862190
.
Citations:
136
Fields:
Neo
Neoplasms
Translation:
Humans
Thomas RK, Nickerson E, Simons JF, Jänne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H,
Lindeman N
, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA,
Greulich H
, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M,
Sellers WR
, Rothberg JM,
Meyerson M
. Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med. 2006 Jul; 12(7):852-5.
PMID:
16799556
.
Citations:
115
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Oh WK, Hayes J, Evan C, Manola J, George DJ, Waldron H, Donovan M, Varner J, Orechia J, Katcher B, Lu D, Nevins A, Wright RL, Tormey L, Talcott J, Rubin MA,
Loda M
,
Sellers WR
, Richie JP,
Kantoff PW
, Weeks J. Development of an integrated prostate cancer research information system. Clin Genitourin Cancer. 2006 Jun; 5(1):61-6.
PMID:
16859581
.
Citations:
24
Fields:
Neo
Neoplasms
Uro
Urology
Translation:
Humans
Benson JD, Chen YN, Cornell-Kennon SA, Dorsch M, Kim S, Leszczyniecka M,
Sellers WR
, Lengauer C. Validating cancer drug targets. Nature. 2006 May 25; 441(7092):451-6.
PMID:
16724057
.
Citations:
37
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Beroukhim R
, Lin M, Park Y, Hao K, Zhao X, Garraway LA, Fox EA,
Hochberg EP
, Mellinghoff IK, Hofer MD, Descazeaud A, Rubin MA,
Meyerson M
, Wong WH,
Sellers WR
, Li C. Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol. 2006 May; 2(5):e41.
PMID:
16699594
.
Citations:
62
Fields:
Com
Computational Biology
Translation:
Humans
Cells
Alvarez JV,
Greulich H
,
Sellers WR
,
Meyerson M
,
Frank DA
. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res. 2006 Mar 15; 66(6):3162-8.
PMID:
16540667
.
Citations:
93
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Garraway LA,
Sellers WR
. From integrated genomics to tumor lineage dependency. Cancer Res. 2006 Mar 01; 66(5):2506-8.
PMID:
16510564
.
Citations:
10
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Vazquez F, Matsuoka S,
Sellers WR
, Yanagida T, Ueda M, Devreotes PN. Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3633-8.
PMID:
16537447
.
Citations:
76
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Mihich E,
Sellers WR
. Seventeenth Annual Pezcoller Symposium: molecular understanding of solid tumors. Cancer Res. 2005 Dec 15; 65(24):11251-4.
PMID:
16357127
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Koochekpour S, Zhuang YJ,
Beroukhim R
, Hsieh CL, Hofer MD, Zhau HE, Hiraiwa M, Pattan DY, Ware JL, Luftig RB, Sandhoff K, Sawyers CL, Pienta KJ, Rubin MA, Vessella RL,
Sellers WR
, Sartor O. Amplification and overexpression of prosaposin in prostate cancer. Genes Chromosomes Cancer. 2005 Dec; 44(4):351-64.
PMID:
16080200
.
Citations:
20
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
LaFramboise T, Weir BA, Zhao X,
Beroukhim R
, Li C,
Harrington D
,
Sellers WR
,
Meyerson M
. Allele-specific amplification in cancer revealed by SNP array analysis. PLoS Comput Biol. 2005 Nov; 1(6):e65.
PMID:
16322765
.
Citations:
59
Fields:
Com
Computational Biology
Translation:
Humans
Cells
Majumder PK,
Sellers WR
. Akt-regulated pathways in prostate cancer. Oncogene. 2005 Nov 14; 24(50):7465-74.
PMID:
16288293
.
Citations:
140
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Mellinghoff IK, Wang MY, Vivanco I,
Haas-Kogan DA
, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN,
Beroukhim R
, Peck TC, Lee JC,
Sellers WR
, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005 Nov 10; 353(19):2012-24.
PMID:
16282176
.
Citations:
537
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I,
Golub TR
, Sebolt-Leopold J,
Sellers WR
, Rosen N. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006 Jan 19; 439(7074):358-62.
PMID:
16273091
.
Citations:
480
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Greulich H
, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE,
Frank DA
,
Hahn WC
,
Sellers WR
,
Meyerson M
. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005 Nov; 2(11):e313.
PMID:
16187797
.
Citations:
243
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Jiang J,
Greulich H
, Jänne PA,
Sellers WR
,
Meyerson M
,
Griffin JD
. Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression. Cancer Res. 2005 Oct 01; 65(19):8968-74.
PMID:
16204070
.
Citations:
65
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Signoretti S
, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F,
Kantoff PW
,
Sellers WR
,
Loda M
. p63 regulates commitment to the prostate cell lineage. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11355-60.
PMID:
16051706
.
Citations:
68
Fields:
Sci
Science
Translation:
Animals
Cells
Garraway LA,
Widlund HR
, Rubin MA,
Getz G
, Berger AJ, Ramaswamy S,
Beroukhim R
,
Milner DA
,
Granter SR
, Du J, Lee C, Wagner SN, Li C,
Golub TR
, Rimm DL,
Meyerson ML
,
Fisher DE
,
Sellers WR
. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 07; 436(7047):117-22.
PMID:
16001072
.
Citations:
514
Fields:
Sci
Science
Translation:
Humans
Cells
Zhao X, Weir BA, LaFramboise T, Lin M,
Beroukhim R
, Garraway L, Beheshti J, Lee JC, Naoki K,
Richards WG
, Sugarbaker D, Chen F, Rubin MA, Jänne PA, Girard L, Minna J,
Christiani D
, Li C,
Sellers WR
,
Meyerson M
. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res. 2005 Jul 01; 65(13):5561-70.
PMID:
15994928
.
Citations:
132
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Krützfeldt M, Ellis M, Weekes DB, Bull JJ, Eilers M, Vivanco MD,
Sellers WR
, Mittnacht S. Selective ablation of retinoblastoma protein function by the RET finger protein. Mol Cell. 2005 Apr 15; 18(2):213-24.
PMID:
15837424
.
Citations:
18
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Levine RL,
Wadleigh M
, Cools J,
Ebert BL
, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T,
D'Andrea A
, Fröhling S, Döhner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A,
Griffin JD
,
Eck MJ
,
Sellers WR
,
Meyerson M
,
Golub TR
, Lee SJ, Gilliland DG. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 Apr; 7(4):387-97.
PMID:
15837627
.
Citations:
883
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Sellers WR
,
Meyerson M
. EGFR gene mutations: a call for global x global views of cancer. J Natl Cancer Inst. 2005 Mar 02; 97(5):326-8.
PMID:
15741561
.
Citations:
3
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Garraway LA, Weir BA, Zhao X,
Widlund H
, Beroukhim R, Berger A, Rimm D, Rubin MA, Fisher DE,
Meyerson ML
,
Sellers WR
. "Lineage addiction" in human cancer: lessons from integrated genomics. Cold Spring Harb Symp Quant Biol. 2005; 70:25-34.
PMID:
16869735
.
Citations:
12
Fields:
Bio
Biology
Translation:
Humans
Cells
Thomas RK,
Greulich H
, Yuza Y, Lee JC, Tengs T, Feng W, Chen TH, Nickerson E, Simons J, Egholm M, Rothberg JM,
Sellers WR
,
Meyerson ML
. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol. 2005; 70:73-81.
PMID:
16869740
.
Citations:
13
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Berger R, Febbo PG, Majumder PK,
Zhao JJ
, Mukherjee S,
Signoretti S
, Campbell KT,
Sellers WR
,
Roberts TM
,
Loda M
,
Golub TR
,
Hahn WC
. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004 Dec 15; 64(24):8867-75.
PMID:
15604246
.
Citations:
78
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ,
Richards WG
, Du J, Girard L, Minna JD, Loh ML,
Fisher DE
, Velculescu VE, Vogelstein B,
Meyerson M
,
Sellers WR
, Neel BG. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 2004 Dec 15; 64(24):8816-20.
PMID:
15604238
.
Citations:
176
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Carroll PR, Chan JM,
D'Amico AV
, Gelmann EP, Iversen P, Klotz L, Nelson JB, Nelson PS, Nelson WG, Oh WK, Rosen N, Rubin MA, Sandler H,
Sellers WR
,
Smith MR
, Xu J, McMann MC,
Kantoff PW
. Fourth International Conference on Innovations and Challenges in Prostate Cancer: Prevention, Detection and Treatment. J Urol. 2004 Nov; 172(5 Pt 2):S3-5.
PMID:
15535434
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Korkmaz CG, Korkmaz KS, Manola J, Xi Z, Risberg B, Danielsen H, Kung J,
Sellers WR
,
Loda M
, Saatcioglu F. Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis. J Urol. 2004 Sep; 172(3):1134-9.
PMID:
15311057
.
Citations:
11
Fields:
Uro
Urology
Translation:
Humans
Animals
Cells
Torres-Arzayus MI, Font de Mora J, Yuan J, Vazquez F,
Bronson R
, Rue M,
Sellers WR
,
Brown M
. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 2004 Sep; 6(3):263-74.
PMID:
15380517
.
Citations:
170
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Krop I
, Player A, Tablante A, Taylor-Parker M, Lahti-Domenici J, Fukuoka J, Batra SK, Papadopoulos N,
Richards WG
, Sugarbaker DJ, Wright RL, Shim J, Stamey TA,
Sellers WR
,
Loda M
,
Meyerson M
, Hruban R, Jen J,
Polyak K
. Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res. 2004 Sep; 2(9):489-94.
PMID:
15383627
.
Citations:
21
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Sansal I,
Sellers WR
. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004 Jul 15; 22(14):2954-63.
PMID:
15254063
.
Citations:
291
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Allinen M,
Beroukhim R
, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A,
Schnitt S
,
Sellers WR
,
Polyak K
. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004 Jul; 6(1):17-32.
PMID:
15261139
.
Citations:
491
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Jiang J, Paez JG, Lee JC, Bo R,
Stone RM
,
DeAngelo DJ
, Galinsky I,
Wolpin BM
, Jonasova A, Herman P, Fox EA, Boggon TJ,
Eck MJ
,
Weisberg E
,
Griffin JD
, Gilliland DG,
Meyerson M
,
Sellers WR
. Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood. 2004 Sep 15; 104(6):1855-8.
PMID:
15178581
.
Citations:
28
Fields:
Hem
Hematology
Translation:
Humans
Cells
Rubin MA, Varambally S,
Beroukhim R
, Tomlins SA, Rhodes DR, Paris PL, Hofer MD, Storz-Schweizer M, Kuefer R,
Fletcher JA
, Hsi BL, Byrne JA, Pienta KJ, Collins C,
Sellers WR
, Chinnaiyan AM. Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer. Cancer Res. 2004 Jun 01; 64(11):3814-22.
PMID:
15172988
.
Citations:
51
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ,
Golub TR
,
Loda M
, Lane HA,
Sellers WR
. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004 Jun; 10(6):594-601.
PMID:
15156201
.
Citations:
346
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Paez JG, Lin M,
Beroukhim R
, Lee JC, Zhao X, Richter DJ, Gabriel S, Herman P, Sasaki H,
Altshuler D
, Li C,
Meyerson M
,
Sellers WR
. Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification. Nucleic Acids Res. 2004 May 18; 32(9):e71.
PMID:
15150323
.
Citations:
91
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Zhao X, Li C, Paez JG, Chin K, Jänne PA, Chen TH, Girard L, Minna J,
Christiani D
, Leo C, Gray JW,
Sellers WR
,
Meyerson M
. An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res. 2004 May 01; 64(9):3060-71.
PMID:
15126342
.
Citations:
187
Fields:
Neo
Neoplasms
Translation:
Humans
Paez JG, Jänne PA, Lee JC, Tracy S,
Greulich H
, Gabriel S, Herman P, Kaye FJ,
Lindeman N
, Boggon TJ, Naoki K, Sasaki H, Fujii Y,
Eck MJ
,
Sellers WR
,
Johnson BE
,
Meyerson M
. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 Jun 04; 304(5676):1497-500.
PMID:
15118125
.
Citations:
2912
Fields:
Sci
Science
Translation:
Humans
Cells
Lin M,
Wei LJ
,
Sellers WR
, Lieberfarb M, Wong WH, Li C. dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics. 2004 May 22; 20(8):1233-40.
PMID:
14871870
.
Citations:
162
Fields:
Com
Computational Biology
Translation:
Humans
Hsieh AC, Bo R, Manola J, Vazquez F, Bare O, Khvorova A, Scaringe S,
Sellers WR
. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res. 2004; 32(3):893-901.
PMID:
14769947
.
Citations:
63
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Febbo PG,
Sellers WR
. Use of expression analysis to predict outcome after radical prostatectomy. J Urol. 2003 Dec; 170(6 Pt 2):S11-9; discussion S19-20.
PMID:
14610405
.
Citations:
7
Fields:
Uro
Urology
Translation:
Humans
Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL,
Zhao JJ
,
Roberts TM
,
Clardy J
,
Sellers WR
,
Silver PA
. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76.
PMID:
14706338
.
Citations:
113
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Carroll PR, Benaron DA, Blackledge G, Coakley FV,
D'Amico AV
, Higano CS, Iversen P, Kattan M, Nanus DM, Nelson JB, Oh WK, Roach M,
Sellers WR
,
Smith MR
, McMann MC,
Kantoff PW
. Third international conference on innovations and challenges in prostate cancer: prevention, detection and treatment. J Urol. 2003 Dec; 170(6 Pt 2):S3-5.
PMID:
14610403
.
Citations:
Fields:
Uro
Urology
Translation:
Humans
Lieberfarb ME, Lin M, Lechpammer M, Li C, Tanenbaum DM, Febbo PG, Wright RL, Shim J,
Kantoff PW
,
Loda M
,
Meyerson M
,
Sellers WR
. Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate cancer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformatics platform dChipSNP. Cancer Res. 2003 Aug 15; 63(16):4781-5.
PMID:
12941794
.
Citations:
32
Fields:
Neo
Neoplasms
Translation:
Humans
Brugarolas JB, Vazquez F, Reddy A,
Sellers WR
,
Kaelin WG
. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 2003 Aug; 4(2):147-58.
PMID:
12957289
.
Citations:
197
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H,
Kantoff PW
,
Golub TR
,
Loda M
,
Sellers WR
. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7841-6.
PMID:
12799464
.
Citations:
114
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Paez J,
Sellers WR
. PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res. 2003; 115:145-67.
PMID:
12613196
.
Citations:
63
Fields:
Neo
Neoplasms
The
Therapeutics
Translation:
Humans
Animals
Cells
Bar-Shira A, Pinthus JH, Rozovsky U, Goldstein M,
Sellers WR
, Yaron Y, Eshhar Z, Orr-Urtreger A. Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft. Cancer Res. 2002 Dec 01; 62(23):6803-7.
PMID:
12460888
.
Citations:
46
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Sellers WR
,
Loda M
. The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer? Cancer Cell. 2002 Nov; 2(5):349-50.
PMID:
12450788
.
Citations:
40
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Ramaswamy S, Nakamura N, Sansal I, Bergeron L,
Sellers WR
. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell. 2002 Jul; 2(1):81-91.
PMID:
12150827
.
Citations:
151
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Gounari F,
Signoretti S
,
Bronson R
, Klein L,
Sellers WR
, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K. Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene. 2002 Jun 13; 21(26):4099-107.
PMID:
12037666
.
Citations:
34
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Animals
Cells
Singh D, Febbo PG,
Ross K
, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA,
D'Amico AV
, Richie JP,
Lander ES
,
Loda M
,
Kantoff PW
,
Golub TR
,
Sellers WR
. Gene expression correlates of clinical prostate cancer behavior. Cancer Cell. 2002 Mar; 1(2):203-9.
PMID:
12086878
.
Citations:
459
Fields:
Neo
Neoplasms
Translation:
Humans
DiRenzo J,
Signoretti S
, Nakamura N, Rivera-Gonzalez R,
Sellers W
,
Loda M
,
Brown M
. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res. 2002 Jan 01; 62(1):89-98.
PMID:
11782364
.
Citations:
48
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N,
Sellers WR
. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem. 2001 Dec 28; 276(52):48627-30.
PMID:
11707428
.
Citations:
143
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Gesbert F,
Sellers WR
,
Signoretti S
,
Loda M
,
Griffin JD
. BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway. J Biol Chem. 2000 Dec 15; 275(50):39223-30.
PMID:
11010972
.
Citations:
49
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Nakamura N, Ramaswamy S, Vazquez F,
Signoretti S
,
Loda M
,
Sellers WR
. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol. 2000 Dec; 20(23):8969-82.
PMID:
11073996
.
Citations:
170
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Cells
Miyake S,
Sellers WR
, Safran M, Li X, Zhao W, Grossman SR, Gan J,
DeCaprio JA
, Adams PD,
Kaelin WG
. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol. 2000 Dec; 20(23):8889-902.
PMID:
11073989
.
Citations:
43
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Cells
Vazquez F, Ramaswamy S, Nakamura N,
Sellers WR
. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000 Jul; 20(14):5010-8.
PMID:
10866658
.
Citations:
264
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Vazquez F,
Sellers WR
. The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta. 2000 Feb 14; 1470(1):M21-35.
PMID:
10656987
.
Citations:
66
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Animals
Cells
Sellers WR
, Fisher DE. Apoptosis and cancer drug targeting. J Clin Invest. 1999 Dec; 104(12):1655-61.
PMID:
10606616
.
Citations:
39
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
McMenamin ME, Soung P, Perera S,
Kaplan I
,
Loda M
,
Sellers WR
. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res. 1999 Sep 01; 59(17):4291-6.
PMID:
10485474
.
Citations:
166
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S,
Roberts TM
,
Sellers WR
. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2110-5.
PMID:
10051603
.
Citations:
210
Fields:
Sci
Science
Translation:
Humans
Cells
Adams PD, Li X,
Sellers WR
, Baker KB, Leng X, Harper JW, Taya Y,
Kaelin WG
. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol Cell Biol. 1999 Feb; 19(2):1068-80.
PMID:
9891042
.
Citations:
62
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans