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Mustafa Sahin, Ph.D., M.D.

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Institution
Department
Address
Phone
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Biography
1988
Award for Best Thesis in Biochemistry
1988
Magna Cum Laude
1988
Sigma Xi Honorary Society
1995
Alpha Omega Alpha Honor Medical Society
1995
M.D./Ph.D. Thesis Award
2000
Outstanding Junior Member Award
2005
Young Investigator Award
2005
Young Investigator Award in SMA
2009
John Merck Scholar Award

Overview

Mentoring
Activation Dependent Modulation of the Neuronal Circadian Clock
Summer, 05/24/10 - 08/31/10
Diffusion Tensor Tractography Reveals Impaired Language Pathways in Tuberous Sclerosis Complex Patients with Autism
Summer, 06/20/11 - 08/12/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32MH112510 (NELSON, CHARLES ALEXANDER) Jul 1, 2017 - Jun 30, 2022
    NIH/NIMH
    Translational Post-doctoral Training in Neurodevelopment
    Role: Co-Principal Investigator
  2. U54HD090255 (POMEROY, SCOTT LOREN) Sep 23, 2016 - May 31, 2021
    NIH/NICHD
    Boston Intellectual and Developmental Disabilities Research Center
    Role: Co-Principal Investigator
  3. U54NS092090 (SAHIN, MUSTAFA) Sep 30, 2014 - Jul 31, 2019
    NIH/NINDS
    Developmental Synaptopathies Associated with TSC, PTEN and SHANK3 Mutations
    Role: Principal Investigator
  4. U01NS082320 (SAHIN, MUSTAFA) Sep 1, 2012 - Aug 31, 2018
    NIH/NINDS
    Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous Sclerosis
    Role: Co-Principal Investigator
  5. R01NS058956 (SAHIN, MUSTAFA) Jun 15, 2007 - May 31, 2011
    NIH/NINDS
    Role of TSC Proteins in Neuronal Polarity and Axon Guidance
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Sahin Lab - Mouse strains (13)
Assay Development and Screening Facility (ADSF) at Boston Children’s Hospital - Core services (4), Instruments (7) and Software (1)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Peters JM, Hyde DE, Chu CJ, Boom M, Scherrer B, Madsen JR, Stone SS, Ouaalam H, Prabhu SP, Sahin M, Warfield SK. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2019 Jun 28. PMID: 31261349.
    Citations:    
  2. Srivastava S, Love-Nichols JA, Dies KA, Ledbetter DH, Martin CL, Chung WK, Firth HV, Frazier T, Hansen RL, Prock L, Brunner H, Hoang N, Scherer SW, Sahin M, Miller DT. Meta-analysis and multidisciplinary consensus statement: exome sequencing is a first-tier clinical diagnostic test for individuals with neurodevelopmental disorders. Genet Med. 2019 Jun 11. PMID: 31182824.
    Citations:    
  3. Yuskaitis CJ, Rossitto LA, Gurnani S, Bainbridge E, Poduri A, Sahin M. Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice. Hum Mol Genet. 2019 Jun 07. PMID: 31174205.
    Citations:    
  4. Giannikou K, Lasseter KD, Grevelink JM, Tyburczy ME, Dies KA, Zhu Z, Hamieh L, Wollison BM, Thorner AR, Ruoss SJ, Thiele EA, Sahin M, Kwiatkowski DJ. Low-level mosaicism in tuberous sclerosis complex: prevalence, clinical features, and risk of disease transmission. Genet Med. 2019 Jun 04. PMID: 31160751.
    Citations:    
  5. Salussolia CL, Klonowska K, Kwiatkowski DJ, Sahin M. Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex. Annu Rev Genomics Hum Genet. 2019 Apr 24. PMID: 31018109.
    Citations:    
  6. Williams ME, Pearson DA, Capal JK, Byars AW, Murray DS, Kissinger R, O'Kelley SE, Hanson E, Bing NM, Kent B, Wu JY, Northrup H, Bebin EM, Sahin M, Krueger D. Impacting development in infants with tuberous sclerosis complex: Multidisciplinary research collaboration. Am Psychol. 2019 Apr; 74(3):356-367. PMID: 30945897.
    Citations:    
  7. Farach LS, Pearson DA, Woodhouse JP, Schraw JM, Sahin M, Krueger DA, Wu JY, Bebin EM, Lupo PJ, Au KS, Northrup H. Tuberous Sclerosis Complex Genotypes and Developmental Phenotype. Pediatr Neurol. 2019 Jul; 96:58-63. PMID: 31005478.
    Citations:    
  8. Sahin M, Jones SR, Sweeney JA, Berry-Kravis E, Connors BW, Ewen JB, Hartman AL, Levin AR, Potter WZ, Mamounas LA. Discovering translational biomarkers in neurodevelopmental disorders. Nat Rev Drug Discov. 2018 Dec 20. PMID: 30936503.
    Citations:    
  9. Marami B, Scherrer B, Khan S, Afacan O, Prabhu SP, Sahin M, Warfield SK, Gholipour A. Motion-robust diffusion compartment imaging using simultaneous multi-slice acquisition. Magn Reson Med. 2019 May; 81(5):3314-3329. PMID: 30443929.
    Citations:    Fields:    
  10. Purtell H, Dhamne SC, Gurnani S, Bainbridge E, Modi ME, Lammers SHT, Super CE, Hameed MQ, Johnson EL, Sahin M, Rotenberg A. Electrographic spikes are common in wildtype mice. Epilepsy Behav. 2018 12; 89:94-98. PMID: 30399547.
    Citations:    Fields:    
  11. Jülich K, Neuberger I, Sahin M, Takeoka M, Pinto A, Prabhu SP. Yield of Emergent Neuroimaging in Patients With Sturge-Weber Syndrome Presenting With Acute Neurologic Symptoms. J Child Neurol. 2019 Jan; 34(1):17-21. PMID: 30378435.
    Citations:    
  12. Qing B, Canovic EP, Mijailovic AS, Jagielska A, Whitfield MJ, Lowe AL, Kelly EH, Turner D, Sahin M, Van Vliet K. PROBING MECHANICAL PROPERTIES OF BRAIN IN A TUBEROUS SCLEROSIS MODEL OF AUTISM. J Biomech Eng. 2018 Oct 22. PMID: 30347048.
    Citations:    Fields:    
  13. Peters JM, Prohl A, Kapur K, Nath A, Scherrer B, Clancy S, Prabhu SP, Sahin M, Franz DN, Warfield SK, Krueger DA. Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex. Pediatr Neurol. 2019 Jan; 90:24-30. PMID: 30424962.
    Citations:    Fields:    
  14. Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. 2018 Nov 20; 91(21):974-976. PMID: 30333165.
    Citations:    
  15. Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr W, Sahin M. Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors. Cell Rep. 2018 Oct 09; 25(2):357-367.e4. PMID: 30304677.
    Citations:    Fields:    
  16. Hussain SA, Schmid E, Peters JM, Goyal M, Bebin EM, Northrup H, Sahin M, Krueger DA, Wu JY. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 12; 148:1-7. PMID: 30296632.
    Citations:    Fields:    
  17. Baumer FM, Peters JM, Clancy S, Prohl AK, Prabhu SP, Scherrer B, Jansen FE, Braun KPJ, Sahin M, Stamm A, Warfield SK. Corpus Callosum White Matter Diffusivity Reflects Cumulative Neurological Comorbidity in Tuberous Sclerosis Complex. Cereb Cortex. 2018 Oct 01; 28(10):3665-3672. PMID: 29939236.
    Citations:    Fields:    
  18. Srivastava S, Scherrer B, Prohl AK, Filip-Dhima R, Kapur K, Kolevzon A, Buxbaum JD, Berry-Kravis E, Soorya L, Thurm A, Powell CM, Bernstein JA, Warfield SK, Sahin M. Volumetric Analysis of the Basal Ganglia and Cerebellar Structures in Patients with Phelan-McDermid Syndrome. Pediatr Neurol. 2019 Jan; 90:37-43. PMID: 30396833.
    Citations:    Fields:    
  19. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 Sep 10; 28(17):R909-R914. PMID: 30205056.
    Citations:    Fields:    
  20. Modi ME, Sahin M. A unified circuit for social behavior. Neurobiol Learn Mem. 2018 Aug 24. PMID: 30149055.
    Citations:    Fields:    
  21. Modi ME, Sahin M. The Way Forward for Mechanism-Based Therapeutics in Genetically Defined Neurodevelopmental Disorders. Clin Pharmacol Ther. 2018 Oct; 104(4):603-606. PMID: 30101418.
    Citations:    Fields:    
  22. Di Nardo A, Sahin M. mTOR'ing across the Cortex by Chopping the Cilia. Neuron. 2018 Jul 11; 99(1):3-5. PMID: 30001510.
    Citations:    Fields:    
  23. Gonçalves IDCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Author Correction: Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018 Jul 03; 8(1):10294. PMID: 29967434.
    Citations:    Fields:    
  24. Charupanit K, Nunez MD, Bernardo D, Bebin M, Krueger DA, Northrup H, Sahin M, Wu JY, Lopour BA. Automated Detection of High Frequency Oscillations in Human Scalp Electroencephalogram. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul; 2018:3116-3119. PMID: 30441054.
    Citations:    Fields:    
  25. Gonçalves IDCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Sci Rep. 2018 May 21; 8(1):7907. PMID: 29784949.
    Citations:    Fields:    
  26. van der Poest Clement EA, Sahin M, Peters JM. Vigabatrin for Epileptic Spasms and Tonic Seizures in Tuberous Sclerosis Complex. J Child Neurol. 2018 07; 33(8):519-524. PMID: 29687739.
    Citations:    Fields:    
  27. Pinto ALR, Ou Y, Sahin M, Grant PE. Quantitative Apparent Diffusion Coefficient Mapping May Predict Seizure Onset in Children With Sturge-Weber Syndrome. Pediatr Neurol. 2018 07; 84:32-38. PMID: 29753575.
    Citations:    Fields:    
  28. Bernardo D, Nariai H, Hussain SA, Sankar R, Salamon N, Krueger DA, Sahin M, Northrup H, Bebin EM, Wu JY. Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex. Clin Neurophysiol. 2018 07; 129(7):1458-1466. PMID: 29673547.
    Citations:    Fields:    
  29. Srivastava S, Prohl AK, Scherrer B, Kapur K, Krueger DA, Warfield SK, Sahin M. Cerebellar volume as an imaging marker of development in infants with tuberous sclerosis complex. Neurology. 2018 Apr 24; 90(17):e1493-e1500. PMID: 29572283.
    Citations:    Fields:    
  30. Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, Cataltepe D, Turner D, Han MJ, Woolf CJ, Hatten ME, Sahin M. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Mol Psychiatry. 2018 11; 23(11):2167-2183. PMID: 29449635.
    Citations: 3     Fields:    
  31. O'Leary HM, Kaufmann WE, Barnes KV, Rakesh K, Kapur K, Tarquinio DC, Cantwell NG, Roche KJ, Rose SA, Walco AC, Bruck NM, Bazin GA, Holm IA, Alexander ME, Swanson LC, Baczewski LM, Poon C, Mayor Torres JM, Nelson CA, Sahin M. Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome. Ann Clin Transl Neurol. 2018 03; 5(3):323-332. PMID: 29560377.
    Citations: 3     
  32. Winden KD, Ebrahimi-Fakhari D, Sahin M. Abnormal mTOR Activation in Autism. Annu Rev Neurosci. 2018 07 08; 41:1-23. PMID: 29490194.
    Citations: 1     Fields:    
  33. Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 2018 03; 111:91-101. PMID: 29274432.
    Citations: 3     Fields:    
  34. Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology. 2018 05; 43(6):1457-1465. PMID: 29206810.
    Citations:    Fields:    
  35. Ebrahimi-Fakhari D, Cheng C, Dies K, Diplock A, Pier DB, Ryan CS, Lanpher BC, Hirst J, Chung WK, Sahin M, Rosser E, Darras B, Bennett JT. Clinical and genetic characterization of AP4B1-associated SPG47. Am J Med Genet A. 2018 02; 176(2):311-318. PMID: 29193663.
    Citations: 1     Fields:    
  36. Krueger DA, Sadhwani A, Byars AW, de Vries PJ, Franz DN, Whittemore VH, Filip-Dhima R, Murray D, Kapur K, Sahin M. Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders. Ann Clin Transl Neurol. 2017 12; 4(12):877-887. PMID: 29296616.
    Citations: 2     
  37. Davis PE, Filip-Dhima R, Sideridis G, Peters JM, Au KS, Northrup H, Bebin EM, Wu JY, Krueger D, Sahin M. Presentation and Diagnosis of Tuberous Sclerosis Complex in Infants. Pediatrics. 2017 Dec; 140(6). PMID: 29101226.
    Citations: 4     Fields:    Translation:Humans
  38. McDonald NM, Varcin KJ, Bhatt R, Wu JY, Sahin M, Nelson CA, Jeste SS. Early autism symptoms in infants with tuberous sclerosis complex. Autism Res. 2017 Dec; 10(12):1981-1990. PMID: 28801991.
    Citations: 2     Fields:    Translation:Humans
  39. Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Rep. 2017 07 25; 20(4):868-880. PMID: 28746872.
    Citations: 6     Fields:    Translation:AnimalsCells
  40. O'Leary HM, Mayor JM, Kaufmann WE, Sahin M. Classification of respiratory disturbances in Rett Syndrome patients using Restricted Boltzmann Machine. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:442-445. PMID: 29059905.
    Citations: 1     Fields:    Translation:Humans
  41. Capal JK, Horn PS, Murray DS, Byars AW, Bing NM, Kent B, Bucher LA, Williams ME, O'Kelley S, Pearson DA, Sahin M, Krueger DA. Utility of the Autism Observation Scale for Infants in Early Identification of Autism in Tuberous Sclerosis Complex. Pediatr Neurol. 2017 Oct; 75:80-86. PMID: 28844798.
    Citations: 1     Fields:    Translation:Humans
  42. Srivastava S, Sahin M. Autism spectrum disorder and epileptic encephalopathy: common causes, many questions. J Neurodev Disord. 2017; 9:23. PMID: 28649286.
    Citations: 1     Fields:    
  43. Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Mol Autism. 2017; 8:26. PMID: 28638591.
    Citations: 7     Fields:    Translation:HumansAnimals
  44. Dy ME, Waugh JL, Sharma N, O'Leary H, Kapur K, D'Gama AM, Sahin M, Urion DK, Kaufmann WE. Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. Pediatr Neurol. 2017 Oct; 75:91-95. PMID: 28838622.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  45. Srivastava S, Gubbels CS, Dies K, Fulton A, Yu T, Sahin M. Increased Survival and Partly Preserved Cognition in a Patient With ACO2-Related Disease Secondary to a Novel Variant. J Child Neurol. 2017 08; 32(9):840-845. PMID: 28545339.
    Citations: 2     Fields:    Translation:Humans
  46. Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer Res. 2017 06 15; 77(12):3255-3267. PMID: 28512249.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Sahin M. Comment on: "Comprehensive first-line magnetic resonance imaging in hypertension: experience from a single-center tertiary referral clinic". J Clin Hypertens (Greenwich). 2017 07; 19(7):677. PMID: 28493420.
    Citations:    Fields:    
  48. Agulnik A, Kelly DP, Bruccoleri R, Yuskaitis C, Ebrahimi-Fakhari D, Sahin M, Burns MM, Kohane DS. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). PMID: 28557718.
    Citations:    Fields:    Translation:HumansPHPublic Health
  49. Capal JK, Bernardino-Cuesta B, Horn PS, Murray D, Byars AW, Bing NM, Kent B, Pearson DA, Sahin M, Krueger DA. Influence of seizures on early development in tuberous sclerosis complex. Epilepsy Behav. 2017 05; 70(Pt A):245-252. PMID: 28457992.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  50. Modi ME, Sahin M. Translational use of event-related potentials to assess circuit integrity in ASD. Nat Rev Neurol. 2017 03; 13(3):160-170. PMID: 28211449.
    Citations: 1     Fields:    
  51. Ercan E, Han JM, Di Nardo A, Winden K, Han MJ, Hoyo L, Saffari A, Leask A, Geschwind DH, Sahin M. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. J Exp Med. 2017 03 06; 214(3):681-697. PMID: 28183733.
    Citations: 6     Fields:    Translation:AnimalsCells
  52. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Sahin M. Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons. Autophagy. 2017 Apr 03; 13(4):754-756. PMID: 28121223.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  53. Ebrahimi-Fakhari D, Saffari A, Wahlster L, DiNardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Cell Rep. 2016 11 15; 17(8):2162. PMID: 27851977.
    Citations: 3     Fields:    
  54. Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J. Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome. Pediatr Neurol. 2017 02; 67:59-63. PMID: 27919468.
    Citations: 2     Fields:    Translation:HumansCells
  55. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Di Nardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep. 2016 10 18; 17(4):1053-1070. PMID: 27760312.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  56. Canovic EP, Qing B, Mijailovic AS, Jagielska A, Whitfield MJ, Kelly E, Turner D, Sahin M, Van Vliet KJ. Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry. J Vis Exp. 2016 09 06; (115). PMID: 27684097.
    Citations: 2     Fields:    Translation:Humans
  57. Jeste SS, Varcin KJ, Hellemann GS, Gulsrud AC, Bhatt R, Kasari C, Wu JY, Sahin M, Nelson CA. Symptom profiles of autism spectrum disorder in tuberous sclerosis complex. Neurology. 2016 Aug 23; 87(8):766-72. PMID: 27440144.
    Citations: 10     Fields:    Translation:Humans
  58. Crall C, Valle M, Kapur K, Dies KA, Liang MG, Sahin M, Huang JT. Effect of Angiofibromas on Quality of Life and Access to Care in Tuberous Sclerosis Patients and Their Caregivers. Pediatr Dermatol. 2016 Sep; 33(5):518-25. PMID: 27436143.
    Citations:    Fields:    Translation:Humans
  59. Weisleder P, Gospe SM, Ng YT, Sahin M. The Pediatric Neurology Trainee Publication Award for 2015. Pediatr Neurol. 2016 Oct; 63:1-2. PMID: 27543367.
    Citations:    
  60. Weisleder P, Gospe SM, Ng YT, Sahin M. The Pediatric Neurology Trainee Publication Award for 2015. Pediatr Neurol. 2016 10; 63:1-2. PMID: 28847386.
    Citations:    Fields:    Translation:Humans
  61. Sun Y, Lipton JO, Boyle LM, Madsen JR, Goldenberg MC, Pascual-Leone A, Sahin M, Rotenberg A. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Ann Neurol. 2016 08; 80(2):233-46. PMID: 27315032.
    Citations: 6     Fields:    Translation:HumansAnimals
  62. Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 07; 60:1-12. PMID: 27267556.
    Citations: 9     Fields:    Translation:HumansAnimals
  63. Wertz MH, Winden K, Neveu P, Ng SY, Ercan E, Sahin M. Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy. Hum Mol Genet. 2016 06 01; 25(11):2168-2181. PMID: 27005422.
    Citations:    
  64. Pinto A, Sahin M, Pearl PL. Epileptogenesis in neurocutaneous disorders with focus in Sturge Weber syndrome. F1000Res. 2016; 5. PMID: 27019697.
    Citations: 4     
  65. Comi AM, Sahin M, Hammill A, Kaplan EH, Juhász C, North P, Ball KL, Levin AV, Cohen B, Morris J, Lo W, Roach ES. Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research. Pediatr Neurol. 2016 05; 58:12-24. PMID: 27268758.
    Citations: 2     Fields:    Translation:HumansAnimals
  66. Tai DJ, Ragavendran A, Manavalan P, Stortchevoi A, Seabra CM, Erdin S, Collins RL, Blumenthal I, Chen X, Shen Y, Sahin M, Zhang C, Lee C, Gusella JF, Talkowski ME. Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR. Nat Neurosci. 2016 Mar; 19(3):517-22. PMID: 26829649.
    Citations: 9     Fields:    Translation:HumansCells
  67. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Lu J, Byrne S, Hoffmann GF, Jungbluth H, Sahin M. Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Brain. 2016 Feb; 139(Pt 2):317-37. PMID: 26715604.
    Citations: 14     Fields:    Translation:HumansCells
  68. Gholipour A, Afacan O, Aganj I, Scherrer B, Prabhu SP, Sahin M, Warfield SK. Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI. Med Phys. 2015 Dec; 42(12):6919-32. PMID: 26632048.
    Citations: 2     Fields:    Translation:Humans
  69. Pinto AL, Chen L, Friedman R, Grant PE, Poduri A, Takeoka M, Prabhu SP, Sahin M. Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. Pediatr Neurol. 2016 05; 58:25-30. PMID: 26706049.
    Citations: 9     Fields:    Translation:Humans
  70. Tyburczy ME, Dies KA, Glass J, Camposano S, Chekaluk Y, Thorner AR, Lin L, Krueger D, Franz DN, Thiele EA, Sahin M, Kwiatkowski DJ. Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing. PLoS Genet. 2015 Nov; 11(11):e1005637. PMID: 26540169.
    Citations: 29     Fields:    Translation:Humans
  71. Sahin M, Sur M. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders. Science. 2015 Nov 20; 350(6263). PMID: 26472761.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  72. Peters JM, Prohl AK, Tomas-Fernandez XK, Taquet M, Scherrer B, Prabhu SP, Lidov HG, Singh JM, Jansen FE, Braun KP, Sahin M, Warfield SK, Stamm A. Tubers are neither static nor discrete: Evidence from serial diffusion tensor imaging. Neurology. 2015 Nov 03; 85(18):1536-45. PMID: 26432846.
    Citations: 4     Fields:    Translation:Humans
  73. Wu JY, Peters JM, Goyal M, Krueger D, Sahin M, Northrup H, Au KS, Cutter G, Bebin EM. Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants. Pediatr Neurol. 2016 Jan; 54:29-34. PMID: 26498039.
    Citations: 15     Fields:    Translation:Humans
  74. Scherrer B, Schwartzman A, Taquet M, Sahin M, Prabhu SP, Warfield SK. Characterizing brain tissue by assessment of the distribution of anisotropic microstructural environments in diffusion-compartment imaging (DIAMOND). Magn Reson Med. 2016 09; 76(3):963-77. PMID: 26362832.
    Citations: 11     Fields:    Translation:HumansAnimals
  75. Sundberg M, Sahin M. Cerebellar Development and Autism Spectrum Disorder in Tuberous Sclerosis Complex. J Child Neurol. 2015 Dec; 30(14):1954-62. PMID: 26303409.
    Citations: 5     Fields:    Translation:Animals
  76. Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015 Jul 29; 35(30):10762-72. PMID: 26224859.
    Citations: 9     Fields:    Translation:AnimalsCells
  77. Wertz MH, Sahin M. Developing therapies for spinal muscular atrophy. Ann N Y Acad Sci. 2016 02; 1366(1):5-19. PMID: 26173388.
    Citations: 6     Fields:    Translation:HumansAnimals
  78. Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, Worley PF, Wang SS. Cerebellar associative sensory learning defects in five mouse autism models. Elife. 2015 Jul 09; 4:e06085. PMID: 26158416.
    Citations: 18     Fields:    Translation:AnimalsCells
  79. Davis PE, Peters JM, Krueger DA, Sahin M. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics. 2015 Jul; 12(3):572-83. PMID: 25986747.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  80. Neul JL, Sahin M. Therapeutic Advances in Autism and Other Neurodevelopmental Disorders. Neurotherapeutics. 2015 Jul; 12(3):519-20. PMID: 26076992.
    Citations: 1     Fields:    Translation:Humans
  81. Varcin KJ, Nelson CA, Ko J, Sahin M, Wu JY, Jeste SS. Visual Evoked Potentials as a Readout of Cortical Function in Infants With Tuberous Sclerosis Complex. J Child Neurol. 2016 Feb; 31(2):195-202. PMID: 26018199.
    Citations: 5     Fields:    Translation:Humans
  82. Tatar EC, Sahin M, Demiral D, Bayir O, Saylam G, Ozdek A, Korkmaz MH. Normative Values of Voice Analysis Parameters With Respect to Menstrual Cycle in Healthy Adult Turkish Women. J Voice. 2016 May; 30(3):322-8. PMID: 26003887.
    Citations: 2     Fields:    Translation:Humans
  83. Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 2015 May 21; 161(5):1138-1151. PMID: 25981667.
    Citations: 51     Fields:    Translation:AnimalsCells
  84. Ng YT, Gospe SM, Sahin M. Pediatric Neurology 2014 Trainee Publication Award Winner: Dr. Mitchel T. Williams. Pediatr Neurol. 2015 Aug; 53(2):103-4. PMID: 26047694.
    Citations:    Fields:    Translation:Humans
  85. DiMario FJ, Sahin M, Ebrahimi-Fakhari D. Tuberous sclerosis complex. Pediatr Clin North Am. 2015 Jun; 62(3):633-48. PMID: 26022167.
    Citations: 16     Fields:    Translation:HumansCells
  86. Ebrahimi-Fakhari D, Sahin M. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr Opin Neurol. 2015 Apr; 28(2):91-102. PMID: 25695134.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  87. Akula JD, Noonan ER, Di Nardo A, Favazza TL, Zhang N, Sahin M, Hansen RM, Fulton AB. Vigabatrin can enhance electroretinographic responses in pigmented and albino rats. Doc Ophthalmol. 2015 Aug; 131(1):1-11. PMID: 25761928.
    Citations:    Fields:    Translation:AnimalsCells
  88. Im K, Ahtam B, Haehn D, Peters JM, Warfield SK, Sahin M, Ellen Grant P. Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex. 2016 May; 26(5):2046-58. PMID: 25750257.
    Citations: 3     Fields:    Translation:Humans
  89. Baumer FM, Song JW, Mitchell PD, Pienaar R, Sahin M, Grant PE, Takahashi E. Longitudinal changes in diffusion properties in white matter pathways of children with tuberous sclerosis complex. Pediatr Neurol. 2015 Jun; 52(6):615-23. PMID: 25817702.
    Citations: 2     Fields:    Translation:HumansCells
  90. Dies KA, Sahin M. Genetics of neurocutaneous disorders: basic principles of inheritance as they apply to neurocutaneous syndromes. Handb Clin Neurol. 2015; 132:3-8. PMID: 26564068.
    Citations:    Fields:    Translation:Humans
  91. Leech JD, Lammers SH, Goldman S, Auricchio N, Bronson RT, Kwiatkowski DJ, Sahin M. A vascular model of Tsc1 deficiency accelerates renal tumor formation with accompanying hemangiosarcomas. Mol Cancer Res. 2015 Mar; 13(3):548-55. PMID: 25548102.
    Citations: 3     Fields:    Translation:AnimalsCells
  92. Lipton JO, Sahin M. The neurology of mTOR. Neuron. 2014 Oct 22; 84(2):275-91. PMID: 25374355.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  93. de Vries PJ, Whittemore VH, Leclezio L, Byars AW, Dunn D, Ess KC, Hook D, King BH, Sahin M, Jansen A. Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist. Pediatr Neurol. 2015 Jan; 52(1):25-35. PMID: 25532776.
    Citations: 31     Fields:    Translation:Humans
  94. Ebrahimi-Fakhari D, Wahlster L, Sahin M. Parkinson's disease: A disorder of axonal mitophagy? Mov Disord. 2014 Nov; 29(13):1582. PMID: 25256171.
    Citations: 1     Fields:    Translation:AnimalsCells
  95. Jamuar SS, Lam AT, Kircher M, D'Gama AM, Wang J, Barry BJ, Zhang X, Hill RS, Partlow JN, Rozzo A, Servattalab S, Mehta BK, Topcu M, Amrom D, Andermann E, Dan B, Parrini E, Guerrini R, Scheffer IE, Berkovic SF, Leventer RJ, Shen Y, Wu BL, Barkovich AJ, Sahin M, Chang BS, Bamshad M, Nickerson DA, Shendure J, Poduri A, Yu TW, Walsh CA. Somatic mutations in cerebral cortical malformations. N Engl J Med. 2014 Aug 21; 371(8):733-43. PMID: 25140959.
    Citations: 60     Fields:    Translation:Humans
  96. Sahin M. Gene therapy for childhood neurological disease. Pediatr Neurol. 2014 Nov; 51(5):595-6. PMID: 25439574.
    Citations: 1     Fields:    Translation:Humans
  97. Greene-Colozzi EA, Sadowski AR, Chadwick E, Tsai PT, Sahin M. Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice. Epilepsy Res Treat. 2014; 2014:784137. PMID: 25165580.
    Citations: 1     
  98. Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M. SMN regulates axonal local translation via miR-183/mTOR pathway. Hum Mol Genet. 2014 Dec 01; 23(23):6318-31. PMID: 25055867.
    Citations: 28     Fields:    Translation:AnimalsCells
  99. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. PMID: 24811917.
    Citations: 33     Fields:    Translation:Humans
  100. Spurling Jeste S, Wu JY, Senturk D, Varcin K, Ko J, McCarthy B, Shimizu C, Dies K, Vogel-Farley V, Sahin M, Nelson CA. Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex. Neurology. 2014 Jul 08; 83(2):160-8. PMID: 24920850.
    Citations: 17     Fields:    Translation:HumansCells
  101. Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest. 2014 Jun; 124(6):2774-84. PMID: 24837431.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  102. Clifford MA, Athar W, Leonard CE, Russo A, Sampognaro PJ, Van der Goes MS, Burton DA, Zhao X, Lalchandani RR, Sahin M, Vicini S, Donoghue MJ. EphA7 signaling guides cortical dendritic development and spine maturation. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4994-9. PMID: 24707048.
    Citations: 11     Fields:    Translation:AnimalsCells
  103. Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet. 2014 Jul 15; 23(14):3865-74. PMID: 24599401.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  104. Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Mol Autism. 2014 Feb 24; 5(1):16. PMID: 24564913.
    Citations: 6     Fields:    
  105. Roach ES, Gospe S, Ng YT, Sahin M. Trust but verify: the introduction of plagiarism detection software. Pediatr Neurol. 2014 Apr; 50(4):287. PMID: 24630278.
    Citations: 1     Fields:    
  106. Jülich K, Sahin M. Mechanism-based treatment in tuberous sclerosis complex. Pediatr Neurol. 2014 Apr; 50(4):290-6. PMID: 24486221.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  107. Taquet M, Scherrer B, Commowick O, Peters JM, Sahin M, Macq B, Warfield SK. A mathematical framework for the registration and analysis of multi-fascicle models for population studies of the brain microstructure. IEEE Trans Med Imaging. 2014 Feb; 33(2):504-17. PMID: 24235301.
    Citations: 11     Fields:    Translation:Humans
  108. Peters JM, Taquet M, Prohl AK, Scherrer B, van Eeghen AM, Prabhu SP, Sahin M, Warfield SK. Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions. Future Neurol. 2013 Sep; 8(5):583-597. PMID: 24489482.
    Citations: 10     
  109. Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol. 2013 Oct; 15(10):1186-96. PMID: 23955302.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  110. Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. J Neurosci. 2013 Apr 10; 33(15):6557-62. PMID: 23575853.
    Citations: 10     Fields:    Translation:AnimalsCells
  111. Peters JM, Taquet M, Vega C, Jeste SS, Fernández IS, Tan J, Nelson CA, Sahin M, Warfield SK. Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity. BMC Med. 2013 Feb 27; 11:54. PMID: 23445896.
    Citations: 44     Fields:    Translation:Humans
  112. Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatr Neurol. 2013 Feb; 48(2):105-10. PMID: 23337002.
    Citations: 9     Fields:    Translation:Humans
  113. Fogarasi A, Loddenkemper T, Mellado C, Tuxhorn I, Evers G, Sarco D, Burgess RC, Halász P, Barsis P, Gyorsok Z, Gyimesi C, Kóbor J, Siegler Z, Janszky J, Jakus R, Rásonyi G, Ebner A, Woermann FG, Sahin M. Sturge-Weber syndrome: clinical and radiological correlates in 86 patients. Ideggyogy Sz. 2013 Jan 30; 66(1-2):53-7. PMID: 23607230.
    Citations: 1     Fields:    Translation:Humans
  114. Lipton J, Sahin M. Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron. 2013 Jan 23; 77(2):212-3. PMID: 23352156.
    Citations: 3     Fields:    
  115. Scherrer B, Schwartzman A, Taquet M, Prabhu SP, Sahin M, Akhondi-Asl A, Warfield SK. Characterizing the distribution of anisotropic micro-structural environments with diffusion-weighted imaging (DIAMOND). Med Image Comput Comput Assist Interv. 2013; 16(Pt 3):518-26. PMID: 24505801.
    Citations: 6     Fields:    Translation:Cells
  116. Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet. 2013 Jan; 43(1):51-9. PMID: 23229624.
    Citations: 9     Fields:    Translation:AnimalsPHPublic Health
  117. Jeste SS, Hirsch S, Vogel-Farley V, Norona A, Navalta MC, Gregas MC, Prabhu SP, Sahin M, Nelson CA. Atypical face processing in children with tuberous sclerosis complex. J Child Neurol. 2013 Dec; 28(12):1569-76. PMID: 23143725.
    Citations: 5     Fields:    Translation:Humans
  118. Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012 Aug 30; 488(7413):647-51. PMID: 22763451.
    Citations: 210     Fields:    Translation:AnimalsCells
  119. Yuan E, Tsai PT, Greene-Colozzi E, Sahin M, Kwiatkowski DJ, Malinowska IA. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Hum Mol Genet. 2012 Oct 01; 21(19):4286-300. PMID: 22752306.
    Citations: 17     Fields:    Translation:HumansAnimals
  120. Poduri A, Chopra SS, Neilan EG, Elhosary PC, Kurian MA, Meyer E, Barry BJ, Khwaja OS, Salih MA, Stödberg T, Scheffer IE, Maher ER, Sahin M, Wu BL, Berry GT, Walsh CA, Picker J, Kothare SV. Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy. Epilepsia. 2012 Aug; 53(8):e146-50. PMID: 22690784.
    Citations: 20     Fields:    Translation:Humans
  121. Lewis WW, Sahin M, Scherrer B, Peters JM, Suarez RO, Vogel-Farley VK, Jeste SS, Gregas MC, Prabhu SP, Nelson CA, Warfield SK. Impaired language pathways in tuberous sclerosis complex patients with autism spectrum disorders. Cereb Cortex. 2013 Jul; 23(7):1526-32. PMID: 22661408.
    Citations: 22     Fields:    Translation:HumansCells
  122. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  123. Sahin M. Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol. 2012 Oct; 22(5):895-901. PMID: 22560338.
    Citations: 30     Fields:    Translation:HumansCells
  124. Olson HE, Shen Y, Poduri A, Gorman MP, Dies KA, Robbins M, Hundley R, Wu B, Sahin M. Micro-duplications of 1q32.1 associated with neurodevelopmental delay. Eur J Med Genet. 2012 Feb; 55(2):145-50. PMID: 22266072.
    Citations: 4     Fields:    Translation:HumansCells
  125. Taquet M, Scherrer B, Commowick O, Peters J, Sahin M, Macq B, Warfield SK. Registration and analysis of white matter group differences with a multi-fiber model. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):313-20. PMID: 23286145.
    Citations: 7     Fields:    Translation:HumansCells
  126. Nie D, Sahin M. A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures. Methods Mol Biol. 2012; 821:393-405. PMID: 22125080.
    Citations: 5     Fields:    Translation:HumansCells
  127. Peters JM, Sahin M, Vogel-Farley VK, Jeste SS, Nelson CA, Gregas MC, Prabhu SP, Scherrer B, Warfield SK. Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex. Acad Radiol. 2012 Jan; 19(1):17-25. PMID: 22142677.
    Citations: 43     Fields:    Translation:HumansCells
  128. Khwaja OS, Sahin M. Translational research: Rett syndrome and tuberous sclerosis complex. Curr Opin Pediatr. 2011 Dec; 23(6):633-9. PMID: 21970827.
    Citations: 10     Fields:    Translation:HumansAnimals
  129. Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):E1070-9. PMID: 22025691.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  130. Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, Kluger G, van Baalen A. Febrile infection-related epilepsy syndrome (FIRES): does duration of anesthesia affect outcome? Epilepsia. 2011 Oct; 52 Suppl 8:28-30. PMID: 21967356.
    Citations: 4     Fields:    Translation:Humans
  131. Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ. NMDA mediated contextual conditioning changes miRNA expression. PLoS One. 2011; 6(9):e24682. PMID: 21931811.
    Citations: 27     Fields:    Translation:AnimalsCells
  132. Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, Nabbout R, Kluger G, Lin JJ, van Baalen A. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia. 2011 Nov; 52(11):1956-65. PMID: 21883180.
    Citations: 23     Fields:    Translation:Humans
  133. Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10337-42. PMID: 21652774.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  134. Sahin M, Miller I, Holmes GL, Sheth RD. Pediatric epileptology. Epilepsy Behav. 2011 Sep; 22(1):32-7. PMID: 21530413.
    Citations:    Fields:    Translation:Humans
  135. Tsai P, Sahin M. Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex. Curr Opin Neurol. 2011 Apr; 24(2):106-13. PMID: 21301339.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  136. Han JM, Sahin M. TSC1/TSC2 signaling in the CNS. FEBS Lett. 2011 Apr 06; 585(7):973-80. PMID: 21329690.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  137. Zou T, Yang X, Pan D, Huang J, Sahin M, Zhou J. SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress. Cell Mol Neurobiol. 2011 May; 31(4):541-50. PMID: 21234798.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  138. Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell. 2010 Dec 03; 7(6):671-81. PMID: 21112562.
    Citations: 49     Fields:    Translation:HumansCells
  139. Ehninger D, Sano Y, de Vries PJ, Dies K, Franz D, Geschwind DH, Kaur M, Lee YS, Li W, Lowe JK, Nakagawa JA, Sahin M, Smith K, Whittemore V, Silva AJ. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Mol Psychiatry. 2012 Jan; 17(1):62-70. PMID: 21079609.
    Citations: 35     Fields:    Translation:HumansAnimals
  140. Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29; 143(3):442-55. PMID: 21029865.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  141. Sahin M. Eph receptor and mTOR pathway crosstalk: implications for cancer. Cell Cycle. 2010 Jun 01; 9(11):2053-4. PMID: 20505333.
    Citations: 5     Fields:    Translation:AnimalsCells
  142. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4153-8. PMID: 20160076.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  143. Krishnan ML, Commowick O, Jeste SS, Weisenfeld N, Hans A, Gregas MC, Sahin M, Warfield SK. Diffusion features of white matter in tuberous sclerosis with tractography. Pediatr Neurol. 2010 Feb; 42(2):101-6. PMID: 20117745.
    Citations: 22     Fields:    Translation:HumansCells
  144. Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci. 2010 Feb; 13(2):163-72. PMID: 20062052.
    Citations: 104     Fields:    Translation:AnimalsCells
  145. Gholipour A, Estroff JA, Sahin M, Prabhu SP, Warfield SK. Maximum a posteriori estimation of isotropic high-resolution volumetric MRI from orthogonal thick-slice scans. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):109-16. PMID: 20879305.
    Citations: 8     Fields:    Translation:Humans
  146. Poduri A, Chitsazzadeh V, D'Arrigo S, Fedrizzi E, Pantaleoni C, Riva D, Busse C, Küster H, Duplessis A, Gaitanis J, Sahin M, Garganta C, Topcu M, Dies KA, Barry BJ, Partlow J, Barkovich AJ, Walsh CA, Chang BS. The syndrome of perisylvian polymicrogyria with congenital arthrogryposis. Brain Dev. 2010 Aug; 32(7):550-5. PMID: 19751967.
    Citations: 1     Fields:    Translation:Humans
  147. Ullner PM, Di Nardo A, Goldman JE, Schobel S, Yang H, Engelstad K, Wang D, Sahin M, De Vivo DC. Murine Glut-1 transporter haploinsufficiency: postnatal deceleration of brain weight and reactive astrocytosis. Neurobiol Dis. 2009 Oct; 36(1):60-9. PMID: 19591936.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  148. Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci. 2009 May 06; 29(18):5926-37. PMID: 19420259.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  149. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 07; 322(5903):963-6. PMID: 18988856.
    Citations: 433     Fields:    Translation:AnimalsCells
  150. Choi YJ, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski DJ, Sahin M, He X. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008 Sep 15; 22(18):2485-95. PMID: 18794346.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  151. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan WM, Law K, Crosier M, Lindsay S, Cheung M, Allen J, Gutowski NJ, Ellard S, Young E, Iannaccone A, Appukuttan B, Stout JT, Christiansen S, Ciccarelli ML, Baldi A, Campioni M, Zenteno JC, Davenport D, Mariani LE, Sahin M, Guthrie S, Engle EC. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science. 2008 Aug 08; 321(5890):839-43. PMID: 18653847.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  152. Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci. 2008 May 21; 28(21):5422-32. PMID: 18495876.
    Citations: 183     Fields:    Translation:AnimalsCells
  153. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008 Mar 14; 29(5):541-51. PMID: 18342602.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  154. Tekin A, Kücükkartallar T, Kartal A, Kaynak A, Ozer S, Tavli S, Belviranli M, Sahin M, Yol S, Aksoy F, Tekin S, Vatansev C, Erikoglu M. Clinical and surgical profile and follow up of patients with liver hydatid cyst from an endemic region. J Gastrointestin Liver Dis. 2008 Mar; 17(1):33-7. PMID: 18392241.
    Citations:    
  155. Datta AN, Hahn CD, Sahin M. Clinical presentation and diagnosis of tuberous sclerosis complex in infancy. J Child Neurol. 2008 Mar; 23(3):268-73. PMID: 18230839.
    Citations: 21     Fields:    Translation:Humans
  156. Jeste SS, Sahin M, Bolton P, Ploubidis GB, Humphrey A. Characterization of autism in young children with tuberous sclerosis complex. J Child Neurol. 2008 May; 23(5):520-5. PMID: 18160549.
    Citations: 56     Fields:    Translation:Humans
  157. Jozwiak J, Sahin M, Jozwiak S, Kotulska K, Ploski R, Szperl M, Wlodarski PK. Cardiac rhabdomyoma in tuberous sclerosis: hyperactive Erk signaling. Int J Cardiol. 2009 Feb 06; 132(1):145-7. PMID: 18037514.
    Citations: 1     Fields:    Translation:HumansCells
  158. Kotulska K, Larysz-Brysz M, Grajkowska W, Józwiak J, Wlodarski P, Sahin M, Lewin-Kowalik J, Domanska-Pakiela D, Józwiak S. Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities. Pediatr Dev Pathol. 2009 Mar-Apr; 12(2):89-95. PMID: 17990907.
    Citations: 5     Fields:    Translation:Humans
  159. Sahin M, Tanaci N, Yucel M, Tutuncu NB, Guvener N. The effect of single-dose orlistat on postprandial serum glucose, insulin and glucagon-like peptide-1 levels in nondiabetic obese patients. Clin Endocrinol (Oxf). 2007 Sep; 67(3):346-50. PMID: 17524030.
    Citations:    
  160. Meikle L, Talos DM, Onda H, Pollizzi K, Rotenberg A, Sahin M, Jensen FE, Kwiatkowski DJ. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. J Neurosci. 2007 May 23; 27(21):5546-58. PMID: 17522300.
    Citations: 176     Fields:    Translation:AnimalsCells
  161. Raju GP, Urion DK, Sahin M. Neonatal subependymal giant cell astrocytoma: new case and review of literature. Pediatr Neurol. 2007 Feb; 36(2):128-31. PMID: 17275668.
    Citations: 14     Fields:    Translation:Humans
  162. Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007 Jan; 10(1):67-76. PMID: 17143272.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  163. Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006 Oct 20; 24(2):185-97. PMID: 17052453.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  164. Neal J, Apse K, Sahin M, Walsh CA, Sheen VL. Deletion of chromosome 1p36 is associated with periventricular nodular heterotopia. Am J Med Genet A. 2006 Aug 01; 140(15):1692-5. PMID: 16835933.
    Citations: 7     Fields:    Translation:HumansCells
  165. Sahin M, Sengul A, Berki Z, Tutuncu NB, Guvener ND. Ultrasound-guided fine-needle aspiration biopsy and ultrasonographic features of infracentimetric nodules in patients with nodular goiter: correlation with pathological findings. Endocr Pathol. 2006; 17(1):67-74. PMID: 16760582.
    Citations: 4     Fields:    Translation:Humans
  166. Ermertcan AT, Oztürkcan S, Sahin MT, Türkdogan P, Saçar T. Erythromelanosis follicularis faciei et colli associated with keratosis pilaris in two brothers. Pediatr Dermatol. 2006 Jan-Feb; 23(1):31-4. PMID: 16445408.
    Citations: 3     Fields:    Translation:Humans
  167. Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R. Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron. 2005 Aug 18; 47(4):515-28. PMID: 16102535.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  168. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005 Apr 21; 46(2):205-17. PMID: 15848800.
    Citations: 99     Fields:    Translation:AnimalsCells
  169. Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005 Apr 21; 46(2):191-204. PMID: 15848799.
    Citations: 94     Fields:    Translation:AnimalsCells
  170. Frye RE, Newburger JW, Nugent A, Sahin M. Focal seizure and cerebral contrast retention after cardiac catheterization. Pediatr Neurol. 2005 Mar; 32(3):213-6. PMID: 15730907.
    Citations: 1     Fields:    Translation:Humans
  171. Sahin M, Menache CC, Holmes GL, Riviello JJ. Prolonged treatment for acute symptomatic refractory status epilepticus: outcome in children. Neurology. 2003 Aug 12; 61(3):398-401. PMID: 12913208.
    Citations: 8     Fields:    Translation:Humans
  172. Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia. 2001 Nov; 42(11):1461-7. PMID: 11879350.
    Citations: 21     Fields:    Translation:Humans
  173. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 2001 Apr 20; 105(2):233-44. PMID: 11336673.
    Citations: 151     Fields:    Translation:AnimalsCells
  174. Sahin M, Riviello JJ. Prolonged treatment of refractory status epilepticus in a child. J Child Neurol. 2001 Feb; 16(2):147-50. PMID: 11292225.
    Citations: 1     Fields:    Translation:Humans
  175. Benatar MG, Sahin M, Davis RG. Antiepileptic drug-induced visual hallucinations in a child. Pediatr Neurol. 2000 Nov; 23(5):439-41. PMID: 11118803.
    Citations: 1     Fields:    Translation:Humans
  176. Sahin M, du Plessis AJ. Hydrocephalus associated with glycogen storage disease type II (Pompe's disease). Pediatr Neurol. 1999 Sep; 21(3):674-6. PMID: 10513698.
    Citations:    Fields:    Translation:Humans
  177. Bellefroid EJ, Sahin M, Poncelet DA, Rivière M, Bourguignon C, Martial JA, Morris PL, Pieler T, Szpirer C, Ward DC. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Biochim Biophys Acta. 1998 Jul 09; 1398(3):321-9. PMID: 9655926.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  178. Sahin M, Slaugenhaupt SA, Gusella JF, Hockfield S. Expression of PTPH1, a rat protein tyrosine phosphatase, is restricted to the derivatives of a specific diencephalic segment. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7859-63. PMID: 7644504.
    Citations: 2     Fields:    Translation:AnimalsCells
  179. Sahin M, Dowling JJ, Hockfield S. Seven protein tyrosine phosphatases are differentially expressed in the developing rat brain. J Comp Neurol. 1995 Jan 23; 351(4):617-31. PMID: 7721987.
    Citations: 11     Fields:    Translation:AnimalsCells
  180. Sahin M, Hockfield S. Protein tyrosine phosphatases expressed in the developing rat brain. J Neurosci. 1993 Nov; 13(11):4968-78. PMID: 8229209.
    Citations: 9     Fields:    Translation:AnimalsCells
  181. Sahin M, Bowen WD, Donoghue JP. Location of nicotinic and muscarinic cholinergic and mu-opiate receptors in rat cerebral neocortex: evidence from thalamic and cortical lesions. Brain Res. 1992 May 01; 579(1):135-47. PMID: 1320443.
    Citations: 7     Fields:    Translation:Animals
  182. Sahin M, Hockfield S. Molecular identification of the Lugaro cell in the cat cerebellar cortex. J Comp Neurol. 1990 Nov 22; 301(4):575-84. PMID: 2273099.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.