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Isabelle M. Rosso, Ph.D.

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University of Pennsylvania, Philadelphia, PAPhD2002Clinical Psychology
Dartmouth College, Hanover, NHA.B.1993Biology & Psychology
French Baccalaureat, Magna cum laude
Golden Key National Honor Society
Rufus Choate Scholar Award
University Fellowship
Dean's Scholar Award
Best Paper in Neuroscience
Blue Ribbon Finalist for Best Clinical/Translational Poster Presentation
Top Paper Finalist

I am an Associate Professor of Psychology at the Center for Depression, Anxiety and Stress Research of McLean Hospital. I also serve as Director of the Anxiety and Traumatic Stress Disorders Laboratory, and I devote approximately 70% of my time to research, 20% to teaching, and 10% to administrative activities. My primary activities involve directing an NIMH R01 study on which I am the Principal Investigator (PI), supervising the execution of an R01 subcontract on which I am the site PI, and co-managing the execution of a DOD grant on which I am a co-investigator. I am also a co-investigator on a multisite study applying the Human Connectome neuroimaging and behavioral protocols in a sample of youth with depression and anxiety.

My research uses brain imaging to characterize neurobiological phenotypes of anxiety and stress-related disorders, and to relate them to behavioral phenotypes and clinical phenomenology. The field of psychiatry has reached an exciting juncture where we have the neuroscience knowledge and methods that can lead to a mechanistic understanding of mental illness -- particularly in the context of the NIMH’s commitment to the dimensional and transdiagnostic research framework known as RDoC. In this vein, one project in my laboratory is studying posttraumatic stress disorder (PTSD) using magnetic resonance spectroscopy, in order to identify alterations in neurochemicals that modulate neuronal excitability. This line of investigation is based on preclinical and clinical evidence that PTSD involves abnormal excitability of brain regions mediating emotional regulation, including fear conditioning. Thus, we are also examining whether neurochemistry is associated with behavioral and phenomenological aspects of PTSD, including fear extinction deficits and hyperarousal symptoms. During the past ten years, I have been continuously funded through independent grants from the Dana Foundation, an NIMH R01, and most recently a NARSAD Independent Investigator Award from the Brain and Behavior Research Foundation. A longstanding interest and theme of my research program has been the identification of neurobehavioral markers of risk versus disease processes in psychiatric disorders. I have pursued this interest in the context of many different research designs, including epidemiological studies of early risk factors, family studies of biological relatives of clinically affected individuals, investigations of patients in the earliest stages of their illness, and most recently studies of trauma-exposed individuals with and without PTSD.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH120400 (ROSSO, ISABELLE M) Jul 1, 2019 - Apr 30, 2024
    Multimodal imaging of hippocampal-cortical networks and mechanisms of trauma-related intrusions
    Role: Principal Investigator
  2. P50MH115874 (CARLEZON, WILLIAM A.) Apr 1, 2019 - Feb 28, 2024
    Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital
    Role: Project 4 Principal Investigator
  3. NARSAD Independent Investigator Award (ROSSO, ISABELLE M) Sep 15, 2016 - Sep 14, 2018
    Brain and Behavior Research Founation
    Impact of riluzole on hippocampal glutamate excitotoxicity in PTSD
    Role Description: This is a proof-of-principle 6-week open label trial of riluzole in chronic PTSD. The major objective is to determine whether riluzole, an agent with established neuroprotective and antiglutamatergic properties, shows efficacy in rescuing a neurochemical phenotype of hippocampal excitotoxicity (high glutamate, low N-acetyl aspartate) in PTSD. A second objective is to determine whether riluzole shows targeted efficacy for symptoms and behaviors that rely on the hippocampus.
    Role: P.I.
  4. R01MH096987 (ROSSO, ISABELLE M) Jul 1, 2012 - Mar 31, 2018
    Cerebral GABA and Fear Conditioning in PTSD
    Role: Principal Investigator
  5. (ROSSO, ISABELLE M) Jun 1, 2010 - May 30, 2014
    The Dana Foundation
    Proton spectroscopy of inhibitory neurotransmission in posttraumatic stress disorder
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lewis MW, Bradford DE, Pace-Schott EF, Rauch SL, Rosso IM. Multiverse analyses of fear acquisition and extinction retention in posttraumatic stress disorder. Psychophysiology. 2023 Feb 14; e14265. PMID: 36786400.
    Citations:    Fields:    
  2. Sun D, Rakesh G, Haswell CC, Logue M, Baird CL, O'Leary EN, Cotton AS, Xie H, Tamburrino M, Chen T, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid F, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein M, Bomyea J, Koerte IK, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog J, Lebois LAM, Baker JT, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh L, Forster G, Simons RM, Simons JS, Magnotta V, Maron-Katz A, du Plessis S, Disner SG, Davenport N, Grupe DW, Nitschke JB, deRoon-Cassini TA, Fitzgerald JM, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton M, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Hosseini B, Phan KL, McLaughlin KA, Davidson RJ, Larson CL, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, van Erp TGM, Quidé Y, Wang X, Thompson PM, Morey RA. A comparison of methods to harmonize cortical thickness measurements across scanners and sites. Neuroimage. 2022 11 01; 261:119509. PMID: 35917919; PMCID: PMC9648725.
    Citations: 5     Fields:    Translation:Humans
  3. Hanuka S, Olson EA, Admon R, Webb CA, Killgore WDS, Rauch SL, Rosso IM, Pizzagalli DA. Reduced anhedonia following internet-based cognitive-behavioral therapy for depression is mediated by enhanced reward circuit activation. Psychol Med. 2022 Jun 17; 1-10. PMID: 35713110.
    Citations:    Fields:    
  4. Casteen EJ, Nielsen SR, Olson EA, Frederiks K, Rosso IM. Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults. Brain Behav. 2022 07; 12(7):e2639. PMID: 35676235; PMCID: PMC9304824.
    Citations: 1     Fields:    Translation:Humans
  5. Ressler KJ, Berretta S, Bolshakov VY, Rosso IM, Meloni EG, Rauch SL, Carlezon WA. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022 05; 18(5):273-288. PMID: 35352034; PMCID: PMC9682920.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Sun D, Rakesh G, Clarke-Rubright EK, Haswell CC, Logue MW, O'Leary EN, Cotton AS, Xie H, Dennis EL, Jahanshad N, Salminen LE, Thomopoulos SI, Rashid FM, Ching CRK, Koch SBJ, Frijling JL, Nawijn L, van Zuiden M, Zhu X, Suarez-Jimenez B, Sierk A, Walter H, Manthey A, Stevens JS, Fani N, van Rooij SJH, Stein MB, Bomyea J, Koerte I, Choi K, van der Werff SJA, Vermeiren RRJM, Herzog JI, Lebois LAM, Baker JT, Ressler KJ, Olson EA, Straube T, Korgaonkar MS, Andrew E, Zhu Y, Li G, Ipser J, Hudson AR, Peverill M, Sambrook K, Gordon E, Baugh LA, Forster G, Simons RM, Simons JS, Magnotta VA, Maron-Katz A, du Plessis S, Disner SG, Davenport ND, Grupe D, Nitschke JB, deRoon-Cassini TA, Fitzgerald J, Krystal JH, Levy I, Olff M, Veltman DJ, Wang L, Neria Y, De Bellis MD, Jovanovic T, Daniels JK, Shenton ME, van de Wee NJA, Schmahl C, Kaufman ML, Rosso IM, Sponheim SR, Hofmann DB, Bryant RA, Fercho KA, Stein DJ, Mueller SC, Phan KL, McLaughlin KA, Davidson RJ, Larson C, May G, Nelson SM, Abdallah CG, Gomaa H, Etkin A, Seedat S, Harpaz-Rotem I, Liberzon I, Wang X, Thompson PM, Morey RA. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 09; 7(9):935-948. PMID: 35307575; PMCID: PMC9835553.
    Citations:    Fields:    
  7. Clausen AN, Fercho KA, Monsour M, Disner S, Salminen L, Haswell CC, Rubright EC, Watts AA, Buckley MN, Maron-Katz A, Sierk A, Manthey A, Suarez-Jimenez B, Olatunji BO, Averill CL, Hofmann D, Veltman DJ, Olson EA, Li G, Forster GL, Walter H, Fitzgerald J, Théberge J, Simons JS, Bomyea JA, Frijling JL, Krystal JH, Baker JT, Phan KL, Ressler K, Han LKM, Nawijn L, Lebois LAM, Schmaal L, Densmore M, Shenton ME, van Zuiden M, Stein M, Fani N, Simons RM, Neufeld RWJ, Lanius R, van Rooij S, Koch SBJ, Bonomo S, Jovanovic T, deRoon-Cassini T, Ely TD, Magnotta VA, He X, Abdallah CG, Etkin A, Schmahl C, Larson C, Rosso IM, Blackford JU, Stevens JS, Daniels JK, Herzog J, Kaufman ML, Olff M, Davidson RJ, Sponheim SR, Mueller SC, Straube T, Zhu X, Neria Y, Baugh LA, Cole JH, Thompson PM, Morey RA. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups. Brain Behav. 2022 01; 12(1):e2413. PMID: 34907666; PMCID: PMC8785613.
    Citations: 3     Fields:    Translation:Humans
  8. Rosso IM, Silveri MM, Olson EA, Eric Jensen J, Ren B. Regional specificity and clinical correlates of cortical GABA alterations in posttraumatic stress disorder. Neuropsychopharmacology. 2022 04; 47(5):1055-1062. PMID: 34675380; PMCID: PMC8938424.
    Citations:    Fields:    Translation:Humans
  9. Furukawa TA, Suganuma A, Ostinelli EG, Andersson G, Beevers CG, Shumake J, Berger T, Boele FW, Buntrock C, Carlbring P, Choi I, Christensen H, Mackinnon A, Dahne J, Huibers MJH, Ebert DD, Farrer L, Forand NR, Strunk DR, Ezawa ID, Forsell E, Kaldo V, Geraedts A, Gilbody S, Littlewood E, Brabyn S, Hadjistavropoulos HD, Schneider LH, Johansson R, Kenter R, Kivi M, Björkelund C, Kleiboer A, Riper H, Klein JP, Schröder J, Meyer B, Moritz S, Bücker L, Lintvedt O, Johansson P, Lundgren J, Milgrom J, Gemmill AW, Mohr DC, Montero-Marin J, Garcia-Campayo J, Nobis S, Zarski AC, O'Moore K, Williams AD, Newby JM, Perini S, Phillips R, Schneider J, Pots W, Pugh NE, Richards D, Rosso IM, Rauch SL, Sheeber LB, Smith J, Spek V, Pop VJ, Ünlü B, van Bastelaar KMP, van Luenen S, Garnefski N, Kraaij V, Vernmark K, Warmerdam L, van Straten A, Zagorscak P, Knaevelsrud C, Heinrich M, Miguel C, Cipriani A, Efthimiou O, Karyotaki E, Cuijpers P. Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data. Lancet Psychiatry. 2021 06; 8(6):500-511. PMID: 33957075; PMCID: PMC8838916.
    Citations: 9     Fields:    Translation:Humans
  10. Karyotaki E, Efthimiou O, Miguel C, Bermpohl FMG, Furukawa TA, Cuijpers P, Riper H, Patel V, Mira A, Gemmil AW, Yeung AS, Lange A, Williams AD, Mackinnon A, Geraedts A, van Straten A, Meyer B, Björkelund C, Knaevelsrud C, Beevers CG, Botella C, Strunk DR, Mohr DC, Ebert DD, Kessler D, Richards D, Littlewood E, Forsell E, Feng F, Wang F, Andersson G, Hadjistavropoulos H, Christensen H, Ezawa ID, Choi I, Rosso IM, Klein JP, Shumake J, Garcia-Campayo J, Milgrom J, Smith J, Montero-Marin J, Newby JM, Bretón-López J, Schneider J, Vernmark K, Bücker L, Sheeber LB, Warmerdam L, Farrer L, Heinrich M, Huibers MJH, Kivi M, Kraepelien M, Forand NR, Pugh N, Lindefors N, Lintvedt O, Zagorscak P, Carlbring P, Phillips R, Johansson R, Kessler RC, Brabyn S, Perini S, Rauch SL, Gilbody S, Moritz S, Berger T, Pop V, Kaldo V, Spek V, Forsell Y. Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis. JAMA Psychiatry. 2021 04 01; 78(4):361-371. PMID: 33471111; PMCID: PMC8027916.
    Citations: 60     Fields:    Translation:Humans
  11. Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O'Leary BM, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan KL, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Mol Psychiatry. 2021 08; 26(8):4331-4343. PMID: 33288872; PMCID: PMC8180531.
    Citations: 6     Fields:    Translation:Humans
  12. Olson EA, Pizzagalli DA, Rosso IM. Social Anhedonia is Associated with Low Social Network Diversity in Trauma-Exposed Adults. J Trauma Stress. 2021 02; 34(1):241-247. PMID: 32816343; PMCID: PMC7903974.
    Citations: 1     Fields:    Translation:Humans
  13. Siless V, Hubbard NA, Jones R, Wang J, Lo N, Bauer CCC, Goncalves M, Frosch I, Norton D, Vergara G, Conroy K, De Souza FV, Rosso IM, Wickham AH, Cosby EA, Pinaire M, Hirshfeld-Becker D, Pizzagalli DA, Henin A, Hofmann SG, Auerbach RP, Ghosh S, Gabrieli J, Whitfield-Gabrieli S, Yendiki A. Image acquisition and quality assurance in the Boston Adolescent Neuroimaging of Depression and Anxiety study. Neuroimage Clin. 2020; 26:102242. PMID: 32339824.
    Citations: 7     Fields:    Translation:Humans
  14. Hubbard NA, Siless V, Frosch IR, Goncalves M, Lo N, Wang J, Bauer CCC, Conroy K, Cosby E, Hay A, Jones R, Pinaire M, Vaz De Souza F, Vergara G, Ghosh S, Henin A, Hirshfeld-Becker DR, Hofmann SG, Rosso IM, Auerbach RP, Pizzagalli DA, Yendiki A, Gabrieli JDE, Whitfield-Gabrieli S. Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study. Neuroimage Clin. 2020; 27:102240. PMID: 32361633.
    Citations: 7     Fields:    Translation:Humans
  15. Olson EA, Overbey TA, Ostrand CG, Pizzagalli DA, Rauch SL, Rosso IM. Childhood maltreatment experiences are associated with altered diffusion in occipito-temporal white matter pathways. Brain Behav. 2020 01; 10(1):e01485. PMID: 31773917.
    Citations: 8     Fields:    Translation:Humans
  16. Sperl MFJ, Panitz C, Rosso IM, Dillon DG, Kumar P, Hermann A, Whitton AE, Hermann C, Pizzagalli DA, Mueller EM. Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity. Cereb Cortex. 2019 02 01; 29(2):701-715. PMID: 29373635; PMCID: PMC6659170.
    Citations: 6     Fields:    Translation:Humans
  17. Talley LD, Rosso I, Kamenkovich I, Mazloff MR, Wang J, Boss E, Gray AR, Johnson KS, Key RM, Riser SC, Williams NL, Sarmiento JL. Southern Ocean Biogeochemical Float Deployment Strategy, With Example From the Greenwich Meridian Line (GO-SHIP A12). J Geophys Res Oceans. 2019 Jan; 124(1):403-431. PMID: 31007997; PMCID: PMC6472510.
    Citations: 3     
  18. Olson EA, Kaiser RH, Pizzagalli DA, Rauch SL, Rosso IM. Regional Prefrontal Resting-State Functional Connectivity in Posttraumatic Stress Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 04; 4(4):390-398. PMID: 30449518; PMCID: PMC6447465.
    Citations: 6     Fields:    Translation:Humans
  19. Bajaj S, Dailey NS, Rosso IM, Rauch SL, Killgore WDS. Time-dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury. Hum Brain Mapp. 2018 05; 39(5):1886-1897. PMID: 29359498.
    Citations: 5     Fields:    Translation:Humans
  20. Olson EA, Kaiser RH, Pizzagalli DA, Rauch SL, Rosso IM. Anhedonia in Trauma-Exposed Individuals: Functional Connectivity and Decision-Making Correlates. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 11; 3(11):959-967. PMID: 30409390.
    Citations: 14     Fields:    Translation:Humans
  21. Webb CA, Olson EA, Killgore WDS, Pizzagalli DA, Rauch SL, Rosso IM. Rostral Anterior Cingulate Cortex Morphology Predicts Treatment Response to Internet-Based Cognitive Behavioral Therapy for Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 03; 3(3):255-262. PMID: 29486867.
    Citations: 10     Fields:    Translation:Humans
  22. Webb CA, Rosso IM, Rauch SL. Internet-Based Cognitive-Behavioral Therapy for Depression: Current Progress and Future Directions. Harv Rev Psychiatry. 2017 May/Jun; 25(3):114-122. PMID: 28475503.
    Citations: 41     Fields:    Translation:Humans
  23. Sugarman DE, Rauch SL, Rosso IM. Introduction. Harv Rev Psychiatry. 2017 May/Jun; 25(3):101-102. PMID: 28475501.
    Citations:    Fields:    Translation:Humans
  24. Olson EA, Cui J, Fukunaga R, Nickerson LD, Rauch SL, Rosso IM. Disruption of white matter structural integrity and connectivity in posttraumatic stress disorder: A TBSS and tractography study. Depress Anxiety. 2017 05; 34(5):437-445. PMID: 28294462.
    Citations: 23     Fields:    Translation:Humans
  25. Rosso IM, Crowley DJ, Silveri MM, Rauch SL, Jensen JE. Hippocampus Glutamate and N-Acetyl Aspartate Markers of Excitotoxic Neuronal Compromise in Posttraumatic Stress Disorder. Neuropsychopharmacology. 2017 Jul; 42(8):1698-1705. PMID: 28195577.
    Citations: 19     Fields:    Translation:Humans
  26. Rosso IM, Killgore WD, Olson EA, Webb CA, Fukunaga R, Auerbach RP, Gogel H, Buchholz JL, Rauch SL. Internet-based cognitive behavior therapy for major depressive disorder: A randomized controlled trial. Depress Anxiety. 2017 03; 34(3):236-245. PMID: 28009467.
    Citations: 13     Fields:    Translation:Humans
  27. Killgore WDS, Sonis LA, Rosso IM, Rauch SL. Emotional Intelligence Partially Mediates the Association between Anxiety Sensitivity and Anxiety Symptoms1,2. Psychol Rep. 2016 Feb; 118(1):23-40. PMID: 29693525.
    Citations: 4     Fields:    
  28. Brent BK, Rosso IM, Thermenos HW, Holt DJ, Faraone SV, Makris N, Tsuang MT, Seidman LJ. Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia. Schizophr Res. 2016 Jan; 170(1):123-9. PMID: 26621001; PMCID: PMC4707114.
    Citations: 4     Fields:    Translation:Humans
  29. Demers LA, Olson EA, Crowley DJ, Rauch SL, Rosso IM. Dorsal Anterior Cingulate Thickness Is Related to Alexithymia in Childhood Trauma-Related PTSD. PLoS One. 2015; 10(10):e0139807. PMID: 26439117.
    Citations: 5     Fields:    Translation:Humans
  30. Mundy EA, Weber M, Rauch SL, Killgore WD, Simon NM, Pollack MH, Rosso IM. ADULT ANXIETY DISORDERS IN RELATION TO TRAIT ANXIETY AND PERCEIVED STRESS IN CHILDHOOD. Psychol Rep. 2015 Oct; 117(2):473-89. PMID: 26340052.
    Citations: 5     Fields:    Translation:Humans
  31. Cohen-Gilbert JE, Sneider JT, Crowley DJ, Rosso IM, Jensen JE, Silveri MM. Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents. Dev Cogn Neurosci. 2015 Dec; 16:147-154. PMID: 26025607.
    Citations: 10     Fields:    Translation:Humans
  32. Rosso IM, Olson EA, Britton JC, Stewart SE, Papadimitriou G, Killgore WD, Makris N, Wilhelm S, Jenike MA, Rauch SL. Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder. Biol Mood Anxiety Disord. 2014; 4(1):13. PMID: 25540681; PMCID: PMC4275938.
    Citations: 10     
  33. Sneider JT, Hamilton DA, Cohen-Gilbert JE, Crowley DJ, Rosso IM, Silveri MM. Sex differences in spatial navigation and perception in human adolescents and emerging adults. Behav Processes. 2015 Feb; 111:42-50. PMID: 25464337; PMCID: PMC4304985.
    Citations: 11     Fields:    Translation:Humans
  34. Cui J, Tkachenko O, Gogel H, Kipman M, Preer LA, Weber M, Divatia SC, Demers LA, Olson EA, Buchholz JL, Bark JS, Rosso IM, Rauch SL, Killgore WD. Microstructure of frontoparietal connections predicts individual resistance to sleep deprivation. Neuroimage. 2015 Feb 01; 106:123-33. PMID: 25463450.
    Citations: 17     Fields:    Translation:Humans
  35. Seidman LJ, Rosso IM, Thermenos HW, Makris N, Juelich R, Gabrieli JD, Faraone SV, Tsuang MT, Whitfield-Gabrieli S. Medial temporal lobe default mode functioning and hippocampal structure as vulnerability indicators for schizophrenia: a MRI study of non-psychotic adolescent first-degree relatives. Schizophr Res. 2014 Nov; 159(2-3):426-34. PMID: 25308834.
    Citations: 13     Fields:    Translation:Humans
  36. Cui J, Olson EA, Weber M, Schwab ZJ, Rosso IM, Rauch SL, Killgore WD. Trait emotional suppression is associated with increased activation of the rostral anterior cingulate cortex in response to masked angry faces. Neuroreport. 2014 Jul 09; 25(10):771-6. PMID: 24858795.
    Citations: 1     Fields:    Translation:Humans
  37. Silveri MM, Cohen-Gilbert J, Crowley DJ, Rosso IM, Jensen JE, Sneider JT. Altered anterior cingulate neurochemistry in emerging adult binge drinkers with a history of alcohol-induced blackouts. Alcohol Clin Exp Res. 2014 Apr; 38(4):969-79. PMID: 24512596.
    Citations: 32     Fields:    Translation:Humans
  38. Dillon DG, Rosso IM, Pechtel P, Killgore WD, Rauch SL, Pizzagalli DA. Peril and pleasure: an rdoc-inspired examination of threat responses and reward processing in anxiety and depression. Depress Anxiety. 2014 Mar; 31(3):233-49. PMID: 24151118.
    Citations: 76     Fields:    Translation:HumansAnimals
  39. Killgore WD, Britton JC, Schwab ZJ, Price LM, Weiner MR, Gold AL, Rosso IM, Simon NM, Pollack MH, Rauch SL. Cortico-limbic responses to masked affective faces across ptsd, panic disorder, and specific phobia. Depress Anxiety. 2014 Feb; 31(2):150-9. PMID: 23861215.
    Citations: 39     Fields:    Translation:Humans
  40. Rosso IM, Weiner MR, Crowley DJ, Silveri MM, Rauch SL, Jensen JE. Insula and anterior cingulate GABA levels in posttraumatic stress disorder: preliminary findings using magnetic resonance spectroscopy. Depress Anxiety. 2014 Feb; 31(2):115-23. PMID: 23861191.
    Citations: 36     Fields:    Translation:Humans
  41. Weber M, Killgore WD, Rosso IM, Britton JC, Schwab ZJ, Weiner MR, Simon NM, Pollack MH, Rauch SL. Voxel-based morphometric gray matter correlates of posttraumatic stress disorder. J Anxiety Disord. 2013 May; 27(4):413-9. PMID: 23746489.
    Citations: 10     Fields:    Translation:Humans
  42. Silveri MM, Sneider JT, Crowley DJ, Covell MJ, Acharya D, Rosso IM, Jensen JE. Frontal lobe ?-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition. Biol Psychiatry. 2013 Aug 15; 74(4):296-304. PMID: 23498139.
    Citations: 69     Fields:    Translation:Humans
  43. Silveri MM, Jensen JE, Rosso IM, Sneider JT, Yurgelun-Todd DA. Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. Psychiatry Res. 2011 Mar 31; 191(3):201-11. PMID: 21334181.
    Citations: 19     Fields:    Translation:HumansCells
  44. Rosso IM, Makris N, Britton JC, Price LM, Gold AL, Zai D, Bruyere J, Deckersbach T, Killgore WD, Rauch SL. Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia. Depress Anxiety. 2010 Dec; 27(12):1104-10. PMID: 21132846.
    Citations: 17     Fields:    Translation:HumansAnimals
  45. Rosso IM, Makris N, Thermenos HW, Hodge SM, Brown A, Kennedy D, Caviness VS, Faraone SV, Tsuang MT, Seidman LJ. Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study. Schizophr Res. 2010 Oct; 123(1):15-21. PMID: 20705433.
    Citations: 19     Fields:    Translation:Humans
  46. Britton JC, Stewart SE, Killgore WD, Rosso IM, Price LM, Gold AL, Pine DS, Wilhelm S, Jenike MA, Rauch SL. Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder. Depress Anxiety. 2010 Jul; 27(7):643-51. PMID: 20602430.
    Citations: 15     Fields:    Translation:Humans
  47. Britton JC, Rauch SL, Rosso IM, Killgore WD, Price LM, Ragan J, Chosak A, Hezel DM, Pine DS, Leibenluft E, Pauls DL, Jenike MA, Stewart SE. Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2010 Sep; 49(9):944-53. PMID: 20732630.
    Citations: 30     Fields:    Translation:Humans
  48. Torrey EF, Buka S, Cannon TD, Goldstein JM, Seidman LJ, Liu T, Hadley T, Rosso IM, Bearden C, Yolken RH. Paternal age as a risk factor for schizophrenia: how important is it? Schizophr Res. 2009 Oct; 114(1-3):1-5. PMID: 19683417.
    Citations: 30     Fields:    Translation:Humans
  49. Killgore WD, Rosso IM, Gruber SA, Yurgelun-Todd DA. Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cogn Behav Neurol. 2009 Mar; 22(1):28-37. PMID: 19372768.
    Citations: 24     Fields:    Translation:Humans
  50. Buka SL, Cannon TD, Torrey EF, Yolken RH, Collaborative Study Group on the Perinatal Origins of Severe Psychiatric Disorders. Biological Psychiatry. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. 2008; 15:809-815.
  51. Gruber SA, Rosso IM, Yurgelun-Todd D. Neuropsychological performance predicts clinical recovery in bipolar patients. J Affect Disord. 2008 Jan; 105(1-3):253-60. PMID: 17524493.
    Citations: 24     Fields:    Translation:Humans
  52. Rosso IM, Killgore WD, Cintron CM, Gruber SA, Tohen M, Yurgelun-Todd DA. Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biol Psychiatry. 2007 Mar 15; 61(6):743-9. PMID: 17123471.
    Citations: 32     Fields:    Translation:HumansCells
  53. Silveri MM, Rohan ML, Pimentel PJ, Gruber SA, Rosso IM, Yurgelun-Todd DA. Sex differences in the relationship between white matter microstructure and impulsivity in adolescents. Magn Reson Imaging. 2006 Sep; 24(7):833-41. PMID: 16916700.
    Citations: 27     Fields:    Translation:Humans
  54. Rosso IM, Coyle JT, Ke Y, Gruber SA, Olson DP, Renshaw PF, Yurgelun-Todd DA. Cingulate cortex GABA concentration in schizophrenia: A two-dimensional proton magnetic resonance spectroscopy study. Biological Psychiatry. 2006; 59(S):1515.
  55. Rosso IM. Review: hippocampal volume is reduced in people with unipolar depression. Evid Based Ment Health. 2005 May; 8(2):45. PMID: 15851808.
    Citations: 1     Fields:    
  56. Rosso IM, Rogowska J, Gruber SA, Yurgelun-Todd DA. Functional MRI correlates of socio-emotional intelligence in adolescence: Implications for the study of schizophrenia. Schizophrenia Bulletin. 2005; 31(2):433.
  57. Olson D, Coyle J, Ke Y, Gruber SA, Rosso IM, Silveri MM, Renshaw PF, Yurgelun-Todd DA. Two dimensional J resolved magnetic resonance spectroscopy (2D JMRS) in schizophrenia. Schizophrenia Bulletin. 2005; 31(2).
  58. Sneider JT, Pope, HG, Silveri MM, Rosso IM, Gruber SA, Yurgelun-Todd DA. Altered regional blood volume in chronic marijuana smokers. Society for Neuroscience Abstracts. 2005; 563(16).
  59. Rosso IM, Cintron CM, Steingard RJ, Renshaw PF, Young AD, Yurgelun-Todd DA. Amygdala and hippocampus volumes in pediatric major depression. Biol Psychiatry. 2005 Jan 01; 57(1):21-6. PMID: 15607296.
    Citations: 79     Fields:    Translation:Humans
  60. Rosso IM, Young AD, Femia LA, Yurgelun-Todd DA. Cognitive and emotional components of frontal lobe functioning in childhood and adolescence. Ann N Y Acad Sci. 2004 Jun; 1021:355-62. PMID: 15251910.
    Citations: 29     Fields:    Translation:Humans
  61. Rosso IM, Yang E, Gruber SA, Yurgelun-Todd DA. Regional gray and white volume abnormalities of the anterior cingulate cortex in first-episode bipolar disorder. Schizophrenia Research. 2004; 70(1):111.
  62. Gruber SA, Rosso, IM, Yurgelun-Todd DA. Neuropsychological performance and functional recovery in bipolar patients. Schizophrenia Research. 2004; 70(1):12.
  63. Niendam TA, Bearden CE, Rosso IM, Sanchez LE, Hadley T, Nuechterlein KH, Cannon TD. A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Am J Psychiatry. 2003 Nov; 160(11):2060-2. PMID: 14594759.
    Citations: 75     Fields:    Translation:Humans
  64. van Erp TGM, Gasperoni TL, Rosso IM, Cannon TD. Investigating gene-environment interaction in schizophrenia using neuroimaging. In: Murray J, Jones P, Susser E, van Os J, Cannon M, editors. The Epidemiology of Schizophrenia. 2003; 254-69.
  65. Ke Y, Coyle J, Gruber SA, Rosso IM, Simpson N, Renshaw PF, Yurgelun-Todd DA. T2 relaxation time of frontal NAA in schizophrenic brains and controls. Schizophrenia Research. 2003.
  66. Ke Y, Coyle J, Simpson N, Gruber SA, Rosso IM, Renshaw PF, Yurgelun-Todd DA. Prefrontal PCr/Cr levels indicate reduced energy demand in schizophrenic brains. Proceedings of the International Society of Magnetic Resonance Imaging. 2003.
  67. Rosso IM, Gruber SA, Yurgelun-Todd DA. Temporal lobe NAA in first-episode schizophrenia and bipolar disorder: preliminary evidence of diagnostic specificity. Schizophrenia Research. 2003.
  68. Rosso IM, Cannon TD. Obstetric complications and neurodevelopmental mechanisms in schizophrenia. In: Cicchetti DC, Walker EF, editors. Neurodevelopmental Mechanisms in the Genesis and Epigenesis of Psychopathology. 2003; 111-37.
  69. Van Erp TG, Saleh PA, Rosso IM, Huttunen M, Lönnqvist J, Pirkola T, Salonen O, Valanne L, Poutanen VP, Standertskjöld-Nordenstam CG, Cannon TD. Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am J Psychiatry. 2002 Sep; 159(9):1514-20. PMID: 12202271.
    Citations: 78     Fields:    Translation:Humans
  70. Cannon TD, Rosso IM. Levels of analysis in etiological research on schizophrenia. Dev Psychopathol. 2002; 14(3):653-66. PMID: 12349878.
    Citations: 5     Fields:    Translation:Humans
  71. Cannon TD, van Erp TG, Rosso IM, Huttunen M, Lönnqvist J, Pirkola T, Salonen O, Valanne L, Poutanen VP, Standertskjöld-Nordenstam CG. Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry. 2002 Jan; 59(1):35-41. PMID: 11779280.
    Citations: 74     Fields:    Translation:Humans
  72. Cannon TD, Gasperoni TL, van Erp TG, Rosso IM. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet. 2001 Jan 08; 105(1):16-9. PMID: 11424984.
    Citations: 10     Fields:    Translation:Humans
  73. Rosso IM, Huttunen M, Pirkola T, Lonnqvist J, Cannon TD. Adverse obstetric influences and negative symptoms of schizophrenia. Schizophrenia Research. 2001.
  74. Rosso IM, Cannon TD, Huttunen T, Huttunen MO, Lönnqvist J, Gasperoni TL. Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Am J Psychiatry. 2000 May; 157(5):801-7. PMID: 10784475.
    Citations: 29     Fields:    Translation:Humans
  75. Cannon TD, Rosso IM, Hollister JM, Bearden CE, Sanchez LE, Hadley T. A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull. 2000; 26(2):351-66. PMID: 10885636.
    Citations: 54     Fields:    Translation:Humans
  76. Bearden CE, Rosso IM, Hollister JM, Sanchez LE, Hadley T, Cannon TD. A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophr Bull. 2000; 26(2):395-410. PMID: 10885639.
    Citations: 43     Fields:    Translation:Humans
  77. Rosso IM, Bearden CE, Hollister JM, Gasperoni TL, Sanchez LE, Hadley T, Cannon TD. Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull. 2000; 26(2):367-78. PMID: 10885637.
    Citations: 46     Fields:    Translation:Humans
  78. Cannon TD, Bearden CE, Hollister JM, Rosso IM, Sanchez LE, Hadley T. Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull. 2000; 26(2):379-93. PMID: 10885638.
    Citations: 77     Fields:    Translation:Humans
  79. Rosso IM, Cannon TD, Huttunen T, Huttunen MO, Lonnqvist J, Gasperoni TL. Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Schizophrenia Research. 1999.
  80. Cannon TD, Rosso IM, Bearden CE, Sanchez LE, Hadley T. A prospective cohort study of neurodevelopmental processes in the genesis and epigenesis of schizophrenia. Dev Psychopathol. 1999; 11(3):467-85. PMID: 10532620.
    Citations: 17     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.