Harvard Catalyst Profiles

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Sanja Sever, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK084195 (GUPTA, VINEET) Sep 20, 2011 - Nov 30, 2023
    Role of beta2 integrin in lupus nephritis
    Role: Co-Principal Investigator
  2. R01DK093773 (SEVER, SANJA) Sep 15, 2011 - Apr 30, 2022
    Dynamin, actin and microtubules: cytoskeletal crosstalk in podocytes
    Role: Principal Investigator
  3. R01DK087985 (SEVER, SANJA) Apr 1, 2010 - Apr 30, 2021
    Role of dynamin oligomerization in podocyte structure and function
    Role: Principal Investigator
  4. R01DK064787 (SEVER, SANJA) Jan 1, 2005 - Dec 31, 2009
    Role of dynamin-auxilin interactions in endocytosis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, Reiser J, Sever S. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022 05 03; 13(1):2422. PMID: 35504916; PMCID: PMC9065033.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Mukherjee K, Chio TI, Gu H, Sackett DL, Bane SL, Sever S. A Novel Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue. ACS Sens. 2021 07 23; 6(7):2523-2528. PMID: 34214393.
    Citations: 2     Fields:    
  3. Sever S. Role of actin cytoskeleton in podocytes. Pediatr Nephrol. 2021 09; 36(9):2607-2614. PMID: 33188449; PMCID: PMC8116355.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday MW, Januzzi JL, Weisbord SD, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med. 2020 01 30; 382(5):416-426. PMID: 31995687; PMCID: PMC7065830.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  5. Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959. PMID: 30730305; PMCID: PMC6486353.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  6. Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 06; 93(6):1298-1307. PMID: 29678354.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  7. Alasfar S, Matar D, Montgomery RA, Desai N, Lonze B, Vujjini V, Estrella MM, Manllo Dieck J, Khneizer G, Sever S, Reiser J, Alachkar N. Rituximab and Therapeutic Plasma Exchange in Recurrent Focal Segmental Glomerulosclerosis Postkidney Transplantation. Transplantation. 2018 03; 102(3):e115-e120. PMID: 29189487.
    Citations: 16     Fields:    Translation:Humans
  8. Schaefer F, Trachtman H, Wühl E, Kirchner M, Hayek SS, Anarat A, Duzova A, Mir S, Paripovic D, Yilmaz A, Lugani F, Arbeiter K, Litwin M, Oh J, Matteucci MC, Gellermann J, Wygoda S, Jankauskiene A, Klaus G, Dusek J, Testa S, Zurowska A, Caldas Afonso A, Tracy M, Wei C, Sever S, Smoyer W, Reiser J. Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children. JAMA Pediatr. 2017 11 06; 171(11):e172914. PMID: 28873129; PMCID: PMC6121753.
    Citations: 21     Fields:    Translation:Humans
  9. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. A tripartite complex of suPAR, APOL1 risk variants and avß3 integrin on podocytes mediates chronic kidney disease. Nat Med. 2017 Aug; 23(8):945-953. PMID: 28650456; PMCID: PMC6019326.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  10. Drechsler C, Hayek SS, Wei C, Sever S, Genser B, Krane V, Meinitzer A, März W, Wanner C, Reiser J. Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis. Clin J Am Soc Nephrol. 2017 Aug 07; 12(8):1265-1273. PMID: 28495863.
    Citations: 13     Fields:    Translation:Humans
  11. Hayek SS, Ko YA, Awad M, Ahmed H, Gray B, Hosny KM, Aida H, Tracy MJ, Wei C, Sever S, Reiser J, Quyyumi AA. Cardiovascular Disease Biomarkers and suPAR in Predicting Decline in Renal Function: A Prospective Cohort Study. Kidney Int Rep. 2017 May; 2(3):425-432. PMID: 29142970; PMCID: PMC5678674.
    Citations: 13     
  12. Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106. PMID: 27941791; PMCID: PMC5405698.
    Citations: 64     Fields:    Translation:AnimalsCells
  13. Müller-Deile J, Teng B, Schenk H, Haller H, Reiser J, Sever S, Schiffer M. Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome. Ann Transl Med. 2016 Nov; 4(21):439. PMID: 27942530; PMCID: PMC5124626.
    Citations: 2     
  14. Lee H, Noh H, Mun J, Gu C, Sever S, Park S. Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. Nat Commun. 2016 09 13; 7:12799. PMID: 27619642.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. J Am Soc Nephrol. 2017 02; 28(2):446-451. PMID: 27432739; PMCID: PMC5280009.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Hayek SS, Sever S, Ko YA, Trachtman H, Awad M, Wadhwani S, Altintas MM, Wei C, Hotton AL, French AL, Sperling LS, Lerakis S, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Chronic Kidney Disease. N Engl J Med. 2015 Nov 12; 373(20):1916-25. PMID: 26539835; PMCID: PMC4701036.
    Citations: 159     Fields:    Translation:Humans
  17. Sever S, Reiser J. CD2AP, dendrin, and cathepsin L in the kidney. Am J Pathol. 2015 Nov; 185(11):3129-30. PMID: 26506476; PMCID: PMC4630172.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015 Jun; 21(6):601-9. PMID: 25962121; PMCID: PMC4458177.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  19. Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J Am Soc Nephrol. 2015 Nov; 26(11):2741-52. PMID: 25858967; PMCID: PMC4625676.
    Citations: 33     Fields:    Translation:AnimalsCells
  20. Trachtman H, Benzing T, Sever S, Harris RC, Reiser J. The grand challenge of nephrology. Front Med (Lausanne). 2014; 1:28. PMID: 25593903; PMCID: PMC4291843.
    Citations: 1     
  21. Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic. 2014 Aug; 15(8):819-38. PMID: 24891099.
    Citations: 17     Fields:    Translation:AnimalsCells
  22. Altintas MM, Moriwaki K, Wei C, Möller CC, Flesche J, Li J, Yaddanapudi S, Faridi MH, Gödel M, Huber TB, Preston RA, Jiang JX, Kerjaschki D, Sever S, Reiser J. Reduction of proteinuria through podocyte alkalinization. J Biol Chem. 2014 Jun 20; 289(25):17454-67. PMID: 24817115.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Reiser J, Sever S, Faul C. Signal transduction in podocytes--spotlight on receptor tyrosine kinases. Nat Rev Nephrol. 2014 Feb; 10(2):104-15. PMID: 24394191.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J. Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. J Biol Chem. 2013 Dec 20; 288(51):36598-609. PMID: 24194522.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  25. Sever S, Chang J, Gu C. Dynamin rings: not just for fission. Traffic. 2013 Dec; 14(12):1194-9. PMID: 23980695.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  26. Sever S, Trachtman H, Wei C, Reiser J. Is there clinical value in measuring suPAR levels in FSGS? Clin J Am Soc Nephrol. 2013 Aug; 8(8):1273-5. PMID: 23886567.
    Citations: 10     Fields:    Translation:Humans
  27. Reiser J, Sever S. Podocyte biology and pathogenesis of kidney disease. Annu Rev Med. 2013; 64:357-66. PMID: 23190150.
    Citations: 80     Fields:    Translation:HumansCells
  28. Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011 Oct; 121(10):3965-80. PMID: 21911934; PMCID: PMC3195478.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  29. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606. PMID: 20935625.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  30. Conery AR, Sever S, Harlow E. Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15461-6. PMID: 20713695.
    Citations: 23     Fields:    Translation:HumansCells
  31. Chiang WC, Geel TM, Altintas MM, Sever S, Ruiters MH, Reiser J. Establishment of protein delivery systems targeting podocytes. PLoS One. 2010 Jul 29; 5(7):e11837. PMID: 20686602.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol. 2010 Jun; 11(6):495-502. PMID: 20473299.
    Citations: 58     Fields:    Translation:AnimalsCells
  33. Sever S, Altintas MM, Nankoe SR, Möller CC, Ko D, Wei C, Henderson J, del Re EC, Hsing L, Erickson A, Cohen CD, Kretzler M, Kerjaschki D, Rudensky A, Nikolic B, Reiser J. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J Clin Invest. 2007 Aug; 117(8):2095-104. PMID: 17671649; PMCID: PMC1934589.
    Citations: 110     Fields:    Translation:AnimalsCells
  34. Nankoe SR, Sever S. Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation. Trends Cell Biol. 2006 Dec; 16(12):607-9. PMID: 17064900.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  35. Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74. PMID: 16946707; PMCID: PMC1570436.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  36. von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem. 2005 May 06; 280(18):17777-85. PMID: 15749709.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  37. Sever S, Skoch J, Bacskai BJ, Newmyer SL. Assays and functional properties of auxilin-dynamin interactions. Methods Enzymol. 2005; 404:570-85. PMID: 16413301.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  38. Sever S. AP-2 makes room for rivals. Dev Cell. 2003 Oct; 5(4):530-2. PMID: 14536052.
    Citations: 1     Fields:    Translation:AnimalsCells
  39. Newmyer SL, Christensen A, Sever S. Auxilin-dynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation. Dev Cell. 2003 Jun; 4(6):929-40. PMID: 12791276.
    Citations: 34     Fields:    Translation:HumansCells
  40. Sever S. Dynamin and endocytosis. Curr Opin Cell Biol. 2002 Aug; 14(4):463-7. PMID: 12383797.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  41. Damke H, Muhlberg AB, Sever S, Sholly S, Warnock DE, Schmid SL. Expression, purification, and functional assays for self-association of dynamin-1. Methods Enzymol. 2001; 329:447-57. PMID: 11210565.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Sever S, Damke H, Schmid SL. Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol. 2000 Sep 04; 150(5):1137-48. PMID: 10974001; PMCID: PMC2175254.
    Citations: 111     Fields:    Translation:HumansCells
  43. Sever S, Damke H, Schmid SL. Garrotes, springs, ratchets, and whips: putting dynamin models to the test. Traffic. 2000 May; 1(5):385-92. PMID: 11208124.
    Citations: 64     Fields:    Translation:AnimalsCells
  44. Sever S, Muhlberg AB, Schmid SL. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature. 1999 Apr 08; 398(6727):481-6. PMID: 10206643.
    Citations: 121     Fields:    Translation:Cells
  45. Ibba M, Hong KW, Sherman JM, Sever S, Söll D. Interactions between tRNA identity nucleotides and their recognition sites in glutaminyl-tRNA synthetase determine the cognate amino acid affinity of the enzyme. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):6953-8. PMID: 8692925; PMCID: PMC38915.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  46. Sever S, Rogers K, Rogers MJ, Carter C, Söll D. Escherichia coli tryptophanyl-tRNA synthetase mutants selected for tryptophan auxotrophy implicate the dimer interface in optimizing amino acid binding. Biochemistry. 1996 Jan 09; 35(1):32-40. PMID: 8555191.
    Citations: 8     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.