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Friedhelm Hildebrandt, M.D.

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Overview
Friedhelm Hildebrandt, M.D is currently a Professor of Pediatrics at Harvard Medical School and Chief of the Division of Nephrology of Boston Children's Hospital. Dr. Hildebrandt is also an Investigator of the Howard Hughes Medical Institute (HHMI).

Dr. Hildebrandt's research work is concerned with the identification and functional characterization of recessive single-gene causes of kidney diseases in children. His group has identified over 30 novel kidney disease genes and delineated the related pathogenesis. His lab studies the function of newly identified disease genes in disease models of mice and zebrafish as well in cell-based systems. His work was involved in the early development of efficient methods for gene identification by combining homozygosity mapping with total human exome resequencing. Recently, his lab discovered that DNA damage repair plays a role in the pathogenesis of ciliopathies (Chaki et al. Cell150:533-48, 2012; Zhou et al., Nat Genet 44:910-15; editorial p. 836-8). The research work of his lab has been supported solely by peer-reviewed research grants, mostly from the NIH, the HHMI, the Doris Duke Charitable Foundation, the March of Dimes, the Thrasher Research Foundation, and formerly the German Research Foundation. He has published over 240 original articles, many of them in high-ranking journals.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RC2DK122397 (HILDEBRANDT, FRIEDHELM ;POLLAK, MARTIN R. ;SAMPSON, MATTHEW GORDON;SANNA-CHERCHI, SIMONE) Aug 15, 2020 - May 31, 2025
    NIH
    Integrating large scale genomics and functional studies to accelerate FSGS/NS discovery
    Role: Co-Principal Investigator
  2. R01DK088767 (HILDEBRANDT, FRIEDHELM) Jul 5, 2010 - Feb 28, 2021
    NIH
    New genes and pathomechanisms of congenital abnormalities of the kidney (CAKUT)
    Role: Principal Investigator
  3. RC1DK086542 (HILDEBRANDT, FRIEDHELM) Sep 30, 2009 - Jul 31, 2012
    NIH
    Exon capture and large-scale sequencing for disease-cause identification, early d
    Role: Principal Investigator
  4. R01DK076683 (HILDEBRANDT, FRIEDHELM) Dec 1, 2006 - Jun 30, 2022
    NIH
    Discover and functionally characterize full-penetrance causes of nephrosis / FSGS
    Role: Principal Investigator
  5. R01DK069274 (HILDEBRANDT, FRIEDHELM) Mar 1, 2005 - Dec 31, 2009
    NIH
    Function of NPHP6 a novel gene for Senior-Loken syndrome
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.