Harvard Catalyst Profiles

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William T. Lester, M.D.


1986 - 1987
Chimes Honorary
1987 - 1989
Eta Kappa Nu
1997 - 1997
Alpha Omega Alpha
2004 - 2004
Award Winner MGH Clinical Research Day: FastTrack to Improved Hyperlipidemia Management: Closing the

My work in medical informatics is the product of my clinical experience in internal medicine with my engineering and medical informatics training. My research focuses on increasing the effectiveness of clinical information systems as it relates to improving evidence based care. By examining physician workflow and identifying and overcoming barriers to effective disease management in primary and specialty care, my health services research activities have focused on improving hyperlipidemia disease management, increasing preventative cancer screening rates and improving timely evidence-based HIV care. I have taken advantage of my expertise in system design and engineering to develop and test hypotheses regarding improved information delivery and medical decision making at the point of care. My work also investigates novel ways to improve care with non-visit and population-based quality improvement interventions. By collaborating with others, I have worked to more completely understand physician decision making in order to lay the groundwork for designing interventions to improve diabetes management in primary and specialty care.

As an instructor, I have focused my efforts on medical student and residency training in primary care internal medicine, urgent care and in medical informatics. I have mentored students for both research and clinically related endeavors. In my role as assistant fellowship director in medical informatics, I advise Biomedical Informatics research fellows for research and thesis projects on an individual basis and I run formal academic meetings for our laboratory. I also serve as preceptor for residents in internal medicine completing their primary care rotations as well as for medical students on core medicine clerkships.

As a primary care clinician, from the beginning of my medical training, I have placed high value on the quality longitudinal relationship that develops between physician and patient. In addition to maintaining a wonderfully rewarding primary care panel and to maintain a broad clinical exposure I see my own inpatients on the wards and continue practicing weekly in The Internal Medicine Associates Urgent Care Clinic.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ronquillo JG, Lester WT. Practical Aspects of Implementing and Applying Health Care Cloud Computing Services and Informatics to Cancer Clinical Trial Data. JCO Clin Cancer Inform. 2021 08; 5:826-832. PMID: 34383582.
    Citations:    Fields:    
  2. Irwin L, Kotton CN, Elias N, Palafox J, Basler D, Shao SH, Lester W, Zhang X, Kimball B, Trencher C, Fishman JA. Utilization of increased risk for transmission of infectious disease donor organs in solid organ transplantation: Retrospective analysis of disease transmission and safety. Transpl Infect Dis. 2017 Dec; 19(6). PMID: 28994164.
    Citations: 4     Fields:    Translation:HumansCells
  3. Robbins GK, Lester W, Johnson KL, Chang Y, Estey G, Surrao D, Zachary K, Lammert SM, Chueh HC, Meigs JB, Freedberg KA. Efficacy of a clinical decision-support system in an HIV practice: a randomized trial. Ann Intern Med. 2012 Dec 04; 157(11):757-66. PMID: 23208165.
    Citations: 15     Fields:    Translation:HumansCells
  4. Atlas SJ, Ashburner JM, Chang Y, Lester WT, Barry MJ, Grant RW. Population-based breast cancer screening in a primary care network. Am J Manag Care. 2012 Dec; 18(12):821-9. PMID: 23286611.
    Citations: 4     Fields:    Translation:Humans
  5. Pablo Moreno-Ger, Javier Torrente, Yichuan Grace Hsieh, William T Lester. Advances in Human-Computer Interaction. Usability Testing for Serious Games: Making Informed Design Decisions with User Data. 2012; 2012:Article ID 369637, 13 pages. View Publication.
  6. Ronquillo JG, Li C, Lester WT. Genetic testing behavior and reporting patterns in electronic medical records for physicians trained in a primary care specialty or subspecialty. J Am Med Inform Assoc. 2012 Jul-Aug; 19(4):570-4. PMID: 22511017.
    Citations: 7     Fields:    Translation:Humans
  7. Celi LA, Tang RJ, Villarroel MC, Davidzon GA, Lester WT, Chueh HC. A Clinical Database-Driven Approach to Decision Support: Predicting Mortality Among Patients with Acute Kidney Injury. J Healthc Eng. 2011 Mar; 2(1):97-110. PMID: 22844575.
    Citations: 14     Fields:    
  8. Atlas SJ, Grant RW, Lester WT, Ashburner JM, Chang Y, Barry MJ, Chueh HC. A cluster-randomized trial of a primary care informatics-based system for breast cancer screening. J Gen Intern Med. 2011 Feb; 26(2):154-61. PMID: 20872083.
    Citations: 8     Fields:    Translation:Humans
  9. Lester WT, Ashburner JM, Grant RW, Chueh HC, Barry MJ, Atlas SJ. Mammography FastTrack: an intervention to facilitate reminders for breast cancer screening across a heterogeneous multi-clinic primary care network. J Am Med Inform Assoc. 2009 Mar-Apr; 16(2):187-95. PMID: 19074304.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  10. Zai AH, Grant RW, Estey G, Lester WT, Andrews CT, Yee R, Mort E, Chueh HC. Lessons from implementing a combined workflow-informatics system for diabetes management. J Am Med Inform Assoc. 2008 Jul-Aug; 15(4):524-33. PMID: 18436907.
    Citations: 10     Fields:    Translation:Humans
  11. Lester WT, Zai AH, Chueh HC, Grant RW. Diabetes information technology: designing informatics systems to catalyze change in clinical care. J Diabetes Sci Technol. 2008 Mar; 2(2):275-83. PMID: 19885355.
    Citations: 2     Fields:    
  12. Lester WT, Zai AH, Grant RW, Chueh HC. Designing healthcare information technology to catalyse change in clinical care. Inform Prim Care. 2008; 16(1):9-19. PMID: 18534073.
    Citations: 6     Fields:    Translation:Humans
  13. Scheufele EL, Blesius C, Lester WT. Facilitating group learning and dialogue between neighboring academic institutions using a collaborative web application framework. AMIA Annu Symp Proc. 2007 Oct 11; 1107. PMID: 18694204.
    Citations:    Fields:    
  14. Jernigan M, Lester W. Facilitating transitions to EMR adoption through client-side electronic documentation. AMIA Annu Symp Proc. 2007 Oct 11; 992. PMID: 18694092.
    Citations:    Fields:    Translation:Humans
  15. Lester WT, Norris R, Chueh HC. Quicksilver: a novel publish and subscribe clinical messaging platform. AMIA Annu Symp Proc. 2007 Oct 11; 1030. PMID: 18694128.
    Citations:    Fields:    
  16. Grant RW, Wexler DJ, Watson AJ, Lester WT, Cagliero E, Campbell EG, Nathan DM. How doctors choose medications to treat type 2 diabetes: a national survey of specialists and academic generalists. Diabetes Care. 2007 Jun; 30(6):1448-53. PMID: 17337497.
    Citations: 24     Fields:    Translation:Humans
  17. Grant RW, Lester WT, Meigs JB, Chueh HC. New models of population management for patients with diabetes--using informatics tools to support primary care. Diabetes Res Clin Pract. 2006 Dec; 74 Suppl 2:S220-4. PMID: 17182326.
    Citations: 1     Fields:    Translation:Humans
  18. Lester WT, Grant RW, Barnett GO, Chueh HC. Randomized controlled trial of an informatics-based intervention to increase statin prescription for secondary prevention of coronary disease. J Gen Intern Med. 2006 Jan; 21(1):22-9. PMID: 16423119.
    Citations: 30     Fields:    Translation:Humans
  19. Lester WT, Grant RW, Chueh HC. Closing the knowledge-performance gap of hperlipidemia management: preliminary results of a randomized controlled trial. Proceedings of the 5th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. 2004.
  20. Lester WT, Grant RW, Chueh HC. Guidelines vs reality: Physician explanations for not adjusting cholesterol therapy. Proceedings of the 27th Annual Meeting of the Society of General Internal Medicine. 2004.
  21. Lester WT, Grant R, Barnett GO, Chueh H. Facilitated lipid management using interactive e-mail: preliminary results of a randomized controlled trial. Stud Health Technol Inform. 2004; 107(Pt 1):232-6. PMID: 15360809.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  22. Marsh DR, Hinds LR, Lester WS, Reinking BE, Booth FW. The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle. Muscle Nerve. 1998 Oct; 21(10):1265-74. PMID: 9736054.
    Citations: 5     Fields:    Translation:Animals
  23. Lester WT, Gonzalez RV, Fernandez B, Barr RE. A neural network approach to electromyographic signal processing for a motor control task. 1997; 119(2):335-337.
  24. Biegler F, Wong C, Reuben J, Lester WT. Cement stresses under all-polyethylene tibial total knee replacements. 42nd Annual Meeting, Orthopaedic Research Society. 1996.
  25. Wong C, Biegler F, Reuben J, Lester WT. Comparison of cement stresses in all-polyethylene and metal-backed total knee replacements. Mid-America Orthopaedic Association Annual Meeting. 1996.
  26. Lester WT, Fernandez B, Gonzalez R, Barr R. A neural network approach to electromyographic signal processing for a motor control task. American Society Of Mechanical Engineers. 1994.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.