Harvard Catalyst Profiles

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Michael Anthony Dyer, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA263969 (DYER, MICHAEL A) Jul 1, 2021 - Jun 30, 2026
    In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
    Role: Principal Investigator
  2. R01CA245508 (DYER, MICHAEL A) May 15, 2020 - Apr 30, 2025
    Modeling Retinoblastoma Initiation Using 3D-Retinal Organoids
    Role: Principal Investigator
  3. R01CA248432 (DYER, MICHAEL A) Apr 1, 2020 - Mar 31, 2025
    Novel Therapeutic Approaches for the Treatment of Neuroblastoma
    Role: Principal Investigator
  4. R01EY030180 (DYER, MICHAEL A) Feb 1, 2020 - Jan 31, 2024
    Cell-type? and developmental stage?specific regulation of gene expression in the retina
    Role: Principal Investigator
  5. R01CA219686 (DYER, MICHAEL A) Jun 15, 2017 - May 31, 2022
    Novel Therapeutic Approaches for the Treatment of Rhabdomyosarcoma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Van Gelder RN, Chiang MF, Dyer MA, Greenwell TN, Levin LA, Wong RO, Svendsen CN. Author Correction: Regenerative and restorative medicine for eye disease. Nat Med. 2022 Oct; 28(10):2218. PMID: 35945286.
    Citations:    Fields:    
  2. Sengupta S, Das S, Crespo AC, Cornel AM, Patel AG, Mahadevan NR, Campisi M, Ali AK, Sharma B, Rowe JH, Huang H, Debruyne DN, Cerda ED, Krajewska M, Dries R, Chen M, Zhang S, Soriano L, Cohen MA, Versteeg R, Jaenisch R, Spranger S, Romee R, Miller BC, Barbie DA, Nierkens S, Dyer MA, Lieberman J, George RE. Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Nat Cancer. 2022 10; 3(10):1228-1246. PMID: 36138189.
    Citations:    Translation:Humans
  3. Zeineldin M, Patel AG, Dyer MA. Neuroblastoma: When differentiation goes awry. Neuron. 2022 09 21; 110(18):2916-2928. PMID: 35985323; PMCID: PMC9509448.
    Citations:    Fields:    Translation:Humans
  4. Whitney IE, Butrus S, Dyer MA, Rieke F, Sanes JR, Shekhar K. Vision-Dependent and -Independent Molecular Maturation of Mouse Retinal Ganglion Cells. Neuroscience. 2022 Jul 21. PMID: 35870562.
    Citations:    Fields:    
  5. Van Gelder RN, Chiang MF, Dyer MA, Greenwell TN, Levin LA, Wong RO, Svendsen CN. Regenerative and restorative medicine for eye disease. Nat Med. 2022 06; 28(6):1149-1156. PMID: 35715505.
    Citations:    Fields:    Translation:Humans
  6. Patel AG, Chen X, Huang X, Clay MR, Komorova N, Krasin MJ, Pappo A, Tillman H, Orr BA, McEvoy J, Gordon B, Blankenship K, Reilly C, Zhou X, Norrie JL, Karlstrom A, Yu J, Wodarz D, Stewart E, Dyer MA. The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma. Dev Cell. 2022 05 23; 57(10):1226-1240.e8. PMID: 35483358; PMCID: PMC9133224.
    Citations: 1     Fields:    Translation:Humans
  7. Kaza E, Lee CY, King MT, Dyer MA, Cormack RA, Buzurovic I. First pointwise encoding time reduction with radial acquisition (PETRA) implementation for catheter detection in interstitial high-dose-rate (HDR) brachytherapy. Brachytherapy. 2022 Jul-Aug; 21(4):501-510. PMID: 35337748.
    Citations:    Fields:    Translation:Humans
  8. Moustaki A, Crawford JC, Alli S, Fan Y, Boi S, Zamora AE, McDonald NMN, Wu G, Nakitandwe J, Newman S, Foy S, Silkov A, Thomas PG, Pappo A, Dyer MA, Stewart E, Federico S, Youngblood B. Antigen cross-presentation in young tumor-bearing hosts promotes CD8+ T cell terminal differentiation. Sci Immunol. 2022 02 04; 7(68):eabf6136. PMID: 35119937; PMCID: PMC8990347.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Honnell V, Norrie JL, Patel AG, Ramirez C, Zhang J, Lai YH, Wan S, Dyer MA. Identification of a modular super-enhancer in murine retinal development. Nat Commun. 2022 01 11; 13(1):253. PMID: 35017532; PMCID: PMC8752785.
    Citations:    Fields:    Translation:AnimalsCells
  10. Clay MR, Patel A, Tran Q, Hedges DJ, Chang TC, Stewart E, Charville G, Cline C, Dyer MA, Orr BA. Methylation profiling reveals novel molecular classes of rhabdomyosarcoma. Sci Rep. 2021 11 15; 11(1):22213. PMID: 34782706; PMCID: PMC8592993.
    Citations: 1     Fields:    Translation:HumansCells
  11. Matthews BJ, Qureshi MM, Fiascone SJ, Nitschmann CC, Oladeru OT, Truong MT, Hirsch AE, Mak KS, Dyer MA. Racial disparities in non-recommendation of adjuvant chemotherapy in stage II-III ovarian cancer. Gynecol Oncol. 2022 01; 164(1):27-33. PMID: 34785030; PMCID: PMC8711036.
    Citations:    Fields:    Translation:Humans
  12. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021 11 09; 12(1):6468. PMID: 34753908; PMCID: PMC8578635.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Huang D, Qureshi MM, Sarfaty S, Truong MT, Dyer MA, Mak KS, Hirsch AE. Longitudinal Outcomes of Medical Student Research Mentorship: a 15-Year Analysis of the Radiation Oncology Mentorship Initiative. J Cancer Educ. 2021 Sep 24. PMID: 34558038.
    Citations:    Fields:    
  14. Norrie JL, Nityanandam A, Lai K, Chen X, Wilson M, Stewart E, Griffiths L, Jin H, Wu G, Orr B, Tran Q, Allen S, Reilly C, Zhou X, Zhang J, Newman K, Johnson D, Brennan R, Dyer MA. Retinoblastoma from human stem cell-derived retinal organoids. Nat Commun. 2021 07 27; 12(1):4535. PMID: 34315877.
    Citations: 7     Fields:    Translation:HumansCells
  15. Shah NK, Qureshi MM, Dyer MA, Truong MT, Mak KS. Optimal Radiotherapy Dose in Anal Cancer: Trends in Prescription Dose and Association with Survival. J Gastrointest Cancer. 2021 Mar; 52(1):229-236. PMID: 32152823.
    Citations:    Fields:    Translation:Humans
  16. Yu S, Xu H, Zhang Y, Zhang X, Dyer MA, Hirsch AE, Tam Truong M, Zhen H. Knowledge-based planning in robotic intracranial stereotactic radiosurgery treatments. J Appl Clin Med Phys. 2021 Mar; 22(3):48-54. PMID: 33560592.
    Citations:    Fields:    Translation:Humans
  17. Qureshi MM, Oladeru OT, Lam CM, Dyer MA, Mak KS, Hirsch AE, Truong MT. Disparities in Laryngeal Cancer Treatment and Outcomes: An Analysis by Hospital Safety-Net Burden. Laryngoscope. 2021 06; 131(6):E1987-E1997. PMID: 33555062.
    Citations:    Fields:    Translation:Humans
  18. McLeod C, Gout AM, Zhou X, Thrasher A, Rahbarinia D, Brady SW, Macias M, Birch K, Finkelstein D, Sunny J, Mudunuri R, Orr BA, Treadway M, Davidson B, Ard TK, Chiao A, Swistak A, Wiggins S, Foy S, Wang J, Sioson E, Wang S, Michael JR, Liu Y, Ma X, Patel A, Edmonson MN, Wilkinson MR, Frantz AM, Chang TC, Tian L, Lei S, Islam SMA, Meyer C, Thangaraj N, Tater P, Kandali V, Ma S, Nguyen T, Serang O, McGuire I, Robison N, Gentry D, Tang X, Palmer LE, Wu G, Suh E, Tanner L, McMurry J, Lear M, Pappo AS, Wang Z, Wilson CL, Cheng Y, Meshinchi S, Alexandrov LB, Weiss MJ, Armstrong GT, Robison LL, Yasui Y, Nichols KE, Ellison DW, Bangur C, Mullighan CG, Baker SJ, Dyer MA, Miller G, Newman S, Rusch M, Daly R, Perry K, Downing JR, Zhang J. St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem. Cancer Discov. 2021 05; 11(5):1082-1099. PMID: 33408242; PMCID: PMC8102307.
    Citations: 29     Fields:    Translation:Humans
  19. Brady SW, Liu Y, Ma X, Gout AM, Hagiwara K, Zhou X, Wang J, Macias M, Chen X, Easton J, Mulder HL, Rusch M, Wang L, Nakitandwe J, Lei S, Davis EM, Naranjo A, Cheng C, Maris JM, Downing JR, Cheung NV, Hogarty MD, Dyer MA, Zhang J. Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations. Nat Commun. 2020 10 14; 11(1):5183. PMID: 33056981.
    Citations: 31     Fields:    Translation:HumansCells
  20. Hawkins C, Pfister S, Jones DTW, Shah NN, Gilbertson RJ, Sweet-Cordero EA, Dyer MA, Mossé YP, Haber M, DuBois SG. Advances and Challenges in Pediatric and Childhood Cancers. Cancer Cell. 2020 10 12; 38(4):429-432. PMID: 33049203.
    Citations:    Fields:    Translation:Humans
  21. Moeller AR, Clancy PE, Qureshi MM, Guill JR, Dyer MA, Hirsch AE, Truong MT, Mak KS. Placard in Hand: A Simple, Inexpensive Intervention to Improve On-Treatment Visit Compliance in a Safety Net Radiation Oncology Patient Population. JCO Oncol Pract. 2020 11; 16(11):e1272-e1281. PMID: 32936711.
    Citations:    Fields:    Translation:Humans
  22. Nguyen R, Patel AG, Griffiths LM, Dapper J, Stewart EA, Houston J, Johnson M, Akers WJ, Furman WL, Dyer MA. Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma. Cancer Immunol Immunother. 2021 Mar; 70(3):721-732. PMID: 32915319; PMCID: PMC8276267.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Slyper M, Porter CBM, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, Smillie C, Smith-Rosario G, Wu J, Dionne D, Vigneau S, Jané-Valbuena J, Tickle TL, Napolitano S, Su MJ, Patel AG, Karlstrom A, Gritsch S, Nomura M, Waghray A, Gohil SH, Tsankov AM, Jerby-Arnon L, Cohen O, Klughammer J, Rosen Y, Gould J, Nguyen L, Hofree M, Tramontozzi PJ, Li B, Wu CJ, Izar B, Haq R, Hodi FS, Yoon CH, Hata AN, Baker SJ, Suvà ML, Bueno R, Stover EH, Clay MR, Dyer MA, Collins NB, Matulonis UA, Wagle N, Johnson BE, Rotem A, Rozenblatt-Rosen O, Regev A. Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 Aug; 26(8):1307. PMID: 32587393.
    Citations: 2     Fields:    
  24. Kim KN, Dyer MA, Qureshi MM, Shah NK, Grillone GA, Faden DL, Jalisi SM, Truong MT. Hypofractionated radiotherapy and surgery compared to standard radiotherapy in early glottic cancer. Am J Otolaryngol. 2020 Sep - Oct; 41(5):102544. PMID: 32505989.
    Citations: 1     Fields:    Translation:Humans
  25. Slyper M, Porter CBM, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, Smillie C, Smith-Rosario G, Wu J, Dionne D, Vigneau S, Jané-Valbuena J, Tickle TL, Napolitano S, Su MJ, Patel AG, Karlstrom A, Gritsch S, Nomura M, Waghray A, Gohil SH, Tsankov AM, Jerby-Arnon L, Cohen O, Klughammer J, Rosen Y, Gould J, Nguyen L, Hofree M, Tramontozzi PJ, Li B, Wu CJ, Izar B, Haq R, Hodi FS, Yoon CH, Hata AN, Baker SJ, Suvà ML, Bueno R, Stover EH, Clay MR, Dyer MA, Collins NB, Matulonis UA, Wagle N, Johnson BE, Rotem A, Rozenblatt-Rosen O, Regev A. A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020 05; 26(5):792-802. PMID: 32405060; PMCID: PMC7220853.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  26. Nguyen R, Sahr N, Sykes A, McCarville MB, Federico SM, Sooter A, Cullins D, Rooney B, Janssen WE, Talleur AC, Triplett BM, Anthony G, Dyer MA, Pappo AS, Leung WH, Furman WL. Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial. J Immunother Cancer. 2020 03; 8(1). PMID: 32221013.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  27. Gamlin CR, Zhang C, Dyer MA, Wong ROL. Distinct Developmental Mechanisms Act Independently to Shape Biased Synaptic Divergence from an Inhibitory Neuron. Curr Biol. 2020 04 06; 30(7):1258-1268.e2. PMID: 32109390; PMCID: PMC7175805.
    Citations: 3     Fields:    Translation:AnimalsCells
  28. Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, Zhou X, Jeon J, Griffiths L, Nguyen R, Norrie J, Easton J, Mulder H, Yergeau D, Liu Y, Wu J, Van Ryn C, Naranjo A, Hogarty MD, Kaminski MM, Valentine M, Pruett-Miller SM, Pappo A, Zhang J, Clay MR, Bahrami A, Vogel P, Lee S, Shelat A, Sarthy JF, Meers MP, George RE, Mardis ER, Wilson RK, Henikoff S, Downing JR, Dyer MA. MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Nat Commun. 2020 02 14; 11(1):913. PMID: 32060267.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  29. Clay MR, Pinto EM, Cline C, Tran QT, Lin T, Dyer MA, Shi L, Wu H, Pounds SB, Zambetti GP, Orr BA, Ribeiro RC. DNA Methylation Profiling Reveals Prognostically Significant Groups in Pediatric Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry. JCO Precis Oncol. 2019; 3. PMID: 32923859.
    Citations: 3     Fields:    
  30. Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, Federico S, Gallego S, Dekio F, Fowkes M, Meni D, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. 2019 11 11; 36(5):512-527.e9. PMID: 31631027; PMCID: PMC6851493.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  31. Norrie JL, Lupo MS, Xu B, Al Diri I, Valentine M, Putnam D, Griffiths L, Zhang J, Johnson D, Easton J, Shao Y, Honnell V, Frase S, Miller S, Stewart V, Zhou X, Chen X, Dyer MA. Nucleome Dynamics during Retinal Development. Neuron. 2019 11 06; 104(3):512-528.e11. PMID: 31493975; PMCID: PMC6842117.
    Citations: 19     Fields:    Translation:AnimalsCells
  32. Nguyen R, Moustaki A, Norrie JL, Brown S, Akers WJ, Shirinifard A, Dyer MA. Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma. Clin Cancer Res. 2019 12 15; 25(24):7554-7564. PMID: 31455682; PMCID: PMC6911623.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, Radko S, Cheah JH, Hon CS, Shamji AF, Clemons PA, Park PJ, Dyer MA, Golub TR, Stegmaier K, Hahn WC, Stewart EA, Schreiber SL, Roberts CWM. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Rep. 2019 08 27; 28(9):2331-2344.e8. PMID: 31461650.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  34. Kerekes RA, Martins RAP, Davis D, Karakaya M, Gleason S, Dyer MA. Correction to: Imaging features of immune-mediated genitourinary disease. Neurochem Res. 2019 Jul; 44(7):1780. PMID: 31104195.
    Citations:    Fields:    
  35. Patel SA, Qureshi MM, Dyer MA, Jalisi S, Grillone G, Truong MT. Comparing surgical and nonsurgical larynx-preserving treatments with total laryngectomy for locally advanced laryngeal cancer. Cancer. 2019 Oct 01; 125(19):3367-3377. PMID: 31206637.
    Citations: 12     Fields:    Translation:Humans
  36. Yan SX, Qureshi MM, Dyer M, Truong MT, Mak KS. Stereotactic body radiation therapy with higher biologically effective dose is associated with improved survival in stage II non-small cell lung cancer. Lung Cancer. 2019 05; 131:147-153. PMID: 31027693.
    Citations: 5     Fields:    Translation:Humans
  37. Brady SW, Ma X, Bahrami A, Satas G, Wu G, Newman S, Rusch M, Putnam DK, Mulder HL, Yergeau DA, Edmonson MN, Easton J, Alexandrov LB, Chen X, Mardis ER, Wilson RK, Downing JR, Pappo AS, Raphael BJ, Dyer MA, Zhang J. The Clonal Evolution of Metastatic Osteosarcoma as Shaped by Cisplatin Treatment. Mol Cancer Res. 2019 04; 17(4):895-906. PMID: 30651371.
    Citations: 12     Fields:    Translation:Humans
  38. Shah NK, Qureshi MM, Dyer MA, Patel SA, Kim K, Everett PC, Grillone GA, Jalisi SM, Truong MT. Optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer. Laryngoscope. 2019 10; 129(10):2313-2320. PMID: 30628077.
    Citations: 1     Fields:    Translation:Humans
  39. Loh AHP, Stewart E, Bradley CL, Chen X, Daryani V, Stewart CF, Calabrese C, Funk A, Miller G, Karlstrom A, Krafcik F, Goshorn DR, Vogel P, Bahrami A, Shelat A, Dyer MA. Combinatorial screening using orthotopic patient derived xenograft-expanded early phase cultures of osteosarcoma identify novel therapeutic drug combinations. Cancer Lett. 2019 02 01; 442:262-270. PMID: 30395907; PMCID: PMC6342199.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  40. Burger EA, Dyer MA, Sy S, Palefsky JM, de Pokomandy A, Coutlee F, Silverberg MJ, Kim JJ. Development and Calibration of a Mathematical Model of Anal Carcinogenesis for High-Risk HIV-Infected Men. J Acquir Immune Defic Syndr. 2018 09 01; 79(1):10-19. PMID: 29757775; PMCID: PMC6092220.
    Citations:    Fields:    Translation:HumansCells
  41. Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, Gordon B, Dapper J, Blankenship K, Yang Y, Li Y, Shaw TI, Cho JH, Wang X, Xu B, Gupta P, Fan Y, Liu Y, Rusch M, Griffiths L, Jeon J, Freeman BB, Clay MR, Pappo A, Easton J, Shurtleff S, Shelat A, Zhou X, Boggs K, Mulder H, Yergeau D, Bahrami A, Mardis ER, Wilson RK, Zhang J, Peng J, Downing JR, Dyer MA. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018 09 10; 34(3):411-426.e19. PMID: 30146332; PMCID: PMC6158019.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  42. Yan SX, Qureshi MM, Suzuki K, Dyer M, Truong MT, Litle V, Mak KS. Definitive treatment patterns and survival in stage II non-small cell lung cancer. Lung Cancer. 2018 10; 124:135-142. PMID: 30268452.
    Citations: 1     Fields:    Translation:Humans
  43. Wang L, Hiler D, Xu B, AlDiri I, Chen X, Zhou X, Griffiths L, Valentine M, Shirinifard A, Sablauer A, Thiagarajan S, Barabas ME, Zhang J, Johnson D, Frase S, Dyer MA. Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures. Cell Rep. 2018 03 06; 22(10):2601-2614. PMID: 29514090; PMCID: PMC5872828.
    Citations: 25     Fields:    Translation:AnimalsCells
  44. Nguyen R, Houston J, Chan WK, Finkelstein D, Dyer MA. The role of interleukin-2, all-trans retinoic acid, and natural killer cells: surveillance mechanisms in anti-GD2 antibody therapy in neuroblastoma. Cancer Immunol Immunother. 2018 Apr; 67(4):615-626. PMID: 29327110; PMCID: PMC5862751.
    Citations: 10     Fields:    Translation:HumansCells
  45. Chang TC, Carter RA, Li Y, Li Y, Wang H, Edmonson MN, Chen X, Arnold P, Geiger TL, Wu G, Peng J, Dyer M, Downing JR, Green DR, Thomas PG, Zhang J. The neoepitope landscape in pediatric cancers. Genome Med. 2017 08 31; 9(1):78. PMID: 28854978.
    Citations: 35     Fields:    Translation:Humans
  46. Stewart E, Federico SM, Chen X, Shelat AA, Bradley C, Gordon B, Karlstrom A, Twarog NR, Clay MR, Bahrami A, Freeman BB, Xu B, Zhou X, Wu J, Honnell V, Ocarz M, Blankenship K, Dapper J, Mardis ER, Wilson RK, Downing J, Zhang J, Easton J, Pappo A, Dyer MA. Orthotopic patient-derived xenografts of paediatric solid tumours. Nature. 2017 09 07; 549(7670):96-100. PMID: 28854174; PMCID: PMC5659286.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  47. Aldiri I, Xu B, Wang L, Chen X, Hiler D, Griffiths L, Valentine M, Shirinifard A, Thiagarajan S, Sablauer A, Barabas ME, Zhang J, Johnson D, Frase S, Zhou X, Easton J, Zhang J, Mardis ER, Wilson RK, Downing JR, Dyer MA. The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis. Neuron. 2017 May 03; 94(3):550-568.e10. PMID: 28472656; PMCID: PMC5508517.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  48. Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. ATRX and DAXX: Mechanisms and Mutations. Cold Spring Harb Perspect Med. 2017 Mar 01; 7(3). PMID: 28062559; PMCID: PMC5334245.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  49. Bharatham N, Finch KE, Min J, Mayasundari A, Dyer MA, Guy RK, Bashford D. Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx. J Mol Graph Model. 2017 06; 74:54-60. PMID: 28351017; PMCID: PMC5508530.
    Citations: 4     Fields:    Translation:HumansCells
  50. Dyer MA. Biomedicine: An eye on retinal recovery. Nature. 2016 12 15; 540(7633):350-351. PMID: 27919071.
    Citations: 5     Fields:    Translation:Humans
  51. Hiler DJ, Barabas ME, Griffiths LM, Dyer MA. Reprogramming of mouse retinal neurons and standardized quantification of their differentiation in 3D retinal cultures. Nat Protoc. 2016 Oct; 11(10):1955-1976. PMID: 27658012.
    Citations: 4     Fields:    
  52. Dyer MA. Lessons from Retinoblastoma: Implications for Cancer, Development, Evolution, and Regenerative Medicine. Trends Mol Med. 2016 Oct; 22(10):863-876. PMID: 27567287; PMCID: PMC5048577.
    Citations: 20     Fields:    Translation:HumansAnimals
  53. Parker H, Rose-Zerilli MJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodríguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS, Chelala C, Oakes CC, Rosenquist R, Stamatopoulos K, Stilgenbauer S, Knight S, Schuh A, Oscier DG, Strefford JC. Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia. 2016 11; 30(11):2179-2186. PMID: 27282254.
    Citations: 31     Fields:    Translation:Humans
  54. Dyer MA. Stem Cells Expand Insights into Human Brain Evolution. Cell Stem Cell. 2016 Apr 07; 18(4):425-6. PMID: 27058930.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  55. Valle-García D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E. ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Epigenetics. 2016 06 02; 11(6):398-414. PMID: 27029610; PMCID: PMC4939920.
    Citations: 28     Fields:    Translation:HumansCells
  56. Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW. Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J Mol Biol. 2016 Mar 27; 428(6):1290-1303. PMID: 26812210; PMCID: PMC4826315.
    Citations: 7     Fields:    Translation:HumansCells
  57. Pritchard EM, Dyer MA, Guy RK. Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma. Mini Rev Med Chem. 2016; 16(6):430-54. PMID: 26202204; PMCID: PMC5509337.
    Citations: 16     Fields:    Translation:HumansAnimals
  58. Schoenfeld JD, Mahadevan A, Floyd SR, Dyer MA, Catalano PJ, Alexander BM, McDermott DF, Kaplan ID. Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review. J Immunother Cancer. 2015; 3:50. PMID: 26672895; PMCID: PMC4678639.
    Citations: 34     Fields:    
  59. Langenau DM, Sweet-Cordero A, Wechsler-Reya R, Dyer MA. Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res. 2015 Dec 15; 75(24):5176-5186. PMID: 26627009; PMCID: PMC4681628.
    Citations: 8     Fields:    Translation:HumansAnimals
  60. Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA. Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 01; 142(23):4092-106. PMID: 26628093.
    Citations: 14     Fields:    Translation:Animals
  61. Kratochvill F, Neale G, Haverkamp JM, Van de Velde LA, Smith AM, Kawauchi D, McEvoy J, Roussel MF, Dyer MA, Qualls JE, Murray PJ. TNF Counterbalances the Emergence of M2 Tumor Macrophages. Cell Rep. 2015 Sep 22; 12(11):1902-14. PMID: 26365184.
    Citations: 96     Fields:    Translation:AnimalsCells
  62. Hiler D, Chen X, Hazen J, Kupriyanov S, Carroll PA, Qu C, Xu B, Johnson D, Griffiths L, Frase S, Rodriguez AR, Martin G, Zhang J, Jeon J, Fan Y, Finkelstein D, Eisenman RN, Baldwin K, Dyer MA. Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors. Cell Stem Cell. 2015 Jul 02; 17(1):101-15. PMID: 26140606; PMCID: PMC4547539.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  63. Stewart E, Federico S, Karlstrom A, Shelat A, Sablauer A, Pappo A, Dyer MA. The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities. Dev Biol. 2016 Mar 15; 411(2):287-293. PMID: 26068307; PMCID: PMC4600003.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  64. Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA. A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. Nat Genet. 2015 Jun; 47(6):615-24. PMID: 25961939; PMCID: PMC4767150.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  65. Chen X, Gupta P, Wang J, Nakitandwe J, Roberts K, Dalton JD, Parker M, Patel S, Holmfeldt L, Payne D, Easton J, Ma J, Rusch M, Wu G, Patel A, Baker SJ, Dyer MA, Shurtleff S, Espy S, Pounds S, Downing JR, Ellison DW, Mullighan CG, Zhang J. CONSERTING: integrating copy-number analysis with structural-variation detection. Nat Methods. 2015 Jun; 12(6):527-30. PMID: 25938371; PMCID: PMC4591043.
    Citations: 42     Fields:    Translation:Humans
  66. Gupte A, Baker EK, Wan SS, Stewart E, Loh A, Shelat AA, Gould CM, Chalk AM, Taylor S, Lackovic K, Karlström Å, Mutsaers AJ, Desai J, Madhamshettiwar PB, Zannettino AC, Burns C, Huang DC, Dyer MA, Simpson KJ, Walkley CR. Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma. Clin Cancer Res. 2015 Jul 15; 21(14):3216-29. PMID: 25862761; PMCID: PMC4506243.
    Citations: 29     Fields:    Translation:HumansAnimals
  67. Stewart E, Shelat A, Bradley C, Chen X, Federico S, Thiagarajan S, Shirinifard A, Bahrami A, Pappo A, Qu C, Finkelstein D, Sablauer A, Dyer MA. Development and characterization of a human orthotopic neuroblastoma xenograft. Dev Biol. 2015 Nov 15; 407(2):344-55. PMID: 25863122; PMCID: PMC4995597.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  68. Pinto EM, Chen X, Easton J, Finkelstein D, Liu Z, Pounds S, Rodriguez-Galindo C, Lund TC, Mardis ER, Wilson RK, Boggs K, Yergeau D, Cheng J, Mulder HL, Manne J, Jenkins J, Mastellaro MJ, Figueiredo BC, Dyer MA, Pappo A, Zhang J, Downing JR, Ribeiro RC, Zambetti GP. Genomic landscape of paediatric adrenocortical tumours. Nat Commun. 2015 Mar 06; 6:6302. PMID: 25743702.
    Citations: 72     Fields:    Translation:HumansCells
  69. Chen X, Pappo A, Dyer MA. Pediatric solid tumor genomics and developmental pliancy. Oncogene. 2015 Oct 08; 34(41):5207-15. PMID: 25639868; PMCID: PMC4522402.
    Citations: 31     Fields:    Translation:Humans
  70. McEvoy JD, Dyer MA. Genetic and Epigenetic Discoveries in Human Retinoblastoma. Crit Rev Oncog. 2015; 20(3-4):217-25. PMID: 26349417.
    Citations: 14     Fields:    Translation:HumansAnimals
  71. Benavente CA, Dyer MA. Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma. Methods Mol Biol. 2015; 1267:307-17. PMID: 25636476.
    Citations: 2     Fields:    Translation:HumansAnimals
  72. Benavente CA, Dyer MA. Genetics and epigenetics of human retinoblastoma. Annu Rev Pathol. 2015; 10:547-62. PMID: 25621664.
    Citations: 46     Fields:    Translation:Humans
  73. Benavente CA, Finkelstein D, Johnson DA, Marine JC, Ashery-Padan R, Dyer MA. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget. 2014 Oct 30; 5(20):9594-608. PMID: 25338120.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  74. Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog NR, Miller GM, Caufield W, Freeman BB, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA. Targeting the DNA repair pathway in Ewing sarcoma. Cell Rep. 2014 Nov 06; 9(3):829-41. PMID: 25437539; PMCID: PMC4386669.
    Citations: 83     Fields:    Translation:AnimalsCells
  75. Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A. The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol. 2015 Mar; 135(3):816-823. PMID: 25268584.
    Citations: 47     Fields:    Translation:Humans
  76. Tirode F, Surdez D, Ma X, Parker M, Le Deley MC, Bahrami A, Zhang Z, Lapouble E, Grossetête-Lalami S, Rusch M, Reynaud S, Rio-Frio T, Hedlund E, Wu G, Chen X, Pierron G, Oberlin O, Zaidi S, Lemmon G, Gupta P, Vadodaria B, Easton J, Gut M, Ding L, Mardis ER, Wilson RK, Shurtleff S, Laurence V, Michon J, Marec-Bérard P, Gut I, Downing J, Dyer M, Zhang J, Delattre O. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. Cancer Discov. 2014 Nov; 4(11):1342-53. PMID: 25223734.
    Citations: 200     Fields:    Translation:HumansCells
  77. Miles WO, Korenjak M, Griffiths LM, Dyer MA, Provero P, Dyson NJ. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014 Oct 01; 33(19):2201-15. PMID: 25100735.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  78. Dyer MA, Arvold ND, Chen YH, Pinnell NE, Mitin T, Lee EQ, Hodi FS, Ibrahim N, Weiss SE, Kelly PJ, Floyd SR, Mahadevan A, Alexander BM. The role of whole brain radiation therapy in the management of melanoma brain metastases. Radiat Oncol. 2014 Jun 22; 9:143. PMID: 24954062.
    Citations: 15     Fields:    Translation:Humans
  79. Pritchard EM, Stewart E, Zhu F, Bradley C, Griffiths L, Yang L, Suryadevara PK, Zhang J, Freeman BB, Guy RK, Dyer MA. Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma. Pharm Res. 2014 Nov; 31(11):3060-72. PMID: 24906597.
    Citations: 10     Fields:    Translation:HumansAnimals
  80. Valle-García D, Griffiths LM, Dyer MA, Bernstein E, Recillas-Targa F. The ATRX cDNA is prone to bacterial IS10 element insertions that alter its structure. Springerplus. 2014; 3:222. PMID: 24834375.
    Citations: 2     
  81. Chen X, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E, Ellison D, Shurtleff S, Wu G, Wei L, Parker M, Rusch M, Nagahawatte P, Wu J, Mao S, Boggs K, Mulder H, Yergeau D, Lu C, Ding L, Edmonson M, Qu C, Wang J, Li Y, Navid F, Daw NC, Mardis ER, Wilson RK, Downing JR, Zhang J, Dyer MA. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep. 2014 Apr 10; 7(1):104-12. PMID: 24703847; PMCID: PMC4096827.
    Citations: 290     Fields:    Translation:Humans
  82. McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, Wilson M, Brennan R, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget. 2014 Jan 30; 5(2):438-50. PMID: 24509483.
    Citations: 45     Fields:    Translation:Humans
  83. Zhang H, Nieves JL, Fraser ST, Isern J, Douvaras P, Papatsenko D, D'Souza SL, Lemischka IR, Dyer MA, Baron MH. Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells. 2014 Jan; 32(1):191-203. PMID: 24022884.
    Citations: 9     Fields:    Translation:AnimalsCells
  84. Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA. Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell. 2013 Dec 09; 24(6):710-24. PMID: 24332040; PMCID: PMC3904731.
    Citations: 135     Fields:    Translation:HumansAnimals
  85. Benavente CA, McEvoy JD, Finkelstein D, Wei L, Kang G, Wang YD, Neale G, Ragsdale S, Valentine V, Bahrami A, Temirov J, Pounds S, Zhang J, Dyer MA. Cross-species genomic and epigenomic landscape of retinoblastoma. Oncotarget. 2013 Jun; 4(6):844-59. PMID: 23765217.
    Citations: 24     Fields:    Translation:HumansAnimals
  86. Cheung NK, Dyer MA. Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer. 2013 Jun; 13(6):397-411. PMID: 23702928.
    Citations: 350     Fields:    Translation:HumansAnimals
  87. Cather C, Dyer MA, Burrell HA, Hoeppner B, Goff DC, Evins AE. An Open Trial of Relapse Prevention Therapy for Smokers With Schizophrenia. J Dual Diagn. 2013; 9(1):87-93. PMID: 23750123.
    Citations: 17     Fields:    
  88. Parker M, Chen X, Bahrami A, Dalton J, Rusch M, Wu G, Easton J, Cheung NK, Dyer M, Mardis ER, Wilson RK, Mullighan C, Gilbertson R, Baker SJ, Zambetti G, Ellison DW, Downing JR, Zhang J. Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data. Genome Biol. 2012 Dec 11; 13(12):R113. PMID: 23232254.
    Citations: 19     Fields:    Translation:HumansCells
  89. McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. PLoS One. 2012; 7(8):e42739. PMID: 22916154.
    Citations: 38     Fields:    Translation:HumansCells
  90. Nittner D, Lambertz I, Clermont F, Mestdagh P, Köhler C, Nielsen SJ, Jochemsen A, Speleman F, Vandesompele J, Dyer MA, Schramm A, Schulte JH, Marine JC. Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol. 2012 Sep; 14(9):958-65. PMID: 22864477.
    Citations: 55     Fields:    Translation:HumansAnimals
  91. Dyer MA, Kelly PJ, Chen YH, Pinnell NE, Claus EB, Lee EQ, Weiss SE, Arvold ND, Lin NU, Alexander BM. Importance of extracranial disease status and tumor subtype for patients undergoing radiosurgery for breast cancer brain metastases. Int J Radiat Oncol Biol Phys. 2012 Jul 15; 83(4):e479-86. PMID: 22704705.
    Citations: 11     Fields:    Translation:Humans
  92. Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012; 7(6):e37518. PMID: 22675482.
    Citations: 25     Fields:    Translation:HumansCells
  93. Cheung NK, Zhang J, Lu C, Parker M, Bahrami A, Tickoo SK, Heguy A, Pappo AS, Federico S, Dalton J, Cheung IY, Ding L, Fulton R, Wang J, Chen X, Becksfort J, Wu J, Billups CA, Ellison D, Mardis ER, Wilson RK, Downing JR, Dyer MA. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA. 2012 Mar 14; 307(10):1062-71. PMID: 22416102; PMCID: PMC3527076.
    Citations: 181     Fields:    Translation:HumansCTClinical Trials
  94. Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29; 44(3):251-3. PMID: 22286216.
    Citations: 719     Fields:    Translation:HumansCells
  95. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11; 481(7381):329-34. PMID: 22237022; PMCID: PMC3289956.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  96. Martins RA, Davis D, Kerekes R, Zhang J, Bayazitov IT, Hiler D, Karakaya M, Frase S, Gleason S, Zakharenko SS, Johnson DA, Dyer MA. Retinoblastoma (Rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21111-6. PMID: 22160703.
    Citations: 2     Fields:    Translation:AnimalsCells
  97. Wilson MW, Haik BG, Dyer MA. Superselective intraophthalmic artery chemotherapy: what we do not know. Arch Ophthalmol. 2011 Nov; 129(11):1490-1. PMID: 22084220.
    Citations: 9     Fields:    Translation:Humans
  98. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75. PMID: 21840489.
    Citations: 74     Fields:    Translation:HumansAnimals
  99. Teitz T, Stanke JJ, Federico S, Bradley CL, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang ZM, Frase S, Rehg JE, Hillenbrand CM, Finkelstein D, Calabrese C, Dyer MA, Lahti JM. Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One. 2011 Apr 29; 6(4):e19133. PMID: 21559450.
    Citations: 44     Fields:    Translation:HumansAnimals
  100. Brennan RC, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res. 2011 Jun 15; 71(12):4205-13. PMID: 21515735.
    Citations: 35     Fields:    Translation:HumansAnimals
  101. Kerekes RA, Martins RA, Davis D, Karakaya M, Gleason S, Dyer MA. Automated tracing of horizontal neuron processes during retinal development. Neurochem Res. 2011 Apr; 36(4):583-93. PMID: 21221777.
    Citations: 2     Fields:    Translation:AnimalsCells
  102. Federico S, Brennan R, Dyer MA. Childhood cancer and developmental biology a crucial partnership. Curr Top Dev Biol. 2011; 94:1-13. PMID: 21295682.
    Citations: 9     Fields:    Translation:HumansAnimals
  103. Dyer MA. Oncogenesis and the development of treatments. Preface. Curr Top Dev Biol. 2011; 94:xiii-xiv. PMID: 21295681.
    Citations:    Fields:    
  104. Zhang F, Tagen M, Throm S, Mallari J, Miller L, Guy RK, Dyer MA, Williams RT, Roussel MF, Nemeth K, Zhu F, Zhang J, Lu M, Panetta JC, Boulos N, Stewart CF. Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration. Drug Metab Dispos. 2011 Jan; 39(1):15-21. PMID: 20947617.
    Citations: 23     Fields:    Translation:AnimalsCells
  105. Nemeth KM, Federico S, Carcaboso AM, Shen Y, Schaiquevich P, Zhang J, Egorin M, Stewart C, Dyer MA. Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer. 2011 Jan 15; 117(2):421-34. PMID: 20818652; PMCID: PMC3000447.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  106. Brennan R, Federico S, Dyer MA. The war on cancer: have we won the battle but lost the war? Oncotarget. 2010 Jun; 1(2):77-83. PMID: 20877440.
    Citations: 6     Fields:    Translation:HumansAnimals
  107. Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 02; 285(14):10786-96. PMID: 20080970.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  108. Davis DM, Dyer MA. Retinal progenitor cells, differentiation, and barriers to cell cycle reentry. Curr Top Dev Biol. 2010; 93:175-88. PMID: 20959166.
    Citations: 10     Fields:    Translation:Cells
  109. Lambertz I, Nittner D, Mestdagh P, Denecker G, Vandesompele J, Dyer MA, Marine JC. Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ. 2010 Apr; 17(4):633-41. PMID: 20019750.
    Citations: 87     Fields:    Translation:HumansAnimals
  110. Laurie N, Mohan A, McEvoy J, Reed D, Zhang J, Schweers B, Ajioka I, Valentine V, Johnson D, Ellison D, Dyer MA. Changes in retinoblastoma cell adhesion associated with optic nerve invasion. Mol Cell Biol. 2009 Dec; 29(23):6268-82. PMID: 19786571.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  111. Dyer MA, Abramson DH. Mutations and cancer: one or two historical perspectives? Lancet Oncol. 2009 Aug; 10(8):834. PMID: 19647204.
    Citations: 1     Fields:    
  112. Dyer MA. In their own words: interviews with Cell Cycle. The first knockout mouse model of retinoblastoma. Cell Cycle. 2009 Jul 15; 8(14):2145. PMID: 19574732.
    Citations:    Fields:    Translation:Animals
  113. Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8963-8. PMID: 19451636.
    Citations: 37     Fields:    Translation:AnimalsCells
  114. Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6685-90. PMID: 19346468.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  115. Shih CS, Laurie N, Holzmacher J, Spence Y, Nathwani AC, Davidoff AM, Dyer MA. AAV-mediated local delivery of interferon-beta for the treatment of retinoblastoma in preclinical models. Neuromolecular Med. 2009; 11(1):43-52. PMID: 19306089.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  116. Rodriguez-Galindo C, Wilson MW, Chantada G, Fu L, Qaddoumi I, Antoneli C, Leal-Leal C, Sharma T, Barnoya M, Epelman S, Pizzarello L, Kane JR, Barfield R, Merchant TE, Robison LL, Murphree AL, Chevez-Barrios P, Dyer MA, O'Brien J, Ribeiro RC, Hungerford J, Helveston EM, Haik BG, Wilimas J. Retinoblastoma: one world, one vision. Pediatrics. 2008 Sep; 122(3):e763-70. PMID: 18762512; PMCID: PMC2844325.
    Citations: 37     Fields:    Translation:Humans
  117. Dyer MA, Freudenreich O, Culhane MA, Pachas GN, Deckersbach T, Murphy E, Goff DC, Evins AE. High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia. Schizophr Res. 2008 Jul; 102(1-3):88-95. PMID: 18325740.
    Citations: 21     Fields:    Translation:Humans
  118. Dyer M. Special issue on retinal development. Brain Res. 2008 Feb 04; 1192:1-2. PMID: 18261521.
    Citations:    Fields:    Translation:HumansAnimalsCells
  119. Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A, Knoepfler PS, Eisenman RN, Roussel MF, Dyer MA. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev. 2008 Jan 15; 22(2):179-93. PMID: 18198336; PMCID: PMC2192753.
    Citations: 24     Fields:    Translation:AnimalsCells
  120. Ajioka I, Dyer MA. A new model of tumor susceptibility following tumor suppressor gene inactivation. Cell Cycle. 2008 Mar 15; 7(6):735-40. PMID: 18239449.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  121. Laurie NA, Shih CS, Schin-Shih C, Dyer MA. Targeting MDM2 and MDMX in retinoblastoma. Curr Cancer Drug Targets. 2007 Nov; 7(7):689-95. PMID: 18045074.
    Citations: 21     Fields:    Translation:Humans
  122. Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007 Oct 19; 131(2):378-90. PMID: 17956737.
    Citations: 105     Fields:    Translation:AnimalsCells
  123. Pounds S, Dyer MA. Statistical analysis of data from retroviral clonal experiments in the developing retina. Brain Res. 2008 Feb 04; 1192:178-85. PMID: 17950704.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  124. MacPherson D, Dyer MA. Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy. Cancer Res. 2007 Aug 15; 67(16):7547-50. PMID: 17699756.
    Citations: 23     Fields:    Translation:HumansAnimals
  125. Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev. 2007 Jul 15; 21(14):1731-46. PMID: 17626791; PMCID: PMC1920168.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  126. Barr RS, Culhane MA, Jubelt LE, Mufti RS, Dyer MA, Weiss AP, Deckersbach T, Kelly JF, Freudenreich O, Goff DC, Evins AE. The effects of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls. Neuropsychopharmacology. 2008 Feb; 33(3):480-90. PMID: 17443126.
    Citations: 108     Fields:    Translation:Humans
  127. Johnson DA, Zhang J, Frase S, Wilson M, Rodriguez-Galindo C, Dyer MA. Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res. 2007 Mar 15; 67(6):2701-11. PMID: 17363591.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  128. Marine JC, Dyer MA, Jochemsen AG. MDMX: from bench to bedside. J Cell Sci. 2007 Feb 01; 120(Pt 3):371-8. PMID: 17251377.
    Citations: 116     Fields:    Translation:HumansAnimals
  129. Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006 Nov 02; 444(7115):61-6. PMID: 17080083.
    Citations: 245     Fields:    Translation:HumansAnimals
  130. Johnson DA, Donovan SL, Dyer MA. Mosaic deletion of Rb arrests rod differentiation and stimulates ectopic synaptogenesis in the mouse retina. J Comp Neurol. 2006 Sep 01; 498(1):112-28. PMID: 16856163.
    Citations: 14     Fields:    Translation:AnimalsCells
  131. Martins RA, Linden R, Dyer MA. Glutamate regulates retinal progenitors cells proliferation during development. Eur J Neurosci. 2006 Aug; 24(4):969-80. PMID: 16925590.
    Citations: 13     Fields:    Translation:AnimalsCells
  132. Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol. 2006 May 03; 4:14. PMID: 16672052.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  133. Sun H, Chang Y, Schweers B, Dyer MA, Zhang X, Hayward SW, Goodrich DW. An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity. Mol Cell Biol. 2006 Feb; 26(4):1527-37. PMID: 16449662; PMCID: PMC1367194.
    Citations: 18     Fields:    Translation:AnimalsCells
  134. Donovan SL, Dyer MA. Preparation and square wave electroporation of retinal explant cultures. Nat Protoc. 2006; 1(6):2710-8. PMID: 17406527.
    Citations: 28     Fields:    Translation:HumansAnimals
  135. Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma. PLoS Med. 2005 Oct; 2(10):e332. PMID: 16231976; PMCID: PMC1261510.
    Citations: 27     Fields:    Translation:HumansAnimals
  136. Laurie NA, Gray JK, Zhang J, Leggas M, Relling M, Egorin M, Stewart C, Dyer MA. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res. 2005 Oct 15; 11(20):7569-78. PMID: 16243833.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  137. Schweers BA, Dyer MA. Perspective: new genetic tools for studying retinal development and disease. Vis Neurosci. 2005 Sep-Oct; 22(5):553-60. PMID: 16332265.
    Citations: 5     Fields:    Translation:Animals
  138. Donovan SL, Dyer MA. Regulation of proliferation during central nervous system development. Semin Cell Dev Biol. 2005 Jun; 16(3):407-21. PMID: 15840449.
    Citations: 30     Fields:    
  139. Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer. 2005 Feb; 5(2):91-101. PMID: 15685194.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  140. Dyer MA, Donovan SL, Zhang J, Gray J, Ortiz A, Tenney R, Kong J, Allikmets R, Sohocki MM. Retinal degeneration in Aipl1-deficient mice: a new genetic model of Leber congenital amaurosis. Brain Res Mol Brain Res. 2004 Dec 20; 132(2):208-20. PMID: 15582159.
    Citations: 18     Fields:    Translation:AnimalsCells
  141. Donovan SL, Dyer MA. Developmental defects in Rb-deficient retinae. Vision Res. 2004 Dec; 44(28):3323-33. PMID: 15536000.
    Citations: 15     Fields:    Translation:AnimalsCells
  142. Zhang J, Schweers B, Dyer MA. The first knockout mouse model of retinoblastoma. Cell Cycle. 2004 Jul; 3(7):952-9. PMID: 15190215.
    Citations: 64     Fields:    Translation:AnimalsCells
  143. Dyer MA. Mouse models of childhood cancer of the nervous system. J Clin Pathol. 2004 Jun; 57(6):561-76. PMID: 15166259; PMCID: PMC1770320.
    Citations: 17     Fields:    Translation:HumansAnimals
  144. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet. 2004 Apr; 36(4):351-60. PMID: 14991054.
    Citations: 74     Fields:    Translation:AnimalsCells
  145. Dyer MA. Regulation of proliferation, cell fate specification and differentiation by the homeodomain proteins Prox1, Six3, and Chx10 in the developing retina. Cell Cycle. 2003 Jul-Aug; 2(4):350-7. PMID: 12851489.
    Citations: 35     Fields:    Translation:AnimalsCells
  146. Dyer MA, Livesey FJ, Cepko CL, Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet. 2003 May; 34(1):53-8. PMID: 12692551.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  147. Mohn D, Chen SW, Dias DC, Weinstein DC, Dyer MA, Sahr K, Ducker CE, Zahradka E, Keller G, Zaret KS, Gudas LJ, Baron MH. Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Dev Dyn. 2003 Mar; 226(3):446-59. PMID: 12619131.
    Citations: 12     Fields:    Translation:AnimalsCells
  148. Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Fukada-Kamitani T, Daiger SP, Craft C, Kamitani T, Sohocki MM. Functional studies of AIPL1: potential role of AIPL1 in cell cycle exit and/or differentiation of photoreceptors. Adv Exp Med Biol. 2003; 533:287-95. PMID: 15180275.
    Citations:    Fields:    Translation:HumansAnimalsCells
  149. Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM. The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. Hum Mol Genet. 2002 Oct 15; 11(22):2723-33. PMID: 12374762; PMCID: PMC2585502.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  150. Zhu CC, Dyer MA, Uchikawa M, Kondoh H, Lagutin OV, Oliver G. Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002 Jun; 129(12):2835-49. PMID: 12050133.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  151. Dyer MA, Cepko CL. p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. J Neurosci. 2001 Jun 15; 21(12):4259-71. PMID: 11404411; PMCID: PMC6762752.
    Citations: 84     Fields:    Translation:AnimalsCells
  152. Dyer MA, Farrington SM, Mohn D, Munday JR, Baron MH. Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development. 2001 May; 128(10):1717-30. PMID: 11311154.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  153. Dyer MA, Cepko CL. Regulating proliferation during retinal development. Nat Rev Neurosci. 2001 May; 2(5):333-42. PMID: 11331917.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  154. Dyer MA, Cepko CL. The p57Kip2 cyclin kinase inhibitor is expressed by a restricted set of amacrine cells in the rodent retina. J Comp Neurol. 2001 Jan 22; 429(4):601-14. PMID: 11135238.
    Citations: 18     Fields:    Translation:AnimalsCells
  155. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci. 2000 Sep; 3(9):873-80. PMID: 10966617.
    Citations: 173     Fields:    Translation:AnimalsCells
  156. Dyer MA, Cepko CL. p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development. 2000 Aug; 127(16):3593-605. PMID: 10903183.
    Citations: 61     Fields:    Translation:AnimalsCells
  157. Tjitra E, Suprianto S, Dyer M, Currie BJ, Anstey NM. Field evaluation of the ICT malaria P.f/P.v immunochromatographic test for detection of Plasmodium falciparum and Plasmodium vivax in patients with a presumptive clinical diagnosis of malaria in eastern Indonesia. J Clin Microbiol. 1999 Aug; 37(8):2412-7. PMID: 10405377; PMCID: PMC85241.
    Citations: 57     Fields:    Translation:HumansAnimals
  158. Dyer MA, Hayes PJ, Baron MH. The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. Mol Cell Biol. 1998 May; 18(5):2617-28. PMID: 9566881.
    Citations: 10     Fields:    Translation:HumansCells
  159. Douglas SL, Daly BJ, Brennan PF, Harris S, Nochomovitz M, Dyer MA. Outcomes of long-term ventilator patients: a descriptive study. Am J Crit Care. 1997 Mar; 6(2):99-105. PMID: 9172858.
    Citations: 7     Fields:    Translation:Humans
  160. Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D. Definition of acute biphenotypic leukemia. Haematologica. 1997 Jan-Feb; 82(1):64-6. PMID: 9107085.
    Citations: 32     Fields:    Translation:HumansCells
  161. Dyer MA, Naidoo R, Hayes RJ, Larson CJ, Verdine GL, Baron MH. A DNA-bending protein interacts with an essential upstream regulatory element of the human embryonic beta-like globin gene. Mol Cell Biol. 1996 Mar; 16(3):829-38. PMID: 8622684.
    Citations: 6     Fields:    Translation:HumansCells
  162. Trepicchio WL, Dyer MA, Baron MH. A novel developmental regulatory motif required for stage-specific activation of the epsilon-globin gene and nuclear factor binding in embryonic erythroid cells. Mol Cell Biol. 1994 Jun; 14(6):3763-71. PMID: 8196619.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  163. Ridge SA, Dyer M, Greaves MF, Wiedemann LM. Lack of MDM2 amplification in human leukaemia. Br J Haematol. 1994 Feb; 86(2):407-9. PMID: 8199038.
    Citations: 4     Fields:    Translation:HumansCells
  164. Trepicchio WL, Dyer MA, Hardison RC, Baron MH. Upstream regulatory region of the human embryonic beta-like globin gene, epsilon. DNA Seq. 1994; 4(6):409-12. PMID: 7841465.
    Citations: 3     Fields:    Translation:HumansCells
  165. Trepicchio WL, Dyer MA, Baron MH. Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements. Mol Cell Biol. 1993 Dec; 13(12):7457-68. PMID: 8246963.
    Citations: 14     Fields:    Translation:HumansCells
  166. Dyer M, Volpe F, Delves CJ, Somia N, Burns S, Scaife JG. Cloning and sequence of a beta-tubulin cDNA from Pneumocystis carinii: possible implications for drug therapy. Mol Microbiol. 1992 Apr; 6(8):991-1001. PMID: 1584027.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.