Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileNicholas John Dyson, PH.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
MGH Cancer Center
149 13th Street
Charlestown MA 02129
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM117413     (DYSON, NICHOLAS J)Jun 1, 2016 - May 31, 2020
The consequences of RB-loss
Role: Principal Investigator

R01CA163698     (DYSON, NICHOLAS J)Sep 26, 2012 - Jul 31, 2017
Dissection and manipulation of RB function
Role: Principal Investigator

R01CA155202     (DYSON, NICHOLAS J)Jul 1, 2011 - May 31, 2016
The Origins of Chromosomal Instability in Human Tumor Cells
Role: Principal Investigator

R01GM081607     (DYSON, NICHOLAS J)May 1, 2008 - Aug 29, 2012
The Enhancement and Suppression of E2F-Dependent Apoptosis
Role: Principal Investigator

P01CA095281     (HABER, DANIEL A.)Sep 4, 2002 - Aug 31, 2008
Genetic Models of Cellular Proliferation
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Drapkin BJ, George J, Christensen CL, Mino-Kenudson M, Dries R, Sundaresan T, Phat S, Myers DT, Zhong J, Igo P, Hazar-Rethinam MH, LiCausi JA, Gomez-Caraballo M, Kem M, Jani KN, Azimi R, Abedpour N, Menon R, Lakis S, Heist RS, Büttner R, Haas S, Sequist LV, Shaw AT, Wong KK, Hata AN, Toner M, Maheswaran S, Haber DA, Peifer M, Dyson N, Thomas RK, Farago AF. Genomic and functional fidelity of small cell lung cancer patient-derived xenografts. Cancer Discov. 2018 Feb 26. PMID: 29483136.
    View in: PubMed
  2. Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017 Dec 18; 43(6):689-703.e5. PMID: 29233476.
    View in: PubMed
  3. Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017 06 15; 546(7658):426-430. PMID: 28607489.
    View in: PubMed
  4. Sanidas I, Dyson NJ. pRB Takes an EZ Path to a Repetitive Task. Mol Cell. 2016 Dec 15; 64(6):1015-1017. PMID: 27984740.
    View in: PubMed
  5. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395. PMID: 27799657.
    View in: PubMed
  6. Miles WO, Lembo A, Volorio A, Brachtel E, Tian B, Sgroi D, Provero P, Dyson N. Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation. Cancer Res. 2016 Dec 15; 76(24):7231-7241. PMID: 27758885.
    View in: PubMed
  7. Dyson NJ. RB1: a prototype tumor suppressor and an enigma. Genes Dev. 2016 07 01; 30(13):1492-502. PMID: 27401552; PMCID: PMC4949322.
  8. Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L. E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest. 2016 Jan; 126(1):137-50. PMID: 26619117; PMCID: PMC4701565.
  9. Miles WO, Lepesant JM, Bourdeaux J, Texier M, Kerenyi MA, Nakakido M, Hamamoto R, Orkin SH, Dyson NJ, Di Stefano L. The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop. Mol Cell Biol. 2015 Dec; 35(24):4199-211. PMID: 26438601; PMCID: PMC4648826.
  10. Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes Dev. 2015 Sep 01; 29(17):1875-89. PMID: 26314710; PMCID: PMC4573859.
  11. Miles WO, Dyson NJ. RB-loss puts focus on Myc. Nat Cell Biol. 2015 Aug; 17(8):968-9. PMID: 26239529.
    View in: PubMed
  12. Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015 Aug 20; 524(7565):361-5. PMID: 26168401.
    View in: PubMed
  13. Miles WO, Dyson NJ. Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation. Mol Cell Oncol. 2014 Oct-Dec; 1(4):e968074. PMID: 27308363; PMCID: PMC4905203.
  14. Miles WO, Korenjak M, Griffiths LM, Dyer MA, Provero P, Dyson NJ. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014 Oct 01; 33(19):2201-15. PMID: 25100735; PMCID: PMC4282507.
  15. Korenjak M, Kwon E, Morris RT, Anderssen E, Amzallag A, Ramaswamy S, Dyson NJ. dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes. Nucleic Acids Res. 2014 Aug; 42(14):8939-53. PMID: 25053843; PMCID: PMC4132727.
  16. Heilmann AM, Perera RM, Ecker V, Nicolay BN, Bardeesy N, Benes CH, Dyson NJ. CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers. Cancer Res. 2014 Jul 15; 74(14):3947-58. PMID: 24986516; PMCID: PMC4122288.
  17. Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ. Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell. 2014 Mar 20; 53(6):993-1004. PMID: 24613344; PMCID: PMC4047977.
  18. Evertts AG, Manning AL, Wang X, Dyson NJ, Garcia BA, Coller HA. H4K20 methylation regulates quiescence and chromatin compaction. Mol Biol Cell. 2013 Oct; 24(19):3025-37. PMID: 23924899; PMCID: PMC3784377.
  19. Nicolay BN, Dyson NJ. The multiple connections between pRB and cell metabolism. Curr Opin Cell Biol. 2013 Dec; 25(6):735-40. PMID: 23916769; PMCID: PMC3836918.
  20. Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR. KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell. 2013 Aug 01; 154(3):541-55. PMID: 23871696; PMCID: PMC3832053.
  21. Manning AL, Benes C, Dyson NJ. Whole chromosome instability resulting from the synergistic effects of pRB and p53 inactivation. Oncogene. 2014 May 08; 33(19):2487-94. PMID: 23792446; PMCID: PMC3884049.
  22. Di Stefano L, Dyson NJ. The emerging roles for histone demethylases in the modulation of signaling pathways. Biomol Concepts. 2013 Feb; 4(1):13-27. PMID: 25436562.
    View in: PubMed
  23. Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ. Loss of RBF1 changes glutamine catabolism. Genes Dev. 2013 Jan 15; 27(2):182-96. PMID: 23322302; PMCID: PMC3566311.
  24. Ji JY, Miles WO, Korenjak M, Zheng Y, Dyson NJ. In vivo regulation of E2F1 by Polycomb group genes in Drosophila. G3 (Bethesda). 2012 Dec; 2(12):1651-60. PMID: 23275887; PMCID: PMC3516486.
  25. Herr A, Longworth M, Ji JY, Korenjak M, Macalpine DM, Dyson NJ. Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. Dev Dyn. 2012 Nov; 241(11):1695-707. PMID: 22972499; PMCID: PMC3760379.
  26. Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ. RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol. 2012 Nov; 32(21):4375-87. PMID: 22927638; PMCID: PMC3486151.
  27. Nicolay BN, Dyson NJ. It's all in the timing: too much E2F is a bad thing. PLoS Genet. 2012; 8(8):e1002909. PMID: 22916039; PMCID: PMC3420940.
  28. Heilmann AM, Dyson NJ. Phosphorylation puts the pRb tumor suppressor into shape. Genes Dev. 2012 Jun 01; 26(11):1128-30. PMID: 22661226; PMCID: PMC3371403.
  29. Longworth MS, Walker JA, Anderssen E, Moon NS, Gladden A, Heck MM, Ramaswamy S, Dyson NJ. A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet. 2012; 8(4):e1002618. PMID: 22496667; PMCID: PMC3320600.
  30. Miles WO, Tschöp K, Herr A, Ji JY, Dyson NJ. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012 Feb 15; 26(4):356-68. PMID: 22345517; PMCID: PMC3289884.
  31. Manning AL, Dyson NJ. RB: mitotic implications of a tumour suppressor. Nat Rev Cancer. 2012 Feb 09; 12(3):220-6. PMID: 22318235; PMCID: PMC3800194.
  32. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11; 481(7381):329-34. PMID: 22237022; PMCID: PMC3289956.
  33. Popova MK, He W, Korenjak M, Dyson NJ, Moon NS. Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. J Cell Sci. 2011 Dec 15; 124(Pt 24):4203-12. PMID: 22193959; PMCID: PMC3258105.
  34. Tschöp K, Dyson N. Identifying players in the functional network around pRB. Cell Cycle. 2011 Nov 15; 10(22):3814-5. PMID: 22142859.
    View in: PubMed
  35. Miles WO, Dyson NJ, Walker JA. Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech. 2011 Nov; 4(6):753-61. PMID: 21979943; PMCID: PMC3209645.
  36. Di Stefano L, Dyson NJ. The complex roles of histone demethylases in vivo. Cell Cycle. 2011 Jul 01; 10(13):2049-50. PMID: 21597322; PMCID: PMC3154358.
  37. Manning AL, Dyson NJ. pRB, a tumor suppressor with a stabilizing presence. Trends Cell Biol. 2011 Aug; 21(8):433-41. PMID: 21664133; PMCID: PMC3149724.
  38. Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM. A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell. 2011 Jun 10; 42(5):689-99. PMID: 21596603; PMCID: PMC3119599.
  39. Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30. PMID: 21498571; PMCID: PMC3078707.
  40. Di Stefano L, Walker JA, Burgio G, Corona DF, Mulligan P, Näär AM, Dyson NJ. Functional antagonism between histone H3K4 demethylases in vivo. Genes Dev. 2011 Jan 01; 25(1):17-28. PMID: 21205864; PMCID: PMC3012933.
  41. Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR. Conserved antagonism between JMJD2A/KDM4A and HP1? during cell cycle progression. Mol Cell. 2010 Dec 10; 40(5):736-48. PMID: 21145482.
    View in: PubMed
  42. Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell. 2010 Oct 08; 40(1):22-33. PMID: 20932472; PMCID: PMC2957874.
  43. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232; PMCID: PMC2895199.
  44. Manning AL, Longworth MS, Dyson NJ. Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev. 2010 Jul 01; 24(13):1364-76. PMID: 20551165; PMCID: PMC2895196.
  45. Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009 Dec; 11(12):1444-50. PMID: 19935651; PMCID: PMC2819909.
  46. Longworth MS, Dyson NJ. pRb, a local chromatin organizer with global possibilities. Chromosoma. 2010 Feb; 119(1):1-11. PMID: 19714354; PMCID: PMC3760338.
  47. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009 Jul; 20(14):3305-16. PMID: 19477924; PMCID: PMC2710831.
  48. Korenjak M, Dyson N. A vanishing act, explained. Dev Cell. 2008 Dec; 15(6):793-4. PMID: 19081066.
    View in: PubMed
  49. Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008 Sep 25; 455(7212):552-6. PMID: 18794899; PMCID: PMC3148807.
  50. van den Heuvel S, Dyson NJ. Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol. 2008 Sep; 9(9):713-24. PMID: 18719710.
    View in: PubMed
  51. Moon NS, Di Stefano L, Morris EJ, Patel R, White K, Dyson NJ. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 2008 Aug 08; 4(8):e1000153. PMID: 18688282; PMCID: PMC2491587.
  52. Longworth MS, Herr A, Ji JY, Dyson NJ. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008 Apr 15; 22(8):1011-24. PMID: 18367646; PMCID: PMC2335323.
  53. Moon NS, Dyson N. E2F7 and E2F8 keep the E2F family in balance. Dev Cell. 2008 Jan; 14(1):1-3. PMID: 18194644.
    View in: PubMed
  54. Di Stefano L, Ji JY, Moon NS, Herr A, Dyson N. Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr Biol. 2007 May 01; 17(9):808-12. PMID: 17462898; PMCID: PMC1909692.
  55. Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol. 2007 Feb; 9(2):225-32. PMID: 17187060.
    View in: PubMed
  56. Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006 Nov 17; 2(11):e196. PMID: 17112319; PMCID: PMC1636698.
  57. Balsitis S, Dick F, Dyson N, Lambert PF. Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. Cancer Res. 2006 Oct 01; 66(19):9393-400. PMID: 17018593; PMCID: PMC2858286.
  58. Moon NS, Di Stefano L, Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol. 2006 Oct; 26(20):7601-15. PMID: 16954388; PMCID: PMC1636876.
  59. Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binné UK, Harrington L, Sicinski P, Bérubé NG, Dyson NJ, Dick FA. The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol. 2006 May; 26(9):3659-71. PMID: 16612004; PMCID: PMC1447412.
  60. Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, Taylor-Harding B, White K, Dyson NJ. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 2005 Oct; 9(4):463-75. PMID: 16198289.
    View in: PubMed
  61. Stevaux O, Dimova DK, Ji JY, Moon NS, Frolov MV, Dyson NJ. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle. 2005 Sep; 4(9):1272-80. PMID: 16082225.
    View in: PubMed
  62. Balsitis S, Dick F, Lee D, Farrell L, Hyde RK, Griep AE, Dyson N, Lambert PF. Examination of the pRb-dependent and pRb-independent functions of E7 in vivo. J Virol. 2005 Sep; 79(17):11392-402. PMID: 16103190; PMCID: PMC1193607.
  63. Dimova DK, Dyson NJ. The E2F transcriptional network: old acquaintances with new faces. Oncogene. 2005 Apr 18; 24(17):2810-26. PMID: 15838517.
    View in: PubMed
  64. Frolov MV, Moon NS, Dyson NJ. dDP is needed for normal cell proliferation. Mol Cell Biol. 2005 Apr; 25(8):3027-39. PMID: 15798191; PMCID: PMC1069608.
  65. Taylor-Harding B, Binné UK, Korenjak M, Brehm A, Dyson NJ. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol Cell Biol. 2004 Oct; 24(20):9124-36. PMID: 15456884; PMCID: PMC517895.
  66. Frolov MV, Dyson NJ. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci. 2004 May 01; 117(Pt 11):2173-81. PMID: 15126619.
    View in: PubMed
  67. Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol. 2004 Jan; 24(2):595-607. PMID: 14701733; PMCID: PMC343811.
  68. Dimova DK, Stevaux O, Frolov MV, Dyson NJ. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 2003 Sep 15; 17(18):2308-20. PMID: 12975318; PMCID: PMC196467.
  69. Kohn MJ, Bronson RT, Harlow E, Dyson NJ, Yamasaki L. Dp1 is required for extra-embryonic development. Development. 2003 Apr; 130(7):1295-305. PMID: 12588846.
    View in: PubMed
  70. Frolov MV, Stevaux O, Moon NS, Dimova D, Kwon EJ, Morris EJ, Dyson NJ. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes Dev. 2003 Mar 15; 17(6):723-8. PMID: 12651890; PMCID: PMC196013.
  71. Stevaux O, Dyson NJ. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol. 2002 Dec; 14(6):684-91. PMID: 12473340.
    View in: PubMed
  72. Stevaux O, Dimova D, Frolov MV, Taylor-Harding B, Morris E, Dyson N. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 2002 Sep 16; 21(18):4927-37. PMID: 12234932; PMCID: PMC126297.
  73. Dick FA, Dyson NJ. Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J Virol. 2002 Jun; 76(12):6224-34. PMID: 12021356; PMCID: PMC136242.
  74. Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ, Loeffler JS. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol. 2002 Feb 15; 20(4):1063-8. PMID: 11844831.
    View in: PubMed
  75. Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 2002 Jan 01; 62(1):200-7. PMID: 11782378.
    View in: PubMed
  76. Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P. Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13138-43. PMID: 11687642; PMCID: PMC60837.
  77. Frolov MV, Huen DS, Stevaux O, Dimova D, Balczarek-Strang K, Elsdon M, Dyson NJ. Functional antagonism between E2F family members. Genes Dev. 2001 Aug 15; 15(16):2146-60. PMID: 11511545; PMCID: PMC312757.
  78. Chakravarti A, Delaney MA, Noll E, Black PM, Loeffler JS, Muzikansky A, Dyson NJ. Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas. Clin Cancer Res. 2001 Aug; 7(8):2387-95. PMID: 11489817.
    View in: PubMed
  79. Morris EJ, Keramaris E, Rideout HJ, Slack RS, Dyson NJ, Stefanis L, Park DS. Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage. J Neurosci. 2001 Jul 15; 21(14):5017-26. PMID: 11438577.
    View in: PubMed
  80. Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M. Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8720-5. PMID: 11447271; PMCID: PMC37502.
  81. Pennaneach V, Salles-Passador I, Munshi A, Brickner H, Regazzoni K, Dick F, Dyson N, Chen TT, Wang JY, Fotedar R, Fotedar A. The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner. Mol Cell. 2001 Apr; 7(4):715-27. PMID: 11336696.
    View in: PubMed
  82. Classon M, Dyson N. p107 and p130: versatile proteins with interesting pockets. Exp Cell Res. 2001 Mar 10; 264(1):135-47. PMID: 11237530.
    View in: PubMed
  83. Morris EJ, Dyson NJ. Retinoblastoma protein partners. Adv Cancer Res. 2001; 82:1-54. PMID: 11447760.
    View in: PubMed
  84. Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E. Nuclear organization of DNA replication in primary mammalian cells. Genes Dev. 2000 Nov 15; 14(22):2855-68. PMID: 11090133; PMCID: PMC317063.
  85. Boulton SJ, Brook A, Staehling-Hampton K, Heitzler P, Dyson N. A role for Ebi in neuronal cell cycle control. EMBO J. 2000 Oct 16; 19(20):5376-86. PMID: 11032805; PMCID: PMC314025.
  86. Bruce JL, Hurford RK, Classon M, Koh J, Dyson N. Requirements for cell cycle arrest by p16INK4a. Mol Cell. 2000 Sep; 6(3):737-42. PMID: 11030353.
    View in: PubMed
  87. Dick FA, Sailhamer E, Dyson NJ. Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins. Mol Cell Biol. 2000 May; 20(10):3715-27. PMID: 10779361; PMCID: PMC85672.
  88. Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem. 2000 Apr 21; 275(16):11553-60. PMID: 10766769.
    View in: PubMed
  89. Staehling-Hampton K, Ciampa PJ, Brook A, Dyson N. A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics. 1999 Sep; 153(1):275-87. PMID: 10471712; PMCID: PMC1460754.
  90. McCaffrey J, Yamasaki L, Dyson NJ, Harlow E, Griep AE. Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol Cell Biol. 1999 Sep; 19(9):6458-68. PMID: 10454591; PMCID: PMC84615.
  91. Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ. No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog. 1999 Aug; 25(4):295-303. PMID: 10449036.
    View in: PubMed
  92. Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999 Feb 15; 18(4):916-25. PMID: 10022834; PMCID: PMC1171184.
  93. Dyson N, Balmain A. Oncogenes and cell proliferation. Curr Opin Genet Dev. 1999 Feb; 9(1):11-4. PMID: 10206674.
    View in: PubMed
  94. Harrington EA, Bruce JL, Harlow E, Dyson N. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11945-50. PMID: 9751770; PMCID: PMC21745.
  95. Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell. 1998 Sep; 2(3):283-92. PMID: 9774967.
    View in: PubMed
  96. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998 Aug 01; 12(15):2245-62. PMID: 9694791.
    View in: PubMed
  97. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet. 1998 Apr; 18(4):360-4. PMID: 9537419.
    View in: PubMed
  98. Hurford RK, Cobrinik D, Lee MH, Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 1997 Jun 01; 11(11):1447-63. PMID: 9192872.
    View in: PubMed
  99. Duronio RJ, Brook A, Dyson N, O'Farrell PH. E2F-induced S phase requires cyclin E. Genes Dev. 1996 Oct 01; 10(19):2505-13. PMID: 8843201.
    View in: PubMed
  100. Brook A, Xie JE, Du W, Dyson N. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 1996 Jul 15; 15(14):3676-83. PMID: 8670871; PMCID: PMC452016.
  101. Du W, Xie JE, Dyson N. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 1996 Jul 15; 15(14):3684-92. PMID: 8670872; PMCID: PMC452020.
  102. Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL. Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood. 1996 Jul 01; 88(1):268-76. PMID: 8704183.
    View in: PubMed
  103. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 01; 10(13):1633-44. PMID: 8682294.
    View in: PubMed
  104. Wu CL, Classon M, Dyson N, Harlow E. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol. 1996 Jul; 16(7):3698-706. PMID: 8668186; PMCID: PMC231365.
  105. Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 01; 10(13):1621-32. PMID: 8682293.
    View in: PubMed
  106. Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996 May 17; 85(4):537-48. PMID: 8653789.
    View in: PubMed
  107. Du W, Vidal M, Xie JE, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 1996 May 15; 10(10):1206-18. PMID: 8675008.
    View in: PubMed
  108. Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995 Jun 15; 9(12):1445-55. PMID: 7601349.
    View in: PubMed
  109. Dynlacht BD, Brook A, Dembski M, Yenush L, Dyson N. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6359-63. PMID: 8022787; PMCID: PMC44201.
  110. Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E. Growth suppression by members of the retinoblastoma protein family. Cold Spring Harb Symp Quant Biol. 1994; 59:75-84. PMID: 7587134.
    View in: PubMed
  111. Dyson N. pRB, p107 and the regulation of the E2F transcription factor. J Cell Sci Suppl. 1994; 18:81-7. PMID: 7883798.
    View in: PubMed
  112. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993 Dec; 13(12):7813-25. PMID: 8246996; PMCID: PMC364853.
  113. Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol. 1993 Dec; 67(12):7641-7. PMID: 8230483; PMCID: PMC238233.
  114. Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov; 8(11):3149-56. PMID: 8414517.
    View in: PubMed
  115. Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 1993 Jul; 7(7A):1111-25. PMID: 8319904.
    View in: PubMed
  116. Dyson N, Guida P, Münger K, Harlow E. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol. 1992 Dec; 66(12):6893-902. PMID: 1331501; PMCID: PMC240306.
  117. Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 1992 Jul 24; 70(2):337-50. PMID: 1638634.
    View in: PubMed
  118. Dyson N, Guida P, McCall C, Harlow E. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J Virol. 1992 Jul; 66(7):4606-11. PMID: 1534854; PMCID: PMC241277.
  119. Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature. 1992 Jan 09; 355(6356):176-9. PMID: 1530885.
    View in: PubMed
  120. Dyson N, Harlow E. Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv. 1992; 12:161-95. PMID: 1353412.
    View in: PubMed
  121. Rustgi AK, Dyson N, Bernards R. Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product. Nature. 1991 Aug 08; 352(6335):541-4. PMID: 1865909.
    View in: PubMed
  122. Larose A, Dyson N, Sullivan M, Harlow E, Bastin M. Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. J Virol. 1991 May; 65(5):2308-13. PMID: 2016761; PMCID: PMC240580.
  123. Rustgi AK, Dyson N, Hill D, Bernards R. The c-myc oncoprotein forms a specific complex with the product of the retinoblastoma gene. Cold Spring Harb Symp Quant Biol. 1991; 56:163-7. PMID: 1840250.
    View in: PubMed
  124. Hu QJ, Dyson N, Harlow E. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 1990 Apr; 9(4):1147-55. PMID: 2138977; PMCID: PMC551790.
  125. Dyson N, Bernards R, Friend SH, Gooding LR, Hassell JA, Major EO, Pipas JM, Vandyke T, Harlow E. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol. 1990 Mar; 64(3):1353-6. PMID: 2154613; PMCID: PMC249255.
  126. Buchkovich K, Dyson N, Whyte P, Harlow E. Cellular proteins that are targets for transformation by DNA tumour viruses. Ciba Found Symp. 1990; 150:262-71; discussion 271-8. PMID: 2142644.
    View in: PubMed
  127. Münger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 1989 Dec 20; 8(13):4099-105. PMID: 2556261; PMCID: PMC401588.
  128. Dyson N, Buchkovich K, Whyte P, Harlow E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell. 1989 Jul 28; 58(2):249-55. PMID: 2546678.
    View in: PubMed
  129. Dyson N, Howley PM, Münger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989 Feb 17; 243(4893):934-7. PMID: 2537532.
    View in: PubMed
  130. Dyson N, Buchkovich K, Whyte P, Harlow E. Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu Symp. 1989; 20:191-8. PMID: 2488232.
    View in: PubMed
  131. Brown TA, Dyson NJ. Similarity of nucleotide sequences at splicing sites. Nature. 1988 Jun 02; 333(6172):402. PMID: 3287170.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Dyson's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description
Physical Neighbors Expand Description