Harvard Catalyst Profiles

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Massimo Loda, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. P50CA211024 (LODA, MASSIMO) Aug 30, 2017 - Jul 31, 2022
    NIH
    Weill Cornell Medicine (WCM) SPORE in Prostate Cancer
    Role: Principal Investigator
  2. R01CA187918 (ROBERTS, THOMAS M) Apr 1, 2015 - Mar 31, 2020
    NIH
    Targeting the p110beta isoform of PI3 kinase in prostate cancer
    Role: Principal Investigator
  3. R01CA131945 (LODA, MASSIMO) Dec 1, 2007 - Jul 31, 2019
    NIH
    Molecular Link Between Metabolic Syndrome and Prostate Cancer
    Role: Principal Investigator
  4. P50CA127003 (SELLERS, WILLIAM R) Apr 1, 2007 - May 31, 2025
    NIH
    Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer
    Role: Co-Principal Investigator
  5. P01CA089021 (CANTLEY, LEWIS C) May 1, 2001 - May 31, 2013
    NIH
    The Role of PTEN and the PI3K Pathway in Prostate Cancer
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 512 total Publications Show all
  1. Chen X, Augello MA, Liu D, Lin K, Hakansson A, Sjöström M, Khani F, Deonarine LD, Liu Y, Travascio-Green J, Wu J, Chan UI, Owiredu J, Loda M, Feng FY, Robinson BD, Davicioni E, Sboner A, Barbieri CE. Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate. Nat Commun. 2024 Dec 13; 15(1):10675. PMID: 39672812; PMCID: PMC11645413.
    Citations:
    Fields: BioBiologySciScienceTranslation:HumansCells
  2. Pallasaho S, Gondane A, Kutz J, Liang J, Yalala S, Duveau DY, Pospiech H, Thomas CJ, Loda M, Itkonen HM. Compromised CDK12 activity causes dependency on the high activity of O-GlcNAc transferase. Glycobiology. 2024 Dec 10; 34(12). PMID: 39361894; PMCID: PMC11632362.
    Citations: 1
    Fields: BioBiochemistryTranslation:HumansCells
  3. Haffner MC, Morris MJ, Ding CC, Sayar E, Mehra R, Robinson B, True LD, Gleave M, Lotan TL, Aggarwal R, Huang J, Loda M, Nelson PS, Rubin MA, Beltran H. Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies. Clin Cancer Res. 2024 Nov 26. PMID: 39589343.
    Citations: 1
    Fields: NeoNeoplasms
  4. Loda M. Expanding Our Horizon to Inform Cutting Edge Mechanistic Studies: Cancer Research Resources. Mol Cancer Res. 2024 11 01; 22(11):995. PMID: 39482973.
    Citations:
    Fields: CelCell BiologyMolMolecular BiologyNeoNeoplasms
  5. Pakula H, Pederzoli F, Fanelli GN, Nuzzo PV, Rodrigues S, Loda M. Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component. Cancers (Basel). 2024 Oct 31; 16(21). PMID: 39518123; PMCID: PMC11544791.
    Citations:
  6. Su XA, Stopsack KH, Schmidt DR, Ma D, Li Z, Scheet PA, Penney KL, Lotan TL, Abida W, DeArment EG, Lu K, Janas T, Hu S, Vander Heiden MG, Loda M, Boselli M, Amon A, Mucci LA. RAD21 promotes oncogenesis and lethal progression of prostate cancer. Proc Natl Acad Sci U S A. 2024 Sep 03; 121(36):e2405543121. PMID: 39190349; PMCID: PMC11388324.
    Citations: 1
    Fields: SciScienceTranslation:HumansCells
  7. Tamarindo GH, Ribeiro CF, Silva ADT, Castro A, Caruso ÍP, Souza FP, Taboga SR, Loda M, Góes RM. The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells. Cancer Metab. 2024 Aug 07; 12(1):24. PMID: 39113152; PMCID: PMC11308158.
    Citations:
  8. Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Thirza Campbell K, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Editor's Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells. Cancer Res. 2024 Aug 01; 84(15):2561. PMID: 39086315.
    Citations:
    Fields: NeoNeoplasms
  9. Omar M, Ullanat V, Loda M, Marchionni L, Umeton R. ChatGPT for digital pathology research. Lancet Digit Health. 2024 Aug; 6(8):e595-e600. PMID: 38987117; PMCID: PMC11299190.
    Citations: 1
    Fields: MedMedical InformaticsPubPublic HealthTranslation:Humans
  10. Song R, Stopsack KH, Ren J, Mucci LA, Clinton SK, Loda M, Wang M, Giovannucci EL, Wilson KM, Smith-Warner SA. Coffee, Phosphoinositide 3-Kinase Signaling Pathway, and Prostate Cancer: A Prospective Study in the Health Professionals Follow-Up Study. J Acad Nutr Diet. 2025 Jan; 125(1):90-98.e5. PMID: 38971221.
    Citations:
    Fields: NutNutritional SciencesTranslation:HumansCells
  11. Boufaied N, Chetta P, Hallal T, Cacciatore S, Lalli D, Luthold C, Homsy K, Imada EL, Syamala S, Photopoulos C, Di Matteo A, de Polo A, Storaci AM, Huang Y, Giunchi F, Sheridan PA, Michelotti G, Nguyen QD, Zhao X, Liu Y, Davicioni E, Spratt DE, Sabbioneda S, Maga G, Mucci LA, Ghigna C, Marchionni L, Butler LM, Ellis L, Bordeleau F, Loda M, Vaira V, Labbé DP, Zadra G. Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer. Cancer Res. 2024 Jun 04; 84(11):1834-1855. PMID: 38831751; PMCID: PMC11148549.
    Citations: 2
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  12. Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, MacConaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. Author Correction: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-?B. Nat Med. 2024 Jun; 30(6):1790. PMID: 38383797.
    Citations:
    Fields: MedMedicine (General)MolMolecular Biology
  13. Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, Sawyers CL, Signoretti S, Hahn WC, Loda M, Sellers WR. A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression. Cancer Cell. 2024 Jun 10; 42(6):1126. PMID: 38866454.
    Citations:
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  14. Ribeiro CF, Rodrigues S, Bastos DC, Fanelli GN, Pakula H, Foiani M, Zadra G, Loda M. Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition. Sci Signal. 2024 04 09; 17(831):eadh1922. PMID: 38593154; PMCID: PMC11161871.
    Citations: 1
    Fields: CelCell BiologyPhyPhysiologySciScienceTranslation:HumansCells
  15. Omar M, Xu Z, Rand SB, Alexanderani MK, Salles DC, Valencia I, Schaeffer EM, Robinson BD, Lotan TL, Loda M, Marchionni L. Semi-Supervised, Attention-Based Deep Learning for Predicting TMPRSS2:ERG Fusion Status in Prostate Cancer Using Whole Slide Images. Mol Cancer Res. 2024 04 02; 22(4):347-359. PMID: 38284821; PMCID: PMC10985477.
    Citations:
    Fields: CelCell BiologyMolMolecular BiologyNeoNeoplasmsTranslation:Humans
  16. Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, Frigo DE. Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity. Cancer Res. 2024 03 04; 84(5):703-724. PMID: 38038968; PMCID: PMC10939928.
    Citations: 5
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  17. Augello MA, Chen X, Liu D, Lin K, Hakansson A, Sjöström M, Khani F, Deonarine LD, Liu Y, Travascio-Green J, Wu J, Loda M, Feng FY, Robinson BD, Davicioni E, Sboner A, Barbieri CE. Canonical AREs are tumor suppressive regulatory elements in the prostate. bioRxiv. 2024 Feb 27. PMID: 38464162; PMCID: PMC10925218.
    Citations:
  18. Pakula H, Omar M, Carelli R, Pederzoli F, Fanelli GN, Pannellini T, Socciarelli F, Van Emmenis L, Rodrigues S, Fidalgo-Ribeiro C, Nuzzo PV, Brady NJ, Dinalankara W, Jere M, Valencia I, Saladino C, Stone J, Unkenholz C, Garner R, Alexanderani MK, Khani F, de Almeida FN, Abate-Shen C, Greenblatt MB, Rickman DS, Barbieri CE, Robinson BD, Marchionni L, Loda M. Distinct mesenchymal cell states mediate prostate cancer progression. Nat Commun. 2024 Jan 08; 15(1):363. PMID: 38191471; PMCID: PMC10774315.
    Citations: 5
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  19. Chaudagar K, Hieromnimon HM, Kelley A, Labadie B, Shafran J, Rameshbabu S, Drovetsky C, Bynoe K, Solanki A, Markiewicz E, Fan X, Loda M, Patnaik A. Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis. Clin Cancer Res. 2023 12 01; 29(23):4930-4940. PMID: 37721526; PMCID: PMC10841690.
    Citations: 8
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  20. Gheybi K, Mmekwa N, Lebelo MT, Patrick SM, Campbell R, Nenzhelele M, Soh PXY, Obida M, Loda M, Shirindi J, Butler EN, Mutambirwa SBA, Bornman MSR, Hayes VM. Linking African ancestral substructure to prostate cancer health disparities. Sci Rep. 2023 11 27; 13(1):20909. PMID: 38017150; PMCID: PMC10684577.
    Citations: 2
    Fields: SciScienceTranslation:Humans
  21. Benedetti E, Chetnik K, Flynn T, Barbieri CE, Scherr DS, Loda M, Krumsiek J. Plasma metabolomics profiling of 580 patients from an Early Detection Research Network prostate cancer cohort. Sci Data. 2023 11 25; 10(1):830. PMID: 38007532; PMCID: PMC10676366.
    Citations: 3
    Fields: SciScienceTranslation:Humans
  22. Geng C, Zhang MC, Manyam GC, Vykoukal JV, Fahrmann JF, Peng S, Wu C, Park S, Kondraganti S, Wang D, Robinson BD, Loda M, Barbieri CE, Yap TA, Corn PG, Hanash S, Broom BM, Pilié PG, Thompson TC. SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression. Clin Cancer Res. 2023 11 01; 29(21):4464-4478. PMID: 37581614; PMCID: PMC11017857.
    Citations: 2
    Fields: NeoNeoplasmsTranslation:Humans
  23. Figiel S, Yin W, Doultsinos D, Erickson A, Poulose N, Singh R, Magnussen A, Anbarasan T, Teague R, He M, Lundeberg J, Loda M, Verrill C, Colling R, Gill PS, Bryant RJ, Hamdy FC, Woodcock DJ, Mills IG, Cussenot O, Lamb AD. Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures. Mol Cancer. 2023 10 03; 22(1):162. PMID: 37789377; PMCID: PMC10546768.
    Citations: 4
    Fields: NeoNeoplasmsTranslation:HumansCells
  24. Ma C, Wang X, Dai JY, Turman C, Kraft P, Stopsack KH, Loda M, Pettersson A, Mucci LA, Stanford JL, Penney KL. Germline Genetic Variants Associated with Somatic TMPRSS2:ERG Fusion Status in Prostate Cancer: A Genome-Wide Association Study. Cancer Epidemiol Biomarkers Prev. 2023 10 02; 32(10):1436-1443. PMID: 37555839; PMCID: PMC10592169.
    Citations:
    Fields: BioBiochemistryEpiEpidemiologyNeoNeoplasmsTranslation:Humans
  25. Papachristodoulou A, Heidegger I, Virk RK, Di Bernardo M, Kim JY, Laplaca C, Picech F, Schäfer G, De Castro GJ, Hibshoosh H, Loda M, Klocker H, Rubin MA, Zheng T, Benson MC, McKiernan JM, Dutta A, Abate-Shen C. Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression. Eur Urol. 2024 Apr; 85(4):361-372. PMID: 37659962; PMCID: PMC10902192.
    Citations: 3
    Fields: UroUrologyTranslation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.