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Edward L. Giovannucci, D.Sc., M.D.

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Overview
My primary research efforts focus on how nutritional, hormonal, and genetic factors are related to various malignancies, especially those of the prostate and large bowel. Much of this work is based on the Nurses' Health Study, the Health Professionals Follow-Up Study and the Physicians' Health Study cohorts. For prostate cancer, my work has centered on the role of specific antioxidants, particularly lycopene, and on the potentially deleterious effects of diets high in calcium and dietary fat. In addition to establishing risk factors, we have been interested in understanding etiologic mechanisms that will help provide a solid scientific rationale for preventive strategies. Specifically, I have studied how nutritional factors influence prostate cancer through modulating levels of insulin-like growth factors (IGFs) and binding proteins, insulin, vitamin D metabolites, and steroid hormones. More recently, our work has examined the role of obesity and energy balance in the progression of prostate cancer.

Regarding colorectal cancer, our work in the Nurses' Health Study and Health Professionals Follow-Up Study has established specific modifiable risk factors that contribute to over 70% of colorectal cancers. We have helped establish several factors that increase risk of colorectal cancer, including central obesity, physical inactivity, smoking, and diets high in red and processed meats. We have also hypothesized and demonstrated that some of these factors increase risk through higher insulin and IGF levels. We have also identified potential protective micronutrients, including vitamin D, folate, calcium and vitamin B6. We are testing the efficacy of some of these potentially protective agents, including folic acid, vitamin D, and vitamin B6 in randomized intervention trials.

Finally, we have undertaken the collection of tumor tissue blocks for prostate cancer and colorectal cancer and precursor lesions (adenomas) within the Nurses' Health Study, Physicians' Health Study, and Health Professionals Follow-Up Study. With these specimens, we are identifying specific somatic molecular alterations in tumors. These alterations have been shown to have powerful influences on survival. We are now linking specific nutritional and lifestyle exposures to the probability of possessing certain of these tissue markers among those who develop cancer. Ultimately, we plan to provide the most comprehensive examination of the relations of dietary and other modifiable factors, hormonal factors, genetic susceptibility, and specific molecular endpoints in tumors. The great strength of our unique approach is to have updated and integrated data on all these factors, over up to a 30 year time period.

My research work is mostly funded through the National Institutes of Health (R01's, R21's, R03's, P01), all from the National Cancer Institute. I also have funding from the American Institute of Cancer Research. My major teaching effort has been as an instructor in two courses, Cancer Epidemiology and Nutritional Epidemiology of Cancer at the Harvard School of Public Health. I do not have clinical duties.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA226942 (GIOVANNUCCI, EDWARD) Jul 1, 2019 - Jun 30, 2021
    NIH
    Impact of screening and diagnostic intensity on the study of prostate cancer epidemiology
    Role: Principal Investigator
  2. R03CA223619 (GIOVANNUCCI, EDWARD) Jul 1, 2018 - Jun 30, 2020
    NIH
    Predicted lean body mass, fat mass, and risk of lung, pancreatic, colorectal, breast, and prostate cancers
    Role: Principal Investigator
  3. R03CA204825 (GIOVANNUCCI, EDWARD) Dec 1, 2016 - Nov 30, 2018
    NIH
    Weight cycling and total and site-specific cancer incidence and mortality
    Role: Principal Investigator
  4. R01CA133891 (GIOVANNUCCI, EDWARD) Sep 26, 2008 - Jul 31, 2015
    NIH
    Energy Balance-Related Hormones & Prostate Cancer Incidence & Progression
    Role: Principal Investigator
  5. P50CA090381 (BELTRAN, HIMISHA) Apr 1, 2001 - Jun 30, 2019
    NIH
    DF/HCC SPORE in Prostate Cancer
    Role: Co-Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.