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Shu-Zhen Guo, PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guo S, Som AT, Waeber C, Lo EH. Vascular neuroprotection via TrkB- and Akt-dependent cell survival signaling. J Neurochem. 2012 Nov; 123 Suppl 2:58-64. PMID: 23050643.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  2. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH. Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab. 2012 Jun; 32(6):983-8. PMID: 22491155.
    Citations: 8     Fields:    Translation:HumansCells
  3. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631.
    Citations: 38     Fields:    Translation:AnimalsCells
  4. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913.
    Citations: 16     Fields:    Translation:AnimalsCells
  5. Simão F, Pagnussat AS, Seo JH, Navaratna D, Leung W, Lok J, Guo S, Waeber C, Salbego CG, Lo EH. Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J Cereb Blood Flow Metab. 2012 May; 32(5):884-95. PMID: 22314268.
    Citations: 14     Fields:    Translation:HumansCells
  6. Seo JH, Guo S, Lok J, Navaratna D, Whalen MJ, Kim KW, Lo EH. Neurovascular matrix metalloproteinases and the blood-brain barrier. Curr Pharm Des. 2012; 18(25):3645-8. PMID: 22574977.
    Citations: 22     Fields:    Translation:Humans
  7. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609.
    Citations: 38     Fields:    Translation:AnimalsCells
  8. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55. PMID: 21534958.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  10. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96. PMID: 21562076.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  11. Ning M, Sarracino DA, Kho AT, Guo S, Lee SR, Krastins B, Buonanno FS, Vizcaíno JA, Orchard S, McMullin D, Wang X, Lo EH. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43. PMID: 21164131.
    Citations: 11     Fields:    Translation:HumansCells
  12. Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol. 2011 Jan; 69(1):119-29. PMID: 21280082.
    Citations: 88     Fields:    Translation:AnimalsCells
  13. Guo S, Stins M, Ning M, Lo EH. Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells. Cerebrovasc Dis. 2010 Aug; 30(3):290-6. PMID: 20664263.
    Citations: 12     Fields:    Translation:HumansCells
  14. Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, Lo EH, Whalen MJ. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma. 2010 Jun; 27(6):1037-46. PMID: 20205514.
    Citations: 22     Fields:    Translation:Animals
  15. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687.
    Citations: 35     Fields:    Translation:AnimalsCells
  16. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X. Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience. 2009 Aug 18; 162(2):396-403. PMID: 19401220.
    Citations: 27     Fields:    Translation:AnimalsCells
  17. Navaratna D, Guo S, Arai K, Lo EH. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23. PMID: 19363301.
    Citations: 34     Fields:    Translation:Humans
  18. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic ZS, Lo EH. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43. PMID: 19240740.
    Citations: 22     Fields:    Translation:AnimalsCells
  19. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728.
    Citations: 42     Fields:    Translation:AnimalsCells
  20. Guo S, Lo EH. Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. Stroke. 2009 Mar; 40(3 Suppl):S4-7. PMID: 19064781.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  21. Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5. PMID: 18974377.
    Citations: 24     Fields:    Translation:HumansCells
  22. Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009 Jan; 29(1):39-43. PMID: 18728681.
    Citations: 13     Fields:    Translation:HumansCells
  23. Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7582-7. PMID: 18495934.
    Citations: 86     Fields:    Translation:AnimalsCells
  24. Besancon E, Guo S, Lok J, Tymianski M, Lo EH. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci. 2008 May; 29(5):268-75. PMID: 18384889.
    Citations: 69     Fields:    Translation:HumansCells
  25. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45. PMID: 17457674.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  26. Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci Lett. 2007 Apr 24; 417(1):1-5. PMID: 17386975.
    Citations: 23     Fields:    Translation:AnimalsCells
  27. Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21; 1111(1):222-6. PMID: 16919608.
    Citations: 8     Fields:    Translation:AnimalsCells
  28. Wang S, Lee SR, Guo SZ, Kim WJ, Montaner J, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke. 2006 Jul; 37(7):1910-2. PMID: 16741180.
    Citations: 19     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.