Harvard Catalyst Profiles

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David Henry Vandorpe, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL073112 (VANDORPE, DAVID H) Mar 17, 2003 - Feb 28, 2006
    Deoxygenation-activated Cation Channel of Sickle RBC
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vandorpe DH, Heneghan JF, Waitzman JS, McCarthy GM, Blasio A, Magraner JM, Donovan OG, Schaller LB, Shah SS, Subramanian B, Riella CV, Friedman DJ, Pollak MR, Alper SL. Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes. Pflugers Arch. 2023 03; 475(3):323-341. PMID: 36449077.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Vandorpe DH, Rivera A, Ganter M, Dankwa S, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Duraisingh M, Alper SL. Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes. Pflugers Arch. 2022 05; 474(5):553-565. PMID: 35169901.
    Citations:    Fields:    Translation:HumansCells
  3. Vandorpe DH, Rivera A, Shmukler BE, Wohlgemuth JG, Dlott JS, Snyder LM, Trudel M, Brugnara C, Alper SL. Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2021 12; 92:102619. PMID: 34768199.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Vandorpe DH, Shmukler BE, Ilboudo Y, Bhasin S, Thomas B, Rivera A, Wohlgemuth JG, Dlott JS, Snyder LM, Sieff C, Bhasin M, Lettre G, Brugnara C, Alper SL. A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. Haematologica. 2021 10 01; 106(10):2759-2762. PMID: 34109777.
    Citations: 1     Fields:    Translation:Humans
  5. Chen H, Vandorpe DH, Xie X, Alper SL, Zeidel ML, Yu W. Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology. Nat Commun. 2020 08 28; 11(1):4328. PMID: 32859919; PMCID: PMC7455701.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6. J Biol Chem. 2019 08 23; 294(34):12655-12669. PMID: 31266804.
    Citations: 7     Fields:    Translation:HumansCells
  7. Rivera A, Vandorpe DH, Shmukler BE, Andolfo I, Iolascon A, Archer NM, Shabani E, Auerbach M, Hamerschlak N, Morton J, Wohlgemuth JG, Brugnara C, Snyder LM, Alper SL. Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C287-C302. PMID: 31091145.
    Citations: 5     Fields:    Translation:HumansCells
  8. Gnanasambandam R, Rivera A, Vandorpe DH, Shmukler BE, Brugnara C, Snyder LM, Andolfo I, Iolascon A, Silveira PA, Hamerschlak N, Gottlieb P, Alper SL. Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M. Hemasphere. 2018 10; 2(5):e55. PMID: 30887001; PMCID: PMC6407803.
    Citations: 3     
  9. Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL. Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc. Am J Hematol. 2017 06; 92(6):E108-E110. PMID: 28295477.
    Citations: 9     Fields:    Translation:HumansCells
  10. Wu M, Heneghan JF, Vandorpe DH, Escobar LI, Wu BL, Alper SL. Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport. Pflugers Arch. 2016 08; 468(8):1311-32. PMID: 27125215; PMCID: PMC4956541.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. Heneghan JF, Vandorpe DH, Shmukler BE, Giovinazzo JA, Giovinnazo JA, Raper J, Friedman DJ, Pollak MR, Alper SL. BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Am J Physiol Cell Physiol. 2015 Sep 01; 309(5):C332-47. PMID: 26108665; PMCID: PMC4556898.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  12. Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG. Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6. PMID: 25044010; PMCID: PMC4237618.
    Citations: 22     Fields:    Translation:HumansCells
  13. Shmukler BE, Vandorpe DH, Rivera A, Auerbach M, Brugnara C, Alper SL. Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4. PMID: 23973043.
    Citations: 15     Fields:    Translation:HumansCells
  14. Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 09; 121(19):3925-35, S1-12. PMID: 23479567.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  15. Shmukler BE, Rivera A, Vandorpe DH, Alves J, Bonfanti U, Paltrinieri S, Alper SL. Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25. PMID: 22406315.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Reimold FR, Heneghan JF, Stewart AK, Zelikovic I, Vandorpe DH, Shmukler BE, Alper SL. Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50. PMID: 22116357.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43. PMID: 21849667.
    Citations: 10     Fields:    Translation:HumansCells
  18. Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko S, Ishiguro H, Alper SL. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C289-303. PMID: 21593449.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  19. Stewart AK, Kedar PS, Shmukler BE, Vandorpe DH, Hsu A, Glader B, Rivera A, Brugnara C, Alper SL. Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46. PMID: 21209359.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  20. Alper SL, Stewart AK, Vandorpe DH, Clark JS, Horack RZ, Simpson JE, Walker NM, Clarke LL. Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol. 2011 Feb; 300(2):C276-86. PMID: 21068358.
    Citations: 22     Fields:    Translation:HumansAnimals
  21. Heneghan JF, Akhavein A, Salas MJ, Shmukler BE, Karniski LP, Vandorpe DH, Alper SL. Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1363-75. PMID: 20219950; PMCID: PMC2889644.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  22. Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732. PMID: 20090940.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  23. Stewart AK, Vandorpe DH, Heneghan JF, Chebib F, Stolpe K, Akhavein A, Edelman EJ, Maksimova Y, Gallagher PG, Alper SL. The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C283-97. PMID: 19907019.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  24. Stewart AK, Shmukler BE, Vandorpe DH, Alper SL. Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct. J Med Invest. 2009; 56 Suppl:329-31. PMID: 20224217.
    Citations: 1     Fields:    Translation:Animals
  25. Alper SL, Vandorpe DH, Peters LL, Brugnara C. Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):22-34. PMID: 18329299.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Clark JS, Vandorpe DH, Chernova MN, Heneghan JF, Stewart AK, Alper SL. Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol. 2008 Mar 01; 586(5):1291-306. PMID: 18174209; PMCID: PMC2375677.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  27. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326.
    Citations: 13     Fields:    Translation:AnimalsCells
  28. Shmukler BE, Clark JS, Hsu A, Vandorpe DH, Stewart AK, Kurschat CE, Choe SK, Zhou Y, Amigo J, Paw BH, Alper SL. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R1081-91. PMID: 18046018.
    Citations: 5     Fields:    Translation:AnimalsCells
  29. Alper SL, Stewart AK, Chernova MN, Zolotarev AS, Clark JS, Vandorpe DH. Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp. 2006; 273:107-19; discussion 119-25, 261-4. PMID: 17120764.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  30. Chernova MN, Vandorpe DH, Clark JS, Williams JI, Zasloff MA, Jiang L, Alper SL. Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1644-58. PMID: 16109810.
    Citations: 4     Fields:    Translation:AnimalsCells
  31. Chernova MN, Vandorpe DH, Clark JS, Alper SL. Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes. Kidney Int. 2005 Aug; 68(2):632-41. PMID: 16014040.
    Citations: 5     Fields:    Translation:AnimalsCells
  32. Shmukler BE, Kurschat CE, Ackermann GE, Jiang L, Zhou Y, Barut B, Stuart-Tilley AK, Zhao J, Zon LI, Drummond IA, Vandorpe DH, Paw BH, Alper SL. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49. PMID: 15914778.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 04; 280(9):8564-80. PMID: 15548529.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  34. Vandorpe DH, Wilhelm S, Jiang L, Ibraghimov-Beskrovnaya O, Chernova MN, Stuart-Tilley AK, Alper SL. Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics. 2002 Feb 28; 8(2):87-98. PMID: 11875186.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Goss GG, Jiang L, Vandorpe DH, Kieller D, Chernova MN, Robertson M, Alper SL. Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1978-90. PMID: 11698257.
    Citations: 9     Fields:    Translation:AnimalsCells
  36. Vandorpe DH, Chernova MN, Jiang L, Sellin LK, Wilhelm S, Stuart-Tilley AK, Walz G, Alper SL. The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel. J Biol Chem. 2001 Feb 09; 276(6):4093-101. PMID: 11044446.
    Citations: 22     Fields:    Translation:AnimalsCells
  37. Vandorpe DH, Shmukler BE, Jiang L, Lim B, Maylie J, Adelman JP, de Franceschi L, Cappellini MD, Brugnara C, Alper SL. cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53. PMID: 9705284.
    Citations: 65     Fields:    Translation:AnimalsCells
  38. Rittenhouse AR, Vandorpe DH, Brugnara C, Alper SL. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J Membr Biol. 1997 May 15; 157(2):177-91. PMID: 9151659.
    Citations: 7     Fields:    Translation:AnimalsCells
  39. Chernova MN, Jiang L, Crest M, Hand M, Vandorpe DH, Strange K, Alper SL. Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q. J Gen Physiol. 1997 Mar; 109(3):345-60. PMID: 9089441; PMCID: PMC2217076.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  40. Vandorpe DH, Ciampolillo F, Green RB, Stanton BA. Cyclic nucleotide-gated cation channels mediate sodium absorption by IMCD (mIMCD-K2) cells. Am J Physiol. 1997 Mar; 272(3 Pt 1):C901-10. PMID: 9124526.
    Citations: 8     Fields:    Translation:AnimalsCells
  41. Vandorpe D, Kizer N, Ciampollilo F, Moyer B, Karlson K, Guggino WB, Stanton BA. CFTR mediates electrogenic chloride secretion in mouse inner medullary collecting duct (mIMCD-K2) cells. Am J Physiol. 1995 Sep; 269(3 Pt 1):C683-9. PMID: 7573398.
    Citations: 12     Fields:    Translation:AnimalsCells
  42. Kizer NL, Vandorpe D, Lewis B, Bunting B, Russell J, Stanton BA. Vasopressin and cAMP stimulate electrogenic chloride secretion in an IMCD cell line. Am J Physiol. 1995 May; 268(5 Pt 2):F854-61. PMID: 7771514.
    Citations: 12     Fields:    Translation:AnimalsCells
  43. Levine DZ, Iacovitti M, Buckman S, Vandorpe D, Harrison V, Boisvert DM, Nadler SP. In vivo adaptation of bicarbonate reabsorption by rat distal tubules during acid loading. Am J Physiol. 1994 Nov; 267(5 Pt 2):F737-47. PMID: 7977778.
    Citations:    Fields:    Translation:Animals
  44. Levine DZ, Iacovitti M, Buckman S, Vandorpe D, Harrison V, Nadler SP. Distal tubule unidirectional HCO3 reabsorption in vivo during acute and chronic metabolic alkalosis in the rat. Am J Physiol. 1994 Jun; 266(6 Pt 2):F919-25. PMID: 8023971.
    Citations:    Fields:    Translation:AnimalsCells
  45. Vandorpe DH, Small DL, Dabrowski AR, Morris CE. FMRFamide and membrane stretch as activators of the Aplysia S-channel. Biophys J. 1994 Jan; 66(1):46-58. PMID: 7510529; PMCID: PMC1275662.
    Citations: 16     Fields:    Translation:AnimalsCells
  46. Vandorpe DH, Morris CE. Stretch activation of the Aplysia S-channel. J Membr Biol. 1992 May; 127(3):205-14. PMID: 1495087.
    Citations: 11     Fields:    Translation:AnimalsCells
  47. Vandorpe DH, Nadler SP, Levine DZ. Distal tubule bicarbonate reabsorption during rebound metabolic alkalosis. Can J Physiol Pharmacol. 1991 Nov; 69(11):1784-8. PMID: 1804523.
    Citations:    Fields:    Translation:AnimalsCells
  48. Narbaitz R, Vandorpe D, Levine DZ. Differentiation of renal intercalated cells in fetal and postnatal rats. Anat Embryol (Berl). 1991; 183(4):353-61. PMID: 1867387.
    Citations: 6     Fields:    Translation:Animals
  49. Levine DZ, Vandorpe D, Iacovitti M. Luminal chloride modulates rat distal tubule bidirectional bicarbonate flux in vivo. J Clin Invest. 1990 Jun; 85(6):1793-8. PMID: 2347913; PMCID: PMC296642.
    Citations: 7     Fields:    Translation:Animals
  50. Vandorpe DH, Levine DZ. Distal tubule bicarbonate reabsorption in NH4Cl acidotic rats. Clin Invest Med. 1989 Aug; 12(4):224-9. PMID: 2535435.
    Citations: 1     Fields:    Translation:AnimalsCells
  51. Levine DZ, Iacovitti M, Nash L, Vandorpe D. Secretion of bicarbonate by rat distal tubules in vivo. Modulation by overnight fasting. J Clin Invest. 1988 Jun; 81(6):1873-8. PMID: 3384953; PMCID: PMC442638.
    Citations: 11     Fields:    Translation:AnimalsCells
  52. Beresford JP, Vandorpe D. Exercise guidelines for physicians. Can Fam Physician. 1980 Apr; 26:549-53. PMID: 21293617.
    Citations: 1     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.