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Francisco J Flores, Ph.D.


University of Santiago de ChileB.Sc.03/2002Biochemistry
University of Santiago de ChileProfessional Title03/2002Biochemist
University of ChilePh.D.07/2008Biomedical Sciences
2002 - 2005
Ph.D. Fellowship

I am interested in using tools and concepts from systems neuroscience to study General Anesthesia. My work is aimed to further the understanding of the mechanisms and processes that participate in the initiation, maintenance and recovery from those anesthetized states.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Becker LA, Penagos H, Flores FJ, Manoach DS, Wilson MA, Varela C. Eszopiclone and Zolpidem Produce Opposite Effects on Hippocampal Ripple Density. Front Pharmacol. 2021; 12:792148. PMID: 35087405; PMCID: PMC8787044.
  2. An J, Flores FJ, Kodandaramaiah SB, Dalla Betta I, Nikolaeva K, Boyden ES, Forest CR, Brown EN. Automated Assessment of Loss of Consciousness Using Whisker And Paw Movements During Anesthetic Dosing in Head-Fixed Rodents. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:730-733. PMID: 30440500.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 01 03; 7. PMID: 29297466.
    Citations: 14     Fields:    Translation:AnimalsCells
  4. S. Chakravarty, K. Nikolaeva, D. Kishnan, F. J. Flores, P. L. Purdon and E. N. Brown. Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. 2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT). 2017; 44-47.
  5. Chakravarty S, Nikolaeva K, Kishnan D, Flores FJ, Purdon PL, Brown EN. Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. Health Innov Point Care Conf. 2017 Nov; 2017:44-47. PMID: 32803192; PMCID: PMC7426181.
    Citations: 2     
  6. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668. PMID: 28743752; PMCID: PMC5558998.
    Citations: 54     Fields:    Translation:Animals
  7. Singer AC, Talei Franzesi G, Kodandaramaiah SB, Flores FJ, Cohen JD, Lee AK, Borgers C, Forest CR, Kopell NJ, Boyden ES. Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain. J Neurophysiol. 2017 08 01; 118(2):1270-1291. PMID: 28566460; PMCID: PMC5558023.
    Citations: 3     Fields:    Translation:Animals
  8. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861.
    Citations: 54     Fields:    Translation:Humans
  9. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13; 4:e08760. PMID: 26460547.
    Citations: 72     Fields:    Translation:Animals
  10. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    Citations: 6     Fields:    Translation:Animals
  11. Berger D, Pazienti A, Flores FJ, Nawrot MP, Maldonado PE, Grün S. Viewing strategy of Cebus monkeys during free exploration of natural images. Brain Res. 2012 Jan 24; 1434:34-46. PMID: 22177664.
    Citations: 7     Fields:    Translation:Animals
  12. Chen Z, Vijayan S, Ching S, Hale G, Flores FJ, Wilson MA, Brown EN. Assessing neuronal interactions of cell assemblies during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4175-8. PMID: 22255259.
    Citations: 3     Fields:    Translation:HumansCells
  13. Pérez H, Soto-Moyano R, Ruiz S, Hernández A, Sierralta W, Olivares R, Núñez H, Flores O, Morgan C, Valladares L, Gatica A, Flores FJ. A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. Neurosci Lett. 2010 Oct 08; 483(1):41-6. PMID: 20674672.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Aylwin ML, Aguilar GA, Flores FJ, Maldonado PE. Odorant modulation of neuronal activity and local field potential in sensory-deprived olfactory bulb. Neuroscience. 2009 Sep 15; 162(4):1265-78. PMID: 19481588.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Soto-Moyano R, Burgos H, Flores F, Valladares L, Sierralta W, Fernández V, Pérez H, Hernández P, Hernández A. Melatonin administration impairs visuo-spatial performance and inhibits neocortical long-term potentiation in rats. Pharmacol Biochem Behav. 2006 Oct; 85(2):408-14. PMID: 17067663.
    Citations: 6     Fields:    Translation:Animals
  16. Laurido C, Pelissie T, Soto-Moyano R, Valladares L, Flores F, Hernández A. Effect of melatonin on rat spinal cord nociceptive transmission. Neuroreport. 2002 Jan 21; 13(1):89-91. PMID: 11924900.
    Citations: 6     Fields:    Translation:AnimalsCells
  17. Laurido C, Pelissier T, Pérez H, Flores F, Hernández A. Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats. Neuroreport. 2001 Jun 13; 12(8):1551-4. PMID: 11409714.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.