Harvard Catalyst Profiles

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Oliver Jamie Cooper, Ph.D.


My goal is to use biology to inform preventative medicine, discover and develop treatments for disease.

By training, I have examined cellular biology and disease risk in patient-derived tissue. Experience in the clinical laboratory fostered a strong interest in using science to improve healthcare. Further training in pathology, tissue regeneration and molecular embryology facilitated discoveries using stem cells as potential regenerative or restorative therapies for disease. Current studies use induced pluripotent stem cells from members of several families to determine drug responsive, disease-associated phenotypes.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cooper O, Hallett P, Isacson O. Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias. FEBS J. 2022 Sep 27. PMID: 36165619.
    Citations:    Fields:    
  2. Lu E, Cooper OJ, Tuna F, Wooles AJ, Kaltsoyannis N, Liddle ST. Uranium-Carbene-Imido Metalla-Allenes: Ancillary-Ligand-Controlled cis-/trans-Isomerisation and Assessment of trans Influence in the R2 C=U(IV) =NR' Unit (R=Ph2 PNSiMe3 ; R'=CPh3 ). Chemistry. 2016 Aug 08; 22(33):11559-63. PMID: 27405793.
    Citations: 6     Fields:    
  3. Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015 Mar 05; 16(3):269-74. PMID: 25732245.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  4. Camp C, Cooper O, Andrez J, Pécaut J, Mazzanti M. CS2 activation at uranium(III) siloxide ate complexes: the effect of a Lewis acidic site. Dalton Trans. 2015 Feb 14; 44(6):2650-6. PMID: 25436831.
    Citations: 3     Fields:    
  5. Cooper OJ, Mills DP, Lewis W, Blake AJ, Liddle ST. Reactivity of the uranium(IV) carbene complex [U(BIPM(TMS))(Cl)(µ-Cl)2Li(THF)2] (BIPM(TMS) = {C(PPh2NSiMe3)2}) towards carbonyl and heteroallene substrates: metallo-Wittig, adduct formation, C-F bond activation, and [2 + 2]-cycloaddition reactions. Dalton Trans. 2014 Oct 14; 43(38):14275-83. PMID: 24798878.
    Citations: 2     Fields:    
  6. Hallett PJ, Cooper O, Sadi D, Robertson H, Mendez I, Isacson O. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Rep. 2014 Jun 26; 7(6):1755-61. PMID: 24910427.
    Citations: 59     Fields:    Translation:HumansCells
  7. Lu E, Cooper OJ, McMaster J, Tuna F, McInnes EJ, Lewis W, Blake AJ, Liddle ST. Synthesis, characterization, and reactivity of a uranium(VI) carbene imido oxo complex. Angew Chem Int Ed Engl. 2014 Jun 23; 53(26):6696-700. PMID: 24842784.
    Citations: 16     Fields:    
  8. Cooper O, Camp C, Pécaut J, Kefalidis CE, Maron L, Gambarelli S, Mazzanti M. Multimetallic cooperativity in uranium-mediated CO2 activation. J Am Chem Soc. 2014 May 07; 136(18):6716-23. PMID: 24712893.
    Citations: 10     Fields:    
  9. Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, Schüle B. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol Dis. 2014 Feb; 62:381-6. PMID: 24148854; PMCID: PMC3877733.
    Citations: 125     Fields:    Translation:HumansCells
  10. Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug; 31(8):1548-62. PMID: 23666606.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  11. Cooper OJ, Mills DP, McMaster J, Tuna F, McInnes EJ, Lewis W, Blake AJ, Liddle ST. The nature of the U=C double bond: pushing the stability of high-oxidation-state uranium carbenes to the limit. Chemistry. 2013 May 27; 19(22):7071-83. PMID: 23559370.
    Citations: 18     Fields:    
  12. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 04; 4(141):141ra90. PMID: 22764206; PMCID: PMC3462009.
    Citations: 240     Fields:    Translation:HumansCells
  13. Mills DP, Cooper OJ, Tuna F, McInnes EJ, Davies ES, McMaster J, Moro F, Lewis W, Blake AJ, Liddle ST. Synthesis of a uranium(VI)-carbene: reductive formation of uranyl(V)-methanides, oxidative preparation of a [R2C-U-O]2+ analogue of the [O-U-O]2+ uranyl ion (R = Ph2PNSiMe3), and comparison of the nature of U(IV)-C, U(V)-C, and U(VI)-C double bonds. J Am Chem Soc. 2012 Jun 20; 134(24):10047-54. PMID: 22621395.
    Citations: 20     Fields:    
  14. Cooper O, Parmar M, Isacson O. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Prog Brain Res. 2012; 200:265-76. PMID: 23195423.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  15. Cooper O, Hallett P, Isacson O. Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism Relat Disord. 2012 Jan; 18 Suppl 1:S14-6. PMID: 22166414.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. McLean JR, Hallett PJ, Cooper O, Stanley M, Isacson O. Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Mol Cell Neurosci. 2012 Feb; 49(2):230-9. PMID: 22155155.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  17. Deleidi M, Cooper O, Hargus G, Levy A, Isacson O. Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. PLoS One. 2011; 6(5):e19926. PMID: 21655272.
    Citations: 19     Fields:    Translation:AnimalsCells
  18. Cooper OJ, Mills DP, McMaster J, Moro F, Davies ES, Lewis W, Blake AJ, Liddle ST. Uranium-carbon multiple bonding: facile access to the pentavalent uranium carbene [U{C(PPh2NSiMe3)2}(Cl)2(I)] and comparison of U(V)=C and U(IV)=C bonds. Angew Chem Int Ed Engl. 2011 Mar 01; 50(10):2383-6. PMID: 21351360.
    Citations: 17     Fields:    
  19. Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15921-6. PMID: 20798034.
    Citations: 194     Fields:    Translation:HumansAnimalsCells
  20. Cooper OJ, Wooles AJ, McMaster J, Lewis W, Blake AJ, Liddle ST. A monomeric dilithio methandiide with a distorted trans-planar four-coordinate carbon. Angew Chem Int Ed Engl. 2010 Jul 26; 49(32):5570-3. PMID: 20589822.
    Citations: 4     Fields:    
  21. Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci. 2010 Nov; 45(3):258-66. PMID: 20603216.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  22. Cooper OJ, McMaster J, Lewis W, Blake AJ, Liddle ST. Synthesis and structure of [U{C(PPh2NMes)2}2] (Mes = 2,4,6-Me3C6H2): A homoleptic uranium bis(carbene) complex with two formal U=C double bonds. Dalton Trans. 2010 Jun 07; 39(21):5074-6. PMID: 20401420.
    Citations: 9     Fields:    
  23. Hallett PJ, Cooper O, Isacson O. No evidence for disease-like processes in fetal transplants. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):E104; author reply E105. PMID: 19805203.
    Citations: 1     Fields:    Translation:HumansCells
  24. Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson O. Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. J Neurol. 2009 Aug; 256 Suppl 3:310-6. PMID: 19711122.
    Citations: 26     Fields:    Translation:HumansCells
  25. Abou-Elhamd A, Cooper O, Münsterberg A. Klhl31 is associated with skeletal myogenesis and its expression is regulated by myogenic signals and Myf-5. Mech Dev. 2009 Oct; 126(10):852-62. PMID: 19643178.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009 Mar 06; 136(5):964-77. PMID: 19269371.
    Citations: 632     Fields:    Translation:HumansCells
  27. de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 2008 Sep; 26(9):2349-60. PMID: 18556510; PMCID: PMC2649803.
    Citations: 22     Fields:    Translation:AnimalsCells
  28. Sweetman D, Wagstaff L, Cooper O, Weijer C, Münsterberg A. The migration of paraxial and lateral plate mesoderm cells emerging from the late primitive streak is controlled by different Wnt signals. BMC Dev Biol. 2008 Jun 09; 8:63. PMID: 18541012.
    Citations: 26     Fields:    Translation:AnimalsCells
  29. Cooper O, Sweetman D, Wagstaff L, Münsterberg A. Expression of avian prickle genes during early development and organogenesis. Dev Dyn. 2008 May; 237(5):1442-8. PMID: 18366142.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  30. Astradsson A, Cooper O, Vinuela A, Isacson O. Recent advances in cell-based therapy for Parkinson disease. Neurosurg Focus. 2008; 24(3-4):E6. PMID: 18341409.
    Citations: 13     Fields:    Translation:HumansAnimals
  31. Baker KL, Daniels SB, Lennington JB, Lardaro T, Czap A, Notti RQ, Cooper O, Isacson O, Frasca S, Conover JC. Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse. J Comp Neurol. 2006 Oct 20; 498(6):747-61. PMID: 16927265.
    Citations: 21     Fields:    Translation:AnimalsCells
  32. Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson O. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 2005 Jul; 128(Pt 7):1498-510. PMID: 15872020; PMCID: PMC2610438.
    Citations: 168     Fields:    Translation:HumansCells
  33. Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005 Mar; 28(3):417-29. PMID: 15737733.
    Citations: 15     Fields:    Translation:AnimalsCells
  34. Cooper O, Isacson O. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. J Neurosci. 2004 Oct 13; 24(41):8924-31. PMID: 15483111; PMCID: PMC2613225.
    Citations: 55     Fields:    Translation:AnimalsCells
  35. Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation. 2004 May 17; 1(1):6. PMID: 15285796.
    Citations: 66     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.