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Anjali Katyal Nath, Ph.D.

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Research Focus:
Our lab works at the interface of human genetics and chemistry. We systematically identify connections between genes and the human biology they regulate through the integration of multiomic human datasets. The overarching goals of these analyses are to determine the function of understudied genes and to identify novel druggable targets. We then use the tools of chemical biology in combination with zebrafish genetic models to dissect the molecular mechanisms of these associations and to identify lead compounds. Our overarching goal is to develop small molecules that modulate the activity of cardiometabolic disease associated genes.

Lab Website:

BIDMC's Division of Cardiovascular Medicine:

Apply to join our group:
Send your research interests, curriculum vitae, and contact information for three references to anath1(AT)bidmc(DOT)harvard(DOT)edu

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HG010392 (NATH, ANJALI K.) Sep 1, 2019 - Aug 31, 2022
    Illuminating the Understudied Druggable Kinome through Human Phenotypes and Model Organisms
    Role Description: Kinases are enzymes that regulate every aspect of cellular activity. However, many human kinases remain poorly characterized. Here we systematically identify connections between these understudied kinases and the human biology they regulate through the integration of genomics, proteomics and metabolomics data. These biochemical signatures will highlight potential new metabolic pathways regulated by kinase biology that can then be validated and studied by genetic manipulation in model systems. Successful completion of this project will provide opportunities to understand the biological functions of understudied kinases and will provide novel mechanistic insights into the biology they regulate.
    Role: Principal Investigator
  2. U54NS112107 (GERSZTEN, ROBERT) Jul 1, 2019 - Jun 30, 2024
    Metabolic Phenotyping and Pharmocokinetics Core
    Role Description: The Core leverages a robust LC-MS/MS-based platform to: 1) Perform detailed pharmacokinetic (PK) studies of countermeasures; 2) Identify metabolic surrogates that track with the efficacy of countermeasures, as well as unanticipated off-target effects; 3) Identify very early markers of cyanide toxicity or persistent changes after prior transient exposure so that countermeasures can be instituted at the earliest possible juncture; 4) Identify the broad spectrum of metabolic derangements secondary to cyanide toxicity thus highlighting enzymes or metabolites for therapeutic intervention.
    Role: Co-Investigator
  3. U54NS112107 (MACRAE, CALUM) Jul 1, 2019 - Jun 30, 2024
    Advancing Novel Cyanide Countermeasures
    Role Description: In prior work within our consortium, we have discovered new compound classes that can counteract the effect of cyanide. Foremost among these are the multivalent cyanide scavenger hexachloroplatinate and the metabolic modulator glyoxylate, but several additional next-generation compounds are in the pipeline. These discoveries pave the way for development of cyanide countermeasures that are fundamentally different from existing countermeasures and have the potential to transform our ability to respond to cyanide exposures. This new U54 will focus on translating these discoveries into optimized, validated leads meeting the formal requirements for advanced development and clinical deployment.
    Role: Co-Investigator
  4. R01HL132320 (GERSZTEN, ROBERT E) Jul 1, 2016 - Apr 30, 2021
    Proteomic Pathway Discovery in Cardiovascular Disease
    Role Description: The major goal of this project is to use a novel aptamer-based proteomic platform to identify new biomarkers of cardiovascular disease.
    Role: Faculty Participant
  5. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2018
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role Description: The goals of this multi-center project are to create a pipeline of scalable technologies to discover novel cyanide countermeasures, to screen large chemical libraries for novel cyanide countermeasures, to optimize initial hits for activity in vivo, and to test these lead compounds in validated mouse and rabbit models of cyanide toxicity.
    Role: Senior Personnel

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Behymer MM, Mo H, Fujii N, Suresh V, Chan A, Lee J, Nath AK, Saha K, Mahon SB, Brenner M, MacRae CA, Peterson R, Boss GR, Knipp GT, Davisson VJ. Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. Chem Res Toxicol. 2022 Nov 21; 35(11):1983-1996. PMID: 36201358; PMCID: PMC9682522.
    Citations:    Fields:    
  2. Nielson JR, Nath AK, Doane KP, Shi X, Lee J, Tippetts EG, Saha K, Morningstar J, Hicks KG, Chan A, Zhao Y, Kelly A, Hendry-Hofer TB, Witeof A, Sips PY, Mahon S, Bebarta VS, Davisson VJ, Boss GR, Rutter J, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Glyoxylate protects against cyanide toxicity through metabolic modulation. Sci Rep. 2022 03 23; 12(1):4982. PMID: 35322094; PMCID: PMC8943054.
    Citations:    Fields:    Translation:Animals
  3. Rodgers M, Migdal AL, Rodríguez TG, Chen ZZ, Nath AK, Gerszten RE, Kasid N, Toschi E, Tripaldi J, Heineman B, Phan M, Ngo L, Maratos-Flier E, Dushay J. Weight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese Women. Front Endocrinol (Lausanne). 2021; 12:742873. PMID: 34867786; PMCID: PMC8635796.
    Citations:    Fields:    Translation:Humans
  4. Schmaier AA, Pajares Hurtado GM, Manickas-Hill ZJ, Sack KD, Chen SM, Bhambhani V, Quadir J, Nath AK, Collier AY, Ngo D, Barouch DH, Shapiro NI, Gerszten RE, Yu XG, Peters KG, Flaumenhaft R, Parikh SM. Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19. JCI Insight. 2021 10 22; 6(20). PMID: 34506304; PMCID: PMC8564889.
    Citations: 10     Fields:    Translation:HumansCells
  5. Ngo D, Benson MD, Long JZ, Chen ZZ, Wang R, Nath AK, Keyes MJ, Shen D, Sinha S, Kuhn E, Morningstar JE, Shi X, Peterson BD, Chan C, Katz DH, Tahir UA, Farrell LA, Melander O, Mosley JD, Carr SA, Vasan RS, Larson MG, Smith JG, Wang TJ, Yang Q, Gerszten RE. Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk. JCI Insight. 2021 03 08; 6(5). PMID: 33591955; PMCID: PMC8021115.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  6. Rodgers M, Migdal A, Ghorbani T, Tripaldi J, Heineman B, Toschi E, Chen Z, Nath A, Phan M, Ngo L, Gerzsten R, Flier E, Dushay J. Patterns and Predictors of Weight Loss with Exenatide Treatment in Overweight and Obese Women. medRxiv. 2020. View Publication.
  7. Nath AK, Ma J, Chen ZZ, Li Z, Vitery MDC, Kelley ML, Peterson RT, Gerszten RE, Yeh JJ. Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB J. 2020 01; 34(1):1546-1557. PMID: 31914600.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. FASEB Bioadv. 2019 Feb; 1(2):81-92. PMID: 31355359.
    Citations: 4     
  9. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
    Citations: 5     Fields:    Translation:Animals
  10. Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE. Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI Insight. 2017 May 04; 2(9). PMID: 28469090.
    Citations: 28     Fields:    
  11. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT. PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Rep. 2015 Feb 10; 10(5):694-701. PMID: 25660020; PMCID: PMC4524786.
    Citations: 24     Fields:    
  13. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455.
    Citations: 22     Fields:    Translation:HumansAnimals
  14. Stankewich MC, Cianci CD, Stabach PR, Ji L, Nath A, Morrow JS. Cell organization, growth, and neural and cardiac development require aII-spectrin. J Cell Sci. 2011 Dec 01; 124(Pt 23):3956-66. PMID: 22159418.
    Citations: 41     Fields:    Translation:AnimalsCells
  15. Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS One. 2009; 4(1):e4221. PMID: 19156209.
    Citations: 15     Fields:    Translation:HumansAnimals
  16. Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. J Cell Biol. 2008 Apr 21; 181(2):367-80. PMID: 18411306.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Nath AK, Madri JA. The roles of nitric oxide in murine cardiovascular development. Dev Biol. 2006 Apr 01; 292(1):25-33. PMID: 16442519.
    Citations: 3     Fields:    Translation:HumansAnimals
  18. Hartman SE, Bertone P, Nath AK, Royce TE, Gerstein M, Weissman S, Snyder M. Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev. 2005 Dec 15; 19(24):2953-68. PMID: 16319195; PMCID: PMC1315400.
    Citations: 56     Fields:    Translation:HumansCells
  19. Cha ST, Talavera D, Demir E, Nath AK, Sierra-Honigmann MR. A method of isolation and culture of microvascular endothelial cells from mouse skin. Microvasc Res. 2005 Nov; 70(3):198-204. PMID: 16188282.
    Citations: 9     Fields:    Translation:AnimalsCells
  20. Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E. Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Development. 2004 May; 131(10):2485-96. PMID: 15128676.
    Citations: 18     Fields:    Translation:Animals
  21. Murad A, Nath AK, Cha ST, Demir E, Flores-Riveros J, Sierra-Honigmann MR. Leptin is an autocrine/paracrine regulator of wound healing. FASEB J. 2003 Oct; 17(13):1895-7. PMID: 12923067.
    Citations: 32     Fields:    Translation:Animals
  22. Rebar EJ, Huang Y, Hickey R, Nath AK, Meoli D, Nath S, Chen B, Xu L, Liang Y, Jamieson AC, Zhang L, Spratt SK, Case CC, Wolffe A, Giordano FJ. Induction of angiogenesis in a mouse model using engineered transcription factors. Nat Med. 2002 Dec; 8(12):1427-32. PMID: 12415262.
    Citations: 78     Fields:    Translation:AnimalsCells
  23. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem. 2002 Sep 13; 277(37):34601-9. PMID: 12084725.
    Citations: 49     Fields:    Translation:HumansCells
  24. Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF. Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7734-9. PMID: 12032352; PMCID: PMC124337.
    Citations: 23     Fields:    Translation:AnimalsCells
  25. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5780-5. PMID: 11331753; PMCID: PMC33290.
    Citations: 140     Fields:    Translation:Animals
  26. Gariano RF, Nath AK, D'Amico DJ, Lee T, Sierra-Honigmann MR. Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3576-81. PMID: 11006255.
    Citations: 23     Fields:    Translation:Humans
  27. Schechner JS, Nath AK, Zheng L, Kluger MS, Hughes CC, Sierra-Honigmann MR, Lorber MI, Tellides G, Kashgarian M, Bothwell AL, Pober JS. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9191-6. PMID: 10890921; PMCID: PMC16844.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  28. O'Connor DS, Schechner JS, Adida C, Mesri M, Rothermel AL, Li F, Nath AK, Pober JS, Altieri DC. Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol. 2000 Feb; 156(2):393-8. PMID: 10666367; PMCID: PMC1850029.
    Citations: 90     Fields:    Translation:HumansCells
  29. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science. 1998 Sep 11; 281(5383):1683-6. PMID: 9733517.
    Citations: 309     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.