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Anjali Katyal Nath, Ph.D.

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Overview
Research Focus:
Our lab works at the interface of human genetics and drug discovery. We systematically identify connections between genes and the human biology they regulate through the integration of multiomic human datasets. The overarching goals of these analyses are to determine the function of understudied genes and to identify novel druggable targets. We then use the tools of chemical biology in combination with zebrafish genetic models to dissect the molecular mechanisms of these associations and to identify lead compounds. Our overarching goal is to develop small molecules that modulate the activity of cardiometabolic disease associated genes.

Lab Website:
https://scholar.harvard.edu/anjali-nath-lab

Apply to join our group:
Send your research interests, curriculum vitae, and contact information for three references to anj.nath.lab(AT)gmail(DOT)com

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54NS112107 (Calum MacRae) Jul 1, 2019 - Jun 30, 2024
    NIH/NIADS
    Advancing Novel Cyanide Countermeasures
    Role Description: In prior work within our consortium, we have discovered new compound classes that can counteract the effect of cyanide. Foremost among these are the multivalent cyanide scavenger hexachloroplatinate and the metabolic modulator glyoxylate, but several additional next-generation compounds are in the pipeline. These discoveries pave the way for development of cyanide countermeasures that are fundamentally different from existing countermeasures and have the potential to transform our ability to respond to cyanide exposures. This new U54 will focus on translating these discoveries into optimized, validated leads meeting the formal requirements for advanced development and clinical deployment.
    Role: Co-Investigator
  2. R01HL132320 (GERSZTEN, ROBERT E) Jul 1, 2016 - Apr 30, 2020
    NIH/NHLBI
    Proteomic Pathway Discovery in Cardiovascular Disease
    Role Description: The major goal of this project is to use a novel aptamer-based proteomic platform to identify new biomarkers of cardiovascular disease.
    Role: Faculty Participant
  3. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2017
    NIH/NINDS
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role Description: The goals of this multi-center project are to create a pipeline of scalable technologies to discover novel cyanide countermeasures, to screen large chemical libraries for novel cyanide countermeasures, to optimize initial hits for activity in vivo, and to test these lead compounds in validated mouse and rabbit models of cyanide toxicity.
    Role: Senior Personnel
  4. 2012A051526 (NATH, ANJALI K) Sep 1, 2012 - Aug 31, 2013
    MGH ECOR Tosteson Postdoctoral Fellowship Award
    Chemical and Genetic Dissection of the Role of Mitochondrial Phosphorylation Events in Pancreatic Beta Cell Biology
    Role Description: The goal of this project is to determine the function of a poorly annotated phosphatase, PTPMT1, and to gain deeper insight into the role of mitochondrial phosphorylation in the regulation of beta cell biology.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
    Citations:    Fields:    Translation:Animals
  2. Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE. Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI Insight. 2017 May 04; 2(9). PMID: 28469090.
    Citations: 2     Fields:    
  3. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT. PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Rep. 2015 Feb 10; 10(5):694-701. PMID: 25660020.
    Citations: 7     Fields:    
  5. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455.
    Citations: 13     Fields:    Translation:HumansAnimals
  6. Stankewich MC, Cianci CD, Stabach PR, Ji L, Nath A, Morrow JS. Cell organization, growth, and neural and cardiac development require aII-spectrin. J Cell Sci. 2011 Dec 01; 124(Pt 23):3956-66. PMID: 22159418.
    Citations: 17     Fields:    Translation:AnimalsCells
  7. Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS One. 2009; 4(1):e4221. PMID: 19156209.
    Citations: 15     Fields:    Translation:HumansAnimals
  8. Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. J Cell Biol. 2008 Apr 21; 181(2):367-80. PMID: 18411306.
    Citations: 12     Fields:    Translation:AnimalsCells
  9. Nath AK, Madri JA. The roles of nitric oxide in murine cardiovascular development. Dev Biol. 2006 Apr 01; 292(1):25-33. PMID: 16442519.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Hartman SE, Bertone P, Nath AK, Royce TE, Gerstein M, Weissman S, Snyder M. Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev. 2005 Dec 15; 19(24):2953-68. PMID: 16319195.
    Citations: 48     Fields:    Translation:HumansCells
  11. Cha ST, Talavera D, Demir E, Nath AK, Sierra-Honigmann MR. A method of isolation and culture of microvascular endothelial cells from mouse skin. Microvasc Res. 2005 Nov; 70(3):198-204. PMID: 16188282.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E. Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Development. 2004 May; 131(10):2485-96. PMID: 15128676.
    Citations: 15     Fields:    Translation:Animals
  13. Murad A, Nath AK, Cha ST, Demir E, Flores-Riveros J, Sierra-Honigmann MR. Leptin is an autocrine/paracrine regulator of wound healing. FASEB J. 2003 Oct; 17(13):1895-7. PMID: 12923067.
    Citations: 20     Fields:    Translation:Animals
  14. Rebar EJ, Huang Y, Hickey R, Nath AK, Meoli D, Nath S, Chen B, Xu L, Liang Y, Jamieson AC, Zhang L, Spratt SK, Case CC, Wolffe A, Giordano FJ. Induction of angiogenesis in a mouse model using engineered transcription factors. Nat Med. 2002 Dec; 8(12):1427-32. PMID: 12415262.
    Citations: 69     Fields:    Translation:AnimalsCells
  15. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem. 2002 Sep 13; 277(37):34601-9. PMID: 12084725.
    Citations: 37     Fields:    Translation:HumansCells
  16. Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF. Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7734-9. PMID: 12032352.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5780-5. PMID: 11331753.
    Citations: 109     Fields:    Translation:Animals
  18. Gariano RF, Nath AK, D'Amico DJ, Lee T, Sierra-Honigmann MR. Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3576-81. PMID: 11006255.
    Citations: 17     Fields:    Translation:Humans
  19. Schechner JS, Nath AK, Zheng L, Kluger MS, Hughes CC, Sierra-Honigmann MR, Lorber MI, Tellides G, Kashgarian M, Bothwell AL, Pober JS. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9191-6. PMID: 10890921.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  20. O'Connor DS, Schechner JS, Adida C, Mesri M, Rothermel AL, Li F, Nath AK, Pober JS, Altieri DC. Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol. 2000 Feb; 156(2):393-8. PMID: 10666367.
    Citations: 77     Fields:    Translation:HumansCells
  21. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science. 1998 Sep 11; 281(5383):1683-6. PMID: 9733517.
    Citations: 266     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.