Anjali Katyal Nath, Ph.D.
Instructor in Medicine
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston MA 02215
Our lab works at the interface of human genetics and drug discovery. We systematically identify connections between genes and the human biology they regulate through the integration of multiomic human datasets. The overarching goals of these analyses are to determine the function of understudied genes and to identify novel druggable targets. We then use the tools of chemical biology in combination with zebrafish genetic models to dissect the molecular mechanisms of these associations and to identify lead compounds. Our overarching goal is to develop small molecules that modulate the activity of cardiometabolic disease associated genes.
Apply to join our group:
Send your research interests, curriculum vitae, and contact information for three references to anj.nath.lab(AT)gmail(DOT)com
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
Jul 1, 2019 - Jun 30, 2024
Advancing Novel Cyanide Countermeasures
Role Description: In prior work within our consortium, we have discovered new compound classes that can counteract the effect of cyanide. Foremost among these are the multivalent cyanide scavenger hexachloroplatinate and the metabolic modulator glyoxylate, but several additional next-generation compounds are in the pipeline. These discoveries pave the way for development of cyanide countermeasures that are fundamentally different from existing countermeasures and have the potential to transform our ability to respond to cyanide exposures. This new U54 will focus on translating these discoveries into optimized, validated leads meeting the formal requirements for advanced development and clinical deployment.
(GERSZTEN, ROBERT E)
Jul 1, 2016 - Apr 30, 2020
Proteomic Pathway Discovery in Cardiovascular Disease
Role Description: The major goal of this project is to use a novel aptamer-based proteomic platform to identify new biomarkers of cardiovascular disease.
Role: Faculty Participant
(MACRAE, CALUM A.)
Sep 30, 2012 - Aug 31, 2017
A Discovery and Development Pipeline for Cyanide Countermeasures
Role Description: The goals of this multi-center project are to create a pipeline of scalable technologies to discover novel cyanide countermeasures, to screen large chemical libraries for novel cyanide countermeasures, to optimize initial hits for activity in vivo, and to test these lead compounds in validated mouse and rabbit models of cyanide toxicity.
(NATH, ANJALI K)
Sep 1, 2012 - Aug 31, 2013
MGH ECOR Tosteson Postdoctoral Fellowship Award
Chemical and Genetic Dissection of the Role of Mitochondrial Phosphorylation Events in Pancreatic Beta Cell Biology
Role Description: The goal of this project is to determine the function of a poorly annotated phosphatase, PTPMT1, and to gain deeper insight into the role of mitochondrial phosphorylation in the regulation of beta cell biology.
Role: Principal Investigator
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