Harvard Catalyst Profiles

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Anjali Katyal Nath, Ph.D.

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Overview
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Research Focus:
Our lab works at the interface of human genetics and chemistry. We systematically identify connections between genes and the human biology they regulate through the integration of multiomic human datasets. The overarching goals of these analyses are to determine the function of understudied genes and to identify novel druggable targets. We then use the tools of chemical biology in combination with zebrafish genetic models to dissect the molecular mechanisms of these associations and to identify lead compounds. Our overarching goal is to develop small molecules that modulate the activity of cardiometabolic disease associated genes.

Lab Website:
https://research.bidmc.org/anjali-nath-lab/

BIDMC's Division of Cardiovascular Medicine:
https://www.bidmc.org/research/research-by-department/medicine/cardiovascular-medicine/basic-cardiology-research/nath-lab

Apply to join our group:
Send your research interests, curriculum vitae, and contact information for three references to anath1(AT)bidmc(DOT)harvard(DOT)edu
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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21HG010392 (NATH, ANJALI K.) Sep 1, 2019 - Mar 30, 2023
    NIH/NHGRI
    Illuminating the Understudied Druggable Kinome through Human Phenotypes and Model Organisms
    Role Description: Kinases are enzymes that regulate every aspect of cellular activity. However, many human kinases remain poorly characterized. Here we systematically identify connections between these understudied kinases and the human biology they regulate through the integration of genomics, proteomics and metabolomics data. These biochemical signatures will highlight potential new metabolic pathways regulated by kinase biology that can then be validated and studied by genetic manipulation in model systems. Successful completion of this project will provide opportunities to understand the biological functions of understudied kinases and will provide novel mechanistic insights into the biology they regulate.
    Role: Principal Investigator
  2. U54NS112107 (GERSZTEN, ROBERT) Jul 1, 2019 - Jun 30, 2024
    NIH/NIADS
    Metabolic Phenotyping and Pharmocokinetics Core
    Role Description: The Core leverages a robust LC-MS/MS-based platform to: 1) Perform detailed pharmacokinetic (PK) studies of countermeasures; 2) Identify metabolic surrogates that track with the efficacy of countermeasures, as well as unanticipated off-target effects; 3) Identify very early markers of cyanide toxicity or persistent changes after prior transient exposure so that countermeasures can be instituted at the earliest possible juncture; 4) Identify the broad spectrum of metabolic derangements secondary to cyanide toxicity thus highlighting enzymes or metabolites for therapeutic intervention.
    Role: Co-Investigator
  3. U54NS112107 (MACRAE, CALUM) Jul 1, 2019 - Jun 30, 2024
    NIH/NIADS
    Advancing Novel Cyanide Countermeasures
    Role Description: In prior work within our consortium, we have discovered new compound classes that can counteract the effect of cyanide. Foremost among these are the multivalent cyanide scavenger hexachloroplatinate and the metabolic modulator glyoxylate, but several additional next-generation compounds are in the pipeline. These discoveries pave the way for development of cyanide countermeasures that are fundamentally different from existing countermeasures and have the potential to transform our ability to respond to cyanide exposures. This new U54 will focus on translating these discoveries into optimized, validated leads meeting the formal requirements for advanced development and clinical deployment.
    Role: Co-Investigator
  4. R01HL132320 (GERSZTEN, ROBERT E) Jul 1, 2016 - Apr 30, 2021
    NIH
    Proteomic Pathway Discovery in Cardiovascular Disease
    Role Description: The major goal of this project is to use a novel aptamer-based proteomic platform to identify new biomarkers of cardiovascular disease.
    Role: Faculty Participant
  5. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2018
    NIH
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role Description: The goals of this multi-center project are to create a pipeline of scalable technologies to discover novel cyanide countermeasures, to screen large chemical libraries for novel cyanide countermeasures, to optimize initial hits for activity in vivo, and to test these lead compounds in validated mouse and rabbit models of cyanide toxicity.
    Role: Senior Personnel

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.