Harvard Catalyst Profiles

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Yan Geng, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Geng Y, Michowski W, Chick JM, Wang YE, Jecrois ME, Sweeney KE, Liu L, Han RC, Ke N, Zagozdzon A, Sicinska E, Bronson RT, Gygi SP, Sicinski P. Kinase-independent function of E-type cyclins in liver cancer. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):1015-1020. PMID: 29339491.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  2. Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W. Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018 01 04; 553(7686):91-95. PMID: 29160310.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  3. Geng YD, Zhang C, Lei JL, Yu P, Xia YZ, Zhang H, Yang L, Kong LY. Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer. Biochem Pharmacol. 2017 10 15; 142:71-86. PMID: 28673807.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  4. Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017 06 15; 546(7658):426-430. PMID: 28607489.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  5. Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kolodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol. 2017 03; 19(3):177-188. PMID: 28192421.
    Citations: 33     Fields:    Translation:AnimalsCells
  6. Odajima J, Saini S, Jung P, Ndassa-Colday Y, Ficaro S, Geng Y, Marco E, Michowski W, Wang YE, DeCaprio JA, Litovchick L, Marto J, Sicinski P. Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 2016 Nov; 12(11):e1006429. PMID: 27828963.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942. PMID: 27237051.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  8. Zhang C, Yang L, Geng YD, An FL, Xia YZ, Guo C, Luo JG, Zhang LY, Guo QL, Kong LY. Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells. Oncotarget. 2016 May 10; 7(19):27819-37. PMID: 27056897.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Li HX, Lu ZM, Geng Y, Gong JS, Zhang XJ, Shi JS, Xu ZH, Ma YH. Efficient production of bioactive metabolites from Antrodia camphorata ATCC 200183 by asexual reproduction-based repeated batch fermentation. Bioresour Technol. 2015 Oct; 194:334-43. PMID: 26210148.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Gao Y, Hu YZ, Li RS, Han ZT, Geng Y, Xia Z, Du WJ, Liu LX, Zhang HH, Wang LN. Cattle encephalon glycoside and ignotin injection improves cognitive impairment in APPswe/PS1dE9 mice used as multitarget anti-Alzheimer's drug candidates. Neuropsychiatr Dis Treat. 2015; 11:537-48. PMID: 25784809.
    Citations: 8     
  11. Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble PW, Jiang D, Ning W. Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med. 2015 Feb 09; 212(2):235-52. PMID: 25584011.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  12. Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91. PMID: 25344755.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  13. Wang LX, Lu ZM, Geng Y, Zhang XM, Xu GH, Shi JS, Xu ZH. Stimulated production of steroids in Inonotus obliquus by host factors from birch. J Biosci Bioeng. 2014 Dec; 118(6):728-31. PMID: 25027706.
    Citations: 3     Fields:    Translation:Animals
  14. Martinerie L, Manterola M, Chung SS, Panigrahi SK, Weisbach M, Vasileva A, Geng Y, Sicinski P, Wolgemuth DJ. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet. 2014 Feb; 10(2):e1004165. PMID: 24586195.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Jirawatnotai S, Sharma S, Michowski W, Suktitipat B, Geng Y, Quackenbush J, Elias JE, Gygi SP, Wang YE, Sicinski P. The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis. Cell Cycle. 2014; 13(18):2889-900. PMID: 25486477.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Hu W, Nevzorova YA, Haas U, Moro N, Sicinski P, Geng Y, Barbacid M, Trautwein C, Liedtke C. Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology. 2014 Feb; 59(2):651-60. PMID: 23787781.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Geng Y, Li L, Dong Y, Liu X, Li XH, Ning W. Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One. 2013; 8(11):e81368. PMID: 24282586.
    Citations: 4     Fields:    Translation:Animals
  18. Liu X, Xu W, Wang Y, Williams JM, Geng Y, Zhang Q, Liu X. Can Inner Peace be Improved by Mindfulness Training: A Randomized Controlled Trial. Stress Health. 2015 Aug; 31(3):245-54. PMID: 24265118.
    Citations: 5     Fields:    Translation:Humans
  19. Yoo JW, Kim SJ, Geng Y, Shin HP, Nakagawa S. Quality and innovations for caring hospitalized older persons in the unites States. Aging Dis. 2014 Feb; 5(1):41-51. PMID: 24490116.
    Citations: 2     
  20. Nakaya T, Ishiguro K, Belzil C, Rietsch AM, Yu Q, Mizuno S, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y. p600 Plays Essential Roles in Fetal Development. PLoS One. 2013; 8(6):e66269. PMID: 23824717.
    Citations: 6     Fields:    Translation:Animals
  21. Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S. p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10. PMID: 23620512.
    Citations: 93     Fields:    Translation:AnimalsCells
  22. Geng Y, Sicinski P. Differences in regulation and function of E-cyclins in human cancer cells. . 2013 Apr 15; 12(8):1165. PMID: 23549169.
    Citations: 6     Translation:Humans
  23. Li L, Li X, Liu X, Dong Y, Geng Y, Liu X, Ning W. Expression, characterization, and preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 expressed in Drosophila S2 cells. Biosci Trends. 2013 Apr; 7(2):93-100. PMID: 23612079.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18; 21(4):655-68. PMID: 21944720.
    Citations: 58     Fields:    Translation:AnimalsCells
  25. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. PMID: 20090754.
    Citations: 127     Fields:    Translation:AnimalsCells
  26. Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell. 2009 Jul 23; 138(2):352-65. PMID: 19592082.
    Citations: 95     Fields:    Translation:AnimalsCells
  27. Nevzorova YA, Tschaharganeh D, Gassler N, Geng Y, Weiskirchen R, Sicinski P, Trautwein C, Liedtke C. Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin. Gastroenterology. 2009 Aug; 137(2):691-703, 703.e1-6. PMID: 19445941.
    Citations: 25     Fields:    Translation:AnimalsCells
  28. Zeng L, Geng Y, Tretiakova M, Yu X, Sicinski P, Kroll TG. Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Res. 2008 Aug 15; 68(16):6578-86. PMID: 18701481.
    Citations: 10     Fields:    Translation:HumansCells
  29. Landis MW, Brown NE, Baker GL, Shifrin A, Das M, Geng Y, Sicinski P, Hinds PW. The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development. Cancer Res. 2007 Aug 15; 67(16):7613-20. PMID: 17699765.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P. Kinase-independent function of cyclin E. Mol Cell. 2007 Jan 12; 25(1):127-39. PMID: 17218276.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  31. Sicinska E, Lee YM, Gits J, Shigematsu H, Yu Q, Rebel VI, Geng Y, Marshall CJ, Akashi K, Dorfman DM, Touw IP, Sicinski P. Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Mol Cell Biol. 2006 Nov; 26(21):8052-60. PMID: 16954383.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. Yu Q, Sicinska E, Geng Y, Ahnström M, Zagozdzon A, Kong Y, Gardner H, Kiyokawa H, Harris LN, Stål O, Sicinski P. Requirement for CDK4 kinase function in breast cancer. Cancer Cell. 2006 Jan; 9(1):23-32. PMID: 16413469.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  33. Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. 2005 Oct; 26(10):1793-803. PMID: 15905199.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  34. Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb; 25(3):1081-8. PMID: 15657434.
    Citations: 28     Fields:    Translation:Animals
  35. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P. Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004 Aug 20; 118(4):477-91. PMID: 15315760.
    Citations: 248     Fields:    Translation:AnimalsCells
  36. Lu XL, Luo JY, Tao M, Zhao P, Zhao HL, Zhang XD, Geng Y. [Analysis of dangerous factors for alcoholic liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2004 Jul; 12(7):442-3. PMID: 15268820.
    Citations: 2     Fields:    Translation:Humans
  37. Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003 Dec; 4(6):451-61. PMID: 14706337.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  38. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H, Sicinski P. Cyclin E ablation in the mouse. Cell. 2003 Aug 22; 114(4):431-43. PMID: 12941272.
    Citations: 248     Fields:    Translation:AnimalsCells
  39. Seth P, Porter D, Lahti-Domenici J, Geng Y, Richardson A, Polyak K. Cellular and molecular targets of estrogen in normal human breast tissue. Cancer Res. 2002 Aug 15; 62(16):4540-4. PMID: 12183401.
    Citations: 34     Fields:    Translation:HumansCells
  40. Melián A, Geng YJ, Sukhova GK, Libby P, Porcelli SA. CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am J Pathol. 1999 Sep; 155(3):775-86. PMID: 10487835.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  41. Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation. 1999 Jan 5-12; 99(1):96-104. PMID: 9884385.
    Citations: 97     Fields:    Translation:HumansCells
  42. Geng YJ, Henderson LE, Levesque EB, Muszynski M, Libby P. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):2200-8. PMID: 9351390.
    Citations: 33     Fields:    Translation:HumansCells
  43. Libby P, Geng YJ, Sukhova GK, Simon DI, Lee RT. Molecular determinants of atherosclerotic plaque vulnerability. Ann N Y Acad Sci. 1997 Apr 15; 811:134-42; discussion 142-5. PMID: 9186592.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  44. Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, Clinton SK, Sukhova GK, Lee RT. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996 Oct; 7(5):330-5. PMID: 8937525.
    Citations: 108     Fields:    Translation:HumansCells
  45. Geng YJ, Wu Q, Muszynski M, Hansson GK, Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol. 1996 Jan; 16(1):19-27. PMID: 8548421.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  46. Geng YJ, Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am J Pathol. 1995 Aug; 147(2):251-66. PMID: 7639325.
    Citations: 99     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.