Harvard Catalyst Profiles

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Florian Winau, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI137921 (WINAU, FLORIAN) May 15, 2018 - Apr 30, 2020
    Targeting scramblase TMEM16F to break T cell exhaustion
    Role: Principal Investigator
  2. R01AI136939 (WINAU, FLORIAN) Jan 22, 2018 - Dec 31, 2022
    Function of CD1a on Langerhans cells in skin inflammation
    Role: Principal Investigator
  3. R56AI127766 (WINAU, FLORIAN) Aug 23, 2017 - Jul 31, 2018
    The role of CD1a-restricted T cells in inflammatory skin diseases
    Role: Principal Investigator
  4. R56AI122291 (WINAU, FLORIAN) Sep 23, 2016 - Sep 30, 2017
    CD1a: a novel target for IL-17-mediated inflammatory skin and gut diseases
    Role: Principal Investigator
  5. R01AI083426 (WINAU, FLORIAN) May 1, 2010 - Apr 30, 2015
    Function of stellate cells in immunity and T cell instruction
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun. 2019 02 06; 10(1):617. PMID: 30728354.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  2. Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017 02; 18(2):184-195. PMID: 27992400; PMCID: PMC5247321.
    Citations: 29     Fields:    Translation:AnimalsCells
  3. Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016 11 14; 213(12):2759-2772. PMID: 27810927; PMCID: PMC5110022.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  4. Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F. CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol. 2016 10; 17(10):1159-66. PMID: 27548435; PMCID: PMC5791155.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  5. Kim J, Kim JH, Winau F. Thinking inside the box: endogenous a-anomeric lipid antigens. Immunity. 2014 Oct 16; 41(4):505-6. PMID: 25367563.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  6. Maschmeyer P, Flach M, Winau F. Seven steps to stellate cells. J Vis Exp. 2011 May 10; (51). PMID: 21610670.
    Citations: 29     Fields:    Translation:AnimalsCells
  7. Darmoise A, Teneberg S, Bouzonville L, Brady RO, Beck M, Kaufmann SH, Winau F. Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells. Immunity. 2010 Aug 27; 33(2):216-28. PMID: 20727792.
    Citations: 62     Fields:    Translation:AnimalsCells
  8. Darmoise A, Maschmeyer P, Winau F. The immunological functions of saposins. Adv Immunol. 2010; 105:25-62. PMID: 20510729.
    Citations: 18     Fields:    Translation:Cells
  9. Lotter H, González-Roldán N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer AJ, Holst O, Tannich E, Jacobs T. Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess. PLoS Pathog. 2009 May; 5(5):e1000434. PMID: 19436711.
    Citations: 48     Fields:    Translation:AnimalsCells
  10. Raftery MJ, Winau F, Giese T, Kaufmann SH, Schaible UE, Schönrich G. Viral danger signals control CD1d de novo synthesis and NKT cell activation. Eur J Immunol. 2008 Mar; 38(3):668-79. PMID: 18253929.
    Citations: 23     Fields:    Translation:HumansCells
  11. Raftery MJ, Hitzler M, Winau F, Giese T, Plachter B, Kaufmann SH, Schönrich G. Inhibition of CD1 antigen presentation by human cytomegalovirus. J Virol. 2008 May; 82(9):4308-19. PMID: 18287231.
    Citations: 27     Fields:    Translation:HumansCells
  12. Winau F, Quack C, Darmoise A, Kaufmann SH. Starring stellate cells in liver immunology. Curr Opin Immunol. 2008 Feb; 20(1):68-74. PMID: 18068343.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  13. Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity. 2007 Jan; 26(1):117-29. PMID: 17239632.
    Citations: 166     Fields:    Translation:AnimalsCells
  14. Raftery MJ, Winau F, Kaufmann SH, Schaible UE, Schönrich G. CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion. J Immunol. 2006 Nov 01; 177(9):6207-14. PMID: 17056550.
    Citations: 30     Fields:    Translation:HumansCells
  15. Wunder C, Churin Y, Winau F, Warnecke D, Vieth M, Lindner B, Zähringer U, Mollenkopf HJ, Heinz E, Meyer TF. Cholesterol glucosylation promotes immune evasion by Helicobacter pylori. Nat Med. 2006 Sep; 12(9):1030-8. PMID: 16951684.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  16. Winau F, Weber S, Sad S, de Diego J, Hoops SL, Breiden B, Sandhoff K, Brinkmann V, Kaufmann SH, Schaible UE. Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis. Immunity. 2006 Jan; 24(1):105-17. PMID: 16413927.
    Citations: 166     Fields:    Translation:AnimalsCellsPHPublic Health
  17. Kaufmann SH, Winau F. From bacteriology to immunology: the dualism of specificity. Nat Immunol. 2005 Nov; 6(11):1063-6. PMID: 16239917.
    Citations: 10     Fields:    
  18. Kolter T, Winau F, Schaible UE, Leippe M, Sandhoff K. Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense. J Biol Chem. 2005 Dec 16; 280(50):41125-8. PMID: 16230343.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  19. Winau F, Hegasy G, Kaufmann SH, Schaible UE. No life without death--apoptosis as prerequisite for T cell activation. Apoptosis. 2005 Aug; 10(4):707-15. PMID: 16133862.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Winau F, Sponaas AM, Weber S, Schwierzeck V, Winter R, Hurwitz R, Kaufmann SH. Scant activation of CD8 T cells by antigen loaded on heat shock protein. Eur J Immunol. 2005 Apr; 35(4):1046-55. PMID: 15739167.
    Citations:    Fields:    Translation:HumansCells
  21. Winau F, Kaufmann SH, Schaible UE. Apoptosis paves the detour path for CD8 T cell activation against intracellular bacteria. Cell Microbiol. 2004 Jul; 6(7):599-607. PMID: 15186397.
    Citations: 38     Fields:    Translation:HumansCells
  22. Winau F, Westphal O, Winau R. Paul Ehrlich--in search of the magic bullet. Microbes Infect. 2004 Jul; 6(8):786-9. PMID: 15207826.
    Citations: 35     Fields:    Translation:Humans
  23. Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE. Saposin C is required for lipid presentation by human CD1b. Nat Immunol. 2004 Feb; 5(2):169-74. PMID: 14716313.
    Citations: 61     Fields:    Translation:HumansCells
  24. Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med. 2003 Aug; 9(8):1039-46. PMID: 12872166.
    Citations: 196     Fields:    Translation:HumansAnimalsCells
  25. Winau F, Winau R. Emil von Behring and serum therapy. Microbes Infect. 2002 Feb; 4(2):185-8. PMID: 11880051.
    Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.