"Saposins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.
Concept/Terms
Saposin B- Saposin B
- Sphingolipid Activator Protein 1
- Sphingolipid Activator Protein-1
- SAP-1 Sphingolipid Activator
- SAP 1 Sphingolipid Activator
- Sphingolipid Activator, SAP-1
Saposin C- Saposin C
- beta-Glucosidase Stimulating Protein
- beta Glucosidase Stimulating Protein
- Coglucosidase
- Sphingolipid Activator Protein 2
- Gaucher Activator Protein
- Co-beta-Glucosidase
- Co beta Glucosidase
- Glucosylceramidase Activator
- beta-Glucosidase Activator Protein
- beta Glucosidase Activator Protein
- SAP-C Protein
- SAP C Protein
Below are MeSH descriptors whose meaning is more general than "Saposins".
Below are MeSH descriptors whose meaning is more specific than "Saposins".
This graph shows the total number of publications written about "Saposins" by people in Harvard Catalyst Profiles by year, and whether "Saposins" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
2004 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
2006 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2016 | 2 | 0 | 2 |
2019 | 1 | 0 | 1 |
2021 | 2 | 0 | 2 |
2023 | 1 | 0 | 1 |
2024 | 1 | 0 | 1 |
Below are the most recent publications written about "Saposins" by people in Profiles.
-
Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape. Science. 2024 01 12; 383(6679):190-200.
-
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues. Cell Metab. 2023 03 07; 35(3):535-549.e7.
-
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nat Neurosci. 2021 07; 24(7):1020-1034.
-
Prosaposin mediates inflammation in atherosclerosis. Sci Transl Med. 2021 03 10; 13(584).
-
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019 12 21; 7(1):215.
-
Prosaposin is a regulator of progranulin levels and oligomerization. Nat Commun. 2016 06 30; 7:11992.
-
Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med. 2016 Mar 09; 8(329):329ra34.
-
Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy. Hum Mutat. 2016 Jan; 37(1):16-27.
-
The role of Rhox homeobox factors in tumorigenesis. Front Biosci (Landmark Ed). 2013 01 01; 18(2):474-92.
-
Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival. Genes Dev. 2012 Apr 15; 26(8):816-29.