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Melanie Haas Kucherlapati, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kucherlapati M. Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes. BMC Cancer. 2018 Aug 14; 18(1):818. PMID: 30107825.
    Citations:    Fields:    Translation:HumansCells
  2. Zhang Y, Yang L, Kucherlapati M, Chen F, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Li W, Park PJ, Kucherlapati R, Creighton CJ. A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. Cell Rep. 2018 Jul 10; 24(2):515-527. PMID: 29996110.
    Citations:    Fields:    
  3. Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. 2018 01 08; 33(1):151. PMID: 29316429.
    Citations: 1     Fields:    
  4. Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. 2017 08 14; 32(2):204-220.e15. PMID: 28810145.
    Citations: 19     Fields:    Translation:HumansCells
  5. Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, Zhang J, Yang L, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Westbrook TF, Shelley CS, Choueiri TK, Ittmann M, Van Waes C, Weinstein JN, Liang H, Henske EP, Godwin AK, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. 2017 06 12; 31(6):820-832.e3. PMID: 28528867.
    Citations: 22     Fields:    Translation:HumansCells
  6. Taguchi A, Rho JH, Yan Q, Zhang Y, Zhao Y, Xu H, Tripathi SC, Wang H, Brenner DE, Kucherlapati M, Kucherlapati R, Boutin AT, Wang YA, DePinho RA, Feng Z, Lampe PD, Hanash SM. MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prev Res (Phila). 2015 Nov; 8(11):1112-9. PMID: 26342024.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Kortüm B, Campregher C, Lang M, Khare V, Pinter M, Evstatiev R, Schmid G, Mittlböck M, Scharl T, Kucherlapati MH, Edelmann W, Gasche C. Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice. Gut. 2015 Dec; 64(12):1905-12. PMID: 25429050.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Turker NS, Heidari P, Kucherlapati R, Kucherlapati M, Mahmood U. An EGFR targeted PET imaging probe for the detection of colonic adenocarcinomas in the setting of colitis. Theranostics. 2014; 4(9):893-903. PMID: 25057314.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Kucherlapati MH, Esfahani S, Habibollahi P, Wang J, Still ER, Bronson RT, Mahmood U, Kucherlapati RS. Genotype directed therapy in murine mismatch repair deficient tumors. PLoS One. 2013; 8(7):e68817. PMID: 23935891.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC. Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. PLoS One. 2012; 7(9):e44273. PMID: 22970194.
    Citations: 13     Fields:    Translation:AnimalsCells
  11. McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila). 2011 May; 4(5):684-93. PMID: 21436383.
    Citations: 17     Fields:    Translation:AnimalsCells
  12. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22. PMID: 20940147.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  13. Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W. An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar; 138(3):993-1002.e1. PMID: 19931261.
    Citations: 27     Fields:    Translation:Animals
  14. Kucherlapati MH, Yang K, Fan K, Kuraguchi M, Sonkin D, Rosulek A, Lipkin M, Bronson RT, Aronow BJ, Kucherlapati R. Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15493-8. PMID: 18832169.
    Citations: 9     Fields:    Translation:Animals
  15. Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R. Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies. Oncogene. 2007 Sep 20; 26(43):6297-306. PMID: 17452984.
    Citations: 11     Fields:    Translation:Animals
  16. Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006 Sep 15; 2(9):e146. PMID: 17002498.
    Citations: 74     Fields:    Translation:HumansAnimals
  17. Kucherlapati MH, Nguyen AA, Bronson RT, Kucherlapati RS. Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract. Cancer Res. 2006 Apr 01; 66(7):3576-83. PMID: 16585182.
    Citations: 17     Fields:    Translation:Animals
  18. Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9924-9. PMID: 12119409.
    Citations: 93     Fields:    Translation:AnimalsCells
  19. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep; 6(9):991-7. PMID: 10973318.
    Citations: 386     Fields:    Translation:HumansCells
  20. Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15; 60(4):803-7. PMID: 10706084.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  21. Lin X, State MW, Vaccarino FM, Greally J, Hass M, Leckman JF. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Genomics. 1999 Aug 15; 60(1):96-104. PMID: 10458915.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  22. Lin X, Swaroop A, Vaccarino FM, Murtha MT, Haas M, Ji X, Ruddle FH, Leckman JF. Characterization and sequence analysis of the human homeobox-containing gene GBX2. Genomics. 1996 Feb 01; 31(3):335-42. PMID: 8838315.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  23. Krainc D, Haas M, Ward DC, Lipton SA, Bruns G, Leifer D. Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved. Genomics. 1995 Oct 10; 29(3):809-11. PMID: 8575784.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Payne JA, Xu JC, Haas M, Lytle CY, Ward D, Forbush B. Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon. J Biol Chem. 1995 Jul 28; 270(30):17977-85. PMID: 7629105.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  25. George AL, Varkony TA, Drabkin HA, Han J, Knops JF, Finley WH, Brown GB, Ward DC, Haas M. Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21. Cytogenet Cell Genet. 1995; 68(1-2):67-70. PMID: 7956363.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  26. Aburatani, H., Stanton, V.P., Bernardini, J., Haas, M., Ward,D.C., Housman, D. Cytogenetics and Cell Genetics. Construction of a YAC contig spanning 20 megabases in human chromosome 3p14-21. 1995; (68):125-146.
  27. Munroe DJ, Haas M, Bric E, Whitton T, Aburatani H, Hunter K, Ward D, Housman DE. IRE-bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics. 1994 Feb; 19(3):506-14. PMID: 8188293.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  28. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B. Localization of Shaw-related K+ channel genes on mouse and human chromosomes. Mamm Genome. 1993 Dec; 4(12):711-5. PMID: 8111118.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Haas M, Aburatani H, Stanton VP, Bhatt M, Housman D, Ward DC. Isolation and FISH mapping of 80 cosmid clones on the short arm of human chromosome 3. Genomics. 1993 Apr; 16(1):90-6. PMID: 8486389.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  30. Haas MW, Ramanujam P, Chandrasekharappa SC, Subramanian KN. Sequence requirements for activation of replication by the SV40 transcriptional promoter or enhancer elements. Virology. 1991 Jan; 180(1):41-8. PMID: 1845833.
    Citations: 6     Fields:    Translation:Cells
  31. Haas MW, Becker JM, Miller RV. Peptidase activity in the inner membrane of Pseudomonas aeruginosa. Biochim Biophys Acta. 1981 Apr 22; 643(1):256-60. PMID: 6786349.
    Citations: 2     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.