Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Joseph Avruch, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. S10OD020112 (AVRUCH, JOSEPH) Feb 19, 2015 - Feb 18, 2016
    TSE Systems Phenomaster Indirect Calorimetry Apparatus
    Role: Principal Investigator
  2. R01CA136567 (AVRUCH, JOSEPH) Jul 6, 2010 - Jul 31, 2015
    Decoding the MST1 and MST2 kinases in cellular physiology and tumor suppression
    Role: Principal Investigator
  3. P30DK057521 (FLOREZ, JOSE CARLOS) Jun 1, 2000 - Mar 31, 2021
    Boston Area Diabetes Endocrinology Research Center
    Role: Principal Investigator
  4. R01CA073818 (AVRUCH, JOSEPH) Apr 1, 1997 - Nov 30, 2012
    Molecular basis of Cell Growth Control by the TOR kinase
    Role: Principal Investigator
  5. R13GM051459 (AVRUCH, JOSEPH) Jun 13, 1994 - Jun 12, 1995
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Regué L, Wang W, Ji F, Avruch J, Wang H, Dai N. Human T2D Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells into Adipogenic Lineage. Diabetes. 2022 Oct 11. PMID: 36219823.
    Citations:    Fields:    
  2. Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N. RNA m6A reader IMP2/IGF2BP2 promotes pancreatic ß-cell proliferation and insulin secretion by enhancing PDX1 expression. Mol Metab. 2021 06; 48:101209. PMID: 33705986; PMCID: PMC8076713.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  3. Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, Tallapragada DSP, Strobel SM, Lee MJ, Tewhey R, Sabeti PC, Schaefer A, Petri A, Kauppinen S, Chung RT, Soukas A, Avruch J, Fried SK, Hauner H, Sadreyev RI, Shulman GI, Claussnitzer M, Näär AM. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020 10 29; 183(3):684-701.e14. PMID: 33058756.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  4. Regué L, Minichiello L, Avruch J, Dai N. Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation. J Biol Chem. 2019 08 02; 294(31):11944-11951. PMID: 31209109.
    Citations: 12     Fields:    Translation:AnimalsCells
  5. Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk. Nat Commun. 2019 05 07; 10(1):2078. PMID: 31064983; PMCID: PMC6505525.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  6. Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J. IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism. Mol Cell Biol. 2019 04 01; 39(7). PMID: 30692269; PMCID: PMC6425142.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Chao LH, Avruch J. Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates. F1000Res. 2019; 8. PMID: 30647914.
    Citations: 5     Fields:    Translation:HumansAnimals
  8. Alsufyani F, Mattoo H, Zhou D, Cariappa A, Van Buren D, Hock H, Avruch J, Pillai S. The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development. Front Immunol. 2018; 9:2393. PMID: 30386341; PMCID: PMC6199389.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Dai N, Ji F, Wright J, Minichiello L, Sadreyev R, Avruch J. IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1. Elife. 2017 07 28; 6. PMID: 28753127; PMCID: PMC5576481.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  10. Galan JA, Avruch J. MST1/MST2 Protein Kinases: Regulation and Physiologic Roles. Biochemistry. 2016 Oct 04; 55(39):5507-5519. PMID: 27618557.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  11. Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015 Nov; 16(11):1142-52. PMID: 26414765; PMCID: PMC4618176.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  12. Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 07; 21(4):609-21. PMID: 25863250; PMCID: PMC4663978.
    Citations: 67     Fields:    Translation:AnimalsCells
  13. Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J. A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation. PLoS One. 2015; 10(3):e0116096. PMID: 25790369; PMCID: PMC4366019.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep. 2015 Mar 17; 10(10):1692-1707. PMID: 25772357.
    Citations: 105     Fields:    
  15. Oshiro N, Rapley J, Avruch J. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem. 2014 Jan 31; 289(5):2658-74. PMID: 24337580; PMCID: PMC3908400.
    Citations: 29     Fields:    Translation:HumansCells
  16. Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D. The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep. 2013 May 30; 3(5):1663-77. PMID: 23684612; PMCID: PMC3855275.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  17. Regué L, Mou F, Avruch J. G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene. Bioessays. 2013 May; 35(5):430-5. PMID: 23450633; PMCID: PMC4092039.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  18. Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ. Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun; 144(7):1543-53, 1553.e1. PMID: 23454691; PMCID: PMC3665616.
    Citations: 71     Fields:    Translation:AnimalsCells
  19. Dai N, Christiansen J, Nielsen FC, Avruch J. mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev. 2013 Feb 01; 27(3):301-12. PMID: 23388827; PMCID: PMC3576515.
    Citations: 41     Fields:    Translation:AnimalsCells
  20. Avruch J, Zhou D, Fitamant J, Bardeesy N, Mou F, Barrufet LR. Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol. 2012 Sep; 23(7):770-84. PMID: 22898666.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  21. Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM. Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One. 2012; 7(8):e41756. PMID: 22905105.
    Citations: 45     Fields:    Translation:HumansCells
  22. Chen L, Qin F, Deng X, Avruch J, Zhou D. Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell. 2012 Apr; 3(4):305-10. PMID: 22492181; PMCID: PMC4875478.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012 Apr; 92(2):689-737. PMID: 22535895.
    Citations: 500     Fields:    Translation:HumansAnimalsCells
  24. Avruch J, Zhou D, Bardeesy N. YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle. 2012 Mar 15; 11(6):1090-6. PMID: 22356765.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  25. Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch J, Zhou D. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med. 2012 Apr 09; 209(4):741-59. PMID: 22412158; PMCID: PMC3328371.
    Citations: 81     Fields:    Translation:AnimalsCells
  26. Papageorgiou A, Avruch J. A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation. Methods Mol Biol. 2012; 821:187-214. PMID: 22125066; PMCID: PMC3535007.
    Citations: 3     Fields:    Translation:HumansCells
  27. Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):E1312-20. PMID: 22042863; PMCID: PMC3241824.
    Citations: 229     Fields:    Translation:HumansAnimalsCells
  28. Rapley J, Oshiro N, Ortiz-Vega S, Avruch J. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem. 2011 Nov 04; 286(44):38043-38053. PMID: 21914810; PMCID: PMC3207408.
    Citations: 22     Fields:    Translation:HumansCells
  29. Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J. 2011 Jun 03; 30(13):2634-47. PMID: 21642957; PMCID: PMC3155310.
    Citations: 82     Fields:    Translation:HumansCells
  30. Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J. mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev. 2011 Jun 01; 25(11):1159-72. PMID: 21576258; PMCID: PMC3110954.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  31. Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD. Yap1 acts downstream of a-catenin to control epidermal proliferation. Cell. 2011 Mar 04; 144(5):782-95. PMID: 21376238; PMCID: PMC3237196.
    Citations: 508     Fields:    Translation:AnimalsCells
  32. Avruch J, Zhou D, Fitamant J, Bardeesy N. Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer. 2011 Jan 04; 104(1):24-32. PMID: 21102585; PMCID: PMC3039822.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  33. Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB. Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 05; 285(45):35029-38. PMID: 20810663; PMCID: PMC2966117.
    Citations: 39     Fields:    Translation:AnimalsCells
  34. Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 06; 16(5):425-38. PMID: 19878874; PMCID: PMC3023165.
    Citations: 454     Fields:    Translation:HumansAnimalsCells
  35. Lin Y, Avruch J. pTOM, a vector for expressing two proteins in mammalian cells. Anal Biochem. 2009 May 15; 388(2):353-5. PMID: 19303393.
    Citations:    Fields:    Translation:HumansCells
  36. Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans. 2009 Feb; 37(Pt 1):223-6. PMID: 19143636.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  37. Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F. Rassf family of tumor suppressor polypeptides. J Biol Chem. 2009 Apr 24; 284(17):11001-5. PMID: 19091744.
    Citations: 63     Fields:    Translation:HumansCells
  38. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20321-6. PMID: 19073936; PMCID: PMC2600581.
    Citations: 77     Fields:    Translation:AnimalsCells
  39. Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, Kasir J, Cybulski N, Avruch J, Rüegg MA, Hall MN, Meyuhas O. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol. 2009 Feb; 29(3):640-9. PMID: 19047368; PMCID: PMC2630691.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  40. Rapley J, Nicolàs M, Groen A, Regué L, Bertran MT, Caelles C, Avruch J, Roig J. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci. 2008 Dec 01; 121(Pt 23):3912-21. PMID: 19001501; PMCID: PMC4066659.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  41. Anguera MC, Liu M, Avruch J, Lee JT. Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov; 237(11):3424-34. PMID: 18942145; PMCID: PMC2596583.
    Citations: 2     Fields:    Translation:Animals
  42. Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N. Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E592-602. PMID: 18765678; PMCID: PMC2670622.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  43. Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP. A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes. Mol Cell Biol. 2008 Jul; 28(13):4215-26. PMID: 18426911; PMCID: PMC2447144.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  44. Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008 Mar 11; 18(5):311-21. PMID: 18328708; PMCID: PMC4682548.
    Citations: 188     Fields:    Translation:AnimalsCells
  45. Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem. 2007 Jul 13; 282(28):20329-39. PMID: 17517883; PMCID: PMC3199301.
    Citations: 139     Fields:    Translation:HumansCells
  46. Long X, Lin Y, Ortiz-Vega S, Busch S, Avruch J. The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. J Biol Chem. 2007 Jun 22; 282(25):18542-18551. PMID: 17470430; PMCID: PMC3205911.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  47. Avruch J. MAP kinase pathways: the first twenty years. Biochim Biophys Acta. 2007 Aug; 1773(8):1150-60. PMID: 17229475; PMCID: PMC2043147.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  48. Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene. 2006 Oct 16; 25(48):6361-72. PMID: 17041622.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  49. Avruch J, Praskova M, Ortiz-Vega S, Liu M, Zhang XF. Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods Enzymol. 2006; 407:290-310. PMID: 16757333.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  50. Lenz G, Avruch J. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem. 2005 Nov 18; 280(46):38121-4. PMID: 16183639.
    Citations: 75     Fields:    Translation:AnimalsCells
  51. Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell. 2005 Oct; 16(10):4733-44. PMID: 16093354; PMCID: PMC1237079.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  52. Roig J, Groen A, Caldwell J, Avruch J. Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly. Mol Biol Cell. 2005 Oct; 16(10):4827-40. PMID: 16079175; PMCID: PMC1237086.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  53. Long X, Ortiz-Vega S, Lin Y, Avruch J. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem. 2005 Jun 24; 280(25):23433-6. PMID: 15878852.
    Citations: 140     Fields:    Translation:HumansCells
  54. Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol. 2005 Apr 26; 15(8):702-13. PMID: 15854902.
    Citations: 431     Fields:    Translation:HumansCells
  55. Avruch J, Lin Y, Long X, Murthy S, Ortiz-Vega S. Recent advances in the regulation of the TOR pathway by insulin and nutrients. Curr Opin Clin Nutr Metab Care. 2005 Jan; 8(1):67-72. PMID: 15586002.
    Citations: 37     Fields:    Translation:HumansCells
  56. Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J. 2004 Jul 15; 381(Pt 2):453-62. PMID: 15109305; PMCID: PMC1133852.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  57. Aoyama Y, Avruch J, Zhang XF. Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases. Oncogene. 2004 Apr 22; 23(19):3426-33. PMID: 15007383.
    Citations: 39     Fields:    Translation:HumansCells
  58. Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem. 2004 Jul 09; 279(28):29247-54. PMID: 15075335.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  59. Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells. 2004 Apr; 9(4):359-66. PMID: 15066126.
    Citations: 113     Fields:    Translation:HumansCells
  60. Shen YH, Godlewski J, Bronisz A, Zhu J, Comb MJ, Avruch J, Tzivion G. Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol Biol Cell. 2003 Nov; 14(11):4721-33. PMID: 14551260; PMCID: PMC266786.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  61. Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem. 2003 Sep 12; 278(37):34897-909. PMID: 12840024.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  62. Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem. 2003 May 02; 278(18):15461-4. PMID: 12604610.
    Citations: 257     Fields:    Translation:HumansCells
  63. Lin Y, Khokhlatchev A, Figeys D, Avruch J. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem. 2002 Dec 13; 277(50):47991-8001. PMID: 12384512.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  64. Long X, Spycher C, Han ZS, Rose AM, Müller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol. 2002 Sep 03; 12(17):1448-61. PMID: 12225660.
    Citations: 114     Fields:    Translation:AnimalsCells
  65. Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26; 110(2):177-89. PMID: 12150926.
    Citations: 734     Fields:    Translation:HumansAnimalsCells
  66. Roig J, Mikhailov A, Belham C, Avruch J. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev. 2002 Jul 01; 16(13):1640-58. PMID: 12101123; PMCID: PMC186374.
    Citations: 65     Fields:    Translation:HumansCells
  67. Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 2002 Apr 18; 21(17):2713-20. PMID: 11965544.
    Citations: 33     Fields:    Translation:HumansCells
  68. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene. 2002 Feb 21; 21(9):1381-90. PMID: 11857081.
    Citations: 71     Fields:    Translation:AnimalsCells
  69. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002 Feb 19; 12(4):253-65. PMID: 11864565.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  70. Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J. Characterization of ubiquilin 1, an mTOR-interacting protein. Biochim Biophys Acta. 2002 Jan 30; 1542(1-3):41-56. PMID: 11853878.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  71. Tzivion G, Avruch J. 14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem. 2002 Feb 01; 277(5):3061-4. PMID: 11709560.
    Citations: 161     Fields:    Translation:AnimalsCells
  72. Force T, Pombo CM, Avruch JA, Bonventre JV, Kyriakis JM. Stress-activated protein kinases in cardiovascular disease. Circ Res. 1996 Jun; 78(6):947-53. PMID: 8635244.
    Citations: 28     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.