Harvard Catalyst Profiles

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Justin Chyles Wheat, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wheat JC, Steidl U. Posttranscriptional Arid3a deregulation in AMKL. Blood. 2022 02 03; 139(5):637-638. PMID: 35113150; PMCID: PMC8814683.
    Citations:    Fields:    
  2. Wheat JC, Steidl U. Gene expression at a single-molecule level: implications for myelodysplastic syndromes and acute myeloid leukemia. Blood. 2021 08 26; 138(8):625-636. PMID: 34436525; PMCID: PMC8394909.
    Citations:    Fields:    Translation:Humans
  3. Prieto C, Nguyen DTT, Liu Z, Wheat J, Perez A, Gourkanti S, Chou T, Barin E, Velleca A, Rohwetter T, Chow A, Taggart J, Savino AM, Hoskova K, Dhodapkar M, Schurer A, Barlowe TS, Vu LP, Leslie C, Steidl U, Rabadan R, Kharas MG. Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. Nat Cancer. 2021 07; 2:741-757. PMID: 34458856; PMCID: PMC8388313.
    Citations: 4     Translation:HumansAnimalsCells
  4. Ueda K, Kumari R, Schwenger E, Wheat JC, Bohorquez O, Narayanagari SR, Taylor SJ, Carvajal LA, Pradhan K, Bartholdy B, Todorova TI, Goto H, Sun D, Chen J, Shan J, Song Y, Montagna C, Xiong S, Lozano G, Pellagatti A, Boultwood J, Verma A, Steidl U. MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism. Cancer Cell. 2021 04 12; 39(4):529-547.e7. PMID: 33667384; PMCID: PMC8575661.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Wheat JC, Sella Y, Willcockson M, Skoultchi AI, Bergman A, Singer RH, Steidl U. Single-molecule imaging of transcription dynamics in somatic stem cells. Nature. 2020 07; 583(7816):431-436. PMID: 32581360; PMCID: PMC8577313.
    Citations: 17     Fields:    Translation:AnimalsCells
  6. Healton SE, Pinto HD, Mishra LN, Hamilton GA, Wheat JC, Swist-Rosowska K, Shukeir N, Dou Y, Steidl U, Jenuwein T, Gamble MJ, Skoultchi AI. H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14251-14258. PMID: 32513732; PMCID: PMC7322038.
    Citations: 23     Fields:    Translation:AnimalsCells
  7. Willcockson MA, Taylor SJ, Ghosh S, Healton SE, Wheat JC, Wilson TJ, Steidl U, Skoultchi AI. Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17841-17847. PMID: 31431533; PMCID: PMC6731665.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med. 2018 08 06; 215(8):2211-2226. PMID: 30045946; PMCID: PMC6080905.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Wheat JC, Steidl U. Linking histone methylation, transcription rates, and stem cell robustness. Haematologica. 2018 07; 103(7):1093. PMID: 29970491; PMCID: PMC6029540.
    Citations:    Fields:    Translation:Cells
  10. Carvajal LA, Neriah DB, Senecal A, Benard L, Thiruthuvanathan V, Yatsenko T, Narayanagari SR, Wheat JC, Todorova TI, Mitchell K, Kenworthy C, Guerlavais V, Annis DA, Bartholdy B, Will B, Anampa JD, Mantzaris I, Aivado M, Singer RH, Coleman RA, Verma A, Steidl U. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 04 11; 10(436). PMID: 29643228; PMCID: PMC6130841.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  11. Wheat JC, Steidl U. ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network. Cancer Cell. 2017 03 13; 31(3):307-308. PMID: 28292433.
    Citations:    Fields:    Translation:Humans
  12. Sato H, Wheat JC, Steidl U, Ito K. DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders. Front Oncol. 2016; 6:187. PMID: 27597933; PMCID: PMC4992944.
    Citations: 17     
  13. Wheat JC, Krause DS, Shin TH, Chen X, Wang J, Ding D, Yamin R, Sweetser DA. The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development. PLoS One. 2014; 9(8):e105557. PMID: 25153823.
    Citations: 16     Fields:    Translation:AnimalsCells
  14. Zhang Y, Wang J, Wheat J, Chen X, Jin S, Sadrzadeh H, Fathi AT, Peterson RT, Kung AL, Sweetser DA, Yeh JR. AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ß-catenin signaling pathway. Blood. 2013 Jun 13; 121(24):4906-16. PMID: 23645839; PMCID: PMC3682341.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.