Harvard Catalyst Profiles

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Daniel Leisman, M.D.

Other Positions

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leisman DE, Mehta A, Thompson BT, Hacohen N, Filbin MR, Goldberg MB. Reply To: High Renin Levels in Severe COVID-19 are Indicative for a Hypo-Renin-Angiotensin-System State. Am J Respir Crit Care Med. 2022 Mar 29. PMID: 35348420.
    Citations:    Fields:    
  2. Leisman DE, Mehta A, Thompson BT, Charland NC, Gonye ALK, Gushterova I, Kays KR, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Filbin MR, Goldberg MB. Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. Am J Respir Crit Care Med. 2022 03 01; 205(5):507-519. PMID: 34878969.
    Citations: 2     Fields:    Translation:HumansCells
  3. Taylor MD, Fernandes TD, Yaipen O, Higgins CE, Capone CA, Leisman DE, Nedeljkovic-Kurepa A, Abraham MN, Brewer MR, Deutschman CS. T cell activation and IFN? modulate organ dysfunction in LPS-mediated inflammation. J Leukoc Biol. 2022 Feb 09. PMID: 35141943.
    Citations:    Fields:    
  4. D'Amore J, Meigher S, Patterson E, Sanapala S, Tarr M, Leisman D, Jones M, Moskovitz JB, Offenbacher J, Sperling J. Intubation outcomes and practice trends during the initial New York SARS-COV-19 surge at an academic, level 1 trauma, urban emergency department. J Am Coll Emerg Physicians Open. 2021 Dec; 2(6):e12563. PMID: 34853833.
  5. Leisman DE, Mehta A, Li Y, Kays KR, Li JZ, Filbin MR, Goldberg MB. Vasopressin infusion in COVID-19 critical illness is not associated with impaired viral clearance: a pilot study. Br J Anaesth. 2021 10; 127(4):e146-e148. PMID: 34399981.
    Citations: 1     Fields:    Translation:HumansCells
  6. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroianni F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS. Assessing the importance of interleukin-6 in COVID-19 - Authors' reply. Lancet Respir Med. 2021 02; 9(2):e14-e15. PMID: 33460572.
    Citations: 2     Fields:    Translation:HumansCells
  7. Leisman DE. The Goldilocks Effect in the ICU-When the Data Speak, but Not the Truth. Crit Care Med. 2020 12; 48(12):1887-1889. PMID: 33255103.
    Citations: 1     Fields:    
  8. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020 12; 8(12):1233-1244. PMID: 33075298.
    Citations: 244     Fields:    Translation:Humans
  9. Mastroianni F, Leisman DE, Fisler G, Narasimhan M. General and Intensive Care Outcomes for Hospitalized Patients With Solid Organ Transplants With COVID-19. J Intensive Care Med. 2021 Apr; 36(4):494-499. PMID: 33034239.
    Citations: 1     Fields:    Translation:HumansCells
  10. Leisman DE, Mastroianni F, Fisler G, Shah S, Hasan Z, Narasimhan M, Taylor MD, Deutschman CS. Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019-Induced Vasodilatory Shock: A Retrospective Matched Cohort Study. Crit Care Explor. 2020 Oct; 2(10):e0230. PMID: 33063034.
    Citations: 4     
  11. Trikha R, Greig D, Kelley BV, Mamouei Z, Sekimura T, Cevallos N, Olson T, Chaudry A, Magyar C, Leisman D, Stavrakis A, Yeaman MR, Bernthal NM. Inhibition of Angiotensin Converting Enzyme Impairs Anti-staphylococcal Immune Function in a Preclinical Model of Implant Infection. Front Immunol. 2020; 11:1919. PMID: 33042111.
    Citations:    Fields:    Translation:AnimalsCells
  12. Leisman DE, Fernandes TD, Bijol V, Abraham MN, Lehman JR, Taylor MD, Capone C, Yaipan O, Bellomo R, Deutschman CS. Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury. Kidney Int. 2021 01; 99(1):148-160. PMID: 32882263.
    Citations: 5     Fields:    Translation:HumansAnimals
  13. Abraham MN, Kelly AP, Brandwein AB, Fernandes TD, Leisman DE, Taylor MD, Brewer MR, Capone CA, Deutschman CS. Use of Organ Dysfunction as a Primary Outcome Variable Following Cecal Ligation and Puncture: Recommendations for Future Studies. Shock. 2020 08; 54(2):168-182. PMID: 31764625.
    Citations: 2     Fields:    Translation:HumansAnimals
  14. Leisman DE, Harhay MO, Lederer DJ, Abramson M, Adjei AA, Bakker J, Ballas ZK, Barreiro E, Bell SC, Bellomo R, Bernstein JA, Branson RD, Brusasco V, Chalmers JD, Chokroverty S, Citerio G, Collop NA, Cooke CR, Crapo JD, Donaldson G, Fitzgerald DA, Grainger E, Hale L, Herth FJ, Kochanek PM, Marks G, Moorman JR, Ost DE, Schatz M, Sheikh A, Smyth AR, Stewart I, Stewart PW, Swenson ER, Szymusiak R, Teboul JL, Vincent JL, Wedzicha JA, Maslove DM. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Crit Care Med. 2020 05; 48(5):623-633. PMID: 32141923.
    Citations: 53     Fields:    Translation:Humans
  15. Leisman DE, Deutschman CS, Legrand M. Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med. 2020 06; 46(6):1105-1108. PMID: 32347323.
    Citations: 127     Fields:    Translation:HumansCellsPHPublic Health
  16. Leisman DE, Angel C, Schneider SM, D'Amore JA, D'Angelo JK, Doerfler ME. Sepsis Presenting in Hospitals versus Emergency Departments: Demographic, Resuscitation, and Outcome Patterns in a Multicenter Retrospective Cohort. J Hosp Med. 2019 06 01; 14(6):340-348. PMID: 30986182.
    Citations: 2     Fields:    Translation:Humans
  17. Leisman DE. Ten Pearls and Pitfalls of Propensity Scores in Critical Care Research: A Guide for Clinicians and Researchers. Crit Care Med. 2019 02; 47(2):176-185. PMID: 30543566.
    Citations: 11     Fields:    Translation:Humans
  18. Maslove DM, Leisman DE. Causal Inference From Observational Data: New Guidance From Pulmonary, Critical Care, and Sleep Journals. Crit Care Med. 2019 01; 47(1):1-2. PMID: 30557240.
    Citations: 6     Fields:    Translation:Humans
  19. Baber U, Leisman DE, Cohen DJ, Gibson CM, Henry TD, Dangas G, Moliterno D, Kini A, Krucoff M, Colombo A, Chieffo A, Sartori S, Witzenbichler B, Steg PG, Pocock SJ, Mehran R. Tailoring Antiplatelet Therapy Intensity to Ischemic and Bleeding Risk. Circ Cardiovasc Qual Outcomes. 2019 01; 12(1):e004945. PMID: 30606052.
    Citations: 4     Fields:    Translation:Humans
  20. Leisman DE. What Do ICU Clinicians Really Need to Know About Statistics: Time to Give Up or Time to Bridge the Gap Between the Evidence and the Reader? Crit Care Med. 2018 12; 46(12):2052-2054. PMID: 30444812.
    Citations:    Fields:    Translation:Humans
  21. Leisman DE, Doerfler ME, Schneider SM, D'Amore JA, D'Angelo JK. The authors reply. Crit Care Med. 2018 08; 46(8):e817-e818. PMID: 30004978.
    Citations:    Fields:    Translation:Humans
  22. Leisman DE. Rare Events in the ICU: An Emerging Challenge in Classification and Prediction. Crit Care Med. 2018 03; 46(3):418-424. PMID: 29474323.
    Citations: 13     Fields:    Translation:Humans
  23. Leisman DE, Doerfler ME, Schneider SM, Masick KD, D'Amore JA, D'Angelo JK. Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock. Crit Care Med. 2018 02; 46(2):189-198. PMID: 29112081.
    Citations: 18     Fields:    Translation:Humans
  24. Leisman DE, Goldman C, Doerfler ME, Masick KD, Dries S, Hamilton E, Narasimhan M, Zaidi G, D'Amore JA, D'Angelo JK. Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort. Crit Care Med. 2017 Oct; 45(10):1596-1606. PMID: 28671898.
    Citations: 23     Fields:    Translation:Humans
  25. Leisman DE, Sethna CB. Renin-Angiotensin-Aldosterone System Blockade Use in Sepsis Patients: Did It Impact Renal Outcomes? Crit Care Med. 2017 06; 45(6):e624. PMID: 28509750.
    Citations:    Fields:    Translation:Humans
  26. Leisman D, Huang V, Zhou Q, Gribben J, Bianculli A, Bernshteyn M, Ward MF, Schneider SM. Delayed Second Dose Antibiotics for Patients Admitted From the Emergency Department With Sepsis: Prevalence, Risk Factors, and Outcomes. Crit Care Med. 2017 Jun; 45(6):956-965. PMID: 28328652.
    Citations: 12     Fields:    Translation:Humans
  27. Leisman DE, Doerfler ME, Ward MF, Masick KD, Wie BJ, Gribben JL, Hamilton E, Klein Z, Bianculli AR, Akerman MB, D'Angelo JK, D'Amore JA. Survival Benefit and Cost Savings From Compliance With a Simplified 3-Hour Sepsis Bundle in a Series of Prospective, Multisite, Observational Cohorts. Crit Care Med. 2017 Mar; 45(3):395-406. PMID: 27941371.
    Citations: 25     Fields:    Translation:Humans
  28. Leisman DE, Zemmel D'Amore JA, Gribben JL, Ward MF, Masick KD, Bianculli AR, Bradburn KH, D'Angelo JK, Doerfler ME. Early sepsis bundle compliance for non-hypotensive patients with intermediate versus severe hyperlactemia. Am J Emerg Med. 2017 Jun; 35(6):811-818. PMID: 28126452.
    Citations: 4     Fields:    Translation:Humans
  29. Leisman DE, Ward MF, D'Amore JA, Doerfler ME. In reply. Ann Emerg Med. 2016 10; 68(4):526-7. PMID: 27666357.
    Citations:    Fields:    
  30. Sethna CB, Leisman DE. Left Ventricular Hypertrophy in Children with Hypertension: in Search of a Definition. Curr Hypertens Rep. 2016 08; 18(8):65. PMID: 27402014.
    Citations: 3     Fields:    Translation:Humans
  31. Leisman D, Wie B, Doerfler M, Bianculli A, Ward MF, Akerman M, D'Angelo JK, Zemmel D'Amore JA. Association of Fluid Resuscitation Initiation Within 30 Minutes of Severe Sepsis and Septic Shock Recognition With Reduced Mortality and Length of Stay. Ann Emerg Med. 2016 09; 68(3):298-311. PMID: 27085369.
    Citations: 17     Fields:    Translation:Humans
  32. Kriplani DS, Sethna CB, Leisman DE, Schneider JB. Acute Kidney Injury in Neonates in the PICU. Pediatr Crit Care Med. 2016 Apr; 17(4):e159-64. PMID: 26863481.
    Citations: 4     Fields:    Translation:Humans
  33. Leisman D, Meyers M, Schnall J, Chorny N, Frank R, Infante L, Sethna CB. Blood pressure variability in children with primary vs secondary hypertension. J Clin Hypertens (Greenwich). 2014 Jun; 16(6):437-41. PMID: 24766484.
    Citations: 5     Fields:    Translation:Humans
  34. Mirchandani D, Bhatia J, Leisman D, Kwon EN, Cooper R, Chorny N, Frank R, Infante L, Sethna C. Concordance of measures of left-ventricular hypertrophy in pediatric hypertension. Pediatr Cardiol. 2014 Apr; 35(4):622-6. PMID: 24253610.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.