Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Liron Bar-Peled, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA256082 (BAR-PELED, LIRON) Mar 1, 2021 - Feb 28, 2024
    Chemical Proteomic Identification of Druggable Oncogenic Transcription Factors
    Role: Principal Investigator
  2. R00CA215249 (BAR-PELED, LIRON) Apr 1, 2017 - Feb 28, 2022
    Mapping druggable co-dependency pathways in NRF2-driven lung cancers
    Role: Principal Investigator
  3. K99CA215249 (BAR-PELED, LIRON) Apr 1, 2017 - Mar 31, 2019
    Mapping druggable co-dependency pathways in NRF2-driven lung cancers
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bar-Peled L, Lamming DW. mTOR gets greasy: lysosomal sensing of cholesterol. Cell Res. 2022 Oct 25. PMID: 36284233.
    Citations:    Fields:    
  2. Bar-Peled L, Kory N. Principles and functions of metabolic compartmentalization. Nat Metab. 2022 10; 4(10):1232-1244. PMID: 36266543.
    Citations:    Fields:    Translation:HumansCells
  3. Tanaka N, Lin JJ, Li C, Ryan MB, Zhang J, Kiedrowski LA, Michel AG, Syed MU, Fella KA, Sakhi M, Baiev I, Juric D, Gainor JF, Klempner SJ, Lennerz JK, Siravegna G, Bar-Peled L, Hata AN, Heist RS, Corcoran RB. Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation. Cancer Discov. 2021 08; 11(8):1913-1922. PMID: 33824136; PMCID: PMC8338755.
    Citations: 40     Fields:    Translation:Humans
  4. Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry. 2020 05 19; 59(19):1793-1799. PMID: 32364701.
    Citations: 7     Fields:    Translation:AnimalsCells
  5. Raffeiner P, Hart JR, García-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6571-6579. PMID: 32156728.
    Citations: 13     Fields:    Translation:HumansCells
  6. Zhang J, Bar-Peled L. How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing. Cell Chem Biol. 2019 09 19; 26(9):1195-1196. PMID: 31539502.
    Citations:    Fields:    
  7. Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. FEBS Open Bio. 2019 09; 9(9):1589-1602. PMID: 31314152; PMCID: PMC6722880.
    Citations: 2     Fields:    Translation:HumansCells
  8. Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nat Chem Biol. 2019 05; 15(5):453-462. PMID: 30911178.
    Citations: 14     Fields:    Translation:AnimalsCells
  9. Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Elife. 2018 11 27; 7. PMID: 30479271.
    Citations: 23     Fields:    Translation:AnimalsCells
  10. Lamming DW, Bar-Peled L. Lysosome: The metabolic signaling hub. Traffic. 2019 01; 20(1):27-38. PMID: 30306667; PMCID: PMC6294686.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  11. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. PMID: 28965760.
    Citations: 67     Fields:    Translation:HumansCells
  12. Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. Cell Rep. 2015 Sep 01; 12(9):1445-55. PMID: 26299971; PMCID: PMC4570232.
    Citations: 20     Fields:    Translation:HumansCells
  13. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94. PMID: 25567906; PMCID: PMC4295826.
    Citations: 371     Fields:    Translation:HumansCells
  14. Bar-Peled L. Science & SciLifeLab Prize Essay. Size does matter. Science. 2014 Dec 05; 346(6214):1191-2. PMID: 25477447.
    Citations:    Fields:    Translation:AnimalsCells
  15. Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 09; 9(1):1-8. PMID: 25263562; PMCID: PMC4223866.
    Citations: 192     Fields:    Translation:HumansCells
  16. Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends Cell Biol. 2014 Jul; 24(7):400-6. PMID: 24698685; PMCID: PMC4074565.
    Citations: 360     Fields:    Translation:HumansAnimalsCells
  17. Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21; 52(4):495-505. PMID: 24095279; PMCID: PMC3867817.
    Citations: 262     Fields:    Translation:HumansCells
  18. Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31; 340(6136):1100-6. PMID: 23723238; PMCID: PMC3728654.
    Citations: 430     Fields:    Translation:HumansCells
  19. Bar-Peled L, Sabatini DM. SnapShot: mTORC1 signaling at the lysosomal surface. Cell. 2012 Dec 07; 151(6):1390-1390.e1. PMID: 23217718.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  20. Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012 Sep 14; 150(6):1196-208. PMID: 22980980; PMCID: PMC3517996.
    Citations: 431     Fields:    Translation:HumansAnimalsCells
  21. Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 2011 Nov 04; 334(6056):678-83. PMID: 22053050; PMCID: PMC3211112.
    Citations: 778     Fields:    Translation:HumansAnimalsCells
  22. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16; 141(2):290-303. PMID: 20381137; PMCID: PMC3024592.
    Citations: 1121     Fields:    Translation:HumansAnimalsCells
  23. Yang T, Bar-Peled L, Gebhart L, Lee SG, Bar-Peled M. Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase. J Biol Chem. 2009 Aug 07; 284(32):21526-35. PMID: 19509290.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13; 320(5882):1496-501. PMID: 18497260; PMCID: PMC2475333.
    Citations: 1234     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Bar-Peled's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (123)
Co-Authors (17)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.