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Liron Bar-Peled, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00CA215249 (BAR-PELED, LIRON) Apr 1, 2017 - Feb 28, 2022
    NIH/NCI
    Mapping druggable co-dependency pathways in NRF2-driven lung cancers
    Role: Principal Investigator
  2. K99CA215249 (BAR-PELED, LIRON) Apr 1, 2017 - Mar 31, 2019
    NIH/NCI
    Mapping druggable co-dependency pathways in NRF2-driven lung cancers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nat Chem Biol. 2019 05; 15(5):453-462. PMID: 30911178.
    Citations:    
  2. Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Elife. 2018 11 27; 7. PMID: 30479271.
    Citations:    
  3. Lamming DW, Bar-Peled L. Lysosome: The metabolic signaling hub. Traffic. 2019 01; 20(1):27-38. PMID: 30306667.
    Citations:    
  4. Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19; 171(3):696-709.e23. PMID: 28965760.
    Citations:    
  5. Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. Cell Rep. 2015 Sep 01; 12(9):1445-55. PMID: 26299971.
    Citations:    
  6. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94. PMID: 25567906.
    Citations: 154     Fields:    Translation:HumansCells
  7. Bar-Peled L. Science & SciLifeLab Prize Essay. Size does matter. Science. 2014 Dec 05; 346(6214):1191-2. PMID: 25477447.
    Citations:    
  8. Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Rep. 2014 Oct 09; 9(1):1-8. PMID: 25263562.
    Citations: 83     Fields:    Translation:HumansCells
  9. Bar-Peled L, Sabatini DM. Regulation of mTORC1 by amino acids. Trends Cell Biol. 2014 Jul; 24(7):400-6. PMID: 24698685.
    Citations:    
  10. Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013 Nov 21; 52(4):495-505. PMID: 24095279.
    Citations:    
  11. Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013 May 31; 340(6136):1100-6. PMID: 23723238.
    Citations: 223     Fields:    Translation:HumansCells
  12. Bar-Peled L, Sabatini DM. SnapShot: mTORC1 signaling at the lysosomal surface. Cell. 2012 Dec 07; 151(6):1390-1390.e1. PMID: 23217718.
    Citations:    
  13. Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012 Sep 14; 150(6):1196-208. PMID: 22980980.
    Citations:    
  14. Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 2011 Nov 04; 334(6056):678-83. PMID: 22053050.
    Citations: 441     Fields:    Translation:HumansAnimalsCells
  15. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16; 141(2):290-303. PMID: 20381137.
    Citations: 687     Fields:    Translation:HumansAnimalsCells
  16. Yang T, Bar-Peled L, Gebhart L, Lee SG, Bar-Peled M. Identification of galacturonic acid-1-phosphate kinase, a new member of the GHMP kinase superfamily in plants, and comparison with galactose-1-phosphate kinase. J Biol Chem. 2009 Aug 07; 284(32):21526-35. PMID: 19509290.
    Citations:    
  17. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13; 320(5882):1496-501. PMID: 18497260.
    Citations: 783     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.