Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Hideko Isozaki, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Harada D, Isozaki H, Kozuki T, Yokoyama T, Yoshioka H, Bessho A, Hosokawa S, Takata I, Takigawa N, Hotta K, Kiura K. Crizotinib for recurring non-small-cell lung cancer with EML4-ALK fusion genes previously treated with alectinib: A phase II trial. Thorac Cancer. 2021 03; 12(5):643-649. PMID: 33470536.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  2. Piotrowska Z, Isozaki H, Lennerz JK, Gainor JF, Lennes IT, Zhu VW, Marcoux N, Banwait MK, Digumarthy SR, Su W, Yoda S, Riley AK, Nangia V, Lin JJ, Nagy RJ, Lanman RB, Dias-Santagata D, Mino-Kenudson M, Iafrate AJ, Heist RS, Shaw AT, Evans EK, Clifford C, Ou SI, Wolf B, Hata AN, Sequist LV. Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion. Cancer Discov. 2018 12; 8(12):1529-1539. PMID: 30257958; PMCID: PMC6279502.
    Citations: 133     Fields:    Translation:HumansCells
  3. Isozaki H, Hotta K, Ichihara E, Takigawa N, Ohashi K, Kubo T, Ninomiya T, Ninomiya K, Oda N, Yoshioka H, Ichikawa H, Inoue M, Takata I, Shibayama T, Kuyama S, Sugimoto K, Harada D, Harita S, Sendo T, Tanimoto M, Kiura K. Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non-Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405). Clin Lung Cancer. 2016 11; 17(6):602-605. PMID: 27405684.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  4. Ochi N, Isozaki H, Takeyama M, Singer JW, Yamane H, Honda Y, Kiura K, Takigawa N. Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer. Exp Cell Res. 2016 06 10; 344(2):194-200. PMID: 27180268.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Isozaki H, Ichihara E, Takigawa N, Ohashi K, Ochi N, Yasugi M, Ninomiya T, Yamane H, Hotta K, Sakai K, Matsumoto K, Hosokawa S, Bessho A, Sendo T, Tanimoto M, Kiura K. Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases. Cancer Res. 2016 Mar 15; 76(6):1506-16. PMID: 26719536.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  6. Minami D, Takigawa N, Kato Y, Kudo K, Isozaki H, Hashida S, Harada D, Ochi N, Fujii M, Kubo T, Ohashi K, Sato A, Tanaka T, Hotta K, Tabata M, Toyooka S, Tanimoto M, Kiura K. Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model. Cancer Sci. 2015 Oct; 106(10):1296-302. PMID: 26211743.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Isozaki H, Takigawa N, Kiura K. Mechanisms of Acquired Resistance to ALK Inhibitors and the Rationale for Treating ALK-positive Lung Cancer. Cancers (Basel). 2015 Apr 30; 7(2):763-83. PMID: 25941796; PMCID: PMC4491683.
    Citations: 19     
  8. Yamane H, Isozaki H, Takeyama M, Ochi N, Kudo K, Honda Y, Yamagishi T, Kubo T, Kiura K, Takigawa N. Programmed cell death protein 1 and programmed death-ligand 1 are expressed on the surface of some small-cell lung cancer lines. Am J Cancer Res. 2015; 5(4):1553-7. PMID: 26101718; PMCID: PMC4473331.
    Citations: 11     
  9. Ochi N, Yamane H, Hotta K, Fujii H, Isozaki H, Honda Y, Yamagishi T, Kubo T, Tanimoto M, Kiura K, Takigawa N. Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation. Drug Des Devel Ther. 2014; 8:2401-8. PMID: 25584019.
    Citations: 1     Fields:    Translation:Humans
  10. Yamane H, Ochi N, Isozaki H, Yamagishi T, Honda Y, Takigawa N. Skin involvement in diffuse large B-cell lymphoma detected using positron emission tomography. Thorac Cancer. 2014 Nov; 5(6):581-2. PMID: 26767056.
    Citations:    Fields:    
  11. Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K. A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene. Jpn J Clin Oncol. 2014 Oct; 44(10):963-8. PMID: 25170107.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Takashima H, Matsumoto Y, Matsubara N, Shirakawa Y, Kawashima R, Tanino M, Ito S, Isozaki H, Ouchida M, Meltzer SJ, Shimizu K, Tanaka N. Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells. Lab Invest. 2001 Nov; 81(11):1565-73. PMID: 11706064.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T, Isozaki H, Sharp GB, Shimizu K, Jass J, Tanaka N. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Res. 2001 Nov 01; 61(21):7743-6. PMID: 11691787.
    Citations: 12     Fields:    Translation:HumansCells
  14. Nakao A, Naomoto Y, Shigemitsu K, Shirakawa Y, Yamatsuji T, Haisa M, Takaoka M, Isozaki H, Ohara N, Notohara K, Tanaka N. Leiomyosarcoma arising in a remnant esophagus after esophagectomy: a case report. Jpn J Clin Oncol. 2001 Oct; 31(10):517-21. PMID: 11696624.
    Citations: 1     Fields:    Translation:Humans
  15. Isozaki H, Tanaka N, Fujii K, Tanigawa N, Okajima K. Improvement of the prognosis of gastric cancer with extensive serosal invasion using left upper abdominal evisceration. Hepatogastroenterology. 2001 Jul-Aug; 48(40):1179-82. PMID: 11490828.
    Citations:    Fields:    Translation:Humans
  16. Chen L, Matsubara N, Yoshino T, Nagasaka T, Hoshizima N, Shirakawa Y, Naomoto Y, Isozaki H, Riabowol K, Tanaka N. Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer. Cancer Res. 2001 Jun 01; 61(11):4345-9. PMID: 11389058.
    Citations: 26     Fields:    Translation:HumansCells
  17. Nakao A, Naomoto Y, Kataoka M, Haisa M, Kataoka K, Saitoh S, Fujiwara T, Yamatsuji T, Shigemitsu K, Umeoka T, Isozaki H, Futami H, Yamaguchi K, Tanaka N. A family of multiple endocrine neoplasia type 2A with the RET proto-oncogene mutation in codon 618 (Cys-->Arg). Jpn J Clin Oncol. 2001 Apr; 31(4):157-61. PMID: 11386462.
    Citations: 2     Fields:    Translation:Humans
  18. Koguchi K, Matsubara N, Hamazaki K, Nowak G, Isozaki H, Tanaka N. Effect of translocation of cirrhotic liver on hepatic venous hemoglobin oxygen saturation during hepatectomy. Hepatogastroenterology. 2001 Jan-Feb; 48(37):174-8. PMID: 11268959.
    Citations:    Fields:    Translation:Humans
  19. Noguchi H, Naomoto Y, Kondo H, Haisa M, Yamatsuji T, Shigemitsu K, Aoki H, Isozaki H, Tanaka N. Evaluation of endoscopic mucosal resection for superficial esophageal carcinoma. Surg Laparosc Endosc Percutan Tech. 2000 Dec; 10(6):343-50. PMID: 11147906.
    Citations: 15     Fields:    Translation:Humans
  20. Nakao A, Iwagaki H, Yoshino T, Jikuhara A, Kanagawa T, Kimura T, Matsubara N, Isozaki H, Takakura N, Tanaka N. Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation. Surg Today. 2000; 30(2):117-21. PMID: 10664332.
    Citations:    Fields:    Translation:Humans
  21. Naomoto Y, Sadamori H, Matsukawa H, Shirakawa Y, Yamatsuji T, Saito S, Hino N, Isozaki H, Takakura N, Tanaka N. Multiple liver metastases of breast cancer: report of a case successfully treated with hormone-cytokine-chemotherapy. Jpn J Clin Oncol. 1999 Aug; 29(8):390-4. PMID: 10494924.
    Citations:    Fields:    Translation:Humans
  22. Naomoto Y, Haisa M, Yamatsuji T, Shirakawa Y, Muramatsu T, Isozaki H, Kamikawa Y, Tanaka N. Multiple primary cancers of the esophagus and thyroid gland. Jpn J Clin Oncol. 1999 Jul; 29(7):349-52. PMID: 10470660.
    Citations: 6     Fields:    Translation:Humans
  23. Isozaki H, Tanaka N, Okajima K. General and specific prognostic factors of early gastric carcinoma treated with curative surgery. Hepatogastroenterology. 1999 May-Jun; 46(27):1800-8. PMID: 10430349.
    Citations: 11     Fields:    Translation:Humans
  24. Ohtani M, Isozaki H, Fujii K, Nomura E, Niki M, Mabuchi H, Nishiguchi K, Toyoda M, Ishibashi T, Tanigawa N. Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma. Cancer. 1999 Apr 15; 85(8):1711-8. PMID: 10223564.
    Citations: 18     Fields:    Translation:Humans
  25. Lu CD, Morita S, Ishibashi T, Hara H, Isozaki H, Tanigawa N. Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer. 1999 Mar 15; 85(6):1250-60. PMID: 10189129.
    Citations: 14     Fields:    Translation:Humans
  26. Iwagaki H, Hizuta A, Kohka H, Kobashi K, Nitta Y, Isozaki H, Takakura N, Tanaka N. Circulating levels of soluble CD30 and other markers in colorectal cancer patients. J Med. 1999; 30(1-2):111-21. PMID: 10515247.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  27. Isozaki H, Ohyama T, Mabuchi H. Expression of cell adhesion molecule CD44 and sialyl Lewis A in gastric carcinoma and colorectal carcinoma in association with hepatic metastasis. Int J Oncol. 1998 Nov; 13(5):935-42. PMID: 9772282.
    Citations: 12     Fields:    Translation:Humans
  28. Isozaki H, Fujii K, Nomura E, Mabuchi H, Hara H, Sako S, Nishiguchi K, Ohtani M, Tenjo T, Nohara T, Tanigawa N. Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery. Int J Oncol. 1998 Aug; 13(2):255-9. PMID: 9664119.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.