Harvard Catalyst Profiles

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Daniel Botelho Costa, M.D., Ph.D.

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Biography
1995 - 2000
MD (FMRP-USP, Brazil)
2001 - 2004
Intern and Resident in Internal Medicine (Yale, New Haven, CT)
2004 - 2007
Fellow in Hematology/Oncology (Harvard-BIDMC, Boston, MA)
2004 - 2008
PhD (UNICAMP, Brazil)
2007 - 2009
MMSc - Clinical Investigator Training Program (Harvard Medical School-MIT)
2007 - 2010
Staff Physician and Instructor in Medicine (Harvard-BIDMC)
2010 - 2015
Staff Physician and Assistant Professor of Medicine (Harvard-BIDMC)
2015 - 2024
Staff Physician and Associate Professor of Medicine (Harvard-BIDMC)
2024
Staff Physician and Professor of Medicine (Harvard-BIDMC)

Overview
Lung cancer is the leading cause of death from cancer in the United States. Better understanding of oncogenes and tumor suppressor genes involved in lung cancer hold the promise of improving clinical care of afflicted patients.

Prior work from our group has focused on transcription factors involved in lung cancer and mechanisms of sensitivity/resistance of oncogene kinases (such as EGFR, ALK, ROS1, MET, BRAF, RET, MET, ERBB2, NTRK, KRAS among others) to tyrosine kinase inhibitors in non-small-cell lung cancer.

Our group is also part of the clinical research effort at Dana-Farber/Harvard Cancer Center (DFHCC), with a focus in lung cancer, tumor genomic biomarkers and immune checkpoint inhibitors. We are supported by both federal and non-federal grants, and are part of the NIH/NCI SPORE in Lung Cancer at DFHCC.

One of the main focuses of the DFHCC Lung Cancer Program, in conjunction with the Cancer Clinical Trials Office (CCTO) at Beth Israel Deaconess Medical Center (BIDMC), is to conduct clinical trials that will establish the future evidence-based strategies to manage local, locally advanced and advanced lung cancers.

(co-investigators at BIDMC: Susumu Kobayashi, MD, PhD, Daniel G. Tenen, MD, Sidharta P. Gangadharan, MD; Adnan Majid, MD; Paul A. VanderLaan, MD, PhD and Deepa Rangachari, MD)
(co-investigators at DFCI: Pasi A. Janne, MD, PhD; Michael Eck, MD, PhD; Matthew Meyerson, MD, PhD; David A. Barbie, MD; Mark Awad, MD, PhD; and Bruce E. Johnson, MD)
(co-investigators at MGH: Lecia V. Sequist, MD, MPH; Zofia Piotrowska, MD; Beow Yeap, ScD; and Justin Gainor, MD)

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50CA265826 (BARBIE, DAVID A ;SEQUIST, LECIA V.) Aug 1, 2022 - Jul 31, 2027
    NIH
    Dana Farber/Harvard Cancer Center SPORE in Lung Cancer
    Role Description: Career Enhancement Program
    Role: Co-Investigator
  2. R37CA218707 (COSTA, DANIEL BOTELHO) Feb 1, 2018 - Jan 31, 2025
    NIH/NCI
    Unmet needs for specific subsets of EGFR mutated lung cancer
    Role: Principal Investigator
  3. R01CA218707 (COSTA, DANIEL BOTELHO) Feb 1, 2018 - Jan 31, 2023
    NIH/NCI
    Unmet needs for specific subsets of EGFR mutated lung cancer
    Role: Principal Investigator
  4. R37CA218707 (COSTA, DANIEL BOTELHO) Feb 1, 2018 - Jan 31, 2023
    NIH
    Unmet needs for specific subsets of EGFR mutated lung cancer
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.