Harvard Catalyst Profiles

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Aoi Akitsu, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigi M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Canadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Janne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA. Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity. Cancer Discov. 2021 Mar 11. PMID: 33707236.
    Citations:    Fields:    
  2. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Akitsu A, Iwakura Y. Interleukin-17-producing ?d T (?d17) cells in inflammatory diseases. Immunology. 2018 12; 155(4):418-426. PMID: 30133701.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  4. Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X. T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Nat Immunol. 2016 May; 17(5):583-92. PMID: 26998763.
    Citations: 46     Fields:    Translation:AnimalsCells
  5. Akitsu A, Ishigame H, Kakuta S, Chung SH, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)V?6(+)?d T cells. Nat Commun. 2015 Jun 25; 6:7464. PMID: 26108163.
    Citations: 42     Fields:    Translation:AnimalsCells
  6. Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem Biophys Res Commun. 2014 Oct 10; 453(1):1-6. PMID: 25204502.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Ikeda S, Saijo S, Murayama MA, Shimizu K, Akitsu A, Iwakura Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-ß-induced Foxp3 expression. J Immunol. 2014 Feb 15; 192(4):1449-58. PMID: 24431229.
    Citations: 36     Fields:    Translation:AnimalsCells
  8. Akitsu A, Kakuta S, Saijo S, Iwakura Y. Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis. Exp Anim. 2014; 63(2):235-46. PMID: 24770649.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Akitsu A, Iwakura Y. [IL-17 family and receptor pathway]. Nihon Rinsho. 2012 Nov; 70 Suppl 8:207-11. PMID: 23513838.
    Citations:    Fields:    Translation:HumansCells
  10. Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010 May 28; 32(5):681-91. PMID: 20493731.
    Citations: 289     Fields:    Translation:AnimalsCells
  11. Akama K, Horikoshi T, Sugiyama A, Nakahata S, Akitsu A, Niwa N, Intoh A, Kakui Y, Sugaya M, Takei K, Imaizumi N, Sato T, Matsumoto R, Iwahashi H, Kashiwabara S, Baba T, Nakamura M, Toda T. Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme. Biochim Biophys Acta. 2010 Jun; 1804(6):1272-84. PMID: 20152940.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan 16; 30(1):108-19. PMID: 19144317.
    Citations: 379     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.