Harvard Catalyst Profiles

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Alex Cuenca, M.D.

Title
Institution
Department
Address

Biography
New College of Florida, FloridaBA1997Biolgy
University of Florida, FloridaMD2006Medicine
University of Florida, FloridaPhD2012Immunology

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cuenca AG, Rosales I, Lee RJ, Wu CL, Colvin R, Feldman AS, Efstathiou JA, Tolkoff-Rubin N, Elias N. Resolution of a High Grade and Metastatic BK Polyomavirus-Associated Urothelial Cell Carcinoma Following Radical Allograft Nephroureterectomy and Immune Checkpoint Treatment: A Case Report. Transplant Proc. 2020 Jul 30. PMID: 32741665.
    Citations:    
  2. Bethea E, Arvind A, Gustafson J, Andersson K, Pratt D, Bhan I, Thiim M, Corey K, Bloom P, Markmann J, Yeh H, Elias N, Kimura S, Dageforde LA, Cuenca A, Kawai T, Safa K, Williams W, Gilligan H, Sise M, Fishman J, Kotton C, Kim A, Rogers CC, Shao S, Cote M, Irwin L, Myoung P, Chung RT. Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning. Am J Transplant. 2020 06; 20(6):1619-1628. PMID: 31887236.
    Citations:    
  3. Cuenca AG, Hardy S, Shah U, Lawlor D, Ordulu Z, Sierra Velez D, Olshan K, Butler W, Yeh H. Pediatric liver transplant following near catastrophic head bleed: Lessons learned. Pediatr Transplant. 2020 03; 24(2):e13646. PMID: 31960553.
    Citations:    
  4. Svetanoff WJ, Zendejas B, Demehri FR, Cuenca A, Nath B, Smithers CJ. Giant Gastroschisis with Complete Liver Herniation: A Case Report of Two Patients. Case Rep Surg. 2019; 2019:4136214. PMID: 30775044.
    Citations:    
  5. Cuenca AG, Kim HB, Vakili K. Pediatric liver transplantation. Semin Pediatr Surg. 2017 Aug; 26(4):217-223. PMID: 28964477.
    Citations: 2     Fields:    Translation:Humans
  6. Vanzant EL, Ozrazgat-Baslanti T, Liu H, Malik S, Davis R, Lanz J, Miggins MV, Gentile LF, Cuenca A, Cuenca AG, Lottenberg L, Moore FA, Ang DN, Bihorac A, Efron PA. Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Surg Infect (Larchmt). 2015 Aug; 16(4):421-7. PMID: 26207402.
    Citations:    Fields:    Translation:HumansCells
  7. Gentile LF, Cuenca AL, Cuenca AG, Nacionales DC, Ungaro R, Efron PA, Moldawer LL, Larson SD. Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation. Immunology. 2015 Jun; 145(2):300-11. PMID: 25684123.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Szpila BE, Ozrazgat-Baslanti T, Zhang J, Lanz J, Davis R, Rebel A, Vanzant E, Gentile LF, Cuenca AG, Ang DN, Liu H, Lottenberg L, Marker P, Zumberg M, Bihorac A, Moore FA, Brakenridge S, Efron PA. Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit. PLoS One. 2015; 10(5):e0126895. PMID: 26010247.
    Citations:    Fields:    Translation:Humans
  9. Cuenca AG, Joiner DN, Gentile LF, Cuenca AL, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Behrns KE, Efron PA, Nacionales D, Lui C, Wallet SM, Reeves WH, Mathews CE, Moldawer LL. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015 Feb 01; 194(3):1169-77. PMID: 25548220.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Cuenca AG, Cuenca AL, Gentile LF, Efron PA, Islam S, Moldawer LL, Kays DW, Larson SD. Delayed emergency myelopoiesis following polymicrobial sepsis in neonates. Innate Immun. 2015 May; 21(4):386-91. PMID: 25106654.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Raza A, Cuenca AG, Tan S, Singhal D. Omental flaps for coverage of sacral or gluteal defects: a useful and potentially underused tool. Am Surg. 2014 Jul; 80(7):e202-4. PMID: 24987886.
    Citations:    Fields:    Translation:Humans
  12. Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Baslanti TO, McKinley BA, Bihorac A, Cuschieri J, Maier RV, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med. 2014 Jun; 42(6):1406-13. PMID: 24413577.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  13. Cuenca AG, Cuenca AL, Winfield RD, Joiner DN, Gentile L, Delano MJ, Kelly-Scumpia KM, Scumpia PO, Matheny MK, Scarpace PJ, Vila L, Efron PA, LaFace DM, Moldawer LL. Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia. J Immunol. 2014 Jun 15; 192(12):6111-9. PMID: 24829407.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Szpila BE, Cuenca AG, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Host responses to sepsis vary in different low-lethality murine models. PLoS One. 2014; 9(5):e94404. PMID: 24788351.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Szpila BE, Larson S, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol. 2014 Apr 01; 192(7):3156-65. PMID: 24591376.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  16. Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R, Cuenca AG, Gentile LF, Nacionales DC, Cuenca AL, Bihorac A, Leeuwenburgh C, Lanz J, Baker HV, McKinley B, Moldawer LL, Moore FA, Efron PA. Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. J Trauma Acute Care Surg. 2014 Jan; 76(1):21-9; discussion 29-30. PMID: 24368353.
    Citations: 32     Fields:    Translation:HumansCells
  17. Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, Ungaro R, Li Y, Baslanti TO, Bihorac A, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Efron PA. Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol. 2014 Jan 15; 192(2):612-22. PMID: 24337739.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Gentile LF, Cuenca AG, Vanzant EL, Efron PA, McKinley B, Moore F, Moldawer LL. Is there value in plasma cytokine measurements in patients with severe trauma and sepsis? Methods. 2013 May 15; 61(1):3-9. PMID: 23669589.
    Citations: 10     Fields:    Translation:Humans
  19. Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Baslanti TO, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL. Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med. 2013 May; 41(5):1175-85. PMID: 23388514.
    Citations: 31     Fields:    Translation:HumansCells
  20. Gentile LF, Nacionales DC, Cuenca AG, Armbruster M, Ungaro RF, Abouhamze AS, Lopez C, Baker HV, Moore FA, Ang DN, Efron PA. Identification and description of a novel murine model for polytrauma and shock. Crit Care Med. 2013 Apr; 41(4):1075-85. PMID: 23399937.
    Citations: 16     Fields:    Translation:AnimalsCells
  21. Bihorac A, Baslanti TO, Cuenca AG, Hobson CE, Ang D, Efron PA, Maier RV, Moore FA, Moldawer LL. Acute kidney injury is associated with early cytokine changes after trauma. J Trauma Acute Care Surg. 2013 Apr; 74(4):1005-13. PMID: 23511138.
    Citations: 14     Fields:    Translation:Humans
  22. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12. PMID: 23401516.
    Citations: 798     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Cuenca AG, Wynn JL, Moldawer LL, Levy O. Role of innate immunity in neonatal infection. Am J Perinatol. 2013 Feb; 30(2):105-12. PMID: 23297181.
    Citations: 36     Fields:    Translation:HumansCells
  24. Efron PA, Liu H, Lottenberg L, Cuenca AG, Gentile LF, Miggins MV, Bihorac A, Baker HV, Moore FA, Moldawer LL, Ang DN. A genomic analysis of Clostridium difficile infections in blunt trauma patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):334-8. PMID: 23271108.
    Citations: 1     Fields:    Translation:HumansCells
  25. Armbruster M, Grimley E, Rodriguez J, Nacionales D, Efron P, Moldawer L, Papadopoulos K, Ungaro R, Cuenca A, Simpkins C. Soybean oil: a potentially new intravascular perfusate. Perfusion. 2013 Mar; 28(2):160-6. PMID: 23257679.
    Citations:    
  26. Nacionales DC, Cuenca AG, Ungaro R, Gentile LF, Joiner D, Satoh M, Lomas-Neira J, Ayala A, Bihorac A, Delano MJ, Ang DN, Efron PA. The acute immunological response to blood transfusion is influenced by polymicrobial sepsis. Shock. 2012 Dec; 38(6):598-606. PMID: 23143057.
    Citations: 3     Fields:    Translation:AnimalsCells
  27. Cuenca AG, Islam S. Pediatric pancreatic trauma: trending toward nonoperative management? Am Surg. 2012 Nov; 78(11):1204-10. PMID: 23089435.
    Citations: 5     Fields:    Translation:Humans
  28. Gentile LF, Cuenca AG, Efron PA, Ang D, Bihorac A, McKinley BA, Moldawer LL, Moore FA. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012 Jun; 72(6):1491-501. PMID: 22695412.
    Citations: 115     Fields:    Translation:Humans
  29. Cuenca AG, Moldawer LL. Myeloid-derived suppressor cells in sepsis: friend or foe? Intensive Care Med. 2012 Jun; 38(6):928-30. PMID: 22552587.
    Citations: 8     Fields:    Translation:HumansCells
  30. Cuschieri J, Johnson JL, Sperry J, West MA, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May; 255(5):993-9. PMID: 22470077.
    Citations: 31     Fields:    Translation:Humans
  31. Cuenca AG, Ali AS, Kays DW, Islam S. "Pulling the plug"--management of meconium plug syndrome in neonates. J Surg Res. 2012 Jun 15; 175(2):e43-6. PMID: 22459290.
    Citations: 1     Fields:    Translation:Humans
  32. Winfield RD, Delano MJ, Cuenca AG, Cendan JC, Lottenberg L, Efron PA, Maier RV, Remick DG, Moldawer LL, Cuschieri J. Obese patients show a depressed cytokine profile following severe blunt injury. Shock. 2012 Mar; 37(3):253-6. PMID: 22266966.
    Citations: 7     Fields:    Translation:Humans
  33. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG. A genomic storm in critically injured humans. J Exp Med. 2011 Dec 19; 208(13):2581-90. PMID: 22110166.
    Citations: 264     Fields:    Translation:HumansCellsCTClinical Trials
  34. Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL. Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage. Lab Invest. 2011 Dec; 91(12):1787-95. PMID: 21931299.
    Citations: 12     Fields:    Translation:HumansCells
  35. Cuenca AG, Maier RV, Cuschieri J, Moore EE, Moldawer LL, Tompkins RG. The Glue Grant experience: characterizing the post injury genomic response. Eur J Trauma Emerg Surg. 2011 Dec; 37(6):549-58. PMID: 26815465.
    Citations: 4     Fields:    
  36. Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med. 2011 Aug 01; 208(8):1673-82. PMID: 21746813.
    Citations: 41     Fields:    Translation:AnimalsCells
  37. Delano MJ, Kelly-Scumpia KM, Thayer TC, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O'Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PG, Ramphal R, Strieter RM, Moldawer LL, Efron PA. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol. 2011 Jul 15; 187(2):911-8. PMID: 21690321.
    Citations: 43     Fields:    Translation:AnimalsCells
  38. Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL. Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun. 2011 Jul; 79(7):2746-54. PMID: 21518789.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Cuenca AG, Reddy SV, Dickie B, Kays DW, Islam S. The usefulness of the upper gastrointestinal series in the pediatric patient before anti-reflux procedure or gastrostomy tube placement. J Surg Res. 2011 Oct; 170(2):247-52. PMID: 21550057.
    Citations: 2     Fields:    Translation:Humans
  40. Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O'Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol. 2011 Jan 01; 186(1):195-202. PMID: 21106855.
    Citations: 45     Fields:    Translation:AnimalsCells
  41. Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, Heyworth PG, Efron PA, Moldawer LL. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 2011 Mar-Apr; 17(3-4):281-92. PMID: 21085745.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  42. Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moldawer LL, Efron PA. Cecal ligation and puncture. Curr Protoc Immunol. 2010 Nov; Chapter 19:Unit 19.13. PMID: 21053304.
    Citations: 21     Fields:    Translation:HumansAnimals
  43. Cuenca AG, Moldawer LL. Do Tregs link sepsis to tumor growth? Blood. 2010 Jun 03; 115(22):4324-5. PMID: 20522717.
    Citations: 1     Fields:    
  44. Scumpia PO, Kelly-Scumpia KM, Delano MJ, Weinstein JS, Cuenca AG, Al-Quran S, Bovio I, Akira S, Kumagai Y, Moldawer LL. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J Immunol. 2010 Mar 01; 184(5):2247-51. PMID: 20130216.
    Citations: 54     Fields:    Translation:AnimalsCells
  45. Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010 Feb 15; 207(2):319-26. PMID: 20071504.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  46. Copeland DR, St Peter SD, Sharp SW, Islam S, Cuenca A, Tolleson JS, Dassinger MS, Little DC, Jackson RJ, Kokoska ER, Smith SD. Diminishing role of contrast enema in simple meconium ileus. J Pediatr Surg. 2009 Nov; 44(11):2130-2. PMID: 19944221.
    Citations: 5     Fields:    Translation:Humans
  47. Cuenca AG, Wiggins A, Chen MK, Kays DW, Islam S, Beierle EA. Equestrian injuries in children. J Pediatr Surg. 2009 Jan; 44(1):148-50. PMID: 19159733.
    Citations: 6     Fields:    Translation:HumansAnimals
  48. Cuenca AG, Beierle EA. Pulmonary surgery in cystic fibrosis. Semin Pediatr Surg. 2008 Feb; 17(1):60-5. PMID: 18158143.
    Citations:    Fields:    Translation:Humans
  49. Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG, Grobmyer SR. Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer. 2006 Aug 01; 107(3):459-66. PMID: 16795065.
    Citations: 66     Fields:    Translation:HumansAnimals
  50. Horna P, Cuenca A, Cheng F, Brayer J, Wang HW, Borrello I, Levitsky H, Sotomayor EM. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood. 2006 Apr 01; 107(7):2871-8. PMID: 16339406.
    Citations: 19     Fields:    Translation:AnimalsCells
  51. Wang H, Cheng F, Cuenca A, Horna P, Zheng Z, Bhalla K, Sotomayor EM. Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance. Blood. 2005 Feb 01; 105(3):1135-43. PMID: 15454486.
    Citations: 29     Fields:    Translation:AnimalsCells
  52. Cuenca A, Cheng F, Wang H, Brayer J, Horna P, Gu L, Bien H, Borrello IM, Levitsky HI, Sotomayor EM. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res. 2003 Dec 15; 63(24):9007-15. PMID: 14695219.
    Citations: 36     Fields:    Translation:AnimalsCells
  53. Cheng F, Wang HW, Cuenca A, Huang M, Ghansah T, Brayer J, Kerr WG, Takeda K, Akira S, Schoenberger SP, Yu H, Jove R, Sotomayor EM. A critical role for Stat3 signaling in immune tolerance. Immunity. 2003 Sep; 19(3):425-36. PMID: 14499117.
    Citations: 106     Fields:    Translation:AnimalsCells
  54. Sotomayor EM, Borrello I, Rattis FM, Cuenca AG, Abrams J, Staveley-O'Carroll K, Levitsky HI. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. 2001 Aug 15; 98(4):1070-7. PMID: 11493453.
    Citations:    
  55. Sebastian A, Cuenca A, Li SF, Carlson J, Lancaster M, Cardello J, Nour B, Katz E. Pancreas transplant graft evaluation using the MIBI scan--a useful tool. Transplant Proc. 1998 Mar; 30(2):257-60. PMID: 9532022.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.