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John Thomas O'Malley, M.D., Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blauvelt A, Guttman-Yassky E, Paller AS, Simpson EL, Cork MJ, Weisman J, Browning J, Soong W, Sun X, Chen Z, Kosloski MP, Kamal MA, Delevry D, Chuang CC, O'Malley JT, Bansal A. Long-Term Efficacy and Safety of Dupilumab in Adolescents with Moderate-to-Severe Atopic Dermatitis: Results Through Week 52 from a Phase III Open-Label Extension Trial (LIBERTY AD PED-OLE). Am J Clin Dermatol. 2022 May; 23(3):365-383. PMID: 35567671; PMCID: PMC9142443.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  2. Beck LA, Deleuran M, Bissonnette R, de Bruin-Weller M, Galus R, Nakahara T, Seo SJ, Khokhar FA, Vakil J, Xiao J, Marco AR, Levit NA, O'Malley JT, Shabbir A. Dupilumab Provides Acceptable Safety and Sustained Efficacy for up to 4 Years in an Open-Label Study of Adults with Moderate-to-Severe Atopic Dermatitis. Am J Clin Dermatol. 2022 May; 23(3):393-408. PMID: 35503163; PMCID: PMC9063621.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  3. Matos TR, Gehad A, Teague JE, Dyring-Andersen B, Benezeder T, Dowlatshahi M, Crouch J, Watanabe Y, O'Malley JT, Kupper TS, Yang C, Watanabe R, Clark RA. Central memory T cells are the most effective precursors of resident memory T cells in human skin. Sci Immunol. 2022 04 22; 7(70):eabn1889. PMID: 35452256; PMCID: PMC9435065.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Zhao Y, Wu L, Lu Q, Gao X, Zhu X, Yao X, Li L, Li W, Ding Y, Song Z, Liu L, Dang N, Zhang C, Liu X, Gu J, Wang J, Geng S, Liu Q, Guo Y, Dong L, Su H, Bai L, O'Malley JT, Luo J, Laws E, Mannent L, Ruddy M, Amin N, Bansal A, Ota T, Wang M, Zhang J. The efficacy and safety of dupilumab in Chinese patients with moderate-to-severe atopic dermatitis: a randomized, double-blind, placebo-controlled study. Br J Dermatol. 2022 04; 186(4):633-641. PMID: 34358343; PMCID: PMC9298048.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  5. Paller AS, Wollenberg A, Siegfried E, Thaçi D, Cork MJ, Arkwright PD, Gooderham M, Sun X, O'Malley JT, Khokhar FA, Vakil J, Bansal A, Rosner K, Shumel B, Levit NA. Laboratory Safety of Dupilumab in Patients Aged 6-11 Years with Severe Atopic Dermatitis: Results from a Phase III Clinical Trial. Paediatr Drugs. 2021 Sep; 23(5):515-527. PMID: 34462864; PMCID: PMC8418591.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  6. Cork MJ, Thaçi D, Eichenfield LF, Arkwright PD, Sun X, Chen Z, Akinlade B, Boklage S, Guillemin I, Kosloski MP, Kamal MA, O'Malley JT, Patel N, Graham NMH, Bansal A. Dupilumab provides favourable long-term safety and efficacy in children aged = 6 to < 12 years with uncontrolled severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study. Br J Dermatol. 2021 05; 184(5):857-870. PMID: 32969489.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  7. Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O'Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS. Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest. 2020 09 01; 130(9):4624-4636. PMID: 32516138; PMCID: PMC7456221.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  8. Paller AS, Siegfried EC, Thaçi D, Wollenberg A, Cork MJ, Arkwright PD, Gooderham M, Beck LA, Boguniewicz M, Sher L, Weisman J, O'Malley JT, Patel N, Hardin M, Graham NMH, Ruddy M, Sun X, Davis JD, Kamal MA, Khokhar FA, Weinreich DM, Yancopoulos GD, Beazley B, Bansal A, Shumel B. Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: A randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020 Nov; 83(5):1282-1293. PMID: 32574587.
    Citations: 37     Fields:    Translation:HumansCTClinical Trials
  9. Hirner JP, O'Malley JT, LeBoeuf NR. Blastic Plasmacytoid Dendritic Cell Neoplasm: The Dermatologist's Perspective. Hematol Oncol Clin North Am. 2020 06; 34(3):501-509. PMID: 32336415.
    Citations: 1     Fields:    Translation:HumansCells
  10. O'Malley JT, de Masson A, Lowry EL, Giobbie-Hurder A, LeBoeuf NR, Larocca C, Gehad A, Seger E, Teague JE, Fisher DC, Kupper TS, Devlin PM, Clark RA. Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides. Clin Cancer Res. 2020 01 15; 26(2):408-418. PMID: 31636100.
    Citations: 1     Fields:    Translation:HumansCells
  11. O'Malley JT, Clark RA, Widlund HR. Skin Inflammation in Human Health and Disease: 2018 International Conference. J Invest Dermatol. 2019 05; 139(5):991-994. PMID: 30684557.
    Citations:    Fields:    Translation:Humans
  12. Vieyra-Garcia P, Crouch JD, O'Malley JT, Seger EW, Yang CH, Teague JE, Vromans AM, Gehad A, Win TS, Yu Z, Lowry EL, Na JI, Rook AH, Wolf P, Clark RA. Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma. JCI Insight. 2019 Jan 10; 4(1). PMID: 30626755; PMCID: PMC6485670.
    Citations: 19     Fields:    
  13. Wu PZ, Liberman LD, Bennett K, de Gruttola V, O'Malley JT, Liberman MC. Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear. Neuroscience. 2019 05 21; 407:8-20. PMID: 30099118; PMCID: PMC6369025.
    Citations: 107     Fields:    Translation:HumansCellsPHPublic Health
  14. de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS. High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 05 09; 10(440). PMID: 29743350; PMCID: PMC6366329.
    Citations: 30     Fields:    Translation:HumansCells
  15. Singer SB, Thomas C, Lezcano C, Robbins M, Gordian A, Nori S, Granter SR, Merola JF, O'Malley JT. Polyarthralgias and Papulonodules in a 56-Year-Old Woman. Arthritis Care Res (Hoboken). 2018 06; 70(6):925-930. PMID: 29342504.
    Citations:    Fields:    Translation:Humans
  16. Gehad A, Teague JE, Matos TR, Huang V, Yang C, Watanabe R, O'Malley JT, Trimble CL, Kupper TS, Clark RA. A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018 02 13; 2(3):292-298. PMID: 29437556; PMCID: PMC5812324.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Tamez RL, Tan WV, O'Malley JT, Broder KR, Garzon MC, LaRussa P, Lauren CT. Influenza B virus infection and Stevens-Johnson syndrome. Pediatr Dermatol. 2018 Jan; 35(1):e45-e48. PMID: 29282756; PMCID: PMC6628912.
    Citations: 4     Fields:    Translation:HumansCells
  18. Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS. Staged development of long-lived T-cell receptor aß TH17 resident memory T-cell population to Candida albicans after skin infection. J Allergy Clin Immunol. 2018 08; 142(2):647-662. PMID: 29128674; PMCID: PMC5943196.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  19. Matos TR, O'Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA. Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing aß T cell clones. J Clin Invest. 2017 Nov 01; 127(11):4031-4041. PMID: 28945199; PMCID: PMC5663366.
    Citations: 75     Fields:    Translation:HumansCells
  20. Sauder MB, O'Malley JT, LeBoeuf NR. CD30+ Lymphoproliferative Disorders of the Skin. Hematol Oncol Clin North Am. 2017 04; 31(2):317-334. PMID: 28340881; PMCID: PMC5776746.
    Citations: 5     Fields:    Translation:Humans
  21. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  22. Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV. Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant. 2016 07; 16(7):2158-71. PMID: 26749226; PMCID: PMC4979599.
    Citations: 15     Fields:    Translation:HumansCells
  23. Vieyra-Garcia PA, Wei T, Naym DG, Fredholm S, Fink-Puches R, Cerroni L, Odum N, O'Malley JT, Gniadecki R, Wolf P. STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides. Clin Cancer Res. 2016 07 01; 22(13):3328-39. PMID: 26851186; PMCID: PMC4967550.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  24. Kirsch IR, Watanabe R, O'Malley JT, Williamson DW, Scott LL, Elco CP, Teague JE, Gehad A, Lowry EL, LeBoeuf NR, Krueger JG, Robins HS, Kupper TS, Clark RA. TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL. Sci Transl Med. 2015 Oct 07; 7(308):308ra158. PMID: 26446955; PMCID: PMC4765389.
    Citations: 59     Fields:    Translation:HumansCells
  25. O'Malley JT, D'Agati VD, Sherman WH, Grossman ME. Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. JAMA Dermatol. 2014 Nov; 150(11):1192-6. PMID: 25133950.
    Citations: 3     Fields:    Translation:Humans
  26. O'Malley JT, Schoppe C, Husain S, Grossman ME. Squamous Cell Carcinoma (Marjolin's Ulcer) Arising in a Sacral Decubitus Ulcer Resulting in Humoral Hypercalcemia of Malignancy. Case Rep Med. 2014; 2014:715809. PMID: 25197285.
    Citations: 2     
  27. O'Malley JT, Lieb JL, Weiser JA, Grossman ME. Persistent serpentine supravenous hyperpigmentation--a possible cutaneous manifestation of HIV infection or a normal racial variant: a report of 3 cases. Skinmed. 2013 Mar-Apr; 11(2):93-4. PMID: 23745227.
    Citations: 1     Fields:    Translation:Humans
  28. Weitz NA, Tlougan BE, O'Malley JT, Lauren CT, Garzon MC. A growing pigmented lesion in a child with a history of bone marrow transplant and irradiation. Pigmented basal cell carcinoma (BCC). Arch Dermatol. 2012 Aug; 148(8):947-52. PMID: 22911197.
    Citations:    Fields:    Translation:Humans
  29. Good SR, Thieu VT, Mathur AN, Yu Q, Stritesky GL, Yeh N, O'Malley JT, Perumal NB, Kaplan MH. Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol. 2009 Sep 15; 183(6):3839-47. PMID: 19710469; PMCID: PMC2748807.
    Citations: 33     Fields:    Translation:AnimalsCells
  30. O'Malley JT, Sehra S, Thieu VT, Yu Q, Chang HC, Stritesky GL, Nguyen ET, Mathur AN, Levy DE, Kaplan MH. Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology. 2009 Aug; 127(4):587-95. PMID: 19604309.
    Citations: 29     Fields:    Translation:AnimalsCells
  31. Mo C, Chearwae W, O'Malley JT, Adams SM, Kanakasabai S, Walline CC, Stritesky GL, Good SR, Perumal NB, Kaplan MH, Bright JJ. Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol. 2008 Oct 15; 181(8):5681-90. PMID: 18832727; PMCID: PMC2581484.
    Citations: 18     Fields:    Translation:AnimalsCells
  32. O'Malley JT, Eri RD, Stritesky GL, Mathur AN, Chang HC, Hogenesch H, Srinivasan M, Kaplan MH. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol. 2008 Oct 01; 181(7):5062-70. PMID: 18802110; PMCID: PMC2596939.
    Citations: 19     Fields:    Translation:AnimalsCells
  33. Kaplan MH, Sehra S, Chang HC, O'Malley JT, Mathur AN, Bruns HA. Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. Blood. 2007 Dec 15; 110(13):4367-9. PMID: 17878403; PMCID: PMC2234780.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Sanchez-Guajardo V, Tanchot C, O'Malley JT, Kaplan MH, Garcia S, Freitas AA. Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J Immunol. 2007 Jun 15; 178(12):7550-6. PMID: 17548589.
    Citations: 17     Fields:    Translation:AnimalsCells
  35. Ndjomou J, Liu Y, O'Malley J, Ericsson M, He JJ. Development and characterization of a recombinant cDNA-based hepatitis C virus system. Biochem Biophys Res Commun. 2007 Jul 20; 359(1):57-62. PMID: 17531196.
    Citations: 1     Fields:    Translation:HumansCells
  36. Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, Kapur R, Levy DE, Kansas GS, Kaplan MH. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol. 2007 Apr 15; 178(8):4901-7. PMID: 17404271.
    Citations: 228     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.