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John Matthew Dubach, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA241179 (DUBACH, JOHN) Aug 1, 2019 - Jul 31, 2024
    Optimizing PARP inhibitor therapy through novel approaches to resolve the molecular mechanisms of response
    Role: Principal Investigator
  2. R00CA198857 (DUBACH, JOHN) Sep 1, 2017 - Jul 31, 2021
    The role of PARP inhibitor target engagement in breast cancer
    Role: Principal Investigator
  3. K99CA198857 (DUBACH, JOHN) Aug 1, 2015 - Jul 31, 2017
    The role of PARP inhibitor target engagement in breast cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rodell CB, Baldwin P, Fernandez B, Weissleder R, Sridhar S, Dubach JM. Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating in vitro and in vivo Encapsulated Drug Delivery. Adv Ther (Weinh). 2021 Mar; 4(3). PMID: 33997266; PMCID: PMC8114878.
  2. Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017 02 08; 8:14293. PMID: 28176769.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  3. Dubach JM, Kim E, Yang K, Cuccarese M, Giedt RJ, Meimetis LG, Vinegoni C, Weissleder R. Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol. 2017 02; 13(2):168-173. PMID: 27918558.
    Citations: 38     Fields:    Translation:HumansCells
  4. Vinegoni C, Dubach JM, Feruglio PF, Weissleder R. Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quantum Electron. 2016 May-Jun; 22(3). PMID: 27440991; PMCID: PMC4946648.
    Citations: 3     
  5. Kim E, Yang KS, Kohler RH, Dubach JM, Mikula H, Weissleder R. Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression. Bioconjug Chem. 2015 Aug 19; 26(8):1513-8. PMID: 26017814; PMCID: PMC4772718.
    Citations: 22     Fields:    Translation:HumansCells
  6. Vinegoni C, Dubach JM, Thurber GM, Miller MA, Mazitschek R, Weissleder R. Advances in measuring single-cell pharmacology in vivo. Drug Discov Today. 2015 Sep; 20(9):1087-92. PMID: 26024776; PMCID: PMC4567932.
    Citations: 12     Fields:    Translation:HumansAnimals
  7. Awqatty B, Samaddar S, Cash KJ, Clark HA, Dubach JM. Fluorescent sensors for the basic metabolic panel enable measurement with a smart phone device over the physiological range. Analyst. 2014 Oct 21; 139(20):5230-8. PMID: 25126649.
    Citations: 3     Fields:    
  8. Dubach JM, Vinegoni C, Weissleder R. Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging. Opt Lett. 2014 Aug 01; 39(15):4482-5. PMID: 25078208.
    Citations: 3     Fields:    Translation:Animals
  9. Ruckh TT, Mehta AA, Dubach JM, Clark HA. Polymer-free optode nanosensors for dynamic, reversible, and ratiometric sodium imaging in the physiological range. Sci Rep. 2013 Nov 28; 3:3366. PMID: 24284431.
    Citations: 11     Fields:    
  10. Dubach JM, Balaconis MK, Clark HA. Fluorescent nanoparticles for the measurement of ion concentration in biological systems. J Vis Exp. 2011 Jul 04; (53). PMID: 21750495.
    Citations: 12     Fields:    Translation:Animals
  11. Ozaydin-Ince G, Dubach JM, Gleason KK, Clark HA. Microworm optode sensors limit particle diffusion to enable in vivo measurements. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2656-61. PMID: 21282619.
    Citations: 10     Fields:    Translation:Cells
  12. Dubach JM, Lim E, Zhang N, Francis KP, Clark H. In vivo sodium concentration continuously monitored with fluorescent sensors. Integr Biol (Camb). 2011 Feb; 3(2):142-8. PMID: 21088796.
    Citations: 19     Fields:    Translation:Animals
  13. Billingsley K, Balaconis MK, Dubach JM, Zhang N, Lim E, Francis KP, Clark HA. Fluorescent nano-optodes for glucose detection. Anal Chem. 2010 May 01; 82(9):3707-13. PMID: 20355725.
    Citations: 19     Fields:    Translation:AnimalsCells
  14. Kohler JE, Dubach JM, Naik HB, Tai K, Blass AL, Soybel DI. Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G170-8. PMID: 20430873.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Dubach JM, Das S, Rosenzweig A, Clark HA. Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16145-50. PMID: 19805271.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  16. Harjes DI, Dubach JM, Rosenzweig A, Das S, Clark HA. Ion-selective optodes measure extracellular potassium flux in excitable cells. Macromol Rapid Commun. 2010 Jan 18; 31(2):217-21. PMID: 21590894.
    Citations: 6     Fields:    
  17. Baxamusa SH, Montero L, Dubach JM, Clark HA, Borros S, Gleason KK. Protection of sensors for biological applications by photoinitiated chemical vapor deposition of hydrogel thin films. Biomacromolecules. 2008 Oct; 9(10):2857-62. PMID: 18783272.
    Citations: 5     Fields:    Translation:Humans
  18. Dubach JM, Harjes DI, Clark HA. Ion-selective nano-optodes incorporating quantum dots. J Am Chem Soc. 2007 Jul 11; 129(27):8418-9. PMID: 17567136.
    Citations: 18     Fields:    
  19. Dubach JM, Harjes DI, Clark HA. Fluorescent ion-selective nanosensors for intracellular analysis with improved lifetime and size. Nano Lett. 2007 Jun; 7(6):1827-31. PMID: 17497824.
    Citations: 17     Fields:    Translation:HumansCells
  20. Walsh BM, Naik HB, Dubach JM, Beshire M, Wieland AM, Soybel DI. Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1687-97. PMID: 17287368.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Cima RR, Dubach JM, Wieland AM, Walsh BM, Soybel DI. Intracellular Ca(2+) and Zn(2+) signals during monochloramine-induced oxidative stress in isolated rat colon crypts. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G250-61. PMID: 16002562.
    Citations: 14     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.