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profileKelly Lynn Arnett, Ph.D.

TitleLecturer on Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
AddressHarvard Medical School
Bldg C, Rm C-303
240 Longwood Ave
Boston MA 02115
Phone617/432-5004
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Sci Signal. 2017 May 02; 10(477). PMID: 28465412.
    View in: PubMed
  2. Arnett K, Sudore RL, Nowels D, Feng CX, Levy CR, Lum HD. Advance Care Planning. Am J Hosp Palliat Care. 2016 Jan 01; 1049909116666358. PMID: 27599724.
    View in: PubMed
  3. Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4946-53. PMID: 25369933; PMCID: PMC4246292.
  4. Arnett KL, Blacklow SC. Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods Mol Biol. 2014; 1187:231-45. PMID: 25053494; PMCID: PMC4410701.
  5. Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):705-10. PMID: 24374627; PMCID: PMC3896193.
  6. Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5. PMID: 22109558; PMCID: PMC3250146.
  7. Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6. PMID: 22006338; PMCID: PMC3203814.
  8. Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14908-13. PMID: 21737748; PMCID: PMC3169118.
  9. Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010 Nov; 17(11):1312-7. PMID: 20972443; PMCID: PMC3024583.
  10. Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 01; 24(21):2395-407. PMID: 20935071; PMCID: PMC2964750.
  11. Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci. 2008 Oct 01; 121(Pt 19):3109-19. PMID: 18799787; PMCID: PMC2696053.
  12. Arnett KL, Harrison SC, Wiley DC. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16268-73. PMID: 15534202; PMCID: PMC528977.
  13. Arnett KL, Huang W, Valiante NM, Barber LD, Parham P. The Bw4/Bw6 difference between HLA-B*0802 and HLA-B*0801 changes the peptides endogenously bound and the stimulation of alloreactive T cells. Immunogenetics. 1998 Jun; 48(1):56-61. PMID: 9601944.
    View in: PubMed
  14. Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity. 1997 Dec; 7(6):739-51. PMID: 9430220.
    View in: PubMed
  15. Parham P, Arnett KL, Adams EJ, Little AM, Tees K, Barber LD, Marsh SG, Ohta T, Markow T, Petzl-Erler ML. Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas. Tissue Antigens. 1997 Sep; 50(3):219-32. PMID: 9331945.
    View in: PubMed
  16. Darke C, Street J, Fussell H, Thomas M, Guttridge M, Goldberg TE, Arnett KL, Parham P. A new HLA-B44 variant (B44BO [B*4408]) identified by serology. Tissue Antigens. 1997 Jul; 50(1):32-7. PMID: 9243752.
    View in: PubMed
  17. Barber LD, Percival L, Arnett KL, Gumperz JE, Chen L, Parham P. Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity. J Immunol. 1997 Feb 15; 158(4):1660-9. PMID: 9029102.
    View in: PubMed
  18. Chandanayingyong D, Adams EJ, Arnett KL, Hildebrand WH, Parham P, Lau M. The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family. Tissue Antigens. 1996 May; 47(5):426-7. PMID: 8795144.
    View in: PubMed
  19. Arnett KL, Moses JH, Williams F, Marsh SG, Bodmer JG, Parham P, Middleton D. HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing which shares the MA2.1 epitope with A*02, B*57 and B*58. Tissue Antigens. 1996 May; 47(5):422-5. PMID: 8795143.
    View in: PubMed
  20. Arnett KL, Adams EJ, Parham P. On the sequence of A*3101. Tissue Antigens. 1996 May; 47(5):428-30. PMID: 8795145.
    View in: PubMed
  21. Cooper S, Kowalski H, Erickson AL, Arnett K, Little AM, Walker CM, Parham P. The presentation of a hepatitis C viral peptide by distinct major histocompatibility complex class I allotypes from two chimpanzee species. J Exp Med. 1996 Feb 01; 183(2):663-8. PMID: 8627179; PMCID: PMC2192456.
  22. Adams EJ, Little AM, Arnett KL, McAuley JE, Williams RC, Parham P. Three new HLA-B alleles found in Mexican-Americans. Tissue Antigens. 1995 Nov; 46(5):414-16. PMID: 8838356.
    View in: PubMed
  23. Arnett KL, Adams EJ, Gumperz JE, Darke C, Marsh SG, Gelsthorpe K, Parham P. Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802]. Tissue Antigens. 1995 Oct; 46(4):316-21. PMID: 8560451.
    View in: PubMed
  24. Adams EJ, Scott I, Shah A, Arnett KL, Marsh SG, Madrigal JA, Parham P. Homogeneity of allelic sequence for serological variants of HLA-B53. Tissue Antigens. 1995 Oct; 46(4):330-2. PMID: 8560454.
    View in: PubMed
  25. Arnett KL, Parham P. HLA class I nucleotide sequences, 1995. Tissue Antigens. 1995 Sep; 46(3 ( Pt 2)):217-57. PMID: 8525484.
    View in: PubMed
  26. Adams EJ, Little AM, Arnett KL, Leushner J, Parham P. Identification of a novel HLA-B40 allele (B*4008) in a patient with leukemia. Tissue Antigens. 1995 Sep; 46(3 ( Pt 1)):204-5. PMID: 8525480.
    View in: PubMed
  27. Moses JH, Marsh SG, Arnett KL, Adams EJ, Bodmer JG, Parham P. On the nucleotide sequences of B*2702 and B*2705. Tissue Antigens. 1995 Jul; 46(1):50-3. PMID: 7482496.
    View in: PubMed
  28. Kubens BS, Arnett KL, Adams EJ, Parham P, Grosse-Wilde H. Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, family studies and DNA sequence analysis. Tissue Antigens. 1995 May; 45(5):322-7. PMID: 7652739.
    View in: PubMed
  29. Browning MJ, Madrigal JA, Krausa P, Kowalski H, Allsopp CE, Little AM, Turner S, Adams EJ, Arnett KL, Bodmer WF, et al. The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles. Tissue Antigens. 1995 Mar; 45(3):177-87. PMID: 7761977.
    View in: PubMed
  30. Parham P, Adams EJ, Arnett KL. The origins of HLA-A,B,C polymorphism. Immunol Rev. 1995 Feb; 143:141-80. PMID: 7558075.
    View in: PubMed
  31. Adams EJ, Martinez-Naves E, Arnett KL, Little AM, Tyan DB, Parham P. HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B*3902. Tissue Antigens. 1995 Jan; 45(1):18-26. PMID: 7725307.
    View in: PubMed
  32. Arnett KL, Adams EJ, Domena JD, Parham P. Structure of a novel subtype of B7 (B*0705) isolated from a Chinese individual. Tissue Antigens. 1994 Nov; 44(5):318-21. PMID: 7878658.
    View in: PubMed
  33. Domena JD, Little AM, Arnett KL, Adams EJ, Marsh SG, Parham P. A small test of a sequence-based typing method: definition of the B*1520 allele. Tissue Antigens. 1994 Oct; 44(4):217-24. PMID: 7871522.
    View in: PubMed
  34. Domena JD, Arnett KL, Marsh SG, Bodmer JG, Parham P. Alloantibodies can discriminate three populations of HLA-B40 molecules encoded by B*4002. Tissue Antigens. 1994 Jul; 44(1):57-8. PMID: 7974470.
    View in: PubMed
  35. Parham P, Arnett KL, Adams EJ, Barber LD, Domena JD, Stewart D, Hildebrand WH, Little AM. The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles. Tissue Antigens. 1994 May; 43(5):302-13. PMID: 7524186.
    View in: PubMed
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