HLA-B Antigens

"HLA-B Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

Descriptor ID

D015235

MeSH Number(s)

D12.776.395.550.489.500

D12.776.543.550.421.500

D23.050.301.500.100.500

D23.050.301.500.450.380

D23.050.705.552.100.500

D23.050.705.552.450.380

Concept/Terms

HLA-B Antigens

Below are MeSH descriptors whose meaning is more general than "HLA-B Antigens".

Chemicals and Drugs [D]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
HLA Antigens [D23.050.301.500.450]
HLA-B Antigens [D23.050.301.500.450.380]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
HLA Antigens [D23.050.705.552.450]
HLA-B Antigens [D23.050.705.552.450.380]

Below are MeSH descriptors whose meaning is related to "HLA-B Antigens".

Below are MeSH descriptors whose meaning is more specific than "HLA-B Antigens".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HLA-B Antigens" by people in Harvard Catalyst Profiles by year, and whether "HLA-B Antigens" was a major or minor topic of these publication.

Below are the most recent publications written about "HLA-B Antigens" by people in Profiles.

Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules. Structure. 2024 Aug 08; 32(8):1121-1136.e5.

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Impact of HLA class I functional divergence on HIV control. Science. 2024 01 19; 383(6680):319-325.

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Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide. Nat Commun. 2023 05 22; 14(1):2929.

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Genetic predisposition for the development of lamotrigine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis. Per Med. 2023 03; 20(2):201-213.

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Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities. JCI Insight. 2022 11 22; 7(22).

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Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer. J Immunother Cancer. 2022 03; 10(3).

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An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults. PLoS Pathog. 2021 11; 17(11):e1010090.

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Lamotrigine and Stevens-Johnson Syndrome Prevention. Psychopharmacol Bull. 2021 03 16; 51(2):96-114.

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ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).

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Clinical Utility of Pharmacogenomic Data Collected by a Health-System Biobank to Predict and Prevent Adverse Drug Events. Drug Saf. 2021 05; 44(5):601-607.

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