Harvard Catalyst Profiles

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Noriko Rapley, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Oshiro N, Rapley J, Avruch J. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem. 2014 Jan 31; 289(5):2658-74. PMID: 24337580; PMCID: PMC3908400.
    Citations: 29     Fields:    Translation:HumansCells
  2. Ishizuka Y, Kakiya N, Witters LA, Oshiro N, Shirao T, Nawa H, Takei N. AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons. J Neurochem. 2013 Oct; 127(1):66-77. PMID: 23841933.
    Citations: 18     Fields:    Translation:AnimalsCells
  3. Nakashima A, Tanimura-Ito K, Oshiro N, Eguchi S, Miyamoto T, Momonami A, Kamada S, Yonezawa K, Kikkawa U. A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A. FEBS Lett. 2013 Sep 17; 587(18):2924-9. PMID: 23892082.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  4. Nakashima A, Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K. Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes. J Biomed Sci. 2013 Apr 18; 20:24. PMID: 23594158; PMCID: PMC3639846.
    Citations: 11     Fields:    Translation:HumansCells
  5. Rapley J, Oshiro N, Ortiz-Vega S, Avruch J. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling. J Biol Chem. 2011 Nov 04; 286(44):38043-38053. PMID: 21914810; PMCID: PMC3207408.
    Citations: 22     Fields:    Translation:HumansCells
  6. Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem. 2010 Jun 25; 285(26):20109-16. PMID: 20427287; PMCID: PMC2888423.
    Citations: 114     Fields:    Translation:HumansCells
  7. Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y. Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol. 2010 Feb; 30(4):1049-58. PMID: 19995911; PMCID: PMC2815578.
    Citations: 204     Fields:    Translation:AnimalsCells
  8. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell. 2009 Apr; 20(7):1981-91. PMID: 19211835; PMCID: PMC2663915.
    Citations: 900     Fields:    Translation:HumansAnimalsCells
  9. Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans. 2009 Feb; 37(Pt 1):223-6. PMID: 19143636.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  10. Eguchi S, Oshiro N, Miyamoto T, Yoshino K, Okamoto S, Ono T, Kikkawa U, Yonezawa K. AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity. Genes Cells. 2009 Feb; 14(2):179-89. PMID: 19170765.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  11. Miyamoto T, Oshiro N, Yoshino K, Nakashima A, Eguchi S, Takahashi M, Ono Y, Kikkawa U, Yonezawa K. AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus. J Biol Chem. 2008 Feb 15; 283(7):4430-8. PMID: 18063581.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  12. Nakashima A, Yoshino K, Miyamoto T, Eguchi S, Oshiro N, Kikkawa U, Yonezawa K. Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. Biochem Biophys Res Commun. 2007 Sep 14; 361(1):218-23. PMID: 17658474.
    Citations: 21     Fields:    Translation:HumansCells
  13. Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem. 2007 Jul 13; 282(28):20329-39. PMID: 17517883; PMCID: PMC3199301.
    Citations: 139     Fields:    Translation:HumansCells
  14. Yamaguchi Y, Shirai Y, Matsubara T, Sanse K, Kuriyama M, Oshiro N, Yoshino K, Yonezawa K, Ono Y, Saito N. Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. J Biol Chem. 2006 Oct 20; 281(42):31627-37. PMID: 16905533.
    Citations: 24     Fields:    Translation:AnimalsCells
  15. Eguchi S, Tokunaga C, Hidayat S, Oshiro N, Yoshino K, Kikkawa U, Yonezawa K. Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size. Genes Cells. 2006 Jul; 11(7):757-66. PMID: 16824195.
    Citations: 8     Fields:    Translation:HumansCells
  16. Ohji G, Hidayat S, Nakashima A, Tokunaga C, Oshiro N, Yoshino K, Yokono K, Kikkawa U, Yonezawa K. Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J Biochem. 2006 Jan; 139(1):129-35. PMID: 16428328.
    Citations: 26     Fields:    Translation:HumansCells
  17. Sakakibara K, Sato K, Yoshino K, Oshiro N, Hirahara S, Mahbub Hasan AK, Iwasaki T, Ueda Y, Iwao Y, Yonezawa K, Fukami Y. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. J Biol Chem. 2005 Apr 15; 280(15):15029-37. PMID: 15699050.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  18. Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol. 2004 Aug; 24(15):6710-8. PMID: 15254238; PMCID: PMC444840.
    Citations: 245     Fields:    Translation:AnimalsCells
  19. Satake H, Villegas E, Oshiro N, Terada K, Shinada T, Corzo G. Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the hexathelid spider Macrothele gigas. Toxicon. 2004 Aug; 44(2):149-56. PMID: 15246762.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells. 2004 Apr; 9(4):359-66. PMID: 15066126.
    Citations: 113     Fields:    Translation:HumansCells
  21. Yonezawa K, Tokunaga C, Oshiro N, Yoshino K. Raptor, a binding partner of target of rapamycin. Biochem Biophys Res Commun. 2004 Jan 09; 313(2):437-41. PMID: 14684181.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  22. Amano M, Kaneko T, Maeda A, Nakayama M, Ito M, Yamauchi T, Goto H, Fukata Y, Oshiro N, Shinohara A, Iwamatsu A, Kaibuchi K. Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem. 2003 Nov; 87(3):780-90. PMID: 14535960.
    Citations: 43     Fields:    Translation:AnimalsCells
  23. Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem. 2003 May 02; 278(18):15461-4. PMID: 12604610.
    Citations: 257     Fields:    Translation:HumansCells
  24. Gan X, Kitakawa M, Yoshino K, Oshiro N, Yonezawa K, Isono K. Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components. Eur J Biochem. 2002 Nov; 269(21):5203-14. PMID: 12392552.
    Citations: 29     Fields:    Translation:AnimalsCells
  25. Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26; 110(2):177-89. PMID: 12150926.
    Citations: 734     Fields:    Translation:HumansAnimalsCells
  26. Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K, Tokunaga C, Shirai Y, Saito N, Gout I, Yonezawa K. Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha. Genes Cells. 2001 Nov; 6(11):1003-15. PMID: 11733037.
    Citations: 7     Fields:    Translation:Cells
  27. Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim L, Kaibuchi K. Phosphorylation of ERM proteins at filopodia induced by Cdc42. Genes Cells. 2000 Jul; 5(7):571-81. PMID: 10947843.
    Citations: 48     Fields:    Translation:AnimalsCells
  28. Fukata Y, Oshiro N, Kaibuchi K. Activation of moesin and adducin by Rho-kinase downstream of Rho. Biophys Chem. 1999 Dec 13; 82(2-3):139-47. PMID: 10631797.
    Citations: 14     Fields:    
  29. Kawano Y, Fukata Y, Oshiro N, Amano M, Nakamura T, Ito M, Matsumura F, Inagaki M, Kaibuchi K. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol. 1999 Nov 29; 147(5):1023-38. PMID: 10579722; PMCID: PMC2169354.
    Citations: 187     Fields:    Translation:AnimalsCells
  30. Fukata Y, Oshiro N, Kinoshita N, Kawano Y, Matsuoka Y, Bennett V, Matsuura Y, Kaibuchi K. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol. 1999 Apr 19; 145(2):347-61. PMID: 10209029; PMCID: PMC2133101.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  31. Oshiro N, Fukata Y, Kaibuchi K. Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem. 1998 Dec 25; 273(52):34663-6. PMID: 9856983.
    Citations: 75     Fields:    Translation:AnimalsCells
  32. Fukata Y, Kimura K, Oshiro N, Saya H, Matsuura Y, Kaibuchi K. Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol. 1998 Apr 20; 141(2):409-18. PMID: 9548719; PMCID: PMC2148462.
    Citations: 62     Fields:    Translation:AnimalsCells
  33. Kamada Y, Oshiro N, Miyagi M, Oku H, Hongo F, Chinen I. Osteopathy in broiler chicks fed toxic mimosine in Leucaena leucocephala. Biosci Biotechnol Biochem. 1998 Jan; 62(1):34-8. PMID: 9501516.
    Citations:    Fields:    Translation:Animals
  34. Kamada Y, Oshiro N, Oku H, Hongo F, Chinen I. Degradation of Toxic Mimosine by a Hydrolytic Enzyme of Leucaena Psyllids (Jumping Plant Lice). Biosci Biotechnol Biochem. 1996 Jan; 60(2):351-2. PMID: 27299408.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.