Harvard Catalyst Profiles

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Ksenia Kastanenka, Ph.D.

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Biography
education and training
Massachusetts General Hospital/Harvard Medical School, Charlestown, MAResearch Fellow03/2017Neurology
Case Western Reserve University, Cleveland, OHPh.D.06/2011Neuroscience

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Algamal M, Russ AN, Miller MR, Hou SS, Maci M, Munting LP, Zhao Q, Gerashchenko D, Bacskai BJ, Kastanenka KV. Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease. Commun Biol. 2022 12 02; 5(1):1323. PMID: 36460716; PMCID: PMC9718858.
    Citations: 1     Translation:AnimalsCells
  2. Thankachan S, Gerashchenko A, Kastanenka KV, Bacskai BJ, Gerashchenko D. Optimization of real-time analysis of sleep-wake cycle in mice. MethodsX. 2022; 9:101811. PMID: 36065218; PMCID: PMC9440422.
    Citations:    
  3. Thankachan S, Yang C, Kastanenka KV, Bacskai BJ, Gerashchenko D. Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice. Sci Rep. 2022 07 19; 12(1):12278. PMID: 35853986; PMCID: PMC9296645.
    Citations:    Fields:    Translation:Animals
  4. Lee YF, Lariviere L, Russ AN, Choi SZ, Bacskai BJ, Kastanenka KV. Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model. eNeuro. 2021 May-Jun; 8(3). PMID: 33926907.
    Citations:    Fields:    Translation:Animals
  5. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. PMID: 33589835; PMCID: PMC8007081.
    Citations: 249     Fields:    Translation:HumansAnimalsCells
  6. Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Front Neurosci. 2020; 14:705. PMID: 32714142.
    Citations: 10     
  7. Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ. Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Sci Rep. 2019 06 20; 9(1):8964. PMID: 31221985.
    Citations: 11     Fields:    Translation:AnimalsCells
  8. Kastanenka KV, Moreno-Bote R, De Pittà M, Perea G, Eraso-Pichot A, Masgrau R, Poskanzer KE, Galea E. A roadmap to integrate astrocytes into Systems Neuroscience. Glia. 2020 01; 68(1):5-26. PMID: 31058383.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018 Jun 01; 11:429-440. PMID: 29858078; PMCID: PMC5992788.
    Citations: 45     
  10. Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-ß oligomers based on calcium imaging. Sci Rep. 2018 03 15; 8(1):4634. PMID: 29545579.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Pagnier GJ, Kastanenka KV, Sohn M, Choi S, Choi SH, Soh H, Bacskai BJ. Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimers Res Ther. 2018 01 29; 10(1):11. PMID: 29378621.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6. PMID: 28132667.
    Citations: 9     Fields:    Translation:AnimalsCells
  13. Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. PLoS One. 2017; 12(1):e0170275. PMID: 28114405.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  14. Kastanenka KV, Herlitze S, Boyden ES, Tsai L-H and Bacskai BJ. EC Neurology. Optogenetics shed light on Alzheimer’s disease. 2017; (01):27-29. View Publication.
  15. Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ. Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice. J Neurosci. 2016 12 14; 36(50):12549-12558. PMID: 27810931; PMCID: PMC5157102.
    Citations: 35     Fields:    Translation:AnimalsCells
  16. Dumurgier J, Schraen S, Gabelle A, Vercruysse O, Bombois S, Laplanche JL, Peoc'h K, Sablonnière B, Kastanenka KV, Delaby C, Pasquier F, Touchon J, Hugon J, Paquet C, Lehmann S. Cerebrospinal fluid amyloid-ß 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015; 7(1):30. PMID: 26034513.
    Citations: 40     Fields:    
  17. Kastanenka KV, Arbel-Ornath M, Hudry E, Galea E, Xie H, and Bacskai BJ. . Optical probes for in-vivo imaging. Optical Probes in Biology. Jin Zhang and Carsten Schultz (Eds). Taylor and Francis Group. USA. 2015.
  18. Wang X, Arbel-Ornath M, Wegmann SK, Kastanenka KV, and Bacskai BJ. . Chapter 3: In vivo imaging in neurodegenerative diseases. Advances in intravital microscopy: from basic to clinical research. R. Weigert (Ed.), Springer. USA. 2014.
  19. Kastanenka KV, Landmesser LT. Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17528-33. PMID: 24101487.
    Citations: 7     Fields:    Translation:AnimalsCells
  20. Maeno-Hikichi Y, Polo-Parada L, Kastanenka KV, Landmesser LT. Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctions. J Neurosci. 2011 Jan 19; 31(3):1093-105. PMID: 21248134.
    Citations: 20     Fields:    Translation:AnimalsCells
  21. Kastanenka KV, Landmesser LT. In vivo activation of channelrhodopsin-2 reveals that normal patterns of spontaneous activity are required for motoneuron guidance and maintenance of guidance molecules. J Neurosci. 2010 Aug 04; 30(31):10575-85. PMID: 20686000.
    Citations: 21     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.