alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Below are MeSH descriptors whose meaning is more general than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
Below are MeSH descriptors whose meaning is more specific than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
This graph shows the total number of publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Harvard Catalyst Profiles by year, and whether "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 5 | 5 |
| 1992 | 0 | 2 | 2 |
| 1993 | 1 | 3 | 4 |
| 1995 | 1 | 3 | 4 |
| 1996 | 0 | 3 | 3 |
| 1997 | 1 | 1 | 2 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 4 | 4 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
Below are the most recent publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Profiles.
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An efficient analytical reduction of detailed nonlinear neuron models. Nat Commun. 2020 01 15; 11(1):288.
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Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats. Brain Res. 2016 07 15; 1643:159-67.
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Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation. Addict Biol. 2017 Jan; 22(1):152-162.
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NMDA receptor activation strengthens weak electrical coupling in mammalian brain. Neuron. 2014 Mar 19; 81(6):1375-1388.
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Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology. PLoS One. 2013; 8(3):e58607.
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A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP. Neuron. 2012 Oct 18; 76(2):309-16.
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A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2012 Dec 01; 72(11):971-7.
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Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem. 2011 Nov 18; 286(46):40205-18.
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Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci. 2011 Jun 15; 31(24):8862-9.
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A positive feedback synapse from retinal horizontal cells to cone photoreceptors. PLoS Biol. 2011 May; 9(5):e1001057.