alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Below are MeSH descriptors whose meaning is more general than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
Below are MeSH descriptors whose meaning is more specific than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
This graph shows the total number of publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Harvard Catalyst Profiles by year, and whether "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 1 | 3 | 4 |
| 1996 | 1 | 2 | 3 |
| 1997 | 2 | 2 | 4 |
| 1998 | 1 | 0 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Profiles.
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Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor. Biomed Pharmacother. 2023 Dec; 168:115842.
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Widespread pesticide contamination of drinking water and impact on cancer risk in Brazil. Environ Int. 2022 07; 165:107321.
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Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at a5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2022 08 01; 92(3):216-226.
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Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1. Cell Rep. 2020 10 13; 33(2):108255.
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An efficient analytical reduction of detailed nonlinear neuron models. Nat Commun. 2020 01 15; 11(1):288.
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Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791.
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Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats. Brain Res. 2016 07 15; 1643:159-67.
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Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation. Addict Biol. 2017 Jan; 22(1):152-162.
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NMDA receptor activation strengthens weak electrical coupling in mammalian brain. Neuron. 2014 Mar 19; 81(6):1375-1388.
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Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology. PLoS One. 2013; 8(3):e58607.