Pituitary Adenylate Cyclase-Activating Polypeptide
"Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
MeSH Number(s)
D12.644.276.860.887
D12.644.400.625
D12.776.467.860.887
D12.776.641.600.887
D12.776.641.650.625
D23.529.850.887
Below are MeSH descriptors whose meaning is more general than "Pituitary Adenylate Cyclase-Activating Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Pituitary Adenylate Cyclase-Activating Polypeptide".
This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Harvard Catalyst Profiles by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 1 | 2 |
| 2014 | 3 | 3 | 6 |
| 2015 | 3 | 0 | 3 |
| 2016 | 4 | 1 | 5 |
| 2018 | 2 | 2 | 4 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles.
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A brainstem peptide system activated at birth protects postnatal breathing. Nature. 2021 01; 589(7842):426-430.
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Neurons that regulate mouse torpor. Nature. 2020 07; 583(7814):115-121.
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Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology. 2019 12 01; 160:107761.
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PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiol Learn Mem. 2019 01; 157:24-34.
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Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. Science. 2018 11 16; 362(6416).
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Current understanding of meningeal and cerebral vascular function underlying migraine headache. Cephalalgia. 2019 11; 39(13):1606-1622.
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PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 06 15; 7.
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The Effects of Prior Stress on Anxiety-Like Responding to Intra-BNST Pituitary Adenylate Cyclase Activating Polypeptide in Male and Female Rats. Neuropsychopharmacology. 2017 Jul; 42(8):1679-1687.
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Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy. Sci Transl Med. 2016 12 21; 8(370):370ra181.
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Stress-related disorders, pituitary adenylate cyclase-activating peptide (PACAP)ergic system, and sex differences. Dialogues Clin Neurosci. 2016 12; 18(4):403-413.