Pituitary Adenylate Cyclase-Activating Polypeptide
"Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
MeSH Number(s)
D12.644.276.860.887
D12.644.400.625
D12.776.467.860.887
D12.776.641.600.887
D12.776.641.650.625
D23.529.850.887
Below are MeSH descriptors whose meaning is more general than "Pituitary Adenylate Cyclase-Activating Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Pituitary Adenylate Cyclase-Activating Polypeptide".
This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Harvard Catalyst Profiles by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 1 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 3 | 4 |
| 2015 | 3 | 0 | 3 |
| 2016 | 5 | 1 | 6 |
| 2017 | 1 | 0 | 1 |
| 2018 | 5 | 2 | 7 |
| 2019 | 2 | 0 | 2 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 1 | 3 |
| 2023 | 1 | 3 | 4 |
| 2024 | 0 | 2 | 2 |
Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles.
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Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder. Eur J Psychotraumatol. 2024; 15(1):2335793.
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Hypersensitivity to PACAP-38 in post-traumatic headache: a randomized clinical trial. Brain. 2024 Apr 04; 147(4):1312-1320.
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Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) of the Bed Nucleus of the Stria Terminalis Mediates Heavy Alcohol Drinking in Mice. eNeuro. 2023 Dec; 10(12).
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Stimulation of lateral parabrachial (LPB) to central amygdala (CeA) pituitary adenylate cyclase-activating polypeptide (PACAP) neurons induces anxiety-like behavior and mechanical allodynia. Pharmacol Biochem Behav. 2023 09; 230:173605.
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The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study. J Headache Pain. 2023 May 25; 24(1):60.
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Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder. Neuropsychopharmacology. 2023 07; 48(8):1245-1254.
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The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) System of the Central Amygdala Mediates the Detrimental Effects of Chronic Social Defeat Stress in Rats. eNeuro. 2022 Sep-Oct; 9(5).
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PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus. Nat Commun. 2022 07 28; 13(1):4374.
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Provoked versus spontaneous migraine attacks: pathophysiological similarities and differences. J Headache Pain. 2022 Jul 23; 23(1):87.
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The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology. 2021 04 01; 162(4).