"Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
MeSH Number(s)
B01.050.150.900.649.865.635.505.500.550.780
Concept/Terms
Mice, SCID- Mice, SCID
- Severe Combined Immunodeficient Mice
- SCID Mice
- Immunodeficient Mice, Severe Combined
- Mouse, SCID
- SCID Mouse
Mouse, SCID-hu- Mouse, SCID-hu
- Mouse, SCID hu
- SCID-hu Mouse
- SCID-hu Mice
- Mice, SCID-hu
- SCID hu Mice
Below are MeSH descriptors whose meaning is more general than "Mice, SCID".
Below are MeSH descriptors whose meaning is more specific than "Mice, SCID".
This graph shows the total number of publications written about "Mice, SCID" by people in Harvard Catalyst Profiles by year, and whether "Mice, SCID" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 17 | 19 |
| 1994 | 2 | 18 | 20 |
| 1995 | 0 | 25 | 25 |
| 1996 | 2 | 26 | 28 |
| 1997 | 2 | 26 | 28 |
| 1998 | 0 | 15 | 15 |
| 1999 | 1 | 37 | 38 |
| 2000 | 0 | 30 | 30 |
| 2001 | 0 | 29 | 29 |
| 2002 | 1 | 39 | 40 |
| 2003 | 0 | 42 | 42 |
| 2004 | 0 | 40 | 40 |
| 2005 | 0 | 42 | 42 |
| 2006 | 0 | 42 | 42 |
| 2007 | 0 | 49 | 49 |
| 2008 | 0 | 43 | 43 |
| 2009 | 0 | 56 | 56 |
| 2010 | 0 | 59 | 59 |
| 2011 | 1 | 81 | 82 |
| 2012 | 0 | 90 | 90 |
| 2013 | 0 | 76 | 76 |
| 2014 | 0 | 94 | 94 |
| 2015 | 0 | 73 | 73 |
| 2016 | 0 | 64 | 64 |
| 2017 | 0 | 70 | 70 |
| 2018 | 0 | 84 | 84 |
| 2019 | 0 | 67 | 67 |
| 2020 | 0 | 52 | 52 |
| 2021 | 0 | 67 | 67 |
| 2022 | 0 | 7 | 7 |
Below are the most recent publications written about "Mice, SCID" by people in Profiles.
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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice. J Vis Exp. 2022 11 18; (189).
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Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2209563119.
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Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance. JCI Insight. 2022 08 22; 7(16).
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Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. Blood. 2022 02 10; 139(6):876-888.
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Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. Blood. 2022 02 03; 139(5):717-731.
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ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells. Blood. 2022 01 20; 139(3):399-412.
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Phase 1 study of anti-CD47 monoclonal antibody CC-90002 in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes. Ann Hematol. 2022 Mar; 101(3):557-569.
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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer. Cell Rep Med. 2021 12 21; 2(12):100471.
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WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. J Clin Invest. 2021 12 15; 131(24).
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A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells. Small. 2022 02; 18(8):e2104899.