"Mice, SCID" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
MeSH Number(s)
B01.050.150.900.649.865.635.505.500.550.780
Concept/Terms
Mice, SCID- Mice, SCID
- Severe Combined Immunodeficient Mice
- SCID Mice
- Immunodeficient Mice, Severe Combined
- Mouse, SCID
- SCID Mouse
Mouse, SCID-hu- Mouse, SCID-hu
- Mouse, SCID hu
- SCID-hu Mouse
- SCID-hu Mice
- Mice, SCID-hu
- SCID hu Mice
Below are MeSH descriptors whose meaning is more general than "Mice, SCID".
Below are MeSH descriptors whose meaning is more specific than "Mice, SCID".
This graph shows the total number of publications written about "Mice, SCID" by people in Harvard Catalyst Profiles by year, and whether "Mice, SCID" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 1 | 2 |
| 1992 | 2 | 9 | 11 |
| 1993 | 2 | 20 | 22 |
| 1994 | 2 | 18 | 20 |
| 1995 | 0 | 26 | 26 |
| 1996 | 2 | 26 | 28 |
| 1997 | 2 | 26 | 28 |
| 1998 | 0 | 15 | 15 |
| 1999 | 1 | 37 | 38 |
| 2000 | 0 | 30 | 30 |
| 2001 | 0 | 29 | 29 |
| 2002 | 1 | 41 | 42 |
| 2003 | 0 | 42 | 42 |
| 2004 | 0 | 40 | 40 |
| 2005 | 0 | 45 | 45 |
| 2006 | 0 | 44 | 44 |
| 2007 | 0 | 55 | 55 |
| 2008 | 0 | 44 | 44 |
| 2009 | 0 | 63 | 63 |
| 2010 | 0 | 63 | 63 |
| 2011 | 1 | 91 | 92 |
| 2012 | 0 | 94 | 94 |
| 2013 | 0 | 81 | 81 |
| 2014 | 0 | 92 | 92 |
| 2015 | 0 | 75 | 75 |
| 2016 | 0 | 72 | 72 |
| 2017 | 0 | 75 | 75 |
| 2018 | 0 | 78 | 78 |
| 2019 | 0 | 66 | 66 |
| 2020 | 0 | 49 | 49 |
| 2021 | 0 | 18 | 18 |
Below are the most recent publications written about "Mice, SCID" by people in Profiles.
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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation. Science. 2021 09 17; 373(6561):1327-1335.
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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nat Commun. 2021 07 12; 12(1):4245.
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Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells. ACS Chem Biol. 2021 07 16; 16(7):1201-1207.
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NK cell memory: discovery of a mystery. Nat Immunol. 2021 06; 22(6):669-671.
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Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma. Commun Biol. 2021 05 24; 4(1):617.
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A SCID mouse-human lung xenograft model of SARS-CoV-2 infection. Theranostics. 2021; 11(13):6607-6615.
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Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors. Eur J Med Chem. 2021 Aug 05; 220:113499.
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Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nat Commun. 2021 04 20; 12(1):2328.
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Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. Commun Biol. 2021 04 14; 4(1):370.
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Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo. Front Immunol. 2021; 12:642198.