Harvard Catalyst Profiles

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Diffuse Cerebral Sclerosis of Schilder

"Diffuse Cerebral Sclerosis of Schilder" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)


This graph shows the total number of publications written about "Diffuse Cerebral Sclerosis of Schilder" by people in Harvard Catalyst Profiles by year, and whether "Diffuse Cerebral Sclerosis of Schilder" was a major or minor topic of these publication.
Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1996 and 1998 and 2008 and 2009 and 2010 and 2011 and 2012 and 2014
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.