Crossing Over, Genetic

"Crossing Over, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.

Descriptor ID

D003434

MeSH Number(s)

G05.355.760.615.200

Concept/Terms

Crossing Over, Genetic

Below are MeSH descriptors whose meaning is more general than "Crossing Over, Genetic".

Below are MeSH descriptors whose meaning is related to "Crossing Over, Genetic".

Below are MeSH descriptors whose meaning is more specific than "Crossing Over, Genetic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Crossing Over, Genetic" by people in Harvard Catalyst Profiles by year, and whether "Crossing Over, Genetic" was a major or minor topic of these publication.

Bar chart showing 59 publications over 26 distinct years, with a maximum of 6 publications in 1992

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1990	0	1	1
1991	2	2	4
1992	0	6	6
1993	0	2	2
1994	3	1	4
1995	0	4	4
1997	1	2	3
1999	0	1	1
2000	0	1	1
2001	0	2	2
2002	1	1	2
2003	0	2	2
2004	1	0	1
2005	1	0	1
2006	0	1	1
2007	1	1	2
2008	1	1	2
2009	2	2	4
2011	1	1	2
2012	0	3	3
2013	1	3	4
2014	1	0	1
2015	1	1	2
2016	1	0	1
2017	1	0	1
2020	1	1	2

Below are the most recent publications written about "Crossing Over, Genetic" by people in Profiles.

Bell AD, Mello CJ, Nemesh J, Brumbaugh SA, Wysoker A, McCarroll SA. Insights into variation in meiosis from 31,228 human sperm genomes. Nature. 2020 07; 583(7815):259-264.

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Cuenca L, Shin N, Lascarez-Lagunas LI, Martinez-Garcia M, Nadarajan S, Karthikraj R, Kannan K, Colaiácovo MP. Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans. PLoS Genet. 2020 01; 16(1):e1008529.

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Hartmann M, Kohl KP, Sekelsky J, Hatkevich T. Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination. Genetics. 2019 06; 212(2):461-468.

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Gao J, Colaiácovo MP. Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics. Trends Genet. 2018 03; 34(3):232-245.

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Nadarajan S, Mohideen F, Tzur YB, Ferrandiz N, Crawley O, Montoya A, Faull P, Snijders AP, Cutillas PR, Jambhekar A, Blower MD, Martinez-Perez E, Harper JW, Colaiacovo MP. The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Elife. 2016 Feb 27; 5:e12039.

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Duyzend MH, Nuttle X, Coe BP, Baker C, Nickerson DA, Bernier R, Eichler EE. Maternal Modifiers and Parent-of-Origin Bias of the Autism-Associated 16p11.2 CNV. Am J Hum Genet. 2016 Jan 07; 98(1):45-57.

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Vincenten N, Kuhl LM, Lam I, Oke A, Kerr AR, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL. The kinetochore prevents centromere-proximal crossover recombination during meiosis. Elife. 2015 Dec 14; 4.

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Seplyarskiy VB, Logacheva MD, Penin AA, Baranova MA, Leushkin EV, Demidenko NV, Klepikova AV, Kondrashov FA, Kondrashov AS, James TY. Crossing-over in a hypervariable species preferentially occurs in regions of high local similarity. Mol Biol Evol. 2014 Nov; 31(11):3016-25.

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Zhang L, Wang S, Yin S, Hong S, Kim KP, Kleckner N. Topoisomerase II mediates meiotic crossover interference. Nature. 2014 Jul 31; 511(7511):551-6.

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Checchi PM, Lawrence KS, Van MV, Larson BJ, Engebrecht J. Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males. Genetics. 2014 Jun; 197(2):543-60.

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