Synaptonemal Complex

"Synaptonemal Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The three-part structure of ribbon-like proteinaceous material that serves to align and join the paired homologous CHROMOSOMES. It is formed during the ZYGOTENE STAGE of the first meiotic division. It is a prerequisite for CROSSING OVER.

Descriptor ID

D013573

MeSH Number(s)

A11.284.430.106.279.345.190.160.830

G04.299.134.220.220.687.444.299.500

G04.299.134.220.220.875.500.299.500

G05.355.105.220.687.500.299.500

G05.355.105.220.875.500.299.500

G05.360.160.830

Concept/Terms

Synaptonemal Complex

Below are MeSH descriptors whose meaning is more general than "Synaptonemal Complex".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Intracellular Space [A11.284.430]
Cell Nucleus [A11.284.430.106]
Cell Nucleus Structures [A11.284.430.106.279]
Intranuclear Space [A11.284.430.106.279.345]
Chromosomes [A11.284.430.106.279.345.190]
Chromosome Structures [A11.284.430.106.279.345.190.160]
Synaptonemal Complex [A11.284.430.106.279.345.190.160.830]
Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Physiological Processes [G04.299]
Cell Cycle [G04.299.134]
Cell Division [G04.299.134.220]
Cell Nucleus Division [G04.299.134.220.220]
Meiosis [G04.299.134.220.220.687]
Meiotic Prophase I [G04.299.134.220.220.687.444]
Chromosome Pairing [G04.299.134.220.220.687.444.299]
Synaptonemal Complex [G04.299.134.220.220.687.444.299.500]
Prophase [G04.299.134.220.220.875]
Meiotic Prophase I [G04.299.134.220.220.875.500]
Chromosome Pairing [G04.299.134.220.220.875.500.299]
Synaptonemal Complex [G04.299.134.220.220.875.500.299.500]
Genetic Phenomena [G05]
Genetic Processes [G05.355]
Cell Division [G05.355.105]
Cell Nucleus Division [G05.355.105.220]
Meiosis [G05.355.105.220.687]
Meiotic Prophase I [G05.355.105.220.687.500]
Chromosome Pairing [G05.355.105.220.687.500.299]
Synaptonemal Complex [G05.355.105.220.687.500.299.500]
Prophase [G05.355.105.220.875]
Meiotic Prophase I [G05.355.105.220.875.500]
Chromosome Pairing [G05.355.105.220.875.500.299]
Synaptonemal Complex [G05.355.105.220.875.500.299.500]
Genetic Structures [G05.360]
Chromosome Structures [G05.360.160]
Synaptonemal Complex [G05.360.160.830]

Below are MeSH descriptors whose meaning is related to "Synaptonemal Complex".

Below are MeSH descriptors whose meaning is more specific than "Synaptonemal Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Synaptonemal Complex" by people in Harvard Catalyst Profiles by year, and whether "Synaptonemal Complex" was a major or minor topic of these publication.

Bar chart showing 22 publications over 17 distinct years, with a maximum of 3 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	1	1
2003	1	0	1
2005	1	0	1
2006	2	0	2
2007	1	1	2
2008	1	0	1
2009	1	0	1
2010	0	1	1
2011	1	0	1
2012	0	2	2
2013	1	0	1
2014	0	1	1
2016	3	0	3
2017	1	0	1
2018	1	0	1
2024	0	1	1

Below are the most recent publications written about "Synaptonemal Complex" by people in Profiles.

Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes. Nat Commun. 2024 Apr 05; 15(1):2941.

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Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing. PLoS Genet. 2019 10; 15(10):e1008412.

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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. PLoS Genet. 2018 11; 14(11):e1007701.

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A ZIP1 separation-of-function allele reveals that centromere pairing drives meiotic segregation of achiasmate chromosomes in budding yeast. PLoS Genet. 2018 08; 14(8):e1007513.

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Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics. Trends Genet. 2018 03; 34(3):232-245.

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Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae. Genetics. 2017 02; 205(2):657-671.

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N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 11 01; 30(21):2404-2416.

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Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat Cell Biol. 2016 Nov; 18(11):1208-1220.

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The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Elife. 2016 Feb 27; 5:e12039.

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Centromere pairing--tethering partner chromosomes in meiosis I. FEBS J. 2015 Jul; 282(13):2458-70.

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