Chromatin Immunoprecipitation

"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

Descriptor ID

D047369

MeSH Number(s)

E05.393.170

E05.478.605.160

Concept/Terms

Chromatin Immunoprecipitation

Below are MeSH descriptors whose meaning is more general than "Chromatin Immunoprecipitation".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Chromatin Immunoprecipitation [E05.393.170]
Immunologic Techniques [E05.478]
Immunoprecipitation [E05.478.605]
Chromatin Immunoprecipitation [E05.478.605.160]

Below are MeSH descriptors whose meaning is related to "Chromatin Immunoprecipitation".

Below are MeSH descriptors whose meaning is more specific than "Chromatin Immunoprecipitation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in Harvard Catalyst Profiles by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publication.

Bar chart showing 619 publications over 18 distinct years, with a maximum of 79 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	2	8	10
2005	5	30	35
2006	5	23	28
2007	2	25	27
2008	6	31	37
2009	4	41	45
2010	3	47	50
2011	6	73	79
2012	5	54	59
2013	4	50	54
2014	3	49	52
2015	3	42	45
2016	6	32	38
2017	3	27	30
2018	2	13	15
2019	2	8	10
2020	0	4	4

Below are the most recent publications written about "Chromatin Immunoprecipitation" by people in Profiles.

p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23663-23673.

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HNF1a controls glucagon secretion in pancreatic a-cells through modulation of SGLT1. Biochim Biophys Acta Mol Basis Dis. 2020 11 01; 1866(11):165898.

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IDR2D identifies reproducible genomic interactions. Nucleic Acids Res. 2020 04 06; 48(6):e31.

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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells. Mol Cell. 2020 05 07; 78(3):459-476.e13.

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A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 10 28; 10(1):4907.

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Loss of RNA Chaperone Hfq Unveils a Toxic Pathway in Pseudomonas aeruginosa. J Bacteriol. 2019 10 15; 201(20).

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Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. Cell Stem Cell. 2019 11 07; 25(5):682-696.e8.

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RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B Lymphocytes. J Virol. 2019 07 01; 93(13).

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The Transcription Factor Deaf1 Modulates Engrailed-1 Expression to Regulate Skin Appendage Fate. J Invest Dermatol. 2019 11; 139(11):2378-2381.e4.

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Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathol. 2019 08; 138(2):295-308.

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