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profileChromatin Immunoprecipitation

"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.


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This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in Harvard Catalyst Profiles by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publication.
Bar chart showing 606 publications over 15 distinct years, with a maximum of 85 publications in 2011
To see the data from this visualization as text, click here.