Harvard Catalyst Profiles

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Chromatin Immunoprecipitation

"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.


This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in Harvard Catalyst Profiles by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publication.
Bar chart showing 610 publications over 18 distinct years, with a maximum of 78 publications in 2011
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.