Harvard Catalyst Profiles

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Antidepressive Agents, Tricyclic

"Antidepressive Agents, Tricyclic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.


This graph shows the total number of publications written about "Antidepressive Agents, Tricyclic" by people in Harvard Catalyst Profiles by year, and whether "Antidepressive Agents, Tricyclic" was a major or minor topic of these publication.
Bar chart showing 228 publications over 30 distinct years, with a maximum of 17 publications in 2003
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.