Antidepressive Agents, Tricyclic

"Antidepressive Agents, Tricyclic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Descriptor ID

D000929

MeSH Number(s)

D27.505.954.427.700.122.055

Concept/Terms

Antidepressive Agents, Tricyclic

Below are MeSH descriptors whose meaning is more general than "Antidepressive Agents, Tricyclic".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Therapeutic Uses [D27.505.954]
Central Nervous System Agents [D27.505.954.427]
Psychotropic Drugs [D27.505.954.427.700]
Antidepressive Agents [D27.505.954.427.700.122]
Antidepressive Agents, Tricyclic [D27.505.954.427.700.122.055]

Below are MeSH descriptors whose meaning is related to "Antidepressive Agents, Tricyclic".

Below are MeSH descriptors whose meaning is more specific than "Antidepressive Agents, Tricyclic".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Antidepressive Agents, Tricyclic" by people in Harvard Catalyst Profiles by year, and whether "Antidepressive Agents, Tricyclic" was a major or minor topic of these publication.

Bar chart showing 225 publications over 30 distinct years, with a maximum of 17 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1990	2	4	6
1991	2	2	4
1992	0	1	1
1993	2	2	4
1994	3	4	7
1995	5	4	9
1996	4	3	7
1997	6	1	7
1998	9	6	15
1999	4	5	9
2000	5	8	13
2001	7	4	11
2002	5	6	11
2003	12	5	17
2004	6	2	8
2005	5	6	11
2006	3	4	7
2007	9	4	13
2008	5	3	8
2009	6	1	7
2010	1	6	7
2011	0	4	4
2012	2	2	4
2013	1	2	3
2014	4	5	9
2015	4	3	7
2016	5	1	6
2017	3	3	6
2018	2	0	2
2019	0	2	2

Below are the most recent publications written about "Antidepressive Agents, Tricyclic" by people in Profiles.

Glymour MM, Gibbons LE, Gilsanz P, Gross AL, Mez J, Brewster PW, Marden J, Zahodne LB, Nho K, Hamilton J, Li G, Larson EB, Crane PK. Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding. Ann Epidemiol. 2019 07; 35:42-47.e1.

View in: PubMed
Hashash JG, Vachon A, Ramos Rivers C, Regueiro MD, Binion DG, Altman L, Williams C, Szigethy E. Predictors of Suicidal Ideation Among IBD Outpatients. J Clin Gastroenterol. 2019 01; 53(1):e41-e45.

View in: PubMed
Goldstein JN, Dudzinski DM, Erickson TB, Linder G. Case 12-2018: A 30-Year-Old Woman with Cardiac Arrest. N Engl J Med. 2018 Apr 19; 378(16):1538-1549.

View in: PubMed
Chen JY, Ren Y, Yan P, Belina ME, Chung RT, Butt AA. Tricyclic antidepressant use and the risk of fibrosis progression in hepatitis C-infected persons: Results from ERCHIVES. J Viral Hepat. 2018 07; 25(7):825-833.

View in: PubMed
Lubna NJ, Wada T, Nakamura Y, Chiba K, Cao X, Izumi-Nakaseko H, Ando K, Naito AT, Satoh Y, Sugiyama A. Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. Cardiovasc Toxicol. 2018 02; 18(1):91-98.

View in: PubMed
Undurraga J, Baldessarini RJ. Tricyclic and selective serotonin-reuptake-inhibitor antidepressants compared with placebo in randomized trials for acute major depression. J Psychopharmacol. 2017 12; 31(12):1624-1625.

View in: PubMed
Chen CH, Huang TH, Elzoghby AO, Wang PW, Chang CW, Fang JY. Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification. Int J Nanomedicine. 2017; 12:8071-8083.

View in: PubMed
Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL. Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form. Neurobiol Dis. 2017 Oct; 106:191-204.

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Zar-Kessler CAM, Belkind-Gerson J, Bender S, Kuo BM. Treatment of Functional Abdominal Pain With Antidepressants: Benefits, Adverse Effects, and the Gastroenterologist's Role. J Pediatr Gastroenterol Nutr. 2017 07; 65(1):16-21.

View in: PubMed
Undurraga J, Baldessarini RJ. Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-to-head trials in acute major depression: Systematic review and meta-analysis. J Psychopharmacol. 2017 09; 31(9):1184-1189.

View in: PubMed

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