1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
This graph shows the total number of publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in Harvard Catalyst Profiles by year, and whether "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 2 | 3 |
1996 | 0 | 1 | 1 |
1997 | 0 | 2 | 2 |
1998 | 1 | 1 | 2 |
1999 | 0 | 1 | 1 |
2000 | 1 | 2 | 3 |
2001 | 2 | 2 | 4 |
2002 | 2 | 0 | 2 |
2003 | 1 | 4 | 5 |
2004 | 0 | 2 | 2 |
2007 | 0 | 2 | 2 |
2008 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2010 | 1 | 3 | 4 |
2011 | 0 | 2 | 2 |
2012 | 1 | 0 | 1 |
2014 | 0 | 1 | 1 |
2015 | 0 | 2 | 2 |
2017 | 1 | 1 | 2 |
2019 | 0 | 1 | 1 |
Below are the most recent publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in Profiles.
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A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice. Brain Behav Immun. 2020 07; 87:429-443.
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The Neuroprotective Role of the GM1 Oligosaccharide, II3Neu5Ac-Gg4, in Neuroblastoma Cells. Mol Neurobiol. 2019 Oct; 56(10):6673-6702.
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TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model. Brain Behav Immun. 2019 02; 76:236-247.
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2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease. Mol Neurobiol. 2018 Dec; 55(12):9251-9266.
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N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice. Mol Neurobiol. 2018 Nov; 55(11):8455-8472.
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Effect of dental pulp stem cells in MPTP-induced old-aged mice model. Eur J Clin Invest. 2017 Jun; 47(6):403-414.
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The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017 03; 15(3):e2000374.
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Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease. Cell Death Dis. 2017 02 09; 8(2):e2611.
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The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival. Ann Neurol. 2017 Mar; 81(3):395-406.
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Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys. Elife. 2016 08 23; 5.