"Caffeine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
MeSH Number(s)
D03.132.960.175
D03.438.759.758.824.175
Concept/Terms
Dexitac- Dexitac
- Republic Drug Brand of Caffeine
Vivarin- Vivarin
- GlaxoSmithKline Brand of Caffeine
Quick-Pep- Quick-Pep
- Thompson Brand 2 of Caffeine
No Doz- No Doz
- Bristol-Myers Squibb Brand of Caffeine
Below are MeSH descriptors whose meaning is more general than "Caffeine".
Below are MeSH descriptors whose meaning is more specific than "Caffeine".
This graph shows the total number of publications written about "Caffeine" by people in Harvard Catalyst Profiles by year, and whether "Caffeine" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 2 | 3 | 5 |
1995 | 2 | 1 | 3 |
1996 | 3 | 6 | 9 |
1997 | 5 | 1 | 6 |
1998 | 3 | 3 | 6 |
1999 | 1 | 4 | 5 |
2000 | 2 | 8 | 10 |
2001 | 4 | 4 | 8 |
2002 | 6 | 6 | 12 |
2003 | 6 | 13 | 19 |
2004 | 9 | 6 | 15 |
2005 | 8 | 4 | 12 |
2006 | 7 | 7 | 14 |
2007 | 5 | 9 | 14 |
2008 | 12 | 4 | 16 |
2009 | 4 | 5 | 9 |
2010 | 15 | 7 | 22 |
2011 | 9 | 5 | 14 |
2012 | 13 | 5 | 18 |
2013 | 11 | 3 | 14 |
2014 | 9 | 6 | 15 |
2015 | 10 | 4 | 14 |
2016 | 10 | 8 | 18 |
2017 | 11 | 4 | 15 |
2018 | 8 | 3 | 11 |
2019 | 7 | 2 | 9 |
2020 | 12 | 5 | 17 |
2021 | 3 | 4 | 7 |
2022 | 3 | 6 | 9 |
2023 | 3 | 3 | 6 |
2024 | 1 | 1 | 2 |
Below are the most recent publications written about "Caffeine" by people in Profiles.
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Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents. Anesthesiology. 2024 Mar 01; 140(3):610-627.
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Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization. BMC Med. 2024 Feb 20; 22(1):81.
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Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics. 2023 Nov; 15(22):1179-1193.
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Changes in Coffee Intake, Added Sugar and Long-Term Weight Gain - Results from Three Large Prospective US Cohort Studies. Am J Clin Nutr. 2023 12; 118(6):1164-1171.
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Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial. BMJ Open. 2023 05 15; 13(5):e073945.
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Chronotype in college science students is associated with behavioral choices and can fluctuate across a semester. Chronobiol Int. 2023 06 03; 40(6):710-724.
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Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa). BMC Med. 2023 04 03; 21(1):125.
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Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat. Clin Nutr. 2023 04; 42(4):477-485.
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Early-life fecal metabolomics of food allergy. Allergy. 2023 02; 78(2):512-521.
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Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss. Hum Reprod. 2022 09 30; 37(10):2264-2274.